Syt11 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Syt11
Entrez Gene ID	60568
Full Name	synaptotagmin 11
General protein information	Preferred Names synaptotagmin 11 Names synaptotagmin-11 synaptotagmin XI sytXI
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 2 Map Location: 2q34
Summary	calcuim-binding protein, component of synaptic vesicles, component of the SNARE complex of proteins; may serve as the calcium sensor in the process of vesicular trafficking and exocytosis [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_006232748.1	XP_006232810.1	synaptotagmin-11 isoform X1
NM_031667.2	NP_113855.2	synaptotagmin-11

Pathways from BioSystems

Homologies

Bos taurus (cattle)	SYT11	NP_001092641.1
Danio rerio (zebrafish)	syt11b	NP_001156003.1
Rattus norvegicus (Norway rat)	Syt11	NP_113855.2
	SYT11	XP_001113446.1
Canis lupus familiaris (dog)	SYT11	XP_005622777.1
Mus musculus (house mouse)	Syt11	NP_061274.2
Gallus gallus (chicken)	SYT11	XP_426721.3
Homo sapiens (human)	SYT11	NP_689493.3
Pan troglodytes (chimpanzee)	SYT11	XP_513867.3
Danio rerio (zebrafish)	syt11a	NP_998625.2

Gene Ontology
Bibliography

Related articles in PubMed

Synaptotagmin-11 is a critical mediator of parkin-linked neurotoxicity and Parkinson's disease-like pathology.
Wang C, Kang X, Zhou L, Chai Z, Wu Q, Huang R, Xu H, Hu M, Sun X, Sun S, Li J, Jiao R, Zuo P, Zheng L, Yue Z, Zhou Z
Nature communications9(1)81(2018 Jan)

The Parkinson's disease-associated genes ATP13A2 and SYT11 regulate autophagy via a common pathway.
Bento CF, Ashkenazi A, Jimenez-Sanchez M, Rubinsztein DC
Nature communications711803(2016 Jun)

Injured astrocytes are repaired by Synaptotagmin XI-regulated lysosome exocytosis.
Sreetama SC, Takano T, Nedergaard M, Simon SM, Jaiswal JK
Cell death and differentiation23(4)596-607(2016 Apr)

Synaptotagmin-11 inhibits clathrin-mediated and bulk endocytosis.
Wang C, Wang Y, Hu M, Chai Z, Wu Q, Huang R, Han W, Zhang CX, Zhou Z
EMBO reports17(1)47-63(2016 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

propose that Syt11 functions to ensure precision in vesicle retrieval, mainly by limiting the sites of membrane invagination at the early stage of endocytosis
Title: Synaptotagmin-11 inhibits clathrin-mediated and bulk endocytosis.

Ca2+ and Sr2+ coordination sites in synaptotagmin I C2B domain were identified using high-resolution crystal structures. have identified
Title: Crystallographic identification of Ca2+ and Sr2+ coordination sites in synaptotagmin I C2B domain.

The following Syt11 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Syt11 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa08424	NM_031667.2 Latest version!	Rattus norvegicus synaptotagmin 11 (Syt11), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00
ORa24943	XM_006232748.1 Latest version!	Rattus norvegicus synaptotagmin 11 (Syt11), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Syt11 ( NM_031667.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_113855.2 Rattus norvegicus synaptotagmin 11 (Syt11), mRNA.

Price & Availability↑

CloneID	ORa08424
Clone ID Related Accession (Same CDS sequence)	NM_031667.2
Accession Version	NM_031667.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1290bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-28
Organism	Rattus norvegicus(Norway rat)
Product	synaptotagmin-11
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC094518.1. On Apr 20, 2007 this sequence version replaced NM_031667.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC094518.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296 [ECO:0000348] ##Evidence-Data-END##

