Slc23a1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Slc23a1
Entrez Gene ID	50621
Full Name	solute carrier family 23 member 1
Synonyms	SVCT1
General protein information	Preferred Names solute carrier family 23 member 1 Names solute carrier family 23 member 1 Na(+)/L-ascorbic acid transporter 1 sodium-coupled ascorbic acid transporter 1 sodium-dependent vitamin C transporter 1 solute carrier family 23 (ascorbic acid transporter), member 1 solute carrier family 23 (nucleobase transporters), member 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 18 Map Location: 18p11
Summary	mediates concentrative, high-affinity L-ascorbic acid transport which is driven by the Na+ electrochemical gradient [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_006254602.3	XP_006254664.1	solute carrier family 23 member 1 isoform X1
NM_017315.2	NP_059011.1	solute carrier family 23 member 1

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Slc23a1	NP_059011.1
Mus musculus (house mouse)	Slc23a1	NP_035527.3
Arabidopsis thaliana (thale cress)	NAT8	NP_172524.1
Xenopus tropicalis (tropical clawed frog)	LOC100493636	XP_002932349.2
Pan troglodytes (chimpanzee)	SLC23A1	XP_517965.3
Bos taurus (cattle)	SLC23A1	XP_002689309.1
Gallus gallus (chicken)	SLC23A1	XP_004944825.1
Arabidopsis thaliana (thale cress)	NAT7	NP_176211.2
Homo sapiens (human)	SLC23A1	NP_689898.2
Canis lupus familiaris (dog)	SLC23A1	NP_001103427.1
Danio rerio (zebrafish)	slc23a1	NP_001166970.1

Gene Ontology
Bibliography

Related articles in PubMed

Liver metabolic/oxidative stress induces hepatic and extrahepatic changes in the expression of the vitamin C transporters SVCT1 and SVCT2.
Hierro C, Monte MJ, Lozano E, Gonzalez-Sanchez E, Marin JJ, Macias RI
European journal of nutrition53(2)401-12(2014)

Essential role of intracellular glutathione in controlling ascorbic acid transporter expression and function in rat hepatocytes and hepatoma cells.
Mardones L, Z??iga FA, Villagr?n M, Sotomayor K, Mendoza P, Escobar D, Gonz?lez M, Ormazabal V, Maldonado M, O?ate G, Angulo C, Concha II, Reyes AM, C?rcamo JG, Barra V, Vera JC, Rivas CI
Free radical biology & medicine52(9)1874-87(2012 May)

Hepatic expression of sodium-dependent vitamin C transporters: ontogeny, subtissular distribution and effect of chronic liver diseases.
Macias RI, Hierro C, de Juan SC, Jimenez F, Gonzalez-San Martin F, Marin JJ
The British journal of nutrition106(12)1814-25(2011 Dec)

Hierarchal contribution of N- and C-terminal sequences to the differential localization of homologous sodium-dependent vitamin C transporters, SVCT1 and SVCT2, in epithelial cells.
Varma S, Sobey K, Campbell CE, Kuo SM
Biochemistry48(13)2969-80(2009 Apr)

Large-scale proteomics and phosphoproteomics of urinary exosomes.
Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal of the American Society of Nephrology : JASN20(2)363-79(2009 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

metabolic/oxidative stress in the liver induce different responses in the expression of ascorbic acid transporters SVCT1 and SVCT2 in intrahepatic and extrahepatic tissues, which may affect the overall bioavailability and cellular uptake of this vitamin
Title: Liver metabolic/oxidative stress induces hepatic and extrahepatic changes in the expression of the vitamin C transporters SVCT1 and SVCT2.

glutathione depletion failed to affect ascorbic acid transport, and SVCT1 and SVCT2 expression in hepatoma cells.
Title: Essential role of intracellular glutathione in controlling ascorbic acid transporter expression and function in rat hepatocytes and hepatoma cells.

In adult rats, when obstructive cholestasis was maintained for 8 weeks, a significant up-regulation of Slc23a2 accompanied by a down-regulation of Slc23a1 was found.
Title: Hepatic expression of sodium-dependent vitamin C transporters: ontogeny, subtissular distribution and effect of chronic liver diseases.

