BMP15 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	BMP15
Entrez Gene ID	9210
Full Name	bone morphogenetic protein 15
Synonyms	GDF9B,ODG2,POF4
General protein information	Preferred Names bone morphogenetic protein 15 Names bone morphogenetic protein 15 growth/differentiation factor 9B
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xp11.22
Summary	This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate subunits of a disulfide-linked homodimer, or alternatively, a heterodimer, with the related protein, growth differentiation factor 9 (GDF9). This protein plays a role in oocyte maturation and follicular development, through activation of granulosa cells. Defects in this gene are the cause of ovarian dysgenesis and are associated with premature ovarian failure. [provided by RefSeq, Aug 2016].
Disorder MIM:	300247
Disorder Html:	Ovarian dysgenesis 2, 300510 (3); Premature ovarian failure 4, 300510 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_005448.2	NP_005439.2	bone morphogenetic protein 15 preproprotein

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Bmp15	NP_033887.1
Bos taurus (cattle)	BMP15	NP_001026922.1
Xenopus tropicalis (tropical clawed frog)	LOC100485893	XP_002936834.2
Homo sapiens (human)	BMP15	NP_005439.2
Pan troglodytes (chimpanzee)	BMP15	XP_529247.2
	BMP15	XP_001083980.1
Rattus norvegicus (Norway rat)	Bmp15	NP_067702.1
Gallus gallus (chicken)	BMP15	NP_001006589.2
Canis lupus familiaris (dog)	BMP15	XP_003640322.1
Danio rerio (zebrafish)	bmp15	NP_001018320.1

Gene Ontology
Bibliography

Related articles in PubMed

Abnormal expression levels of BMP15/Smad1 are associated with granulosa cell apoptosis in patients with polycystic ovary syndrome.
Cui X, Jing X, Wu X, Bi X, Liu J, Long Z, Zhang X, Zhang D, Jia H, Su D, Huo K
Molecular medicine reports16(6)8231-8236(2017 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Mutations in BMP15 associated with primary ovarian insufficiency reduce mature protein production, activity, or synergy with GDF9.
Title: BMP15 Mutations Associated With Primary Ovarian Insufficiency Reduce Expression, Activity, or Synergy With GDF9.

results support a model of activation for human GDF9 dependent on cumulin formation through heterodimerization with BMP15. Oocyte-secreted cumulin is likely to be a central regulator of fertility in mono-ovular mammals.
Title: Cumulin, an Oocyte-secreted Heterodimer of the Transforming Growth Factor-? Family, Is a Potent Activator of Granulosa Cells and Improves Oocyte Quality.

GDF9 c.169G>T (D57Y), c.546G>A (rs1049127), and BMP15 rs79377927 (788_789insTCT) were associated with premature ovarian failure in the Chinese Hui population.
Title: Single nucleotide polymorphisms in premature ovarian failure-associated genes in a Chinese Hui population.

BMP15 supplementation differentially modulates reductive metabolism and mitochondrial localization within the oocyte.
Title: Redox and anti-oxidant state within cattle oocytes following in vitro maturation with bone morphogenetic protein 15 and follicle stimulating hormone.

The results showed no direct association between BMP15-9G or 852T and the development of premature ovarian failure (POF). Women with the 538A mutation are up to five times more likely to develop POF. The 788insTCT polymorphism had low biological impact.
Title: Gene variation and premature ovarian failure: a meta-analysis.

The following BMP15 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the BMP15 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu19062	NM_005448.2 Latest version!	Homo sapiens bone morphogenetic protein 15 (BMP15), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

BMP15 ( NM_005448.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_005439.2 Homo sapiens bone morphogenetic protein 15 (BMP15), mRNA.