ATGGCTGAGA TCACAAATAT ACGCCCCAGC TTTGATGTGT CACCAGTAGC GGCTGGCCTC 
ATCGGCGCCT CTGTGCTGGT GGTGTGTGTC TCTGTGACTG TCTTTGTGTG GACATGCTGC 
CACCAGCAGG CGGAGAAGAA GCACAAGACC CCACCGTACA AGTTTATTCA TATGCTGAAA 
GGCATTAGCA TCTACCCAGA GACCCTCAGC AACAAGAAGA AAATCATCAA AGTTCGGAGG 
GACAAAGATG GTTCTCATAG GGAAAGTGGA CGAGGGAACC TGTTAGTAAA TGCGGAGTCT 
GGCCTGCTGA GCCATGACAG GGATCCCAGA GGGCCTAGCC CTGCATCTTG TATAGACCAG 
TTACCCATCA AAAGAGACTA TGGGGAAGAA CTGAGGAGCC CCATGACCAG CCTGACCCCC 
GGTGAAAGCA AGCCCACCTC CCCATCATCG CCAGAGGAAG ATGTGATGCT AGGGTCCCTT 
ACCTTCTCGG TGGACTACAA CTTTCCCAAG AAAGCTCTGG TGGTGACAAT CCAAGAGGCG 
CATGGGCTGC CAGTGATGGA TGGCCAGACC CAGGGCTCCG ATCCCTACAT CAAAATGACC 
ATTCTTCCTG ACAAGCGGCA TCGAGTGAAG ACCCGGGTGC TTCGCAAGAC CCTGGACCCC 
GTGTTTGATG AGACCTTCAC CTTCTACGGC ATTCCCTACA GCCAGCTACA GGACCTGGTG 
CTGCACTTCC TTGTGCTCAG CTTTGATCGC TTCTCTCGGG ATGACGTCAT CGGGGAGGTC 
ATGGTGCCCT TGGCTGGAGT GGACCCCAGC ACAGGCAAGG TTCAGCTGAC CAGGGACATC 
ATCAAGAGGA ACATTCAGAA GTGCATTAGC AGAGGGGAAC TCCAGGTATC TCTGTCATAC 
CAGCCCGTCG CACAGAGAAT GACAGTGGTG GTCCTCAAAG CCAGACACTT GCCGAAGATG 
GATATCACCG GTCTCTCAGA TCCTTATGTC AAGGTGAACG TCTACTACGG CAGAAAACGC 
ATTGCCAAGA AGAAAACTCA TGTAAAGAAG TGCACTTTGA ACCCCATCTT CAATGAGTCC 
TTCATCTATG ACATCCCCAC CGATCTCCTG CCTGATATCA GCATCGAGTT CCTTGTCATT 
GACTTCGATC GTACTACTAA GAATGAGGTG GTAGGGAGGC TGATCTTGGG GGCACACAGT 
GTCACAACCA GTGGTGCAGA ACACTGGAGA GAGGTGTGCG AGAGTCCCCG CAAGCCTGTA 
GCCAAGTGGC ACAGTCTGAG CGAGTACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_113855.2
CDS	202..1491
Translation	MAEITNIRPSFDVSPVAAGLIGASVLVVCVSVTVFVWTCCHQQAEKKHKTPPYKFIHMLKGISIYPETLSNKKKIIKVRRDKDGSHRESGRGNLLVNAESGLLSHDRDPRGPSPASCIDQLPIKRDYGEELRSPMTSLTPGESKPTSPSSPEEDVMLGSLTFSVDYNFPKKALVVTIQEAHGLPVMDGQTQGSDPYIKMTILPDKRHRVKTRVLRKTLDPVFDETFTFYGIPYSQLQDLVLHFLVLSFDRFSRDDVIGEVMVPLAGVDPSTGKVQLTRDIIKRNIQKCISRGELQVSLSYQPVAQRMTVVVLKARHLPKMDITGLSDPYVKVNVYYGRKRIAKKKTHVKKCTLNPIFNESFIYDIPTDLLPDISIEFLVIDFDRTTKNEVVGRLILGAHSVTTSGAEHWREVCESPRKPVAKWHSLSEY

Target ORF information:

RefSeq Version	NM_031667.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus synaptotagmin 11 (Syt11), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031667.2

