DYNLL1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	DYNLL1
Entrez Gene ID	8655
Full Name	dynein light chain LC8-type 1
Synonyms	DLC1,DLC8,DNCL1,DNCLC1,LC8,LC8a,PIN,hdlc1
General protein information	Preferred Names dynein light chain LC8-type 1 Names dynein light chain 1, cytoplasmic 8 kDa dynein light chain cytoplasmic dynein light polypeptide dynein, cytoplasmic, light polypeptide 1 protein inhibitor of neuronal nitric oxide synthase
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12q24.31
Summary	Cytoplasmic dyneins are large enzyme complexes with a molecular mass of about 1,200 kD. They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain, which contains a varying number of accessory intermediate chains. The complex is involved in intracellular transport and motility. The protein described in this record is a light chain and exists as part of this complex but also physically interacts with and inhibits the activity of neuronal nitric oxide synthase. Binding of this protein destabilizes the neuronal nitric oxide synthase dimer, a conformation necessary for activity, and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008].
Disorder MIM:	601562

mRNA and Protein(s)

mRNA	Protein	Name
NM_003746.2	NP_003737.1	dynein light chain 1, cytoplasmic
NM_001037495.1	NP_001032584.1	dynein light chain 1, cytoplasmic
NM_001037494.2	NP_001032583.1	dynein light chain 1, cytoplasmic
NM_003746.3	NP_003737.1	dynein light chain 1, cytoplasmic
NM_001037494.1	NP_001032583.1	dynein light chain 1, cytoplasmic
NM_001037495.2	NP_001032584.1	dynein light chain 1, cytoplasmic

Pathways from BioSystems

Homologies

Bos taurus (cattle)	DYNLL1	NP_001003901.1
Rattus norvegicus (Norway rat)	Dynll1	NP_445771.1
Canis lupus familiaris (dog)	DYNLL1	XP_863417.1
	DYNLL1	XP_001089607.1
Mus musculus (house mouse)	Dynll1	NP_062656.3
Homo sapiens (human)	DYNLL1	NP_001032583.1
Pan troglodytes (chimpanzee)	DYNLL1	XP_003952374.1

Gene Ontology
Bibliography

Related articles in PubMed

Novel linear motif filtering protocol reveals the role of the LC8 dynein light chain in the Hippo pathway.
Erd?s G, Szaniszl? T, Pajkos M, Hajdu-Solt?sz B, Kiss B, P?l G, Nyitray L, Doszt?nyi Z
PLoS computational biology13(12)e1005885(2017 12)

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

DLC1 binding to nNOS-calmodulin complex does not affect the electron transport from the reductase to the oxygenase domain.
Title: The protein inhibitor of nNOS (PIN/DLC1/LC8) binding does not inhibit the NADPH-dependent heme reduction in nNOS, a key step in NO synthesis.

NMR-derived secondary chemical shifts and relaxation properties show that the Chica LC8 binding domain is essentially disordered with a dynamically restricted segment in one linker between motifs.
Title: The Anchored Flexibility Model in LC8 Motif Recognition: Insights from the Chica Complex.

DLC1 binding motif in L is involved in cytoskeleton localization and reorganization, primary transcription regulation by DLC1, and regulation of cellular DLC1 gene expression.
Title: A Dynein Light Chain 1 Binding Motif in Rabies Virus Polymerase L Protein Plays a Role in Microtubule Reorganization and Viral Primary Transcription.

Studies indicate that dynein light chain LC8 has been termed an intrinsically disordered proteins (IDPs) dimerization 'hub' protein.
Title: Multivalent IDP assemblies: Unique properties of LC8-associated, IDP duplex scaffolds.

Authors demonstrate that the interaction between ebola virus VP35 and dynein LC8 is direct and of high affinity and that binding stabilizes the VP35 N-terminal oligomerization domain and enhances viral RNA synthesis.
Title: Ebola virus VP35 interaction with dynein LC8 regulates viral RNA synthesis.

