Bmp15 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Bmp15
Entrez Gene ID	59302
Full Name	bone morphogenetic protein 15
Synonyms	Gdf-9b
General protein information	Preferred Names bone morphogenetic protein 15 Names bone morphogenetic protein 15 growth differentiation factor-9B
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: X Map Location: Xq12
Summary	may regulate granulosa cell growth and ovarian follicle formation [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_021670.1	NP_067702.1	bone morphogenetic protein 15 precursor

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Bmp15	NP_033887.1
Bos taurus (cattle)	BMP15	NP_001026922.1
Xenopus tropicalis (tropical clawed frog)	LOC100485893	XP_002936834.2
Homo sapiens (human)	BMP15	NP_005439.2
Pan troglodytes (chimpanzee)	BMP15	XP_529247.2
	BMP15	XP_001083980.1
Rattus norvegicus (Norway rat)	Bmp15	NP_067702.1
Gallus gallus (chicken)	BMP15	NP_001006589.2
Canis lupus familiaris (dog)	BMP15	XP_003640322.1
Danio rerio (zebrafish)	bmp15	NP_001018320.1

Gene Ontology
Bibliography

Related articles in PubMed

Estrogen-related genes and postmenopausal osteoporosis risk.
Mendoza N, Quereda F, Presa J, Salamanca A, S?nchez-Borrego R, V?zquez F, Mart?nez Astorquiza T
Climacteric : the journal of the International Menopause Society15(6)587-93(2012 Dec)

The bioactivity of human bone morphogenetic protein-15 is sensitive to C-terminal modification: characterization of the purified untagged processed mature region.
Pulkki MM, Myllymaa S, Pasternack A, Lun S, Ludlow H, Al-Qahtani A, Korchynskyi O, Groome N, Juengel JL, Kalkkinen N, Laitinen M, Ritvos O, Mottershead DG
Molecular and cellular endocrinology332(1-2)106-15(2011 Jan)

Oogenesis specific genes (Nobox, Oct4, Bmp15, Gdf9, Oogenesin1 and Oogenesin2) are differentially expressed during natural and gonadotropin-induced mouse follicular development.
Monti M, Redi C
Molecular reproduction and development76(10)994-1003(2009 Oct)

Growth differentiation factor 9 is a germ cell regulator of Sertoli cell function.
Nicholls PK, Harrison CA, Gilchrist RB, Farnworth PG, Stanton PG
Endocrinology150(5)2481-90(2009 May)

The cooperative effect of growth and differentiation factor-9 and bone morphogenetic protein (BMP)-15 on granulosa cell function is modulated primarily through BMP receptor II.
Edwards SJ, Reader KL, Lun S, Western A, Lawrence S, McNatty KP, Juengel JL
Endocrinology149(3)1026-30(2008 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results describe a purified untagged human BMP15 mature region, which is stable and highly bioactive in human and rodent granulosa cells and as such is of importance for studies on human fertility.
Title: The bioactivity of human bone morphogenetic protein-15 is sensitive to C-terminal modification: characterization of the purified untagged processed mature region.

GDF9 and BMP15 are germ cell-specific factors in the rat testis, and GDF9 can modulate key Sertoli cell functions.
Title: Growth differentiation factor 9 is a germ cell regulator of Sertoli cell function.

The initial interaction of oGDF9 and oBMP15 is with BMPRII and that a type I receptor is either recruited or already associated with BMPRII to mediate the cooperative effects of these growth factors.
Title: The cooperative effect of growth and differentiation factor-9 and bone morphogenetic protein (BMP)-15 on granulosa cell function is modulated primarily through BMP receptor II.

BMP-15 and GDF-9 have roles in fertility; critical sequences are determined by mutagenesis
Title: Functional and molecular characterization of naturally occurring mutations in the oocyte-secreted factors bone morphogenetic protein-15 and growth and differentiation factor-9.

negative feedback with bmp15 and granulosa cell kit ligand regulates granulosa cell mitosis
Title: A negative feedback system between oocyte bone morphogenetic protein 15 and granulosa cell kit ligand: its role in regulating granulosa cell mitosis.

The following Bmp15 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Bmp15 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa05016	NM_021670.1 Latest version!	Rattus norvegicus bone morphogenetic protein 15 (Bmp15), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Bmp15 ( NM_021670.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_067702.1 Rattus norvegicus bone morphogenetic protein 15 (Bmp15), mRNA.