ORF Insert Sequence:

ATGGCTGAGA TCACAAATAT ACGCCCCAGC TTTGATGTGT CACCAGTAGC GGCTGGCCTC 
ATCGGCGCCT CTGTGCTGGT GGTGTGTGTC TCTGTGACTG TCTTTGTGTG GACATGCTGC 
CACCAGCAGG CGGAGAAGAA GCACAAGACC CCACCGTACA AGTTTATTCA TATGCTGAAA 
GGCATTAGCA TCTACCCAGA GACCCTCAGC AACAAGAAGA AAATCATCAA AGTTCGGAGG 
GACAAAGATG GTTCTCATAG GGAAAGTGGA CGAGGGAACC TGTTAGTAAA TGCGGAGTCT 
GGCCTGCTGA GCCATGACAG GGATCCCAGA GGGCCTAGCC CTGCATCTTG TATAGACCAG 
TTACCCATCA AAAGAGACTA TGGGGAAGAA CTGAGGAGCC CCATGACCAG CCTGACCCCC 
GGTGAAAGCA AGCCCACCTC CCCATCATCG CCAGAGGAAG ATGTGATGCT AGGGTCCCTT 
ACCTTCTCGG TGGACTACAA CTTTCCCAAG AAAGCTCTGG TGGTGACAAT CCAAGAGGCG 
CATGGGCTGC CAGTGATGGA TGGCCAGACC CAGGGCTCCG ATCCCTACAT CAAAATGACC 
ATTCTTCCTG ACAAGCGGCA TCGAGTGAAG ACCCGGGTGC TTCGCAAGAC CCTGGACCCC 
GTGTTTGATG AGACCTTCAC CTTCTACGGC ATTCCCTACA GCCAGCTACA GGACCTGGTG 
CTGCACTTCC TTGTGCTCAG CTTTGATCGC TTCTCTCGGG ATGACGTCAT CGGGGAGGTC 
ATGGTGCCCT TGGCTGGAGT GGACCCCAGC ACAGGCAAGG TTCAGCTGAC CAGGGACATC 
ATCAAGAGGA ACATTCAGAA GTGCATTAGC AGAGGGGAAC TCCAGGTATC TCTGTCATAC 
CAGCCCGTCG CACAGAGAAT GACAGTGGTG GTCCTCAAAG CCAGACACTT GCCGAAGATG 
GATATCACCG GTCTCTCAGA TCCTTATGTC AAGGTGAACG TCTACTACGG CAGAAAACGC 
ATTGCCAAGA AGAAAACTCA TGTAAAGAAG TGCACTTTGA ACCCCATCTT CAATGAGTCC 
TTCATCTATG ACATCCCCAC CGATCTCCTG CCTGATATCA GCATCGAGTT CCTTGTCATT 
GACTTCGATC GTACTACTAA GAATGAGGTG GTAGGGAGGC TGATCTTGGG GGCACACAGT 
GTCACAACCA GTGGTGCAGA ACACTGGAGA GAGGTGTGCG AGAGTCCCCG CAAGCCTGTA 
GCCAAGTGGC ACAGTCTGAG CGAGTACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Syt11 ( XM_006232748.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006232810.1 Rattus norvegicus synaptotagmin 11 (Syt11), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa24943
Clone ID Related Accession (Same CDS sequence)	XM_006232748.1
Accession Version	XM_006232748.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1293bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	synaptotagmin-11 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005101.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCTGAGA TCACAAATAT ACGCCCCAGC TTTGATGTGT CACCAGTAGC GGCTGGCCTC 
