Kcnmb4 cDNA ORF clone, Rattus norvegicus(Norway rat)

Impairment of brain mitochondrial charybdotoxin- and ATP-insensitive BK channel activities in diabetes.
Noursadeghi E, Jafari A, Saghiri R, Sauve R, Eliassi A
Neuromolecular medicine16(4)862-71(2014 Dec)

An endoplasmic reticulum trafficking signal regulates surface expression of ?4 subunit of a voltage- and Ca??-activated K? channel.
Cox N, Toro B, Pacheco-Otalora LF, Garrido-Sanabria ER, Zarei MM
Brain research155312-23(2014 Mar)

Modulation by the BK accessory ?4 subunit of phosphorylation-dependent changes in excitability of dentate gyrus granule neurons.
Petrik D, Wang B, Brenner R
The European journal of neuroscience34(5)695-704(2011 Sep)

Expression of the voltage- and Ca2+-dependent BK potassium channel subunits BK?1 and BK?4 in rodent astrocytes.
Seidel KN, Derst C, Salzmann M, H?ltje M, Priller J, Markgraf R, Heinemann SH, Heilmann H, Skatchkov SN, Eaton MJ, Veh RW, Pr?ss H
Glia59(6)893-902(2011 Jun)

Compartmentalized beta subunit distribution determines characteristics and ethanol sensitivity of somatic, dendritic, and terminal large-conductance calcium-activated potassium channels in the rat central nervous system.
Wynne PM, Puig SI, Martin GE, Treistman SN
The Journal of pharmacology and experimental therapeutics329(3)978-86(2009 Jun)

The results demonstrate a modification in the mitochondrial BKCa channel gating properties in membrane preparations coming from a streptozotocin model of diabetic rats, an effect potentially linked to a change in BKCa beta4 and alpha subunits expression.
Title: Impairment of brain mitochondrial charybdotoxin- and ATP-insensitive BK channel activities in diabetes.

Study shows that beta4 subunit of the MaxiK channel has no potential endocytic signal and 2 specific amino acids in the functional basic motif retention/retrieval trafficking signal at the C-terminus may play a role in controlling cellular excitability
Title: An endoplasmic reticulum trafficking signal regulates surface expression of ?4 subunit of a voltage- and Ca??-activated K? channel.

These results suggest that fast-gating, type I BK channels lacking beta4 can increase neuronal excitability in response to reduced phosphatase activity and activation of calcium channels.
Title: Modulation by the BK accessory ?4 subunit of phosphorylation-dependent changes in excitability of dentate gyrus granule neurons.

BKbeta4 expression in astrocytes likely participates in regulating astrocytic voltage gradients and maintaining poassium homeostasis, hence enabling astrocytes to fulfill their complex regulatory influence on proper brain function.
Title: Expression of the voltage- and Ca2+-dependent BK potassium channel subunits BK?1 and BK?4 in rodent astrocytes.

There is a selective distribution of auxiliary beta1 subunits to the somatic and dendritic compartments and beta4 subunits to the terminal compartment of neurons in the hypothalamic-neurohypophysial system.
Title: Compartmentalized beta subunit distribution determines characteristics and ethanol sensitivity of somatic, dendritic, and terminal large-conductance calcium-activated potassium channels in the rat central nervous system.