Icos cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Icos
Entrez Gene ID	64545
Full Name	inducible T-cell co-stimulator
Synonyms	Ailim
General protein information	Preferred Names inducible T-cell co-stimulator Names inducible T-cell costimulator activation-inducible lymphocyte immunomediatory molecule
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 9 Map Location: 9q32
Summary	activation-inducible lymphocyte immunomediatory molecule; involved in the immune response in CD45RA-positive B-cells [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_008767136.2	XP_008765358.1	inducible T-cell costimulator isoform X1
XM_017596625.1	XP_017452114.1	inducible T-cell costimulator isoform X1
XM_006245037.3	XP_006245099.1	inducible T-cell costimulator isoform X1
XM_006245038.3	XP_006245100.1	inducible T-cell costimulator isoform X2
NM_022610.1	NP_072132.1	inducible T-cell costimulator precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	ICOS	NP_036224.1
	ICOS	XP_001104581.1
Canis lupus familiaris (dog)	ICOS	NP_001002972.1
Rattus norvegicus (Norway rat)	Icos	NP_072132.1
Pan troglodytes (chimpanzee)	ICOS	XP_001173460.1
Bos taurus (cattle)	ICOS	NP_001029447.1
Mus musculus (house mouse)	Icos	NP_059508.2

Gene Ontology
Bibliography

Related articles in PubMed

Effect of siRNA silencing of inducible co-stimulatory molecule on myocardial cell hypertrophy after cardiac infarction in rats.
Wang WM, Liu Z, Chen G
Genetics and molecular research : GMR15(2)(2016 May)

Effect of Inducible Co-Stimulatory Molecule siRNA in Cerebral Infarction Rat Models.
Luo Y, Yang Y, Zhang H, Zhang T, Wang Y, Tan S, Xu Y, Li D, Ye L, Chen P
Medical science monitor : international medical journal of experimental and clinical research213003-7(2015 Oct)

Increased production of interleukin-17 over interleukin-10 by treg cells implicates inducible costimulator molecule in experimental spondyloarthritis.
Araujo LM, Fert I, Jouhault Q, Labroqu?re K, Andrieu M, Chiocchia G, Breban M
Arthritis & rheumatology (Hoboken, N.J.)66(9)2412-22(2014 Sep)

Roquin paralogs 1 and 2 redundantly repress the Icos and Ox40 costimulator mRNAs and control follicular helper T cell differentiation.
Vogel KU, Edelmann SL, Jeltsch KM, Bertossi A, Heger K, Heinz GA, Z?ller J, Warth SC, Hoefig KP, Lohs C, Neff F, Kremmer E, Schick J, Repsilber D, Geerlof A, Blum H, Wurst W, Heikenw?lder M, Schmidt-Supprian M, Heissmeyer V
Immunity38(4)655-68(2013 Apr)

The shared CTLA4-ICOS risk locus in celiac disease, IgA deficiency and common variable immunodeficiency.
Haimila K, Einarsdottir E, de Kauwe A, Koskinen LL, Pan-Hammarstr?m Q, Kaartinen T, Kurppa K, Ziberna F, Not T, Vatta S, Ventura A, Korponay-Szabo IR, Ad?ny R, Pocsai Z, Sz?les G, Dukes E, Kaukinen K, M?ki M, Koskinen S, Partanen J, Hammarstr?m L, Saavalainen P
Genes and immunity10(2)151-61(2009 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

ICOS-targeted siRNA can effectively silence gene expression of ICOS, and provided satisfactory treatment efficacy for myocardial cell hypertrophy after infarction.
Title: Effect of siRNA silencing of inducible co-stimulatory molecule on myocardial cell hypertrophy after cardiac infarction in rats.

