Preb cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Preb
Entrez Gene ID	58842
Full Name	prolactin regulatory element binding
General protein information	Preferred Names prolactin regulatory element binding Names prolactin regulatory element-binding protein mammalian guanine nucleotide exchange factor mSec12
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 6 Map Location: 6q14
Summary	WD-repeat containing regulatory transcription factor; may mediate gene transcription in the pituitary and in other organs [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001170708.1	NP_001164179.1	prolactin regulatory element-binding protein

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	PREB	XP_515352.3
Bos taurus (cattle)	PREB	NP_001070343.2
Homo sapiens (human)	PREB	NP_037520.1
	PREB	XP_001088763.2
Mus musculus (house mouse)	Preb	NP_057912.2
Danio rerio (zebrafish)	preb	NP_001002638.1
Caenorhabditis elegans (roundworm)	sec-12	NP_492305.2
Canis lupus familiaris (dog)	PREB	XP_540122.2
Drosophila melanogaster (fruit fly)	CG9175	NP_608995.2
Rattus norvegicus (Norway rat)	Preb	NP_001164179.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP009942	XP_319071.3
Xenopus tropicalis (tropical clawed frog)	preb	NP_001001231.1
Gallus gallus (chicken)	PREB	XP_003643564.1

Gene Ontology
Bibliography

Related articles in PubMed

TANGO1 recruits Sec16 to coordinately organize ER exit sites for efficient secretion.
Maeda M, Katada T, Saito K
The Journal of cell biology216(6)1731-1743(2017 Jun)

Dual function of cTAGE5 in collagen export from the endoplasmic reticulum.
Tanabe T, Maeda M, Saito K, Katada T
Molecular biology of the cell27(13)2008-13(2016 07)

Concentration of Sec12 at ER exit sites via interaction with cTAGE5 is required for collagen export.
Saito K, Yamashiro K, Shimazu N, Tanabe T, Kontani K, Katada T
The Journal of cell biology206(6)751-62(2014 Sep)

Transcriptional factor prolactin regulatory element-binding protein-mediated gene transcription of ABCA1 via 3',5'-cyclic adenosine-5'-monophosphate.
Nishiuchi Y, Murao K, Imachi H, Nishiuchi T, Iwama H, Ishida T
Atherosclerosis212(2)418-25(2010 Oct)

The transcription factor prolactin regulatory element-binding protein mediates prolactin transcription induced by thyrotropin-releasing hormone in GH3 cells.
Yu X, Murao K, Imachi H, Li J, Nishiuchi T, Dobashi H, Hosomi N, Masugata H, Zhang GX, Iwama H, Ishida T
Endocrine38(1)53-9(2010 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

PREB regulates the cAMP-mediated transcription of the ABCA1 gene in vascular smooth muscle cells
Title: Transcriptional factor prolactin regulatory element-binding protein-mediated gene transcription of ABCA1 via 3',5'-cyclic adenosine-5'-monophosphate.

PREB can function as a transcriptional regulator of prolactin promoter activity and might be involved in TRH-induced PRL gene transcription
Title: The transcription factor prolactin regulatory element-binding protein mediates prolactin transcription induced by thyrotropin-releasing hormone in GH3 cells.

The transcriptional factor PREB mediates MCP-1 transcription induced by cytokines in human vascular endothelial cells.
Title: The transcriptional factor PREB mediates MCP-1 transcription induced by cytokines in human vascular endothelial cells.

PREB may contribute to the regulation of insulin gene transcription and insulin secretion in response to glucose stimulation.
Title: Prolactin regulatory element binding protein as a potential transcriptional factor for the insulin gene in response to glucose stimulation.

The following Preb gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Preb cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa05923	NM_001170708.1 Latest version!	Rattus norvegicus prolactin regulatory element binding (Preb), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Preb ( NM_001170708.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001164179.1 Rattus norvegicus prolactin regulatory element binding (Preb), mRNA.

