gRNAs
The following Lyn gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Lyn cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | ORa00884 | |
| Clone ID Related Accession (Same CDS sequence) | NM_001111098.1 | |
| Accession Version | NM_001111098.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1476bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-06-06 | |
| Organism | Rattus norvegicus(Norway rat) | |
| Product | tyrosine-protein kinase Lyn isoform B | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AF000301.1 and AABR07047038.1. Transcript Variant: This variant (2) uses an alternate splice site in the 5' coding region, compared to variant 1, resulting in a shorter protein (isoform B). Sequence Note: This RefSeq record was created from transcript and genomic sequence data because transcript sequence consistent with the reference genome assembly was not available for all regions of the RefSeq transcript. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF000301.1, AF000302.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## | |
1 | ATGGGATGTA TTAAATCAAA AAGGAAAGAC AATCTGAATG ACGATGGAGT AGATATGAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001104568.1 |
| CDS | 231..1706 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_001111098.1 |
1 | ATGGGATGTA TTAAATCAAA AAGGAAAGAC AATCTGAATG ACGATGGAGT AGATATGAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | ORa07212 | |
| Clone ID Related Accession (Same CDS sequence) | XM_006237834.3 , NM_030857.2 | |
| Accession Version | NM_030857.2 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1539bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-12-25 | |
| Organism | Rattus norvegicus(Norway rat) | |
| Product | tyrosine-protein kinase Lyn isoform A | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AF000301.1, AF000300.1 and AABR07047038.1. On Dec 11, 2007 this sequence version replaced NM_030857.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (A). Sequence Note: This RefSeq record was created from transcript and genomic sequence data because transcript sequence consistent with the reference genome assembly was not available for all regions of the RefSeq transcript. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: L14951.1, AF000300.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## | |
1 | ATGGGATGTA TTAAATCAAA AAGGAAAGAC AATCTGAATG ACGATGGAGT AGATATGAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_110484.1 |
| CDS | 231..1769 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_030857.2 |
1 | ATGGGATGTA TTAAATCAAA AAGGAAAGAC AATCTGAATG ACGATGGAGT AGATATGAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | ORa07212 | |
| Clone ID Related Accession (Same CDS sequence) | XM_006237834.3 , NM_030857.2 | |
| Accession Version | XM_006237834.3 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1539bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2016-07-25 | |
| Organism | Rattus norvegicus(Norway rat) | |
| Product | tyrosine-protein kinase Lyn isoform X1 | |
| Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005104.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006237834.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGGGATGTA TTAAATCAAA AAGGAAAGAC AATCTGAATG ACGATGGAGT AGATATGAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_006237896.1 |
| CDS | 546..2084 |
| Translation |
Target ORF information:
Target ORF information:
|
XM_006237834.3 |
1 | ATGGGATGTA TTAAATCAAA AAGGAAAGAC AATCTGAATG ACGATGGAGT AGATATGAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Ligand-dependent activation of EphA4 signaling regulates the proteolysis of amyloid precursor protein through a Lyn-mediated pathway. |
Regulation of the tyrosine phosphorylation of Phospholipid Scramblase 1 in mast cells that are stimulated through the high-affinity IgE receptor. |
FCRL5 exerts binary and compartment-specific influence on innate-like B-cell receptor signaling. |
The Lyn kinase C-lobe mediates Golgi export of Lyn through conformation-dependent ACSL3 association. |
Activation of murine macrophages via TLR2 and TLR4 is negatively regulated by a Lyn/PI3K module and promoted by SHIP1. |
