Dynll1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Dynll1
Entrez Gene ID	58945
Full Name	dynein light chain LC8-type 1
Synonyms	8kDLC,Dlc8,Dnclc1,Pin
General protein information	Preferred Names dynein light chain LC8-type 1 Names dynein light chain 1, cytoplasmic 8 kDa dynein light chain 8kD LC dynein LC8 dynein, cytoplasmic, light chain 1 protein inhibitor of neuronal nitric oxide synthase
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 12 Map Location: 12q16
Summary	inhibitor of neuronal nitric oxide synthase, a mediator of apoptosis, synaptogenesis, and neuronal development in the brain [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_053319.3	NP_445771.1	dynein light chain 1, cytoplasmic

Pathways from BioSystems

Homologies

Bos taurus (cattle)	DYNLL1	NP_001003901.1
Rattus norvegicus (Norway rat)	Dynll1	NP_445771.1
Canis lupus familiaris (dog)	DYNLL1	XP_863417.1
	DYNLL1	XP_001089607.1
Mus musculus (house mouse)	Dynll1	NP_062656.3
Homo sapiens (human)	DYNLL1	NP_001032583.1
Pan troglodytes (chimpanzee)	DYNLL1	XP_003952374.1

Gene Ontology
Bibliography

Related articles in PubMed

Dynein Light Chain LC8 Is Required for RNA Polymerase I-Mediated Transcription in Trypanosoma brucei, Facilitating Assembly and Promoter Binding of Class I Transcription Factor A.
Kirkham JK, Park SH, Nguyen TN, Lee JH, G?nzl A
Molecular and cellular biology36(1)95-107(2016 Jan)

Tctex1d2 associates with short-rib polydactyly syndrome proteins and is required for ciliogenesis.
Gholkar AA, Senese S, Lo YC, Capri J, Deardorff WJ, Dharmarajan H, Contreras E, Hodara E, Whitelegge JP, Jackson PK, Torres JZ
Cell cycle (Georgetown, Tex.)14(7)1116-25(2015)

Role of nitric oxide synthase uncoupling at rostral ventrolateral medulla in redox-sensitive hypertension associated with metabolic syndrome.
Wu KL, Chao YM, Tsay SJ, Chen CH, Chan SH, Dovinova I, Chan JY
Hypertension (Dallas, Tex. : 1979)64(4)815-24(2014 Oct)

ATMIN is a transcriptional regulator of both lung morphogenesis and ciliogenesis.
Goggolidou P, Stevens JL, Agueci F, Keynton J, Wheway G, Grimes DT, Patel SH, Hilton H, Morthorst SK, DiPaolo A, Williams DJ, Sanderson J, Khoronenkova SV, Powles-Glover N, Ermakov A, Esapa CT, Romero R, Dianov GL, Briscoe J, Johnson CA, Pedersen LB, Norris DP
Development (Cambridge, England)141(20)3966-77(2014 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

silencing of Dynein light chain LC8 or class I transcription factor A2 resulted in a loss of CITFA from RNA Pol I promoters
Title: Dynein Light Chain LC8 Is Required for RNA Polymerase I-Mediated Transcription in Trypanosoma brucei, Facilitating Assembly and Promoter Binding of Class I Transcription Factor A.

Data suggest that redox-sensitive and protein inhibitor of nNOS (PIN)-mediated neuronal NO synthase (nNOS) uncoupling is engaged in a vicious cycle that sustains the production of reactive oxygen species in rostral ventrolateral medulla (RVLM).
Title: Role of nitric oxide synthase uncoupling at rostral ventrolateral medulla in redox-sensitive hypertension associated with metabolic syndrome.

results suggest that PIN is involved in the development of hypertension.
Title: RNA silencing targeting PIN (protein inhibitor of neuronal nitric oxide synthase) attenuates the development of hypertension in young spontaneously hypertensive rats.

Our results show a novel intermediary mechanism that leads to decreased levels of active nNOS in the PVN, involved in subsequent reduction in sympathoinhibition during CHF, offering a new target for the treatment of CHF and other cardiovascular diseases.
Title: Angiotensin II-mediated posttranslational modification of nNOS in the PVN of rats with CHF: role for PIN.