ATCGGCGCCT CTGTGCTGGT GGTGTGTGTC TCTGTGACTG TCTTTGTGTG GACATGCTGC 
CACCAGCAGG CGGAGAAGAA GCACAAGACC CCACCGTACA AGTTTATTCA TATGCTGAAA 
GGCATTAGCA TCTACCCAGA GACCCTCAGC AACAAGAAGA AAATCATCAA AGTTCGGAGG 
GACAAAGATG GTTCTCATAG GGAAAGTGGA CGAGGGAACC TGTTAGTAAA TGCGGAGTCT 
GGCCTGCTGA GCCATGACAG GGATCCCAGA GGGCCTAGCC CTGCATCTTG TATAGACCAG 
TTACCCATCA AAAGAGACTA TGGGGAAGAA CTGAGGAGCC CCATGACCAG CCTGACCCCC 
GGTGAAAGCA AGCCCACCTC CCCATCATCG CCAGAGGAAG ATGTGATGCT AGGGTCCCTT 
ACCTTCTCGG TGGACTACAA CTTTCCCAAG AAAGCTCTGG TGGTGACAAT CCAAGAGGCG 
CATGGGCTGC CAGTGATGGA TGGCCAGACC CAGGGCTCCG ATCCCTACAT CAAAATGACC 
ATTCTTCCTG ACAAGCGGCA TCGAGTGAAG ACCCGGGTGC TTCGCAAGAC CCTGGACCCC 
GTGTTTGATG AGACCTTCAC CTTCTACGGC ATTCCCTACA GCCAGCTACA GGACCTGGTG 
CTGCACTTCC TTGTGCTCAG CTTTGATCGC TTCTCTCGGG ATGACGTCAT CGGGGAGGTC 
ATGGTGCCCT TGGCTGGAGT GGACCCCAGC ACAGGCAAGG TTCAGCTGAC CAGGGACATC 
ATCAAGAGGA ACATTCAGAA GTGCATTAGC AGAGGGGAAC TCCAGGTATC TCTGTCATAC 
CAGCCCGTCG CACAGAGAAT GACAGTGGTG GTCCTCAAAG CCAGACACTT GCCGAAGATG 
GATATCACCG GTCTCTCAGG TAATCCTTAT GTCAAGGTGA ACGTCTACTA CGGCAGAAAA 
CGCATTGCCA AGAAGAAAAC TCATGTAAAG AAGTGCACTT TGAACCCCAT CTTCAATGAG 
TCCTTCATCT ATGACATCCC CACCGATCTC CTGCCTGATA TCAGCATCGA GTTCCTTGTC 
ATTGACTTCG ATCGTACTAC TAAGAATGAG GTGGTAGGGA GGCTGATCTT GGGGGCACAC 
AGTGTCACAA CCAGTGGTGC AGAACACTGG AGAGAGGTGT GCGAGAGTCC CCGCAAGCCT 
GTAGCCAAGT GGCACAGTCT GAGCGAGTAC TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006232810.1
CDS	194..1486
Translation	MAEITNIRPSFDVSPVAAGLIGASVLVVCVSVTVFVWTCCHQQAEKKHKTPPYKFIHMLKGISIYPETLSNKKKIIKVRRDKDGSHRESGRGNLLVNAESGLLSHDRDPRGPSPASCIDQLPIKRDYGEELRSPMTSLTPGESKPTSPSSPEEDVMLGSLTFSVDYNFPKKALVVTIQEAHGLPVMDGQTQGSDPYIKMTILPDKRHRVKTRVLRKTLDPVFDETFTFYGIPYSQLQDLVLHFLVLSFDRFSRDDVIGEVMVPLAGVDPSTGKVQLTRDIIKRNIQKCISRGELQVSLSYQPVAQRMTVVVLKARHLPKMDITGLSGNPYVKVNVYYGRKRIAKKKTHVKKCTLNPIFNESFIYDIPTDLLPDISIEFLVIDFDRTTKNEVVGRLILGAHSVTTSGAEHWREVCESPRKPVAKWHSLSEY