The following DYNLL1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DYNLL1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu18857	NM_001037494.2 Latest version!	Homo sapiens dynein light chain LC8-type 1 (DYNLL1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu18857	NM_003746.3 Latest version!	Homo sapiens dynein light chain LC8-type 1 (DYNLL1), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu18857	NM_001037495.2 Latest version!	Homo sapiens dynein light chain LC8-type 1 (DYNLL1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu18857	NM_003746.2	Homo sapiens dynein light chain LC8-type 1 (DYNLL1), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu18857	NM_001037494.1	Homo sapiens dynein light chain LC8-type 1 (DYNLL1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu18857	NM_001037495.1	Homo sapiens dynein light chain LC8-type 1 (DYNLL1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

DYNLL1 ( NM_003746.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_003737.1 Homo sapiens dynein light chain LC8-type 1 (DYNLL1), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu18857
Clone ID Related Accession (Same CDS sequence)	NM_003746.2 , NM_001037495.1 , NM_001037494.2 , NM_003746.3 , NM_001037494.1 , NM_001037495.2
Accession Version	NM_003746.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 270bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-09
Organism	Homo sapiens(human)
Product	dynein light chain 1, cytoplasmic
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG705617.1, BU598428.1, AC063943.23 and BI491360.1. On Dec 5, 2005 this sequence version replaced NM_003746.1. Transcript Variant: This variant (3) contains a distinct 5' UTR, including an alternate, downstream transcription initiation site. Variants 1, 2 and 3 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BU601070.1, SRR1163658.394024.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTGCGACC GAAAGGCCGT GATCAAAAAT GCGGACATGT CGGAAGAGAT GCAACAGGAC 
TCGGTGGAGT GCGCTACTCA GGCGCTGGAG AAATACAACA TAGAGAAGGA CATTGCGGCT 
CATATCAAGA AGGAATTTGA CAAGAAGTAC AATCCCACCT GGCATTGCAT CGTGGGGAGG 
AACTTCGGTA GTTATGTGAC ACATGAAACC AAACACTTCA TCTACTTCTA CCTGGGCCAA 
GTGGCCATTC TTCTGTTCAA ATCTGGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003737.1
CDS	168..437
Translation	MCDRKAVIKNADMSEEMQQDSVECATQALEKYNIEKDIAAHIKKEFDKKYNPTWHCIVGRNFGSYVTHETKHFIYFYLGQVAILLFKSG

Target ORF information:

RefSeq Version	NM_003746.2
Organism	Homo sapiens(human)
Definition	Homo sapiens dynein light chain LC8-type 1 (DYNLL1), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003746.2

ORF Insert Sequence:

ATGTGCGACC GAAAGGCCGT GATCAAAAAT GCGGACATGT CGGAAGAGAT GCAACAGGAC 
TCGGTGGAGT GCGCTACTCA GGCGCTGGAG AAATACAACA TAGAGAAGGA CATTGCGGCT 
CATATCAAGA AGGAATTTGA CAAGAAGTAC AATCCCACCT GGCATTGCAT CGTGGGGAGG 
AACTTCGGTA GTTATGTGAC ACATGAAACC AAACACTTCA TCTACTTCTA CCTGGGCCAA 
GTGGCCATTC TTCTGTTCAA ATCTGGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DYNLL1 ( NM_001037495.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001032584.1 Homo sapiens dynein light chain LC8-type 1 (DYNLL1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu18857
Clone ID Related Accession (Same CDS sequence)	NM_003746.2 , NM_001037495.1 , NM_001037494.2 , NM_003746.3 , NM_001037494.1 , NM_001037495.2
Accession Version	NM_001037495.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 270bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-16
Organism	Homo sapiens(human)
Product	dynein light chain 1, cytoplasmic
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG705617.1, BU598428.1, BM817665.1, BC104244.1, CD678447.1 and BI491360.1. Transcript Variant: This variant (2) contains a distinct 5' UTR including an alternate, downstream transcription initiation site. Variants 1, 2 and 3 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.215862.1, SRR1163657.188046.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTGCGACC GAAAGGCCGT GATCAAAAAT GCGGACATGT CGGAAGAGAT GCAACAGGAC 
TCGGTGGAGT GCGCTACTCA GGCGCTGGAG AAATACAACA TAGAGAAGGA CATTGCGGCT 
CATATCAAGA AGGAATTTGA CAAGAAGTAC AATCCCACCT GGCATTGCAT CGTGGGGAGG 
AACTTCGGTA GTTATGTGAC ACATGAAACC AAACACTTCA TCTACTTCTA CCTGGGCCAA 
GTGGCCATTC TTCTGTTCAA ATCTGGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001032584.1
CDS	182..451
Translation	MCDRKAVIKNADMSEEMQQDSVECATQALEKYNIEKDIAAHIKKEFDKKYNPTWHCIVGRNFGSYVTHETKHFIYFYLGQVAILLFKSG

