GNB2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	GNB2
Entrez Gene ID	2783
Full Name	G protein subunit beta 2
General protein information	Preferred Names G protein subunit beta 2 Names guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 G protein, beta-2 subunit g protein subunit beta-2 guanine nucleotide binding protein (G protein), beta polypeptide 2 guanine nucleotide-binding protein G(I)/G(S)/G(T) beta subunit 2 signal-transducing guanine nucleotide-binding regulatory protein beta subunit transducin beta chain 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 7 Map Location: 7q22.1
Summary	Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. This gene contains a trinucleotide (CCG) repeat length polymorphism in its 5' UTR. [provided by RefSeq, Jul 2008].
Disorder MIM:	139390

mRNA and Protein(s)

mRNA	Protein	Name
NM_005273.3	NP_005264.2	guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
NM_005273.4	NP_005264.2	guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	gnb2	NP_001013515.1
Homo sapiens (human)	GNB2	NP_005264.2
Pan troglodytes (chimpanzee)	GNB2	XP_001152250.1
Canis lupus familiaris (dog)	GNB2	XP_536861.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP005913	XP_315943.3
Rattus norvegicus (Norway rat)	Gnb2	NP_112299.1
Bos taurus (cattle)	GNB2	NP_001091030.1
Mus musculus (house mouse)	Gnb2	NP_034442.1

Gene Ontology
Bibliography

Related articles in PubMed

A Mutation in the G-Protein Gene
Stallmeyer B, Ku? J, Kotthoff S, Zumhagen S, Vowinkel K, Rinn? S, Matschke LA, Friedrich C, Schulze-Bahr E, Rust S, Seebohm G, Decher N, Schulze-Bahr E
Circulation research120(10)e33-e44(2017 May)

Pathogenic mechanism of recurrent mutations of SCN8A in epileptic encephalopathy.
Wagnon JL, Barker BS, Hounshell JA, Haaxma CA, Shealy A, Moss T, Parikh S, Messer RD, Patel MK, Meisler MH
Annals of clinical and translational neurology3(2)114-23(2016 Feb)

Mutations in G protein ? subunits promote transformation and kinase inhibitor resistance.
Yoda A, Adelmant G, Tamburini J, Chapuy B, Shindoh N, Yoda Y, Weigert O, Kopp N, Wu SC, Kim SS, Liu H, Tivey T, Christie AL, Elpek KG, Card J, Gritsman K, Gotlib J, Deininger MW, Makishima H, Turley SJ, Javidi-Sharifi N, Maciejewski JP, Jaiswal S, Ebert BL, Rodig SJ, Tyner JW, Marto JA, Weinstock DM, Lane AA
Nature medicine21(1)71-5(2015 Jan)

KIF14 negatively regulates Rap1a-Radil signaling during breast cancer progression.
Ahmed SM, Th?riault BL, Uppalapati M, Chiu CW, Gallie BL, Sidhu SS, Angers S
The Journal of cell biology199(6)951-67(2012 Dec)

Identification of cellular proteins interacting with influenza A?virus PB1-F2 protein.
Guan ZH, Zhang ML, Hou PL, Duan M, Cui YM, Wang XR
Acta virologica56(3)199-207(2012)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

A GNB2 gene mutation is associated with familial sinus node and atrioventricular conduction dysfunction.
Title: A Mutation in the G-Protein Gene

GNB1 and GNB2 alterations confer transformed and resistance phenotypes across a range of human tumors and may be targetable with inhibitors of G protein signaling.
Title: Mutations in G protein ? subunits promote transformation and kinase inhibitor resistance.

Results indicate that G protein beta2 (Gbeta2) is required for starvation-induced NF-kappaB activation and constitutive NF-kappaB activity.
Title: Serum starvation activates NF-?B through G protein ?2 subunit-mediated signal.

MIF and GNbeta2 interacted with influenza A H1N1 virus PB1-F2 protein.
Title: Identification of cellular proteins interacting with influenza A?virus PB1-F2 protein.

This protein has been found differentially expressed in the anterior cingulate cortex from patients with schizophrenia
Title: Sex-specific proteome differences in the anterior cingulate cortex of schizophrenia.

The following GNB2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GNB2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu09130	NM_005273.4 Latest version!	Homo sapiens G protein subunit beta 2 (GNB2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
View Old Accession Versions >>
OHu09130	NM_005273.3	Homo sapiens G protein subunit beta 2 (GNB2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GNB2 ( NM_005273.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_005264.2 Homo sapiens G protein subunit beta 2 (GNB2), mRNA.

