ICOS cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ICOS
Entrez Gene ID	29851
Full Name	inducible T cell costimulator
Synonyms	AILIM,CD278,CVID1
General protein information	Preferred Names inducible T cell costimulator Names inducible T-cell costimulator activation-inducible lymphocyte immunomediatory molecule inducible T-cell co-stimulator inducible costimulator
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2q33.2
Summary	The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation. [provided by RefSeq, Jul 2008].
Disorder MIM:	604558
Disorder Html:	Immunodeficiency, common variable, 1, 607594 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_012092.4	NP_036224.1	inducible T-cell costimulator precursor
NM_012092.3	NP_036224.1	inducible T-cell costimulator precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	ICOS	NP_036224.1
	ICOS	XP_001104581.1
Canis lupus familiaris (dog)	ICOS	NP_001002972.1
Rattus norvegicus (Norway rat)	Icos	NP_072132.1
Pan troglodytes (chimpanzee)	ICOS	XP_001173460.1
Bos taurus (cattle)	ICOS	NP_001029447.1
Mus musculus (house mouse)	Icos	NP_059508.2

Gene Ontology

The following ICOS gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ICOS cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu18444	NM_012092.4 Latest version!	Homo sapiens inducible T cell costimulator (ICOS), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu18444	NM_012092.3	Homo sapiens inducible T cell costimulator (ICOS), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ICOS ( NM_012092.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_036224.1 Homo sapiens inducible T cell costimulator (ICOS), mRNA.

Price & Availability↑

CloneID	OHu18444
Clone ID Related Accession (Same CDS sequence)	NM_012092.4 , NM_012092.3
Accession Version	NM_012092.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 600bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-04
Organism	Homo sapiens(human)
Product	inducible T-cell costimulator precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff in collaboration with Jouni Valiaho, Mauno Vihinen. The reference sequence was derived from AJ277832.1 and CB528580.1. On Aug 31, 2019 this sequence version replaced NM_012092.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC028210.1, AB023135.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAAGTCAG GCCTCTGGTA TTTCTTTCTC TTCTGCTTGC GCATTAAAGT TTTAACAGGA 
GAAATCAATG GTTCTGCCAA TTATGAGATG TTTATATTTC ACAACGGAGG TGTACAAATT 
TTATGCAAAT ATCCTGACAT TGTCCAGCAA TTTAAAATGC AGTTGCTGAA AGGGGGGCAA 
ATACTCTGCG ATCTCACTAA GACAAAAGGA AGTGGAAACA CAGTGTCCAT TAAGAGTCTG 
AAATTCTGCC ATTCTCAGTT ATCCAACAAC AGTGTCTCTT TTTTTCTATA CAACTTGGAC 
CATTCTCATG CCAACTATTA CTTCTGCAAC CTATCAATTT TTGATCCTCC TCCTTTTAAA 
GTAACTCTTA CAGGAGGATA TTTGCATATT TATGAATCAC AACTTTGTTG CCAGCTGAAG 
TTCTGGTTAC CCATAGGATG TGCAGCCTTT GTTGTAGTCT GCATTTTGGG ATGCATACTT 
ATTTGTTGGC TTACAAAAAA GAAGTATTCA TCCAGTGTGC ACGACCCTAA CGGTGAATAC 
ATGTTCATGA GAGCAGTGAA CACAGCCAAA AAATCTAGAC TCACAGATGT GACCCTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036224.1
CDS	53..652
Translation	MKSGLWYFFLFCLRIKVLTGEINGSANYEMFIFHNGGVQILCKYPDIVQQFKMQLLKGGQILCDLTKTKGSGNTVSIKSLKFCHSQLSNNSVSFFLYNLDHSHANYYFCNLSIFDPPPFKVTLTGGYLHIYESQLCCQLKFWLPIGCAAFVVVCILGCILICWLTKKKYSSSVHDPNGEYMFMRAVNTAKKSRLTDVTL

Target ORF information:

RefSeq Version	NM_012092.4
Organism	Homo sapiens(human)
Definition	Homo sapiens inducible T cell costimulator (ICOS), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012092.4

ORF Insert Sequence:

ATGAAGTCAG GCCTCTGGTA TTTCTTTCTC TTCTGCTTGC GCATTAAAGT TTTAACAGGA 
GAAATCAATG GTTCTGCCAA TTATGAGATG TTTATATTTC ACAACGGAGG TGTACAAATT 
TTATGCAAAT ATCCTGACAT TGTCCAGCAA TTTAAAATGC AGTTGCTGAA AGGGGGGCAA 
ATACTCTGCG ATCTCACTAA GACAAAAGGA AGTGGAAACA CAGTGTCCAT TAAGAGTCTG 
AAATTCTGCC ATTCTCAGTT ATCCAACAAC AGTGTCTCTT TTTTTCTATA CAACTTGGAC 
CATTCTCATG CCAACTATTA CTTCTGCAAC CTATCAATTT TTGATCCTCC TCCTTTTAAA 
GTAACTCTTA CAGGAGGATA TTTGCATATT TATGAATCAC AACTTTGTTG CCAGCTGAAG 
TTCTGGTTAC CCATAGGATG TGCAGCCTTT GTTGTAGTCT GCATTTTGGG ATGCATACTT 
ATTTGTTGGC TTACAAAAAA GAAGTATTCA TCCAGTGTGC ACGACCCTAA CGGTGAATAC 
ATGTTCATGA GAGCAGTGAA CACAGCCAAA AAATCTAGAC TCACAGATGT GACCCTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ICOS ( NM_012092.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_036224.1 Homo sapiens inducible T cell costimulator (ICOS), mRNA.

Price & Availability↑

CloneID	OHu18444
Clone ID Related Accession (Same CDS sequence)	NM_012092.4 , NM_012092.3
Accession Version	NM_012092.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 600bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-06
Organism	Homo sapiens(human)
Product	inducible T-cell costimulator precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff in collaboration with Jouni Valiaho, Mauno Vihinen. The reference sequence was derived from AJ277832.1 and CB528580.1. This sequence is a reference standard in the RefSeqGene project. On Jul 8, 2009 this sequence version replaced NM_012092.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ277832.1, AK314985.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAAGTCAG GCCTCTGGTA TTTCTTTCTC TTCTGCTTGC GCATTAAAGT TTTAACAGGA 
GAAATCAATG GTTCTGCCAA TTATGAGATG TTTATATTTC ACAACGGAGG TGTACAAATT 
TTATGCAAAT ATCCTGACAT TGTCCAGCAA TTTAAAATGC AGTTGCTGAA AGGGGGGCAA 
ATACTCTGCG ATCTCACTAA GACAAAAGGA AGTGGAAACA CAGTGTCCAT TAAGAGTCTG 
AAATTCTGCC ATTCTCAGTT ATCCAACAAC AGTGTCTCTT TTTTTCTATA CAACTTGGAC 
CATTCTCATG CCAACTATTA CTTCTGCAAC CTATCAATTT TTGATCCTCC TCCTTTTAAA 
GTAACTCTTA CAGGAGGATA TTTGCATATT TATGAATCAC AACTTTGTTG CCAGCTGAAG 
TTCTGGTTAC CCATAGGATG TGCAGCCTTT GTTGTAGTCT GCATTTTGGG ATGCATACTT 
ATTTGTTGGC TTACAAAAAA GAAGTATTCA TCCAGTGTGC ACGACCCTAA CGGTGAATAC 
ATGTTCATGA GAGCAGTGAA CACAGCCAAA AAATCTAGAC TCACAGATGT GACCCTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036224.1
CDS	68..667
Translation	MKSGLWYFFLFCLRIKVLTGEINGSANYEMFIFHNGGVQILCKYPDIVQQFKMQLLKGGQILCDLTKTKGSGNTVSIKSLKFCHSQLSNNSVSFFLYNLDHSHANYYFCNLSIFDPPPFKVTLTGGYLHIYESQLCCQLKFWLPIGCAAFVVVCILGCILICWLTKKKYSSSVHDPNGEYMFMRAVNTAKKSRLTDVTL

Target ORF information:

RefSeq Version	NM_012092.3
Organism	Homo sapiens(human)
Definition	Homo sapiens inducible T cell costimulator (ICOS), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012092.3

ORF Insert Sequence:

ATGAAGTCAG GCCTCTGGTA TTTCTTTCTC TTCTGCTTGC GCATTAAAGT TTTAACAGGA 
GAAATCAATG GTTCTGCCAA TTATGAGATG TTTATATTTC ACAACGGAGG TGTACAAATT 
TTATGCAAAT ATCCTGACAT TGTCCAGCAA TTTAAAATGC AGTTGCTGAA AGGGGGGCAA 
ATACTCTGCG ATCTCACTAA GACAAAAGGA AGTGGAAACA CAGTGTCCAT TAAGAGTCTG 
AAATTCTGCC ATTCTCAGTT ATCCAACAAC AGTGTCTCTT TTTTTCTATA CAACTTGGAC 
CATTCTCATG CCAACTATTA CTTCTGCAAC CTATCAATTT TTGATCCTCC TCCTTTTAAA 
GTAACTCTTA CAGGAGGATA TTTGCATATT TATGAATCAC AACTTTGTTG CCAGCTGAAG 
TTCTGGTTAC CCATAGGATG TGCAGCCTTT GTTGTAGTCT GCATTTTGGG ATGCATACTT 
ATTTGTTGGC TTACAAAAAA GAAGTATTCA TCCAGTGTGC ACGACCCTAA CGGTGAATAC 
ATGTTCATGA GAGCAGTGAA CACAGCCAAA AAATCTAGAC TCACAGATGT GACCCTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.