ICOS siRNA can protect brain tissues from ischemia injuries after cerebral infarction, improve limb movement and coordination, lower the mortality rate of rats, and inhibit T cell-induced cytokines
Title: Effect of Inducible Co-Stimulatory Molecule siRNA in Cerebral Infarction Rat Models.

our data highlight a key role for ICOS signaling in the generation of imbalanced production of IL-10 and IL-17 by Treg cells in a rat model of spondyloarthritis.
Title: Increased production of interleukin-17 over interleukin-10 by treg cells implicates inducible costimulator molecule in experimental spondyloarthritis.

The following Icos gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Icos cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa06124	NM_022610.1 Latest version!	Rattus norvegicus inducible T-cell co-stimulator (Icos), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
ORa06124	XM_006245038.3 Latest version!	Rattus norvegicus inducible T-cell co-stimulator (Icos), transcript variant X4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
ORa32266	XM_008767136.2 Latest version!	Rattus norvegicus inducible T-cell co-stimulator (Icos), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
ORa32266	XM_006245037.3 Latest version!	Rattus norvegicus inducible T-cell co-stimulator (Icos), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
ORa32266	XM_017596625.1 Latest version!	Rattus norvegicus inducible T-cell co-stimulator (Icos), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Icos ( NM_022610.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_072132.1 Rattus norvegicus inducible T-cell co-stimulator (Icos), mRNA.

Price & Availability↑

CloneID	ORa06124
Clone ID Related Accession (Same CDS sequence)	XM_006245038.3 , NM_022610.1
Accession Version	NM_022610.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 603bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	inducible T-cell costimulator precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB023134.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB023134.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689594, SAMEA2689599 [ECO:0000348] ##Evidence-Data-END##

ATGAAGCCCT ACTTCTCGTG CGTCTTTGTC TTCTGCTTCC TAATCAAACT TTTAACAGGA 
GAACTCAATG ACTTGGCCAA TCACAGGATG TTTTCGTTTC ACGATGGAGG TGTACAGATT 
TCTTGTAACT ACCCTGAGAC TGTCCAGCAG TTAAAAATGC AGTTGTTCAA AGACAGAGAA 
GTCCTCTGCG ACCTCACCAA GACCAAGGGA AGCGGAAACA CCGTGTCCAT CAAGAATCCG 
ATGTCCTGTC CATATCAGCT GTCCAACAAC AGTGTCTCTT TTTTCCTAGA CAACGCAGAC 
AGCTCCCAGG GCAGCTACTT TTTATGCAGC CTGTCGATTT TCGACCCACC CCCTTTTCAA 
GAAAAGAACC TTAGTGGAGG ATATTTGCTT ATTTATGAAT CCCAGCTTTG TTGCCAGCTG 
AAGCTTTGGT TACCCGTAGG GTGTGCAGCT TTTGTGGCAG CGCTCCTTTT TGGATGCATA 
TTTATCGTCT GGTTTGCAAA AAAGAAGTAC AGATCCAGTG TGCACGACCC TAATAGCGAG 
TACATGTTCA TGGCGGCAGT CAACACAAAC AAAAAGTCCA GACTTGCAGG TATGACCTCA 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_072132.1
CDS	35..637
Translation	MKPYFSCVFVFCFLIKLLTGELNDLANHRMFSFHDGGVQISCNYPETVQQLKMQLFKDREVLCDLTKTKGSGNTVSIKNPMSCPYQLSNNSVSFFLDNADSSQGSYFLCSLSIFDPPPFQEKNLSGGYLLIYESQLCCQLKLWLPVGCAAFVAALLFGCIFIVWFAKKKYRSSVHDPNSEYMFMAAVNTNKKSRLAGMTS

Target ORF information:

RefSeq Version	NM_022610.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus inducible T-cell co-stimulator (Icos), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022610.1

ORF Insert Sequence:

ATGAAGCCCT ACTTCTCGTG CGTCTTTGTC TTCTGCTTCC TAATCAAACT TTTAACAGGA 
GAACTCAATG ACTTGGCCAA TCACAGGATG TTTTCGTTTC ACGATGGAGG TGTACAGATT 
TCTTGTAACT ACCCTGAGAC TGTCCAGCAG TTAAAAATGC AGTTGTTCAA AGACAGAGAA 
GTCCTCTGCG ACCTCACCAA GACCAAGGGA AGCGGAAACA CCGTGTCCAT CAAGAATCCG 
ATGTCCTGTC CATATCAGCT GTCCAACAAC AGTGTCTCTT TTTTCCTAGA CAACGCAGAC 
AGCTCCCAGG GCAGCTACTT TTTATGCAGC CTGTCGATTT TCGACCCACC CCCTTTTCAA 
GAAAAGAACC TTAGTGGAGG ATATTTGCTT ATTTATGAAT CCCAGCTTTG TTGCCAGCTG 
AAGCTTTGGT TACCCGTAGG GTGTGCAGCT TTTGTGGCAG CGCTCCTTTT TGGATGCATA 
TTTATCGTCT GGTTTGCAAA AAAGAAGTAC AGATCCAGTG TGCACGACCC TAATAGCGAG 
TACATGTTCA TGGCGGCAGT CAACACAAAC AAAAAGTCCA GACTTGCAGG TATGACCTCA 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Icos ( XM_006245038.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006245100.1 Rattus norvegicus inducible T-cell co-stimulator (Icos), transcript variant X4, mRNA.

Price & Availability↑

CloneID	ORa06124
Clone ID Related Accession (Same CDS sequence)	XM_006245038.3 , NM_022610.1
Accession Version	XM_006245038.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 603bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	inducible T-cell costimulator isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005108.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006245038.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAGCCCT ACTTCTCGTG CGTCTTTGTC TTCTGCTTCC TAATCAAACT TTTAACAGGA 
GAACTCAATG ACTTGGCCAA TCACAGGATG TTTTCGTTTC ACGATGGAGG TGTACAGATT 
TCTTGTAACT ACCCTGAGAC TGTCCAGCAG TTAAAAATGC AGTTGTTCAA AGACAGAGAA 
GTCCTCTGCG ACCTCACCAA GACCAAGGGA AGCGGAAACA CCGTGTCCAT CAAGAATCCG 
ATGTCCTGTC CATATCAGCT GTCCAACAAC AGTGTCTCTT TTTTCCTAGA CAACGCAGAC 
AGCTCCCAGG GCAGCTACTT TTTATGCAGC CTGTCGATTT TCGACCCACC CCCTTTTCAA 
GAAAAGAACC TTAGTGGAGG ATATTTGCTT ATTTATGAAT CCCAGCTTTG TTGCCAGCTG 
AAGCTTTGGT TACCCGTAGG GTGTGCAGCT TTTGTGGCAG CGCTCCTTTT TGGATGCATA 
TTTATCGTCT GGTTTGCAAA AAAGAAGTAC AGATCCAGTG TGCACGACCC TAATAGCGAG 
TACATGTTCA TGGCGGCAGT CAACACAAAC AAAAAGTCCA GACTTGCAGG TATGACCTCA 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006245100.1
CDS	286..888
Translation	MKPYFSCVFVFCFLIKLLTGELNDLANHRMFSFHDGGVQISCNYPETVQQLKMQLFKDREVLCDLTKTKGSGNTVSIKNPMSCPYQLSNNSVSFFLDNADSSQGSYFLCSLSIFDPPPFQEKNLSGGYLLIYESQLCCQLKLWLPVGCAAFVAALLFGCIFIVWFAKKKYRSSVHDPNSEYMFMAAVNTNKKSRLAGMTS

Target ORF information:

RefSeq Version	XM_006245038.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus inducible T-cell co-stimulator (Icos), transcript variant X4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006245038.3

ORF Insert Sequence:

ATGAAGCCCT ACTTCTCGTG CGTCTTTGTC TTCTGCTTCC TAATCAAACT TTTAACAGGA 
GAACTCAATG ACTTGGCCAA TCACAGGATG TTTTCGTTTC ACGATGGAGG TGTACAGATT 
TCTTGTAACT ACCCTGAGAC TGTCCAGCAG TTAAAAATGC AGTTGTTCAA AGACAGAGAA 
GTCCTCTGCG ACCTCACCAA GACCAAGGGA AGCGGAAACA CCGTGTCCAT CAAGAATCCG 
ATGTCCTGTC CATATCAGCT GTCCAACAAC AGTGTCTCTT TTTTCCTAGA CAACGCAGAC 
AGCTCCCAGG GCAGCTACTT TTTATGCAGC CTGTCGATTT TCGACCCACC CCCTTTTCAA 
GAAAAGAACC TTAGTGGAGG ATATTTGCTT ATTTATGAAT CCCAGCTTTG TTGCCAGCTG 
AAGCTTTGGT TACCCGTAGG GTGTGCAGCT TTTGTGGCAG CGCTCCTTTT TGGATGCATA 
TTTATCGTCT GGTTTGCAAA AAAGAAGTAC AGATCCAGTG TGCACGACCC TAATAGCGAG 
TACATGTTCA TGGCGGCAGT CAACACAAAC AAAAAGTCCA GACTTGCAGG TATGACCTCA 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Icos ( XM_008767136.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008765358.1 Rattus norvegicus inducible T-cell co-stimulator (Icos), transcript variant X3, mRNA.

Price & Availability↑

CloneID	ORa32266
Clone ID Related Accession (Same CDS sequence)	XM_008767136.2 , XM_017596625.1 , XM_006245037.3
Accession Version	XM_008767136.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 651bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	inducible T-cell costimulator isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005108.4) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008767136.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAGCCCT ACTTCTCGTG CGTCTTTGTC TTCTGCTTCC TAATCAAACT TTTAACAGGA 
GAACTCAATG ACTTGGCCAA TCACAGGATG TTTTCGTTTC ACGATGGAGG TGTACAGATT 
TCTTGTAACT ACCCTGAGAC TGTCCAGCAG TTAAAAATGC AGTTGTTCAA AGACAGAGAA 
GTCCTCTGCG ACCTCACCAA GACCAAGGGA AGCGGAAACA CCGTGTCCAT CAAGAATCCG 
ATGTCCTGTC CATATCAGCT GTCCAACAAC AGTGTCTCTT TTTTCCTAGA CAACGCAGAC 
AGCTCCCAGG GCAGCTACTT TTTATGCAGC CTGTCGATTT TCGACCCACC CCCTTTTCAA 
GAAAAGAACC TTAGTGGAGG ATATTTGCTT ATTTATGAAT CCCAGCTTTG TTGCCAGCTG 
AAGCTTTGGT TACCCGTAGG GTGTGCAGCT TTTGTGGCAG CGCTCCTTTT TGGATGCATA 
TTTATCGTCT GGTTTGCAAA AAAGAAGTAC AGATCCAGTG TGCACGACCC TAATAGCGAG 
TACATGTTCA TGGCGGCAGT CAACACAAAC AAAAAGTCCA GACTTGCAGG TACAGCACCC 
CTTAGGGCTT TGGGGAGAGG AGAACACTCT TCATGTCAAG ACCGGAATTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008765358.1
CDS	302..952
Translation	MKPYFSCVFVFCFLIKLLTGELNDLANHRMFSFHDGGVQISCNYPETVQQLKMQLFKDREVLCDLTKTKGSGNTVSIKNPMSCPYQLSNNSVSFFLDNADSSQGSYFLCSLSIFDPPPFQEKNLSGGYLLIYESQLCCQLKLWLPVGCAAFVAALLFGCIFIVWFAKKKYRSSVHDPNSEYMFMAAVNTNKKSRLAGTAPLRALGRGEHSSCQDRN

Target ORF information:

RefSeq Version	XM_008767136.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus inducible T-cell co-stimulator (Icos), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008767136.2

ORF Insert Sequence:

ATGAAGCCCT ACTTCTCGTG CGTCTTTGTC TTCTGCTTCC TAATCAAACT TTTAACAGGA 
GAACTCAATG ACTTGGCCAA TCACAGGATG TTTTCGTTTC ACGATGGAGG TGTACAGATT 
TCTTGTAACT ACCCTGAGAC TGTCCAGCAG TTAAAAATGC AGTTGTTCAA AGACAGAGAA 
GTCCTCTGCG ACCTCACCAA GACCAAGGGA AGCGGAAACA CCGTGTCCAT CAAGAATCCG 
ATGTCCTGTC CATATCAGCT GTCCAACAAC AGTGTCTCTT TTTTCCTAGA CAACGCAGAC 
AGCTCCCAGG GCAGCTACTT TTTATGCAGC CTGTCGATTT TCGACCCACC CCCTTTTCAA 
GAAAAGAACC TTAGTGGAGG ATATTTGCTT ATTTATGAAT CCCAGCTTTG TTGCCAGCTG 
AAGCTTTGGT TACCCGTAGG GTGTGCAGCT TTTGTGGCAG CGCTCCTTTT TGGATGCATA 
TTTATCGTCT GGTTTGCAAA AAAGAAGTAC AGATCCAGTG TGCACGACCC TAATAGCGAG 
TACATGTTCA TGGCGGCAGT CAACACAAAC AAAAAGTCCA GACTTGCAGG TACAGCACCC 
CTTAGGGCTT TGGGGAGAGG AGAACACTCT TCATGTCAAG ACCGGAATTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Icos ( XM_017596625.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017452114.1 Rattus norvegicus inducible T-cell co-stimulator (Icos), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa32266
Clone ID Related Accession (Same CDS sequence)	XM_008767136.2 , XM_017596625.1 , XM_006245037.3
Accession Version	XM_017596625.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 651bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	inducible T-cell costimulator isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005108.4) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAGCCCT ACTTCTCGTG CGTCTTTGTC TTCTGCTTCC TAATCAAACT TTTAACAGGA 
GAACTCAATG ACTTGGCCAA TCACAGGATG TTTTCGTTTC ACGATGGAGG TGTACAGATT 
TCTTGTAACT ACCCTGAGAC TGTCCAGCAG TTAAAAATGC AGTTGTTCAA AGACAGAGAA 
GTCCTCTGCG ACCTCACCAA GACCAAGGGA AGCGGAAACA CCGTGTCCAT CAAGAATCCG 
ATGTCCTGTC CATATCAGCT GTCCAACAAC AGTGTCTCTT TTTTCCTAGA CAACGCAGAC 
AGCTCCCAGG GCAGCTACTT TTTATGCAGC CTGTCGATTT TCGACCCACC CCCTTTTCAA 
GAAAAGAACC TTAGTGGAGG ATATTTGCTT ATTTATGAAT CCCAGCTTTG TTGCCAGCTG 
AAGCTTTGGT TACCCGTAGG GTGTGCAGCT TTTGTGGCAG CGCTCCTTTT TGGATGCATA 
TTTATCGTCT GGTTTGCAAA AAAGAAGTAC AGATCCAGTG TGCACGACCC TAATAGCGAG 
TACATGTTCA TGGCGGCAGT CAACACAAAC AAAAAGTCCA GACTTGCAGG TACAGCACCC 
CTTAGGGCTT TGGGGAGAGG AGAACACTCT TCATGTCAAG ACCGGAATTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017452114.1
CDS	264..914
Translation	MKPYFSCVFVFCFLIKLLTGELNDLANHRMFSFHDGGVQISCNYPETVQQLKMQLFKDREVLCDLTKTKGSGNTVSIKNPMSCPYQLSNNSVSFFLDNADSSQGSYFLCSLSIFDPPPFQEKNLSGGYLLIYESQLCCQLKLWLPVGCAAFVAALLFGCIFIVWFAKKKYRSSVHDPNSEYMFMAAVNTNKKSRLAGTAPLRALGRGEHSSCQDRN

Target ORF information:

RefSeq Version	XM_017596625.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus inducible T-cell co-stimulator (Icos), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017596625.1