Price & Availability↑

CloneID	ORa05923
Clone ID Related Accession (Same CDS sequence)	NM_001170708.1
Accession Version	NM_001170708.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1254bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Rattus norvegicus(Norway rat)
Product	prolactin regulatory element-binding protein
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC078936.1. On or before May 13, 2010 this sequence version replaced XM_002726713.1, XM_002729612.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC078936.1, AF061817.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGGCCGGC GCCGGGGTGT GGAGCTGTAC CGGGCCCCGT TCCCGTTGTA CGCGCTTCGG 
ATAGACCCCA AGACTGGACT GCTCATCGCT GCGGGCGGAG GAGGAGCTGC CAAGACCGGC 
ATAAAGAATG GCGTGCATTT TCTGCAGCTA GAGCAGATCA GCGGGTGCCT GAGCGCCTCC 
TTGCTGCACT CTCATGACAC GGAGACAAGG GCCACTATGA ATTTGGCGCT GGCTGGTGAC 
ATCCTTGCTG CTGGACAGGA TGCCCAGTGT CAGCTTCTTC GTTTCCAGAT CCATCAACAG 
AAGGGCAGTA AAGCAGAGAA GTCAGGTTCC AAGGAGCAGG GGCCTCGGCA GAGGAAGGGG 
GCAGCTCCAG CAGAGAAGAA ATCGGGAGCG GAAGTTCACC CGGAAGGGGT TGAGCTCAAA 
GTAAAGAATT TGGAGGCAGT ACAGACAGAC TTCAGCACTG AACCGCTGCA GAAAGTTGTG 
TGCTTCAACC ATGATAACAC CCTGCTTGCC ACCGGAGGAT CTGACGGTCA TGTTCGTGTC 
TGGAAGGTAC CTAGCCTAGA GAAAGTTCTG GAGTTTAAAG CCCACGAAGG GGAGATTGGA 
GATTTGGCTT TGGGTCCTGA TGGCAAGTTG GTTACTGTGG GCTGGGACTT TAAGGCCTCC 
GTGTGGCAGA AGGATCAACT GGTGACACAG CTACAGTGGC AAGAGAATGG ACCCACCTCT 
TCTAACACAC CGTACCGCTA CCAGGCCTGC AGGTTTGGGC AGGTTCCAGA TCAGCCTGGT 
GGGCTGCGAC TCTTCACAGT GCAGATACCC CACAAGCGCC TACGACAGCC CCCACCCTGC 
TACCTCACAG CCTGGGACAG TTCCACCTTC TTGCCTCTTC AGACCAGGTC CTGTGGCCAT 
GAAGTCATTT CCTGCCTCAC TGTCAGTGAA TCGGGTACCT TCCTAGGCCT AGGCACGGTC 
ACTGGCTCTG TCGCCATCTA CATAGCTTTC TCTCTCCAGC GCCTGTATTA TGTGAAGGAG 
GCCCATGGCA TTGTGGTGAC AGATGTGACC TTTCTACCTG AGAAGGGTTG CGGTCCAAAG 
CTCCTTGGGC CCCATGAAAC GGCCCTGTTC TCTGTGGCTG TGGATAGTCG TTGCCAGTTG 
CACCTGCTGC CCTCACGTCG GAGTGTTCCC GTATGGCTCC TGCTCCTGCT ATGTGTTGGC 
CTTATTATCG TGACCATCCT GCTGCTCCAG AGTGCCTTCC CGGGGTTTCT TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001164179.1
CDS	171..1424
Translation	MGRRRGVELYRAPFPLYALRIDPKTGLLIAAGGGGAAKTGIKNGVHFLQLEQISGCLSASLLHSHDTETRATMNLALAGDILAAGQDAQCQLLRFQIHQQKGSKAEKSGSKEQGPRQRKGAAPAEKKSGAEVHPEGVELKVKNLEAVQTDFSTEPLQKVVCFNHDNTLLATGGSDGHVRVWKVPSLEKVLEFKAHEGEIGDLALGPDGKLVTVGWDFKASVWQKDQLVTQLQWQENGPTSSNTPYRYQACRFGQVPDQPGGLRLFTVQIPHKRLRQPPPCYLTAWDSSTFLPLQTRSCGHEVISCLTVSESGTFLGLGTVTGSVAIYIAFSLQRLYYVKEAHGIVVTDVTFLPEKGCGPKLLGPHETALFSVAVDSRCQLHLLPSRRSVPVWLLLLLCVGLIIVTILLLQSAFPGFL

Target ORF information:

RefSeq Version	NM_001170708.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus prolactin regulatory element binding (Preb), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001170708.1

ORF Insert Sequence:

ATGGGCCGGC GCCGGGGTGT GGAGCTGTAC CGGGCCCCGT TCCCGTTGTA CGCGCTTCGG 
ATAGACCCCA AGACTGGACT GCTCATCGCT GCGGGCGGAG GAGGAGCTGC CAAGACCGGC 
ATAAAGAATG GCGTGCATTT TCTGCAGCTA GAGCAGATCA GCGGGTGCCT GAGCGCCTCC 
TTGCTGCACT CTCATGACAC GGAGACAAGG GCCACTATGA ATTTGGCGCT GGCTGGTGAC 
ATCCTTGCTG CTGGACAGGA TGCCCAGTGT CAGCTTCTTC GTTTCCAGAT CCATCAACAG 
AAGGGCAGTA AAGCAGAGAA GTCAGGTTCC AAGGAGCAGG GGCCTCGGCA GAGGAAGGGG 
GCAGCTCCAG CAGAGAAGAA ATCGGGAGCG GAAGTTCACC CGGAAGGGGT TGAGCTCAAA 
GTAAAGAATT TGGAGGCAGT ACAGACAGAC TTCAGCACTG AACCGCTGCA GAAAGTTGTG 
TGCTTCAACC ATGATAACAC CCTGCTTGCC ACCGGAGGAT CTGACGGTCA TGTTCGTGTC 
TGGAAGGTAC CTAGCCTAGA GAAAGTTCTG GAGTTTAAAG CCCACGAAGG GGAGATTGGA 
GATTTGGCTT TGGGTCCTGA TGGCAAGTTG GTTACTGTGG GCTGGGACTT TAAGGCCTCC 
GTGTGGCAGA AGGATCAACT GGTGACACAG CTACAGTGGC AAGAGAATGG ACCCACCTCT 
TCTAACACAC CGTACCGCTA CCAGGCCTGC AGGTTTGGGC AGGTTCCAGA TCAGCCTGGT 
GGGCTGCGAC TCTTCACAGT GCAGATACCC CACAAGCGCC TACGACAGCC CCCACCCTGC 
TACCTCACAG CCTGGGACAG TTCCACCTTC TTGCCTCTTC AGACCAGGTC CTGTGGCCAT 
GAAGTCATTT CCTGCCTCAC TGTCAGTGAA TCGGGTACCT TCCTAGGCCT AGGCACGGTC 
ACTGGCTCTG TCGCCATCTA CATAGCTTTC TCTCTCCAGC GCCTGTATTA TGTGAAGGAG 
GCCCATGGCA TTGTGGTGAC AGATGTGACC TTTCTACCTG AGAAGGGTTG CGGTCCAAAG 
CTCCTTGGGC CCCATGAAAC GGCCCTGTTC TCTGTGGCTG TGGATAGTCG TTGCCAGTTG 
CACCTGCTGC CCTCACGTCG GAGTGTTCCC GTATGGCTCC TGCTCCTGCT ATGTGTTGGC 
CTTATTATCG TGACCATCCT GCTGCTCCAG AGTGCCTTCC CGGGGTTTCT TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

TANGO1 recruits Sec16 to coordinately organize ER exit sites for efficient secretion.
The Journal of cell biology216(6)1731-1743(2017 Jun)
Maeda M,Katada T,Saito K

Dual function of cTAGE5 in collagen export from the endoplasmic reticulum.
Molecular biology of the cell27(13)2008-13(2016 07)
Tanabe T,Maeda M,Saito K,Katada T

Concentration of Sec12 at ER exit sites via interaction with cTAGE5 is required for collagen export.
The Journal of cell biology206(6)751-62(2014 Sep)
Saito K,Yamashiro K,Shimazu N,Tanabe T,Kontani K,Katada T

Transcriptional factor prolactin regulatory element-binding protein-mediated gene transcription of ABCA1 via 3',5'-cyclic adenosine-5'-monophosphate.
Atherosclerosis212(2)418-25(2010 Oct)
Nishiuchi Y,Murao K,Imachi H,Nishiuchi T,Iwama H,Ishida T

The transcription factor prolactin regulatory element-binding protein mediates prolactin transcription induced by thyrotropin-releasing hormone in GH3 cells.
Endocrine38(1)53-9(2010 Aug)
Yu X,Murao K,Imachi H,Li J,Nishiuchi T,Dobashi H,Hosomi N,Masugata H,Zhang GX,Iwama H,Ishida T

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Preb cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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