SVCT1 immunoreactivity was observed in the brush border of proximal straight tubules in the medullary ray of renal cortex and the outer stripe of outer medulla, while SVCT2 was not localized in any region of the kidney.
Title: Immunohistochemical localization of sodium-dependent L-ascorbic acid transporter 1 protein in rat kidney.

SVCT1 declines 45% with age
Title: Age-related decline of sodium-dependent ascorbic acid transport in isolated rat hepatocytes.

The following Slc23a1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Slc23a1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa03623	NM_017315.2 Latest version!	Rattus norvegicus solute carrier family 23 member 1 (Slc23a1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$356.30 $509.00
ORa38317	XM_006254602.3 Latest version!	Rattus norvegicus solute carrier family 23 member 1 (Slc23a1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Slc23a1 ( NM_017315.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_059011.1 Rattus norvegicus solute carrier family 23 member 1 (Slc23a1), mRNA.

Price & Availability↑

CloneID	ORa03623
Clone ID Related Accession (Same CDS sequence)	NM_017315.2
Accession Version	NM_017315.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1815bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-18
Organism	Rattus norvegicus(Norway rat)
Product	solute carrier family 23 member 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC078851.1. On Jun 10, 2007 this sequence version replaced NM_017315.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC078851.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052297, SAMEA2689597 [ECO:0000350] ##Evidence-Data-END##