In the glaucoma model DYNLL1 was strongly and persistently downregulated at all timepoints
Title: The expression of dynein light chain DYNLL1 (LC8-1) is persistently downregulated in glaucomatous rat retinal ganglion cells.

The following Dynll1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Dynll1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa09266	NM_053319.3 Latest version!	Rattus norvegicus dynein light chain LC8-type 1 (Dynll1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
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5 or more Clone	50% OFF
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Dynll1 ( NM_053319.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_445771.1 Rattus norvegicus dynein light chain LC8-type 1 (Dynll1), mRNA.

Price & Availability↑

CloneID	ORa09266
Clone ID Related Accession (Same CDS sequence)	NM_053319.3
Accession Version	NM_053319.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 270bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-02
Organism	Rattus norvegicus(Norway rat)
Product	dynein light chain 1, cytoplasmic
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC063183.1. On Aug 31, 2012 this sequence version replaced NM_053319.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC063183.1, CO403508.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGTGCGACC GGAAGGCGGT GATCAAAAAT GCAGACATGT CGGAAGAGAT GCAACAGGAC 
TCGGTGGAGT GCGCTACTCA GGCGTTGGAG AAGTACAACA TAGAGAAGGA TATCGCGGCC 
CATATCAAGA AGGAGTTTGA CAAGAAGTAC AACCCCACCT GGCACTGCAT CGTGGGCCGG 
AACTTCGGTA GCTACGTGAC ACACGAGACC AAACACTTCA TCTACTTCTA CCTGGGTCAG 
GTGGCCATTC TCCTGTTCAA ATCTGGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_445771.1
CDS	110..379
Translation	MCDRKAVIKNADMSEEMQQDSVECATQALEKYNIEKDIAAHIKKEFDKKYNPTWHCIVGRNFGSYVTHETKHFIYFYLGQVAILLFKSG

Target ORF information:

RefSeq Version	NM_053319.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus dynein light chain LC8-type 1 (Dynll1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053319.3

ORF Insert Sequence:

ATGTGCGACC GGAAGGCGGT GATCAAAAAT GCAGACATGT CGGAAGAGAT GCAACAGGAC 
TCGGTGGAGT GCGCTACTCA GGCGTTGGAG AAGTACAACA TAGAGAAGGA TATCGCGGCC 
CATATCAAGA AGGAGTTTGA CAAGAAGTAC AACCCCACCT GGCACTGCAT CGTGGGCCGG 
AACTTCGGTA GCTACGTGAC ACACGAGACC AAACACTTCA TCTACTTCTA CCTGGGTCAG 
GTGGCCATTC TCCTGTTCAA ATCTGGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Dynein Light Chain LC8 Is Required for RNA Polymerase I-Mediated Transcription in Trypanosoma brucei, Facilitating Assembly and Promoter Binding of Class I Transcription Factor A.
Molecular and cellular biology36(1)95-107(2016 Jan)
Kirkham JK,Park SH,Nguyen TN,Lee JH,G?nzl A

Tctex1d2 associates with short-rib polydactyly syndrome proteins and is required for ciliogenesis.
Cell cycle (Georgetown, Tex.)14(7)1116-25(2015)
Gholkar AA,Senese S,Lo YC,Capri J,Deardorff WJ,Dharmarajan H,Contreras E,Hodara E,Whitelegge JP,Jackson PK,Torres JZ

Role of nitric oxide synthase uncoupling at rostral ventrolateral medulla in redox-sensitive hypertension associated with metabolic syndrome.
Hypertension (Dallas, Tex. : 1979)64(4)815-24(2014 Oct)
Wu KL,Chao YM,Tsay SJ,Chen CH,Chan SH,Dovinova I,Chan JY

ATMIN is a transcriptional regulator of both lung morphogenesis and ciliogenesis.
Development (Cambridge, England)141(20)3966-77(2014 Oct)
Goggolidou P,Stevens JL,Agueci F,Keynton J,Wheway G,Grimes DT,Patel SH,Hilton H,Morthorst SK,DiPaolo A,Williams DJ,Sanderson J,Khoronenkova SV,Powles-Glover N,Ermakov A,Esapa CT,Romero R,Dianov GL,Briscoe J,Johnson CA,Pedersen LB,Norris DP

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Dynll1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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