ORF Insert Sequence:

ATGAAGCCCT ACTTCTCGTG CGTCTTTGTC TTCTGCTTCC TAATCAAACT TTTAACAGGA 
GAACTCAATG ACTTGGCCAA TCACAGGATG TTTTCGTTTC ACGATGGAGG TGTACAGATT 
TCTTGTAACT ACCCTGAGAC TGTCCAGCAG TTAAAAATGC AGTTGTTCAA AGACAGAGAA 
GTCCTCTGCG ACCTCACCAA GACCAAGGGA AGCGGAAACA CCGTGTCCAT CAAGAATCCG 
ATGTCCTGTC CATATCAGCT GTCCAACAAC AGTGTCTCTT TTTTCCTAGA CAACGCAGAC 
AGCTCCCAGG GCAGCTACTT TTTATGCAGC CTGTCGATTT TCGACCCACC CCCTTTTCAA 
GAAAAGAACC TTAGTGGAGG ATATTTGCTT ATTTATGAAT CCCAGCTTTG TTGCCAGCTG 
AAGCTTTGGT TACCCGTAGG GTGTGCAGCT TTTGTGGCAG CGCTCCTTTT TGGATGCATA 
TTTATCGTCT GGTTTGCAAA AAAGAAGTAC AGATCCAGTG TGCACGACCC TAATAGCGAG 
TACATGTTCA TGGCGGCAGT CAACACAAAC AAAAAGTCCA GACTTGCAGG TACAGCACCC 
CTTAGGGCTT TGGGGAGAGG AGAACACTCT TCATGTCAAG ACCGGAATTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Icos ( XM_006245037.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006245099.1 Rattus norvegicus inducible T-cell co-stimulator (Icos), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa32266
Clone ID Related Accession (Same CDS sequence)	XM_008767136.2 , XM_017596625.1 , XM_006245037.3
Accession Version	XM_006245037.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 651bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	inducible T-cell costimulator isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005108.4) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006245037.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAGCCCT ACTTCTCGTG CGTCTTTGTC TTCTGCTTCC TAATCAAACT TTTAACAGGA 
GAACTCAATG ACTTGGCCAA TCACAGGATG TTTTCGTTTC ACGATGGAGG TGTACAGATT 
TCTTGTAACT ACCCTGAGAC TGTCCAGCAG TTAAAAATGC AGTTGTTCAA AGACAGAGAA 
GTCCTCTGCG ACCTCACCAA GACCAAGGGA AGCGGAAACA CCGTGTCCAT CAAGAATCCG 
ATGTCCTGTC CATATCAGCT GTCCAACAAC AGTGTCTCTT TTTTCCTAGA CAACGCAGAC 
AGCTCCCAGG GCAGCTACTT TTTATGCAGC CTGTCGATTT TCGACCCACC CCCTTTTCAA 
GAAAAGAACC TTAGTGGAGG ATATTTGCTT ATTTATGAAT CCCAGCTTTG TTGCCAGCTG 
AAGCTTTGGT TACCCGTAGG GTGTGCAGCT TTTGTGGCAG CGCTCCTTTT TGGATGCATA 
TTTATCGTCT GGTTTGCAAA AAAGAAGTAC AGATCCAGTG TGCACGACCC TAATAGCGAG 
TACATGTTCA TGGCGGCAGT CAACACAAAC AAAAAGTCCA GACTTGCAGG TACAGCACCC 
CTTAGGGCTT TGGGGAGAGG AGAACACTCT TCATGTCAAG ACCGGAATTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006245099.1
CDS	287..937
Translation	MKPYFSCVFVFCFLIKLLTGELNDLANHRMFSFHDGGVQISCNYPETVQQLKMQLFKDREVLCDLTKTKGSGNTVSIKNPMSCPYQLSNNSVSFFLDNADSSQGSYFLCSLSIFDPPPFQEKNLSGGYLLIYESQLCCQLKLWLPVGCAAFVAALLFGCIFIVWFAKKKYRSSVHDPNSEYMFMAAVNTNKKSRLAGTAPLRALGRGEHSSCQDRN