ATGAAAGCTC AGGAGGACCC CGGGAGCTCA AAGCAGCATG AATGCCCAGA TTCAGCAGGG 
ACTTCCACCA GGGACCAGCA GGCACCTTTG CCCGCGGAGC CCAAGTTTGA CATGTTGTAC 
AAGATTGAGG ACGTGCCACC ATGGTACCTG TGTATCCTGC TGGGCTTCCA GCATTACCTG 
ACATGCTTCA GTGGTACCAT TGCTGTGCCC TTCCTCCTGG CTGAGGCGCT GTGTGTGGGC 
CGCGACCAGC ACATGATCAG TCAGCTCATT GGTACCATCT TCACCTGCGT GGGTATCACC 
ACTCTCATTC AGACTACAGT GGGCATCCGG CTGCCGCTGT TCCAGGCCAG TGCCTTTGCG 
TTTCTGGTTC CAGCCAAGGC TATCCTGGCC TTGGAGAGGT GGAAGTGTCC TCCAGAAGAG 
GAGATCTACG GTAACTGGAG TATGCCCCTG AACACCTCTC ATATCTGGCA TCCTCGGATT 
CGGGAGGTCC AGGGTGCAAT CATGGTGTCC AGCGTGGTAG AGGTGGTGAT TGGGCTGTTG 
GGGCTGCCTG GGGCCCTGCT CAGCTACATT GGACCTCTCA CAGTCACCCC CACTGTCTCC 
CTTATCGGTC TCTCTGTTTT CCAAGCTGCT GGCGACCGAG CTGGCTCCCA TTGGGGCATT 
TCGGCTTGCT CCATTCTACT GATCGTCCTG TTCTCCCAGT ATCTACGCAA CCTCACCTTC 
CTGTTGCCTG TTTACCGATG GGGCAAGGGT CTTACTCTCT TCCGCATCCA GATCTTTAAG 
ATGTTTCCGA TCGTGCTGGC CATCATGACC GTGTGGCTAC TCTGCTATGT GCTGACTCTG 
ACAGACGTGC TGCCCGCAGA TCCCACAGTC TACGGTTTCC AGGCTCGAAC TGATGCCCGA 
GGGGACATCA TGGCTATCTC TCCCTGGATC CGGATCCCCT ACCCATGTCA ATGGGGCCTA 
CCCACAGTGA CCGTGGCTGC AGTTCTGGGA ATGTTCAGCG CCACACTGGC GGGCATCATC 
GAGTCCATCG GTGATTACTA TGCCTGCGCC CGGTTGGCTG GAGCACCACC CCCTCCAGTC 
CATGCTATCA ACAGGGGGAT TTTCACCGAA GGCGTCTGCT GCATCATCGC TGGGCTACTG 
GGCACAGGCA ACGGGTCCAC CTCTTCCAGC CCCAACATCG GGGTCCTAGG GATTACCAAG 
GTGGGCAGCC GAAGAGTCGT GCAGTATGGT GCAGGTATCA TGCTAATCCT GGGGGCCATT 
GGCAAATTCA CAGCTCTCTT CGCCTCACTG CCGGACCCCA TCCTGGGAGG GATGTTCTGC 
ACTCTTTTCG GTATGATCAC CGCTGTGGGA CTGTCCAATC TGCAGTTTGT GGACATGAAC 
TCCTCCCGCA ACCTCTTTGT ATTGGGATTC TCCATGTTCT TCGGCCTCAC GCTACCCAAC 
TACCTGGATT CCAACCCAGG TGCCATCAAC ACAGGCGTTC CTGAAGTGGA TCAGATCCTA 
ACTGTGCTGC TGACCACAGA GATGTTTGTT GGTGGCTGTC TTGCTTTCAT ACTGGACAAC 
ACAGTACCAG GGAGCCCAGA GGAAAGAGGT CTGATACAGT GGAAAGCCGG GGCACACGCC 
AACAGTGAGA CGCTGGCCAG TCTCAAGAGC TACGATTTCC CGTTCGGGAT GGGCATGGTA 
AAAAGGACCA CCTTTTTTAG ATACATCCCC ATCTGCCCAG TCTTCAGAGG ATTCTCTAAG 
ACAGAAAATC AGCCTGCAGT TCTAGAAGAC GCTCCAGACA ACACAGAAAC TGGGTCTGTG 
TGTACCAAGG TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_059011.1
CDS	6..1820
Translation	MKAQEDPGSSKQHECPDSAGTSTRDQQAPLPAEPKFDMLYKIEDVPPWYLCILLGFQHYLTCFSGTIAVPFLLAEALCVGRDQHMISQLIGTIFTCVGITTLIQTTVGIRLPLFQASAFAFLVPAKAILALERWKCPPEEEIYGNWSMPLNTSHIWHPRIREVQGAIMVSSVVEVVIGLLGLPGALLSYIGPLTVTPTVSLIGLSVFQAAGDRAGSHWGISACSILLIVLFSQYLRNLTFLLPVYRWGKGLTLFRIQIFKMFPIVLAIMTVWLLCYVLTLTDVLPADPTVYGFQARTDARGDIMAISPWIRIPYPCQWGLPTVTVAAVLGMFSATLAGIIESIGDYYACARLAGAPPPPVHAINRGIFTEGVCCIIAGLLGTGNGSTSSSPNIGVLGITKVGSRRVVQYGAGIMLILGAIGKFTALFASLPDPILGGMFCTLFGMITAVGLSNLQFVDMNSSRNLFVLGFSMFFGLTLPNYLDSNPGAINTGVPEVDQILTVLLTTEMFVGGCLAFILDNTVPGSPEERGLIQWKAGAHANSETLASLKSYDFPFGMGMVKRTTFFRYIPICPVFRGFSKTENQPAVLEDAPDNTETGSVCTKV

Target ORF information:

RefSeq Version	NM_017315.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus solute carrier family 23 member 1 (Slc23a1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017315.2

ORF Insert Sequence:

ATGAAAGCTC AGGAGGACCC CGGGAGCTCA AAGCAGCATG AATGCCCAGA TTCAGCAGGG 
ACTTCCACCA GGGACCAGCA GGCACCTTTG CCCGCGGAGC CCAAGTTTGA CATGTTGTAC 
AAGATTGAGG ACGTGCCACC ATGGTACCTG TGTATCCTGC TGGGCTTCCA GCATTACCTG 
ACATGCTTCA GTGGTACCAT TGCTGTGCCC TTCCTCCTGG CTGAGGCGCT GTGTGTGGGC 
CGCGACCAGC ACATGATCAG TCAGCTCATT GGTACCATCT TCACCTGCGT GGGTATCACC 
ACTCTCATTC AGACTACAGT GGGCATCCGG CTGCCGCTGT TCCAGGCCAG TGCCTTTGCG 
TTTCTGGTTC CAGCCAAGGC TATCCTGGCC TTGGAGAGGT GGAAGTGTCC TCCAGAAGAG 
GAGATCTACG GTAACTGGAG TATGCCCCTG AACACCTCTC ATATCTGGCA TCCTCGGATT 
CGGGAGGTCC AGGGTGCAAT CATGGTGTCC AGCGTGGTAG AGGTGGTGAT TGGGCTGTTG 
GGGCTGCCTG GGGCCCTGCT CAGCTACATT GGACCTCTCA CAGTCACCCC CACTGTCTCC 
CTTATCGGTC TCTCTGTTTT CCAAGCTGCT GGCGACCGAG CTGGCTCCCA TTGGGGCATT 
TCGGCTTGCT CCATTCTACT GATCGTCCTG TTCTCCCAGT ATCTACGCAA CCTCACCTTC 
CTGTTGCCTG TTTACCGATG GGGCAAGGGT CTTACTCTCT TCCGCATCCA GATCTTTAAG 
ATGTTTCCGA TCGTGCTGGC CATCATGACC GTGTGGCTAC TCTGCTATGT GCTGACTCTG 
ACAGACGTGC TGCCCGCAGA TCCCACAGTC TACGGTTTCC AGGCTCGAAC TGATGCCCGA 
GGGGACATCA TGGCTATCTC TCCCTGGATC CGGATCCCCT ACCCATGTCA ATGGGGCCTA 
CCCACAGTGA CCGTGGCTGC AGTTCTGGGA ATGTTCAGCG CCACACTGGC GGGCATCATC 
GAGTCCATCG GTGATTACTA TGCCTGCGCC CGGTTGGCTG GAGCACCACC CCCTCCAGTC 
CATGCTATCA ACAGGGGGAT TTTCACCGAA GGCGTCTGCT GCATCATCGC TGGGCTACTG 
GGCACAGGCA ACGGGTCCAC CTCTTCCAGC CCCAACATCG GGGTCCTAGG GATTACCAAG 
GTGGGCAGCC GAAGAGTCGT GCAGTATGGT GCAGGTATCA TGCTAATCCT GGGGGCCATT 
GGCAAATTCA CAGCTCTCTT CGCCTCACTG CCGGACCCCA TCCTGGGAGG GATGTTCTGC 
ACTCTTTTCG GTATGATCAC CGCTGTGGGA CTGTCCAATC TGCAGTTTGT GGACATGAAC 
TCCTCCCGCA ACCTCTTTGT ATTGGGATTC TCCATGTTCT TCGGCCTCAC GCTACCCAAC 
TACCTGGATT CCAACCCAGG TGCCATCAAC ACAGGCGTTC CTGAAGTGGA TCAGATCCTA 
ACTGTGCTGC TGACCACAGA GATGTTTGTT GGTGGCTGTC TTGCTTTCAT ACTGGACAAC 
ACAGTACCAG GGAGCCCAGA GGAAAGAGGT CTGATACAGT GGAAAGCCGG GGCACACGCC 
AACAGTGAGA CGCTGGCCAG TCTCAAGAGC TACGATTTCC CGTTCGGGAT GGGCATGGTA 
AAAAGGACCA CCTTTTTTAG ATACATCCCC ATCTGCCCAG TCTTCAGAGG ATTCTCTAAG 
ACAGAAAATC AGCCTGCAGT TCTAGAAGAC GCTCCAGACA ACACAGAAAC TGGGTCTGTG 
TGTACCAAGG TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Slc23a1 ( XM_006254602.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006254664.1 Rattus norvegicus solute carrier family 23 member 1 (Slc23a1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa38317