Price & Availability↑

CloneID	ORa05016
Clone ID Related Accession (Same CDS sequence)	NM_021670.1
Accession Version	NM_021670.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1176bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-26
Organism	Rattus norvegicus(Norway rat)
Product	bone morphogenetic protein 15 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AJ132407.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ132407.1, CO406048.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGCCCTTC TCACAATTCT TAGAATTCTT TTGTGGGGAA TGGTGCTTTT TATGGAACAC 
AAGGTCCAAA TGGCAAAGGT AGAGTGGCCC TCCACTACCC TCCTTGCTGA AAACCCTACA 
TTGCCCTCGA GTTTGGATCT GGCCAAAGAA GCCCCTGGCA AGGAGATGAA GCAGTGGCCC 
CAAGGATATC CCCTGAGGTA CATGCTGAAG TTATACCAGC GTTCGGCTGA CCCACATGGG 
CACCCGAGGG AGAACCGCAC GATTGGAGCT AAAATGGTGA GGCTGATAAA GCCGTCAGCC 
AGTGCAATGA GGCTTCTCAG AGGTCCTTGG CATATACAGA CCCTGGACTT TCCTCTAGCA 
TCAAACGAGG TAGCATACCA ACTAATCAGA GCCACTGTGG TCTACCGCCA TCAACTTCAT 
CTAGTTCATT ACCATCTCTC CTGCCATGTG GAACCTTGGG TCCCTAAATG TCGAACCAAG 
CACTTTCCAT CTAAATCGGG TTCTGCAAAG CCTTCTTCTG TGTCTAAAGC CTGGAGAGAG 
ATGAATATTA CCCACTGTAT TCAGCAGAAG CTCTGGAATC GCAAGGGACG GAGAGTCCTT 
CGCCTCCGCT TCATGTGTCA GCAGCAAAAA GGCAATGAGA CTCTTGAGCT CCGGTGGCAT 
GGCATGACCT CCTTGGATGT TGCCTTCTTG CTACTCTATT TCGATGACAC TGATGAGAGT 
GCTCAGGCTA AACTTCTTGC AAGAGGTCAA GAGGAGTTAA CTGATAGGGA ATCTCCTTTT 
CTTATGCGGA GTGTCCGGCA AACATGCAGC ATAGCATCTG ATGTCCCTTG TCCTTCTCAG 
GAACAGGATA GGTCTGTAAA TAACCAGTGT TCCCTCCATC CTTACAAGGT CAGCTTCCAT 
CAATTGGGCT GGGATCACTG GATCATTGCT CCCCGTCTCT ATACCCCAAA TTACTGTAAA 
GGAATCTGTA CTGGAGTATT ACCCTATGGT CTAAATTCAC CCAACCATGC CATCATACAG 
AGCCTTGTCA ATGAACTAGT GAATCGCAGT GTGCCTCAGC TTTCCTGTGT CCCTTATAAG 
TTTCTTCCTA TGAGTATCCT TCTGATTGAG GCAAATGGGA GTATCTTGTA CAAGGAGTAT 
GAGGGTATGA TTGCTCAGTC CTGCACATGT AGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_067702.1
CDS	247..1422
Translation	MALLTILRILLWGMVLFMEHKVQMAKVEWPSTTLLAENPTLPSSLDLAKEAPGKEMKQWPQGYPLRYMLKLYQRSADPHGHPRENRTIGAKMVRLIKPSASAMRLLRGPWHIQTLDFPLASNEVAYQLIRATVVYRHQLHLVHYHLSCHVEPWVPKCRTKHFPSKSGSAKPSSVSKAWREMNITHCIQQKLWNRKGRRVLRLRFMCQQQKGNETLELRWHGMTSLDVAFLLLYFDDTDESAQAKLLARGQEELTDRESPFLMRSVRQTCSIASDVPCPSQEQDRSVNNQCSLHPYKVSFHQLGWDHWIIAPRLYTPNYCKGICTGVLPYGLNSPNHAIIQSLVNELVNRSVPQLSCVPYKFLPMSILLIEANGSILYKEYEGMIAQSCTCR

Target ORF information:

RefSeq Version	NM_021670.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus bone morphogenetic protein 15 (Bmp15), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021670.1

ORF Insert Sequence:

ATGGCCCTTC TCACAATTCT TAGAATTCTT TTGTGGGGAA TGGTGCTTTT TATGGAACAC 
AAGGTCCAAA TGGCAAAGGT AGAGTGGCCC TCCACTACCC TCCTTGCTGA AAACCCTACA 
TTGCCCTCGA GTTTGGATCT GGCCAAAGAA GCCCCTGGCA AGGAGATGAA GCAGTGGCCC 
CAAGGATATC CCCTGAGGTA CATGCTGAAG TTATACCAGC GTTCGGCTGA CCCACATGGG 
CACCCGAGGG AGAACCGCAC GATTGGAGCT AAAATGGTGA GGCTGATAAA GCCGTCAGCC 
AGTGCAATGA GGCTTCTCAG AGGTCCTTGG CATATACAGA CCCTGGACTT TCCTCTAGCA 
TCAAACGAGG TAGCATACCA ACTAATCAGA GCCACTGTGG TCTACCGCCA TCAACTTCAT 
CTAGTTCATT ACCATCTCTC CTGCCATGTG GAACCTTGGG TCCCTAAATG TCGAACCAAG 
CACTTTCCAT CTAAATCGGG TTCTGCAAAG CCTTCTTCTG TGTCTAAAGC CTGGAGAGAG 
ATGAATATTA CCCACTGTAT TCAGCAGAAG CTCTGGAATC GCAAGGGACG GAGAGTCCTT 
CGCCTCCGCT TCATGTGTCA GCAGCAAAAA GGCAATGAGA CTCTTGAGCT CCGGTGGCAT 
GGCATGACCT CCTTGGATGT TGCCTTCTTG CTACTCTATT TCGATGACAC TGATGAGAGT 
GCTCAGGCTA AACTTCTTGC AAGAGGTCAA GAGGAGTTAA CTGATAGGGA ATCTCCTTTT 
CTTATGCGGA GTGTCCGGCA AACATGCAGC ATAGCATCTG ATGTCCCTTG TCCTTCTCAG 
GAACAGGATA GGTCTGTAAA TAACCAGTGT TCCCTCCATC CTTACAAGGT CAGCTTCCAT 
CAATTGGGCT GGGATCACTG GATCATTGCT CCCCGTCTCT ATACCCCAAA TTACTGTAAA 
GGAATCTGTA CTGGAGTATT ACCCTATGGT CTAAATTCAC CCAACCATGC CATCATACAG 
AGCCTTGTCA ATGAACTAGT GAATCGCAGT GTGCCTCAGC TTTCCTGTGT CCCTTATAAG 
TTTCTTCCTA TGAGTATCCT TCTGATTGAG GCAAATGGGA GTATCTTGTA CAAGGAGTAT 
GAGGGTATGA TTGCTCAGTC CTGCACATGT AGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Estrogen-related genes and postmenopausal osteoporosis risk.
Climacteric : the journal of the International Menopause Society15(6)587-93(2012 Dec)
Mendoza N,Quereda F,Presa J,Salamanca A,S?nchez-Borrego R,V?zquez F,Mart?nez Astorquiza T

The bioactivity of human bone morphogenetic protein-15 is sensitive to C-terminal modification: characterization of the purified untagged processed mature region.
Molecular and cellular endocrinology332(1-2)106-15(2011 Jan)
Pulkki MM,Myllymaa S,Pasternack A,Lun S,Ludlow H,Al-Qahtani A,Korchynskyi O,Groome N,Juengel JL,Kalkkinen N,Laitinen M,Ritvos O,Mottershead DG

Oogenesis specific genes (Nobox, Oct4, Bmp15, Gdf9, Oogenesin1 and Oogenesin2) are differentially expressed during natural and gonadotropin-induced mouse follicular development.
Molecular reproduction and development76(10)994-1003(2009 Oct)
Monti M,Redi C

Growth differentiation factor 9 is a germ cell regulator of Sertoli cell function.
Endocrinology150(5)2481-90(2009 May)
Nicholls PK,Harrison CA,Gilchrist RB,Farnworth PG,Stanton PG

The cooperative effect of growth and differentiation factor-9 and bone morphogenetic protein (BMP)-15 on granulosa cell function is modulated primarily through BMP receptor II.
Endocrinology149(3)1026-30(2008 Mar)
Edwards SJ,Reader KL,Lun S,Western A,Lawrence S,McNatty KP,Juengel JL

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Bmp15 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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