Target ORF information:

RefSeq Version	XM_006245037.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus inducible T-cell co-stimulator (Icos), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006245037.3

ORF Insert Sequence:

ATGAAGCCCT ACTTCTCGTG CGTCTTTGTC TTCTGCTTCC TAATCAAACT TTTAACAGGA 
GAACTCAATG ACTTGGCCAA TCACAGGATG TTTTCGTTTC ACGATGGAGG TGTACAGATT 
TCTTGTAACT ACCCTGAGAC TGTCCAGCAG TTAAAAATGC AGTTGTTCAA AGACAGAGAA 
GTCCTCTGCG ACCTCACCAA GACCAAGGGA AGCGGAAACA CCGTGTCCAT CAAGAATCCG 
ATGTCCTGTC CATATCAGCT GTCCAACAAC AGTGTCTCTT TTTTCCTAGA CAACGCAGAC 
AGCTCCCAGG GCAGCTACTT TTTATGCAGC CTGTCGATTT TCGACCCACC CCCTTTTCAA 
GAAAAGAACC TTAGTGGAGG ATATTTGCTT ATTTATGAAT CCCAGCTTTG TTGCCAGCTG 
AAGCTTTGGT TACCCGTAGG GTGTGCAGCT TTTGTGGCAG CGCTCCTTTT TGGATGCATA 
TTTATCGTCT GGTTTGCAAA AAAGAAGTAC AGATCCAGTG TGCACGACCC TAATAGCGAG 
TACATGTTCA TGGCGGCAGT CAACACAAAC AAAAAGTCCA GACTTGCAGG TACAGCACCC 
CTTAGGGCTT TGGGGAGAGG AGAACACTCT TCATGTCAAG ACCGGAATTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Effect of siRNA silencing of inducible co-stimulatory molecule on myocardial cell hypertrophy after cardiac infarction in rats.
Genetics and molecular research : GMR15(2)(2016 May)
Wang WM,Liu Z,Chen G

Effect of Inducible Co-Stimulatory Molecule siRNA in Cerebral Infarction Rat Models.
Medical science monitor : international medical journal of experimental and clinical research213003-7(2015 Oct)
Luo Y,Yang Y,Zhang H,Zhang T,Wang Y,Tan S,Xu Y,Li D,Ye L,Chen P

Increased production of interleukin-17 over interleukin-10 by treg cells implicates inducible costimulator molecule in experimental spondyloarthritis.
Arthritis & rheumatology (Hoboken, N.J.)66(9)2412-22(2014 Sep)
Araujo LM,Fert I,Jouhault Q,Labroqu?re K,Andrieu M,Chiocchia G,Breban M

Roquin paralogs 1 and 2 redundantly repress the Icos and Ox40 costimulator mRNAs and control follicular helper T cell differentiation.
Immunity38(4)655-68(2013 Apr)
Vogel KU,Edelmann SL,Jeltsch KM,Bertossi A,Heger K,Heinz GA,Z?ller J,Warth SC,Hoefig KP,Lohs C,Neff F,Kremmer E,Schick J,Repsilber D,Geerlof A,Blum H,Wurst W,Heikenw?lder M,Schmidt-Supprian M,Heissmeyer V

The shared CTLA4-ICOS risk locus in celiac disease, IgA deficiency and common variable immunodeficiency.
Genes and immunity10(2)151-61(2009 Mar)
Haimila K,Einarsdottir E,de Kauwe A,Koskinen LL,Pan-Hammarstr?m Q,Kaartinen T,Kurppa K,Ziberna F,Not T,Vatta S,Ventura A,Korponay-Szabo IR,Ad?ny R,Pocsai Z,Sz?les G,Dukes E,Kaukinen K,M?ki M,Koskinen S,Partanen J,Hammarstr?m L,Saavalainen P

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Icos cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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