Pawr cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Pawr
Entrez Gene ID	64513
Full Name	pro-apoptotic WT1 regulator
Synonyms	Par-4,Par4
General protein information	Preferred Names pro-apoptotic WT1 regulator Names PRKC apoptosis WT1 regulator protein PRKC, apoptosis, WT1, regulator Prostate apoptosis response protein 4 par-4 induced by effectors of apoptosis prostate apoptosis response 4 protein transcriptional repressor Par-4-like protein PAWR
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 7 Map Location: 7q21
Summary	expression is induced by apoptosis effector ionomycin; may play a role in apoptosis [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_006241317.3	XP_006241379.1	PRKC apoptosis WT1 regulator protein isoform X1
NM_033485.2	NP_277020.1	PRKC apoptosis WT1 regulator protein

Pathways from BioSystems

Homologies

Homo sapiens (human)	PAWR	NP_002574.2
Pan troglodytes (chimpanzee)	PAWR	XP_001163796.1
Bos taurus (cattle)	PAWR	XP_002687221.2
Danio rerio (zebrafish)	pawr	NP_001006015.1
	PAWR	XP_001085206.1
Xenopus tropicalis (tropical clawed frog)	pawr	XP_002935689.2
Mus musculus (house mouse)	Pawr	NP_473397.1
Rattus norvegicus (Norway rat)	Pawr	NP_277020.1
Canis lupus familiaris (dog)	PAWR	XP_005629237.1
Gallus gallus (chicken)	PAWR	XP_416112.4

Gene Ontology
Bibliography

Related articles in PubMed

The microRNA miR-17-3p inhibits mouse cardiac fibroblast senescence by targeting Par4.
Du WW, Li X, Li T, Li H, Khorshidi A, Liu F, Yang BB
Journal of cell science128(2)293-304(2015 Jan)

Regulation of the proapoptotic functions of prostate apoptosis response-4 (Par-4) by casein kinase 2 in prostate cancer cells.
de Thonel A, Hazoum? A, Kochin V, Isoniemi K, Jego G, Fourmaux E, Hammann A, Mjahed H, Filhol O, Micheau O, Rocchi P, Mezger V, Eriksson JE, Rangnekar VM, Garrido C
Cell death & disease5e1016(2014 Jan)

Interleukin-1? increased the expression of protease-activated receptor 4 mRNA and protein in dorsal root ganglion neurons.
Wang Z, Chen D, Zhang R, An S, Zhang Z, Ma Q
Neurochemical research38(9)1895-903(2013 Sep)

Prostate-apoptosis response-4 phosphorylation in vascular smooth muscle.
MacDonald JA, Moffat LD, Al-Ghabkari A, Sutherland C, Walsh MP
Archives of biochemistry and biophysics535(1)84-90(2013 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Phosphorylation by CK2 impairs Par-4 proapoptotic functions.
Title: Regulation of the proapoptotic functions of prostate apoptosis response-4 (Par-4) by casein kinase 2 in prostate cancer cells.

Par-4 binding does not block MYPT1 phosphorylation in rat caudal arterial smooth muscle.
Title: Prostate-apoptosis response-4 phosphorylation in vascular smooth muscle.

depression-like behaviors is associated with down-regulated Par-4 and dopamine receptor D2 gene expression in the striatum through a non-methylation mechanism
Title: Stress-induced depressive behaviors are correlated with Par-4 and DRD2 expression in rat striatum.

Par-4 and caspase-3 immunoreactivity in specific brain areas including the hippocampus CA1, CA3 and dentate gyrus, the adjacent cortex and the striatum in adult and aged rats from control and neonatally ferrous iron (Fe+2)-treated groups.
Title: Neonatal iron treatment increases apoptotic markers in hippocampal and cortical areas of adult rats.

PAR4 activation in the knee joint leads to mast cell-dependent changes in joint mechanosensitivity and pain behavior.
Title: The pronociceptive effect of proteinase-activated receptor-4 stimulation in rat knee joints is dependent on mast cell activation.

The following Pawr gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Pawr cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa06036	NM_033485.2 Latest version!	Rattus norvegicus pro-apoptotic WT1 regulator (Pawr), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$188.30 $269.00
ORa30106	XM_006241317.3 Latest version!	Rattus norvegicus pro-apoptotic WT1 regulator (Pawr), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$139.30 $199.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Pawr ( NM_033485.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_277020.1 Rattus norvegicus pro-apoptotic WT1 regulator (Pawr), mRNA.