Target ORF information:

RefSeq Version	XM_006232748.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus synaptotagmin 11 (Syt11), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006232748.1

ORF Insert Sequence:

ATGGCTGAGA TCACAAATAT ACGCCCCAGC TTTGATGTGT CACCAGTAGC GGCTGGCCTC 
ATCGGCGCCT CTGTGCTGGT GGTGTGTGTC TCTGTGACTG TCTTTGTGTG GACATGCTGC 
CACCAGCAGG CGGAGAAGAA GCACAAGACC CCACCGTACA AGTTTATTCA TATGCTGAAA 
GGCATTAGCA TCTACCCAGA GACCCTCAGC AACAAGAAGA AAATCATCAA AGTTCGGAGG 
GACAAAGATG GTTCTCATAG GGAAAGTGGA CGAGGGAACC TGTTAGTAAA TGCGGAGTCT 
GGCCTGCTGA GCCATGACAG GGATCCCAGA GGGCCTAGCC CTGCATCTTG TATAGACCAG 
TTACCCATCA AAAGAGACTA TGGGGAAGAA CTGAGGAGCC CCATGACCAG CCTGACCCCC 
GGTGAAAGCA AGCCCACCTC CCCATCATCG CCAGAGGAAG ATGTGATGCT AGGGTCCCTT 
ACCTTCTCGG TGGACTACAA CTTTCCCAAG AAAGCTCTGG TGGTGACAAT CCAAGAGGCG 
CATGGGCTGC CAGTGATGGA TGGCCAGACC CAGGGCTCCG ATCCCTACAT CAAAATGACC 
ATTCTTCCTG ACAAGCGGCA TCGAGTGAAG ACCCGGGTGC TTCGCAAGAC CCTGGACCCC 
GTGTTTGATG AGACCTTCAC CTTCTACGGC ATTCCCTACA GCCAGCTACA GGACCTGGTG 
CTGCACTTCC TTGTGCTCAG CTTTGATCGC TTCTCTCGGG ATGACGTCAT CGGGGAGGTC 
ATGGTGCCCT TGGCTGGAGT GGACCCCAGC ACAGGCAAGG TTCAGCTGAC CAGGGACATC 
ATCAAGAGGA ACATTCAGAA GTGCATTAGC AGAGGGGAAC TCCAGGTATC TCTGTCATAC 
CAGCCCGTCG CACAGAGAAT GACAGTGGTG GTCCTCAAAG CCAGACACTT GCCGAAGATG 
GATATCACCG GTCTCTCAGG TAATCCTTAT GTCAAGGTGA ACGTCTACTA CGGCAGAAAA 
CGCATTGCCA AGAAGAAAAC TCATGTAAAG AAGTGCACTT TGAACCCCAT CTTCAATGAG 
TCCTTCATCT ATGACATCCC CACCGATCTC CTGCCTGATA TCAGCATCGA GTTCCTTGTC 
ATTGACTTCG ATCGTACTAC TAAGAATGAG GTGGTAGGGA GGCTGATCTT GGGGGCACAC 
AGTGTCACAA CCAGTGGTGC AGAACACTGG AGAGAGGTGT GCGAGAGTCC CCGCAAGCCT 
GTAGCCAAGT GGCACAGTCT GAGCGAGTAC TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Synaptotagmin-11 is a critical mediator of parkin-linked neurotoxicity and Parkinson's disease-like pathology.
Nature communications9(1)81(2018 Jan)
Wang C,Kang X,Zhou L,Chai Z,Wu Q,Huang R,Xu H,Hu M,Sun X,Sun S,Li J,Jiao R,Zuo P,Zheng L,Yue Z,Zhou Z

The Parkinson's disease-associated genes ATP13A2 and SYT11 regulate autophagy via a common pathway.
Nature communications711803(2016 Jun)
Bento CF,Ashkenazi A,Jimenez-Sanchez M,Rubinsztein DC

Injured astrocytes are repaired by Synaptotagmin XI-regulated lysosome exocytosis.
Cell death and differentiation23(4)596-607(2016 Apr)
Sreetama SC,Takano T,Nedergaard M,Simon SM,Jaiswal JK

Synaptotagmin-11 inhibits clathrin-mediated and bulk endocytosis.
EMBO reports17(1)47-63(2016 Jan)
Wang C,Wang Y,Hu M,Chai Z,Wu Q,Huang R,Han W,Zhang CX,Zhou Z

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Syt11 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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