Price & Availability↑

CloneID	OHu19062
Clone ID Related Accession (Same CDS sequence)	NM_005448.2
Accession Version	NM_005448.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1179bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Homo sapiens(human)
Product	bone morphogenetic protein 15 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC117264.1. This sequence is a reference standard in the RefSeqGene project. On Sep 10, 2009 this sequence version replaced NM_005448.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC117264.1, BC069155.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2151119 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGGTCCTCC TCAGTATTCT TAGAATTCTT TTTCTTTGTG AACTCGTGCT TTTCATGGAA 
CACAGGGCCC AAATGGCAGA AGGAGGGCAG TCCTCTATTG CCCTTCTGGC TGAGGCCCCT 
ACTTTGCCCC TGATTGAGGA GCTGCTAGAA GAATCCCCTG GCGAACAGCC AAGGAAGCCC 
CGGCTCCTAG GGCATTCACT GCGGTACATG CTGGAGTTGT ACCGGCGTTC AGCTGACTCG 
CATGGGCACC CTAGAGAGAA CCGCACCATT GGGGCCACCA TGGTGAGGCT GGTGAAGCCC 
TTGACCAATG TGGCAAGGCC TCACAGAGGT ACCTGGCATA TACAGATCCT GGGCTTTCCT 
CTCAGACCAA ACCGAGGACT ATACCAACTA GTTAGAGCCA CTGTGGTTTA CCGCCATCAT 
CTCCAACTAA CTCGCTTCAA TCTCTCCTGC CATGTGGAGC CCTGGGTGCA GAAAAACCCA 
ACCAACCACT TCCCTTCCTC AGAAGGAGAT TCCTCAAAAC CTTCCCTGAT GTCTAACGCT 
TGGAAAGAGA TGGATATCAC ACAACTTGTT CAGCAAAGGT TCTGGAATAA CAAGGGACAC 
AGGATCCTAC GACTCCGTTT TATGTGTCAG CAGCAAAAAG ATAGTGGTGG TCTTGAGCTC 
TGGCATGGCA CTTCATCCTT GGACATTGCC TTCTTGTTAC TCTATTTCAA TGATACTCAT 
AAAAGCATTC GGAAGGCTAA ATTTCTTCCC AGGGGCATGG AGGAGTTCAT GGAAAGGGAA 
TCTCTTCTCC GGAGAACCCG ACAAGCAGAT GGTATCTCAG CTGAGGTTAC TGCCTCTTCC 
TCAAAACATA GCGGGCCTGA AAATAACCAG TGTTCCCTCC ACCCTTTCCA AATCAGCTTC 
CGCCAGCTGG GTTGGGATCA CTGGATCATT GCTCCCCCTT TCTACACCCC AAACTACTGT 
AAAGGAACTT GTCTCCGAGT ACTACGCGAT GGTCTCAATT CCCCCAATCA CGCCATTATT 
CAGAACCTTA TCAATCAGTT GGTGGACCAG AGTGTCCCCC GGCCCTCCTG TGTCCCGTAT 
AAGTATGTTC CAATTAGTGT CCTTATGATT GAGGCAAATG GGAGTATTTT GTACAAGGAG 
TATGAGGGTA TGATTGCTGA GTCTTGTACA TGCAGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005439.2
CDS	50..1228
Translation	MVLLSILRILFLCELVLFMEHRAQMAEGGQSSIALLAEAPTLPLIEELLEESPGEQPRKPRLLGHSLRYMLELYRRSADSHGHPRENRTIGATMVRLVKPLTNVARPHRGTWHIQILGFPLRPNRGLYQLVRATVVYRHHLQLTRFNLSCHVEPWVQKNPTNHFPSSEGDSSKPSLMSNAWKEMDITQLVQQRFWNNKGHRILRLRFMCQQQKDSGGLELWHGTSSLDIAFLLLYFNDTHKSIRKAKFLPRGMEEFMERESLLRRTRQADGISAEVTASSSKHSGPENNQCSLHPFQISFRQLGWDHWIIAPPFYTPNYCKGTCLRVLRDGLNSPNHAIIQNLINQLVDQSVPRPSCVPYKYVPISVLMIEANGSILYKEYEGMIAESCTCR

Target ORF information:

RefSeq Version	NM_005448.2
Organism	Homo sapiens(human)
Definition	Homo sapiens bone morphogenetic protein 15 (BMP15), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005448.2

ORF Insert Sequence:

ATGGTCCTCC TCAGTATTCT TAGAATTCTT TTTCTTTGTG AACTCGTGCT TTTCATGGAA 
CACAGGGCCC AAATGGCAGA AGGAGGGCAG TCCTCTATTG CCCTTCTGGC TGAGGCCCCT 
ACTTTGCCCC TGATTGAGGA GCTGCTAGAA GAATCCCCTG GCGAACAGCC AAGGAAGCCC 
CGGCTCCTAG GGCATTCACT GCGGTACATG CTGGAGTTGT ACCGGCGTTC AGCTGACTCG 
CATGGGCACC CTAGAGAGAA CCGCACCATT GGGGCCACCA TGGTGAGGCT GGTGAAGCCC 
TTGACCAATG TGGCAAGGCC TCACAGAGGT ACCTGGCATA TACAGATCCT GGGCTTTCCT 
CTCAGACCAA ACCGAGGACT ATACCAACTA GTTAGAGCCA CTGTGGTTTA CCGCCATCAT 
CTCCAACTAA CTCGCTTCAA TCTCTCCTGC CATGTGGAGC CCTGGGTGCA GAAAAACCCA 
ACCAACCACT TCCCTTCCTC AGAAGGAGAT TCCTCAAAAC CTTCCCTGAT GTCTAACGCT 
TGGAAAGAGA TGGATATCAC ACAACTTGTT CAGCAAAGGT TCTGGAATAA CAAGGGACAC 
AGGATCCTAC GACTCCGTTT TATGTGTCAG CAGCAAAAAG ATAGTGGTGG TCTTGAGCTC 
TGGCATGGCA CTTCATCCTT GGACATTGCC TTCTTGTTAC TCTATTTCAA TGATACTCAT 
AAAAGCATTC GGAAGGCTAA ATTTCTTCCC AGGGGCATGG AGGAGTTCAT GGAAAGGGAA 
TCTCTTCTCC GGAGAACCCG ACAAGCAGAT GGTATCTCAG CTGAGGTTAC TGCCTCTTCC 
TCAAAACATA GCGGGCCTGA AAATAACCAG TGTTCCCTCC ACCCTTTCCA AATCAGCTTC 
CGCCAGCTGG GTTGGGATCA CTGGATCATT GCTCCCCCTT TCTACACCCC AAACTACTGT 
AAAGGAACTT GTCTCCGAGT ACTACGCGAT GGTCTCAATT CCCCCAATCA CGCCATTATT 
CAGAACCTTA TCAATCAGTT GGTGGACCAG AGTGTCCCCC GGCCCTCCTG TGTCCCGTAT 
AAGTATGTTC CAATTAGTGT CCTTATGATT GAGGCAAATG GGAGTATTTT GTACAAGGAG 
TATGAGGGTA TGATTGCTGA GTCTTGTACA TGCAGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Abnormal expression levels of BMP15/Smad1 are associated with granulosa cell apoptosis in patients with polycystic ovary syndrome.
Molecular medicine reports16(6)8231-8236(2017 Dec)
Cui X,Jing X,Wu X,Bi X,Liu J,Long Z,Zhang X,Zhang D,Jia H,Su D,Huo K

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BMP15 cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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