Price & Availability↑

CloneID	ORa06036
Clone ID Related Accession (Same CDS sequence)	NM_033485.2
Accession Version	NM_033485.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 999bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-22
Organism	Rattus norvegicus(Norway rat)
Product	PRKC apoptosis WT1 regulator protein
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U05989.1. On Nov 2, 2002 this sequence version replaced NM_033485.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U05989.1, BE109657.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGGCGACCG GCGGCTATCG GAGCAGCGGC AGCACCACGG ACTTCCTGGA GGAGTGGAAA 
GCGAAGCGCG AGAAGATGCG CGCCAAGCAG AACCCCGTGG GCCCGGGTTC GAGCGGCGGG 
GATCCAGCCG CCAAGTCCCC TGCGGGACCG CTCGCCCAGA CTACGGCCGC GGGGACCTCG 
GAACTCAACC ACGGCCCCGC CGGCGCGGCC GCACCTGCCG CCCCCGGGCC GGGCGCCCTG 
AACTGCGCTC ACGGCTCGTC CGCGCTGCCC CGCGGGGCTC CCGGCTCCCG GCGGCCGGAG 
GACGAGTGTC CTATTGCCGC TGGGGCCGCG GGAGCACCCG CGTCCCGGGG AGACGAGGAG 
GAGCCGGATA GCGCCCCGGA GAAGGGCCGC AGCTCGGGGC CCAGCGCCAG GAAAGGCAAA 
GGGCAGATCG AGAAGAGGAA GCTGCGGGAG AAGCGCCGCT CCACCGGCGT GGTCAACATC 
CCCGCGGCGG AGTGCTTAGA TGAGTACGAA GATGACGAAG CAGGACAGAA GGAACGGAAG 
CGAGAGGATG CTATCACACA GCAGAACACC ATCCAGAATG AAGCTGCGAG CCTCCCAGAT 
CCAGGAACCT CCTACCTGCC CCAGGACCCG TCGAGAACAG TCCCAGGCAG ATACAAAAGC 
ACAATCAGTG CCCCAGAAGA AGAAATCTTA AATAGATATC CCCGAACAGA TAGAAGTGGC 
TTCAGTAGAC ACAACAGAGA TACCAGTGCG CCTGCTAACT TCGCTTCAAG TAGCACCTTG 
GAAAAGAGAA TTGAAGATCT TGAGAAGGAA GTCTTGAGAG AAAGGCAAGA AAACCTTCGA 
CTTACGAGGC TGATGCAAGA TAAAGAAGAA ATGATTGGAA AACTCAAGGA AGAGATTGAT 
TTGTTAAATA GAGACCTCGA TGACATGGAA GACGAAAACG AGCAACTAAA GCAGGAAAAT 
AAAACTCTTT TGAAAGTTGT TGGGCAGCTG ACAAGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_277020.1
CDS	67..1065
Translation	MATGGYRSSGSTTDFLEEWKAKREKMRAKQNPVGPGSSGGDPAAKSPAGPLAQTTAAGTSELNHGPAGAAAPAAPGPGALNCAHGSSALPRGAPGSRRPEDECPIAAGAAGAPASRGDEEEPDSAPEKGRSSGPSARKGKGQIEKRKLREKRRSTGVVNIPAAECLDEYEDDEAGQKERKREDAITQQNTIQNEAASLPDPGTSYLPQDPSRTVPGRYKSTISAPEEEILNRYPRTDRSGFSRHNRDTSAPANFASSSTLEKRIEDLEKEVLRERQENLRLTRLMQDKEEMIGKLKEEIDLLNRDLDDMEDENEQLKQENKTLLKVVGQLTR

Target ORF information:

RefSeq Version	NM_033485.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus pro-apoptotic WT1 regulator (Pawr), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_033485.2

ORF Insert Sequence:

ATGGCGACCG GCGGCTATCG GAGCAGCGGC AGCACCACGG ACTTCCTGGA GGAGTGGAAA 
GCGAAGCGCG AGAAGATGCG CGCCAAGCAG AACCCCGTGG GCCCGGGTTC GAGCGGCGGG 
GATCCAGCCG CCAAGTCCCC TGCGGGACCG CTCGCCCAGA CTACGGCCGC GGGGACCTCG 
GAACTCAACC ACGGCCCCGC CGGCGCGGCC GCACCTGCCG CCCCCGGGCC GGGCGCCCTG 
AACTGCGCTC ACGGCTCGTC CGCGCTGCCC CGCGGGGCTC CCGGCTCCCG GCGGCCGGAG 
GACGAGTGTC CTATTGCCGC TGGGGCCGCG GGAGCACCCG CGTCCCGGGG AGACGAGGAG 
GAGCCGGATA GCGCCCCGGA GAAGGGCCGC AGCTCGGGGC CCAGCGCCAG GAAAGGCAAA 
GGGCAGATCG AGAAGAGGAA GCTGCGGGAG AAGCGCCGCT CCACCGGCGT GGTCAACATC 
CCCGCGGCGG AGTGCTTAGA TGAGTACGAA GATGACGAAG CAGGACAGAA GGAACGGAAG 
CGAGAGGATG CTATCACACA GCAGAACACC ATCCAGAATG AAGCTGCGAG CCTCCCAGAT 
CCAGGAACCT CCTACCTGCC CCAGGACCCG TCGAGAACAG TCCCAGGCAG ATACAAAAGC 
ACAATCAGTG CCCCAGAAGA AGAAATCTTA AATAGATATC CCCGAACAGA TAGAAGTGGC 
TTCAGTAGAC ACAACAGAGA TACCAGTGCG CCTGCTAACT TCGCTTCAAG TAGCACCTTG 
GAAAAGAGAA TTGAAGATCT TGAGAAGGAA GTCTTGAGAG AAAGGCAAGA AAACCTTCGA 
CTTACGAGGC TGATGCAAGA TAAAGAAGAA ATGATTGGAA AACTCAAGGA AGAGATTGAT 
TTGTTAAATA GAGACCTCGA TGACATGGAA GACGAAAACG AGCAACTAAA GCAGGAAAAT 
AAAACTCTTT TGAAAGTTGT TGGGCAGCTG ACAAGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Pawr ( XM_006241317.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006241379.1 Rattus norvegicus pro-apoptotic WT1 regulator (Pawr), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa30106
Clone ID Related Accession (Same CDS sequence)	XM_006241317.3
Accession Version	XM_006241317.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 999bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	PRKC apoptosis WT1 regulator protein isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005106.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006241317.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGACCG GCGGCTATCG GAGCAGCGGC AGCACCACGG ACTTCCTGGA GGAGTGGAAA 
GCGAAGCGCG AGAAGATGCG CGCCAAGCAG AACCCCGTGG GCCCGGGTTC GAGCGGCGGG 
GATCCAGCCG CCAAGTCCCC TGCGGGACCG CTCGCCCAGA CTACGGCCGC GGGGACCTCG 
GAACTCAACC ACGGCCCCGC CGGCGCGGCC GCACCTGCCG CCCCCGGGCC GGGCGCCCTG 
AACTGCGCTC ACGGCTCGTC CGCGCTGCCC CGCGGGGCTC CCGGCTCCCG GCGGCCGGAG 
GACGAGTGTC CTATTGCCGC TGGGGCCGCG GGAGCACCCG CGTCCCGGGG AGACGAGGAG 
GAGCCGGATA GCGCCCCGGA GAAGGGCCGC AGCTCGGGGC CCAGCGCCAG GAAAGGCAAA 
GGGCAGATCG AGAAGAGGAA GCTGCGGGAG AAGCGCCGCT CCACCGGCGT GGTCAACATC 
CCCGCGGCGG AGTGCTTAGA TGAGTACGAA GATGACGAAG CAGGACAGAA GGAACGGAAG 
CGAGAGGATG CTATCACACA GCAGAACACC ATCCAGAATG AAGCTGCGAG CCTCCCAGAT 
CCAGGAACCT CCTACCTGCC CCAGGACCCG TCGAGAACAG TCCCAGGCAG ATACAAAAGC 
ACAACCAGTG CCCCAGAAGA AGAAATCTTA AATAGATATC CCCGAACAGA TAGAAGTGGC 
TTCAGTAGAC ACAACAGAGA TACCAGTGCG CCTGCTAACT TCGCTTCAAG TAGCACCTTG 
GAAAAGAGAA TTGAAGATCT TGAGAAGGAA GTCTTGAGAG AAAGGCAAGA AAACCTTCGA 
CTTACGAGGC TGATGCAAGA TAAAGAAGAA ATGATTGGAA AACTCAAGGA AGAGATTGAT 
TTGTTAAATA GAGACCTCGA TGACATGGAA GACGAAAACG AGCAACTAAA GCAGGAAAAT 
AAAACTCTTT TGAAAGTTGT TGGGCAGCTG ACAAGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006241379.1
CDS	281..1279
Translation	MATGGYRSSGSTTDFLEEWKAKREKMRAKQNPVGPGSSGGDPAAKSPAGPLAQTTAAGTSELNHGPAGAAAPAAPGPGALNCAHGSSALPRGAPGSRRPEDECPIAAGAAGAPASRGDEEEPDSAPEKGRSSGPSARKGKGQIEKRKLREKRRSTGVVNIPAAECLDEYEDDEAGQKERKREDAITQQNTIQNEAASLPDPGTSYLPQDPSRTVPGRYKSTTSAPEEEILNRYPRTDRSGFSRHNRDTSAPANFASSSTLEKRIEDLEKEVLRERQENLRLTRLMQDKEEMIGKLKEEIDLLNRDLDDMEDENEQLKQENKTLLKVVGQLTR