Target ORF information:

RefSeq Version	NM_001037495.1
Organism	Homo sapiens(human)
Definition	Homo sapiens dynein light chain LC8-type 1 (DYNLL1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001037495.1

ORF Insert Sequence:

ATGTGCGACC GAAAGGCCGT GATCAAAAAT GCGGACATGT CGGAAGAGAT GCAACAGGAC 
TCGGTGGAGT GCGCTACTCA GGCGCTGGAG AAATACAACA TAGAGAAGGA CATTGCGGCT 
CATATCAAGA AGGAATTTGA CAAGAAGTAC AATCCCACCT GGCATTGCAT CGTGGGGAGG 
AACTTCGGTA GTTATGTGAC ACATGAAACC AAACACTTCA TCTACTTCTA CCTGGGCCAA 
GTGGCCATTC TTCTGTTCAA ATCTGGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DYNLL1 ( NM_001037494.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001032583.1 Homo sapiens dynein light chain LC8-type 1 (DYNLL1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu18857
Clone ID Related Accession (Same CDS sequence)	NM_003746.2 , NM_001037495.1 , NM_001037494.2 , NM_003746.3 , NM_001037494.1 , NM_001037495.2
Accession Version	NM_001037494.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 270bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-03
Organism	Homo sapiens(human)
Product	dynein light chain 1, cytoplasmic
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL021546.1, BG474448.1, CB992195.1, CD678447.1 and BI491360.1. On Jun 1, 2019 this sequence version replaced NM_001037494.1. Transcript Variant: This variant (1) represents the longest transcript. . Variants 1, 2 and 3 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR7410570.510238.1, DRR138512.19037.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTGCGACC GAAAGGCCGT GATCAAAAAT GCGGACATGT CGGAAGAGAT GCAACAGGAC 
TCGGTGGAGT GCGCTACTCA GGCGCTGGAG AAATACAACA TAGAGAAGGA CATTGCGGCT 
CATATCAAGA AGGAATTTGA CAAGAAGTAC AATCCCACCT GGCATTGCAT CGTGGGGAGG 
AACTTCGGTA GTTATGTGAC ACATGAAACC AAACACTTCA TCTACTTCTA CCTGGGCCAA 
GTGGCCATTC TTCTGTTCAA ATCTGGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001032583.1
CDS	270..539
Translation	MCDRKAVIKNADMSEEMQQDSVECATQALEKYNIEKDIAAHIKKEFDKKYNPTWHCIVGRNFGSYVTHETKHFIYFYLGQVAILLFKSG

Target ORF information:

RefSeq Version	NM_001037494.2
Organism	Homo sapiens(human)
Definition	Homo sapiens dynein light chain LC8-type 1 (DYNLL1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001037494.2

ORF Insert Sequence:

ATGTGCGACC GAAAGGCCGT GATCAAAAAT GCGGACATGT CGGAAGAGAT GCAACAGGAC 
TCGGTGGAGT GCGCTACTCA GGCGCTGGAG AAATACAACA TAGAGAAGGA CATTGCGGCT 
CATATCAAGA AGGAATTTGA CAAGAAGTAC AATCCCACCT GGCATTGCAT CGTGGGGAGG 
AACTTCGGTA GTTATGTGAC ACATGAAACC AAACACTTCA TCTACTTCTA CCTGGGCCAA 
GTGGCCATTC TTCTGTTCAA ATCTGGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DYNLL1 ( NM_003746.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_003737.1 Homo sapiens dynein light chain LC8-type 1 (DYNLL1), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu18857
Clone ID Related Accession (Same CDS sequence)	NM_003746.2 , NM_001037495.1 , NM_001037494.2 , NM_003746.3 , NM_001037494.1 , NM_001037495.2
Accession Version	NM_003746.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 270bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	dynein light chain 1, cytoplasmic
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BU598428.1 and AC063943.23. On Nov 22, 2018 this sequence version replaced NM_003746.2. Transcript Variant: This variant (3) contains a distinct 5' UTR, including an alternate, downstream transcription initiation site. Variants 1, 2 and 3 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AV759540.1, BM765041.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000242577.11/ ENSP00000242577.6 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTGCGACC GAAAGGCCGT GATCAAAAAT GCGGACATGT CGGAAGAGAT GCAACAGGAC 
TCGGTGGAGT GCGCTACTCA GGCGCTGGAG AAATACAACA TAGAGAAGGA CATTGCGGCT 
CATATCAAGA AGGAATTTGA CAAGAAGTAC AATCCCACCT GGCATTGCAT CGTGGGGAGG 
AACTTCGGTA GTTATGTGAC ACATGAAACC AAACACTTCA TCTACTTCTA CCTGGGCCAA 
GTGGCCATTC TTCTGTTCAA ATCTGGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003737.1
CDS	111..380
Translation	MCDRKAVIKNADMSEEMQQDSVECATQALEKYNIEKDIAAHIKKEFDKKYNPTWHCIVGRNFGSYVTHETKHFIYFYLGQVAILLFKSG

Target ORF information:

RefSeq Version	NM_003746.3
Organism	Homo sapiens(human)
Definition	Homo sapiens dynein light chain LC8-type 1 (DYNLL1), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003746.3

ORF Insert Sequence:

ATGTGCGACC GAAAGGCCGT GATCAAAAAT GCGGACATGT CGGAAGAGAT GCAACAGGAC 
TCGGTGGAGT GCGCTACTCA GGCGCTGGAG AAATACAACA TAGAGAAGGA CATTGCGGCT 
CATATCAAGA AGGAATTTGA CAAGAAGTAC AATCCCACCT GGCATTGCAT CGTGGGGAGG 
AACTTCGGTA GTTATGTGAC ACATGAAACC AAACACTTCA TCTACTTCTA CCTGGGCCAA 
GTGGCCATTC TTCTGTTCAA ATCTGGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DYNLL1 ( NM_001037494.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001032583.1 Homo sapiens dynein light chain LC8-type 1 (DYNLL1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu18857
Clone ID Related Accession (Same CDS sequence)	NM_003746.2 , NM_001037495.1 , NM_001037494.2 , NM_003746.3 , NM_001037494.1 , NM_001037495.2
Accession Version	NM_001037494.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 270bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-16
Organism	Homo sapiens(human)
Product	dynein light chain 1, cytoplasmic
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG474448.1, CB992195.1, CD678447.1 and BI491360.1. Transcript Variant: This variant (1) represents the longest transcript. . Variants 1, 2 and 3 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CB992195.1, SRR1163658.97443.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTGCGACC GAAAGGCCGT GATCAAAAAT GCGGACATGT CGGAAGAGAT GCAACAGGAC 
TCGGTGGAGT GCGCTACTCA GGCGCTGGAG AAATACAACA TAGAGAAGGA CATTGCGGCT 
CATATCAAGA AGGAATTTGA CAAGAAGTAC AATCCCACCT GGCATTGCAT CGTGGGGAGG 
AACTTCGGTA GTTATGTGAC ACATGAAACC AAACACTTCA TCTACTTCTA CCTGGGCCAA 
GTGGCCATTC TTCTGTTCAA ATCTGGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001032583.1
CDS	255..524
Translation	MCDRKAVIKNADMSEEMQQDSVECATQALEKYNIEKDIAAHIKKEFDKKYNPTWHCIVGRNFGSYVTHETKHFIYFYLGQVAILLFKSG