Price & Availability↑

CloneID	OHu09130
Clone ID Related Accession (Same CDS sequence)	NM_005273.3 , NM_005273.4
Accession Version	NM_005273.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1023bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BM763069.1, AL535249.3, CV569909.1, AK291592.1 and BC012348.1. On Aug 23, 2008 this sequence version replaced NM_005273.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC012348.1, SRR1163655.118055.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1970526 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGTGAGC TGGAGCAACT GAGACAGGAG GCCGAGCAGC TCCGGAACCA GATCCGGGAT 
GCCCGAAAAG CATGTGGGGA CTCAACACTG ACCCAGATCA CAGCTGGGCT GGACCCAGTG 
GGGAGAATCC AGATGAGGAC CCGGAGGACC CTCCGTGGGC ACCTGGCAAA GATCTATGCC 
ATGCACTGGG GGACCGACTC AAGGCTGCTG GTCAGCGCCT CCCAGGATGG GAAGCTCATC 
ATCTGGGACA GCTACACCAC CAACAAGGTC CACGCCATCC CGCTGCGCTC CTCCTGGGTA 
ATGACCTGTG CCTACGCGCC CTCAGGGAAC TTTGTGGCCT GTGGGGGGTT GGACAACATC 
TGCTCCATCT ACAGCCTCAA GACCCGCGAG GGCAACGTCA GGGTCAGCCG GGAGCTGCCT 
GGCCACACTG GGTACCTGTC GTGTTGCCGC TTCCTGGATG ACAACCAAAT CATCACCAGC 
TCTGGGGATA CCACCTGTGC CCTGTGGGAC ATTGAGACAG GCCAGCAGAC AGTGGGTTTT 
GCTGGACACA GTGGGGATGT GATGTCCCTG TCCCTGGCCC CCGATGGCCG CACGTTTGTG 
TCAGGCGCCT GTGATGCCTC TATCAAGCTG TGGGACGTGC GGGATTCCAT GTGCCGACAG 
ACCTTCATCG GCCATGAATC CGACATCAAT GCAGTGGCTT TCTTCCCCAA CGGCTACGCC 
TTCACCACCG GCTCTGACGA CGCCACGTGC CGCCTCTTCG ACCTGCGGGC CGATCAGGAG 
CTCCTCATGT ACTCCCATGA CAACATCATC TGTGGCATCA CCTCTGTTGC CTTCTCGCGC 
AGCGGACGGC TGCTGCTCGC TGGCTACGAC GACTTCAACT GCAACATCTG GGATGCCATG 
AAGGGCGACC GTGCAGGAGT CCTCGCTGGC CACGACAACC GCGTGAGCTG CCTCGGGGTC 
ACCGACGATG GCATGGCTGT GGCCACGGGC TCCTGGGACT CCTTCCTCAA GATCTGGAAC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005264.2
CDS	274..1296
Translation	MSELEQLRQEAEQLRNQIRDARKACGDSTLTQITAGLDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIITSSGDTTCALWDIETGQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFDLRADQELLMYSHDNIICGITSVAFSRSGRLLLAGYDDFNCNIWDAMKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN

Target ORF information:

RefSeq Version	NM_005273.3
Organism	Homo sapiens(human)
Definition	Homo sapiens G protein subunit beta 2 (GNB2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005273.3

ORF Insert Sequence:

ATGAGTGAGC TGGAGCAACT GAGACAGGAG GCCGAGCAGC TCCGGAACCA GATCCGGGAT 
GCCCGAAAAG CATGTGGGGA CTCAACACTG ACCCAGATCA CAGCTGGGCT GGACCCAGTG 
GGGAGAATCC AGATGAGGAC CCGGAGGACC CTCCGTGGGC ACCTGGCAAA GATCTATGCC 
ATGCACTGGG GGACCGACTC AAGGCTGCTG GTCAGCGCCT CCCAGGATGG GAAGCTCATC 
ATCTGGGACA GCTACACCAC CAACAAGGTC CACGCCATCC CGCTGCGCTC CTCCTGGGTA 
ATGACCTGTG CCTACGCGCC CTCAGGGAAC TTTGTGGCCT GTGGGGGGTT GGACAACATC 
TGCTCCATCT ACAGCCTCAA GACCCGCGAG GGCAACGTCA GGGTCAGCCG GGAGCTGCCT 
GGCCACACTG GGTACCTGTC GTGTTGCCGC TTCCTGGATG ACAACCAAAT CATCACCAGC 
TCTGGGGATA CCACCTGTGC CCTGTGGGAC ATTGAGACAG GCCAGCAGAC AGTGGGTTTT 
GCTGGACACA GTGGGGATGT GATGTCCCTG TCCCTGGCCC CCGATGGCCG CACGTTTGTG 
TCAGGCGCCT GTGATGCCTC TATCAAGCTG TGGGACGTGC GGGATTCCAT GTGCCGACAG 
ACCTTCATCG GCCATGAATC CGACATCAAT GCAGTGGCTT TCTTCCCCAA CGGCTACGCC 
TTCACCACCG GCTCTGACGA CGCCACGTGC CGCCTCTTCG ACCTGCGGGC CGATCAGGAG 
CTCCTCATGT ACTCCCATGA CAACATCATC TGTGGCATCA CCTCTGTTGC CTTCTCGCGC 
AGCGGACGGC TGCTGCTCGC TGGCTACGAC GACTTCAACT GCAACATCTG GGATGCCATG 
AAGGGCGACC GTGCAGGAGT CCTCGCTGGC CACGACAACC GCGTGAGCTG CCTCGGGGTC 
ACCGACGATG GCATGGCTGT GGCCACGGGC TCCTGGGACT CCTTCCTCAA GATCTGGAAC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GNB2 ( NM_005273.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_005264.2 Homo sapiens G protein subunit beta 2 (GNB2), mRNA.

Price & Availability↑

CloneID	OHu09130
Clone ID Related Accession (Same CDS sequence)	NM_005273.3 , NM_005273.4
Accession Version	NM_005273.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1023bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BM763069.1, AL535249.3, CV569909.1, AK291592.1 and BC012348.1. On Nov 23, 2018 this sequence version replaced NM_005273.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC012348.1, SRR1163655.99858.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1970526 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000303210.9/ ENSP00000305260.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAGTGAGC TGGAGCAACT GAGACAGGAG GCCGAGCAGC TCCGGAACCA GATCCGGGAT 
GCCCGAAAAG CATGTGGGGA CTCAACACTG ACCCAGATCA CAGCTGGGCT GGACCCAGTG 
GGGAGAATCC AGATGAGGAC CCGGAGGACC CTCCGTGGGC ACCTGGCAAA GATCTATGCC 
ATGCACTGGG GGACCGACTC AAGGCTGCTG GTCAGCGCCT CCCAGGATGG GAAGCTCATC 
ATCTGGGACA GCTACACCAC CAACAAGGTC CACGCCATCC CGCTGCGCTC CTCCTGGGTA 
ATGACCTGTG CCTACGCGCC CTCAGGGAAC TTTGTGGCCT GTGGGGGGTT GGACAACATC 
TGCTCCATCT ACAGCCTCAA GACCCGCGAG GGCAACGTCA GGGTCAGCCG GGAGCTGCCT 
GGCCACACTG GGTACCTGTC GTGTTGCCGC TTCCTGGATG ACAACCAAAT CATCACCAGC 
TCTGGGGATA CCACCTGTGC CCTGTGGGAC ATTGAGACAG GCCAGCAGAC AGTGGGTTTT 
GCTGGACACA GTGGGGATGT GATGTCCCTG TCCCTGGCCC CCGATGGCCG CACGTTTGTG 
TCAGGCGCCT GTGATGCCTC TATCAAGCTG TGGGACGTGC GGGATTCCAT GTGCCGACAG 
ACCTTCATCG GCCATGAATC CGACATCAAT GCAGTGGCTT TCTTCCCCAA CGGCTACGCC 
TTCACCACCG GCTCTGACGA CGCCACGTGC CGCCTCTTCG ACCTGCGGGC CGATCAGGAG 
CTCCTCATGT ACTCCCATGA CAACATCATC TGTGGCATCA CCTCTGTTGC CTTCTCGCGC 
AGCGGACGGC TGCTGCTCGC TGGCTACGAC GACTTCAACT GCAACATCTG GGATGCCATG 
AAGGGCGACC GTGCAGGAGT CCTCGCTGGC CACGACAACC GCGTGAGCTG CCTCGGGGTC 
ACCGACGATG GCATGGCTGT GGCCACGGGC TCCTGGGACT CCTTCCTCAA GATCTGGAAC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005264.2
CDS	274..1296
Translation	MSELEQLRQEAEQLRNQIRDARKACGDSTLTQITAGLDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIITSSGDTTCALWDIETGQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFDLRADQELLMYSHDNIICGITSVAFSRSGRLLLAGYDDFNCNIWDAMKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN

Target ORF information:

RefSeq Version	NM_005273.4
Organism	Homo sapiens(human)
Definition	Homo sapiens G protein subunit beta 2 (GNB2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005273.4

ORF Insert Sequence:

ATGAGTGAGC TGGAGCAACT GAGACAGGAG GCCGAGCAGC TCCGGAACCA GATCCGGGAT 
GCCCGAAAAG CATGTGGGGA CTCAACACTG ACCCAGATCA CAGCTGGGCT GGACCCAGTG 
GGGAGAATCC AGATGAGGAC CCGGAGGACC CTCCGTGGGC ACCTGGCAAA GATCTATGCC 
ATGCACTGGG GGACCGACTC AAGGCTGCTG GTCAGCGCCT CCCAGGATGG GAAGCTCATC 
ATCTGGGACA GCTACACCAC CAACAAGGTC CACGCCATCC CGCTGCGCTC CTCCTGGGTA 
ATGACCTGTG CCTACGCGCC CTCAGGGAAC TTTGTGGCCT GTGGGGGGTT GGACAACATC 
TGCTCCATCT ACAGCCTCAA GACCCGCGAG GGCAACGTCA GGGTCAGCCG GGAGCTGCCT 
GGCCACACTG GGTACCTGTC GTGTTGCCGC TTCCTGGATG ACAACCAAAT CATCACCAGC 
TCTGGGGATA CCACCTGTGC CCTGTGGGAC ATTGAGACAG GCCAGCAGAC AGTGGGTTTT 
GCTGGACACA GTGGGGATGT GATGTCCCTG TCCCTGGCCC CCGATGGCCG CACGTTTGTG 
TCAGGCGCCT GTGATGCCTC TATCAAGCTG TGGGACGTGC GGGATTCCAT GTGCCGACAG 
ACCTTCATCG GCCATGAATC CGACATCAAT GCAGTGGCTT TCTTCCCCAA CGGCTACGCC 
TTCACCACCG GCTCTGACGA CGCCACGTGC CGCCTCTTCG ACCTGCGGGC CGATCAGGAG 
CTCCTCATGT ACTCCCATGA CAACATCATC TGTGGCATCA CCTCTGTTGC CTTCTCGCGC 
AGCGGACGGC TGCTGCTCGC TGGCTACGAC GACTTCAACT GCAACATCTG GGATGCCATG 
AAGGGCGACC GTGCAGGAGT CCTCGCTGGC CACGACAACC GCGTGAGCTG CCTCGGGGTC 
ACCGACGATG GCATGGCTGT GGCCACGGGC TCCTGGGACT CCTTCCTCAA GATCTGGAAC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A Mutation in the G-Protein Gene
Circulation research120(10)e33-e44(2017 May)
Stallmeyer B,Ku? J,Kotthoff S,Zumhagen S,Vowinkel K,Rinn? S,Matschke LA,Friedrich C,Schulze-Bahr E,Rust S,Seebohm G,Decher N,Schulze-Bahr E

Pathogenic mechanism of recurrent mutations of SCN8A in epileptic encephalopathy.
Annals of clinical and translational neurology3(2)114-23(2016 Feb)
Wagnon JL,Barker BS,Hounshell JA,Haaxma CA,Shealy A,Moss T,Parikh S,Messer RD,Patel MK,Meisler MH

Mutations in G protein ? subunits promote transformation and kinase inhibitor resistance.
Nature medicine21(1)71-5(2015 Jan)
Yoda A,Adelmant G,Tamburini J,Chapuy B,Shindoh N,Yoda Y,Weigert O,Kopp N,Wu SC,Kim SS,Liu H,Tivey T,Christie AL,Elpek KG,Card J,Gritsman K,Gotlib J,Deininger MW,Makishima H,Turley SJ,Javidi-Sharifi N,Maciejewski JP,Jaiswal S,Ebert BL,Rodig SJ,Tyner JW,Marto JA,Weinstock DM,Lane AA

KIF14 negatively regulates Rap1a-Radil signaling during breast cancer progression.
The Journal of cell biology199(6)951-67(2012 Dec)
Ahmed SM,Th?riault BL,Uppalapati M,Chiu CW,Gallie BL,Sidhu SS,Angers S

Identification of cellular proteins interacting with influenza A?virus PB1-F2 protein.
Acta virologica56(3)199-207(2012)
Guan ZH,Zhang ML,Hou PL,Duan M,Cui YM,Wang XR

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GNB2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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