Target ORF information:

RefSeq Version	XM_006241317.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus pro-apoptotic WT1 regulator (Pawr), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006241317.3

ORF Insert Sequence:

ATGGCGACCG GCGGCTATCG GAGCAGCGGC AGCACCACGG ACTTCCTGGA GGAGTGGAAA 
GCGAAGCGCG AGAAGATGCG CGCCAAGCAG AACCCCGTGG GCCCGGGTTC GAGCGGCGGG 
GATCCAGCCG CCAAGTCCCC TGCGGGACCG CTCGCCCAGA CTACGGCCGC GGGGACCTCG 
GAACTCAACC ACGGCCCCGC CGGCGCGGCC GCACCTGCCG CCCCCGGGCC GGGCGCCCTG 
AACTGCGCTC ACGGCTCGTC CGCGCTGCCC CGCGGGGCTC CCGGCTCCCG GCGGCCGGAG 
GACGAGTGTC CTATTGCCGC TGGGGCCGCG GGAGCACCCG CGTCCCGGGG AGACGAGGAG 
GAGCCGGATA GCGCCCCGGA GAAGGGCCGC AGCTCGGGGC CCAGCGCCAG GAAAGGCAAA 
GGGCAGATCG AGAAGAGGAA GCTGCGGGAG AAGCGCCGCT CCACCGGCGT GGTCAACATC 
CCCGCGGCGG AGTGCTTAGA TGAGTACGAA GATGACGAAG CAGGACAGAA GGAACGGAAG 
CGAGAGGATG CTATCACACA GCAGAACACC ATCCAGAATG AAGCTGCGAG CCTCCCAGAT 
CCAGGAACCT CCTACCTGCC CCAGGACCCG TCGAGAACAG TCCCAGGCAG ATACAAAAGC 
ACAACCAGTG CCCCAGAAGA AGAAATCTTA AATAGATATC CCCGAACAGA TAGAAGTGGC 
TTCAGTAGAC ACAACAGAGA TACCAGTGCG CCTGCTAACT TCGCTTCAAG TAGCACCTTG 
GAAAAGAGAA TTGAAGATCT TGAGAAGGAA GTCTTGAGAG AAAGGCAAGA AAACCTTCGA 
CTTACGAGGC TGATGCAAGA TAAAGAAGAA ATGATTGGAA AACTCAAGGA AGAGATTGAT 
TTGTTAAATA GAGACCTCGA TGACATGGAA GACGAAAACG AGCAACTAAA GCAGGAAAAT 
AAAACTCTTT TGAAAGTTGT TGGGCAGCTG ACAAGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The microRNA miR-17-3p inhibits mouse cardiac fibroblast senescence by targeting Par4.
Journal of cell science128(2)293-304(2015 Jan)
Du WW,Li X,Li T,Li H,Khorshidi A,Liu F,Yang BB

Regulation of the proapoptotic functions of prostate apoptosis response-4 (Par-4) by casein kinase 2 in prostate cancer cells.
Cell death & disease5e1016(2014 Jan)
de Thonel A,Hazoum? A,Kochin V,Isoniemi K,Jego G,Fourmaux E,Hammann A,Mjahed H,Filhol O,Micheau O,Rocchi P,Mezger V,Eriksson JE,Rangnekar VM,Garrido C

Interleukin-1? increased the expression of protease-activated receptor 4 mRNA and protein in dorsal root ganglion neurons.
Neurochemical research38(9)1895-903(2013 Sep)
Wang Z,Chen D,Zhang R,An S,Zhang Z,Ma Q

Prostate-apoptosis response-4 phosphorylation in vascular smooth muscle.
Archives of biochemistry and biophysics535(1)84-90(2013 Jul)
MacDonald JA,Moffat LD,Al-Ghabkari A,Sutherland C,Walsh MP

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Pawr cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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