Target ORF information:

RefSeq Version	NM_001037494.1
Organism	Homo sapiens(human)
Definition	Homo sapiens dynein light chain LC8-type 1 (DYNLL1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001037494.1

ORF Insert Sequence:

ATGTGCGACC GAAAGGCCGT GATCAAAAAT GCGGACATGT CGGAAGAGAT GCAACAGGAC 
TCGGTGGAGT GCGCTACTCA GGCGCTGGAG AAATACAACA TAGAGAAGGA CATTGCGGCT 
CATATCAAGA AGGAATTTGA CAAGAAGTAC AATCCCACCT GGCATTGCAT CGTGGGGAGG 
AACTTCGGTA GTTATGTGAC ACATGAAACC AAACACTTCA TCTACTTCTA CCTGGGCCAA 
GTGGCCATTC TTCTGTTCAA ATCTGGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DYNLL1 ( NM_001037495.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001032584.1 Homo sapiens dynein light chain LC8-type 1 (DYNLL1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu18857
Clone ID Related Accession (Same CDS sequence)	NM_003746.2 , NM_001037495.1 , NM_001037494.2 , NM_003746.3 , NM_001037494.1 , NM_001037495.2
Accession Version	NM_001037495.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 270bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	dynein light chain 1, cytoplasmic
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BM817665.1, BC104244.1 and CD678447.1. On May 31, 2019 this sequence version replaced NM_001037495.1. Transcript Variant: This variant (2) contains a distinct 5' UTR including an alternate, downstream transcription initiation site. Variants 1, 2 and 3 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR7410570.510350.1, BG714280.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTGCGACC GAAAGGCCGT GATCAAAAAT GCGGACATGT CGGAAGAGAT GCAACAGGAC 
TCGGTGGAGT GCGCTACTCA GGCGCTGGAG AAATACAACA TAGAGAAGGA CATTGCGGCT 
CATATCAAGA AGGAATTTGA CAAGAAGTAC AATCCCACCT GGCATTGCAT CGTGGGGAGG 
AACTTCGGTA GTTATGTGAC ACATGAAACC AAACACTTCA TCTACTTCTA CCTGGGCCAA 
GTGGCCATTC TTCTGTTCAA ATCTGGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001032584.1
CDS	125..394
Translation	MCDRKAVIKNADMSEEMQQDSVECATQALEKYNIEKDIAAHIKKEFDKKYNPTWHCIVGRNFGSYVTHETKHFIYFYLGQVAILLFKSG

Target ORF information:

RefSeq Version	NM_001037495.2
Organism	Homo sapiens(human)
Definition	Homo sapiens dynein light chain LC8-type 1 (DYNLL1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001037495.2

ORF Insert Sequence:

ATGTGCGACC GAAAGGCCGT GATCAAAAAT GCGGACATGT CGGAAGAGAT GCAACAGGAC 
TCGGTGGAGT GCGCTACTCA GGCGCTGGAG AAATACAACA TAGAGAAGGA CATTGCGGCT 
CATATCAAGA AGGAATTTGA CAAGAAGTAC AATCCCACCT GGCATTGCAT CGTGGGGAGG 
AACTTCGGTA GTTATGTGAC ACATGAAACC AAACACTTCA TCTACTTCTA CCTGGGCCAA 
GTGGCCATTC TTCTGTTCAA ATCTGGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Novel linear motif filtering protocol reveals the role of the LC8 dynein light chain in the Hippo pathway.
PLoS computational biology13(12)e1005885(2017 12)
Erd?s G,Szaniszl? T,Pajkos M,Hajdu-Solt?sz B,Kiss B,P?l G,Nyitray L,Doszt?nyi Z

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

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DYNLL1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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