Clone ID Related Accession (Same CDS sequence)	XM_006254602.3
Accession Version	XM_006254602.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2001bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	solute carrier family 23 member 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005117.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006254602.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAGCAGC TGCCTAGCTG GAAAGCCATG CTGCCCGTGG GCCCTTGGCT TAGCCTGTGC 
CCCTGTGCCC CAGACGGGAC ACGGGCGCAG CAACTCAGAA TGAAAGAGTT AACACATGCA 
GCCCCAGAGG GTAGATGTGA CAGCGCATAT ACAAATACAG AGATTTCTCA AACCCGTGTC 
TCAGAGATGA AAGCTCAGGA GGACCCCGGG AGCTCAAAGC AGCATGAATG CCCAGATTCA 
GCAGGGACTT CCACCAGGGA CCAGCAGGCA CCTTTGCCCG CGGAGCCCAA GTTTGACATG 
TTGTACAAGA TTGAGGACGT GCCACCATGG TACCTGTGTA TCCTGCTGGG CTTCCAGCAT 
TACCTGACAT GCTTCAGTGG TACCATTGCT GTGCCCTTCC TCCTGGCTGA GGCGCTGTGT 
GTGGGCCGCG ACCAGCACAT GATCAGTCAG CTCATTGGTA CCATCTTCAC CTGCGTGGGT 
ATCACCACTC TCATTCAGAC TACAGTGGGC ATCCGGCTGC CGCTGTTCCA GGCCAGTGCC 
TTTGCGTTTC TGGTTCCAGC CAAGGCTATC CTGGCCTTGG AGAGGTGGAA GTGTCCTCCA 
GAAGAGGAGA TCTACGGTAA CTGGAGTATG CCCCTGAACA CCTCTCATAT CTGGCATCCT 
CGGATTCGGG AGGTCCAGGG TGCAATCATG GTGTCCAGCG TGGTAGAGGT GGTGATTGGG 
CTGTTGGGGC TGCCTGGGGC CCTGCTCAGC TACATTGGAC CTCTCACAGT CACCCCCACT 
GTCTCCCTTA TCGGTCTCTC TGTTTTCCAA GCTGCTGGCG ACCGAGCTGG CTCCCATTGG 
GGCATTTCGG CTTGCTCCAT TCTACTGATC GTCCTGTTCT CCCAGTATCT ACGCAACCTC 
ACCTTCCTGT TGCCTGTTTA CCGATGGGGC AAGGGTCTTA CTCTCTTCCG CATCCAGATC 
TTTAAGATGT TTCCGATCGT GCTGGCCATC ATGACCGTGT GGCTACTCTG CTATGTGCTG 
ACTCTGACAG ACGTGCTGCC CGCAGATCCC ACAGTCTACG GTTTCCAGGC TCGAACTGAT 
GCCCGAGGGG ACATCATGGC TATCTCTCCC TGGATCCGGA TCCCCTACCC ATGTCAATGG 
GGCCTACCCA CAGTGACCGT GGCTGCAGTT CTGGGAATGT TCAGCGCCAC ACTGGCGGGC 
ATCATCGAGT CCATCGGTGA TTACTATGCC TGCGCCCGGT TGGCTGGAGC ACCACCCCCT 
CCAGTCCATG CTATCAACAG GGGGATTTTC ACCGAAGGCG TCTGCTGCAT CATCGCTGGG 
CTACTGGGCA CAGGCAACGG GTCCACCTCT TCCAGCCCCA ACATCGGGGT CCTAGGGATT 
ACCAAGGTGG GCAGCCGAAG AGTCGTGCAG TATGGTGCAG GTATCATGCT AATCCTGGGG 
GCCATTGGCA AATTCACAGC TCTCTTCGCC TCACTGCCGG ACCCCATCCT GGGAGGGATG 
TTCTGCACTC TTTTCGGTAT GATCACCGCT GTGGGACTGT CCAATCTGCA GTTTGTGGAC 
ATGAACTCCT CCCGCAACCT CTTTGTATTG GGATTCTCCA TGTTCTTCGG CCTCACGCTA 
CCCAACTACC TGGATTCCAA CCCAGGTGCC ATCAACACAG GCGTTCCTGA AGTGGATCAG 
ATCCTAACTG TGCTGCTGAC CACAGAGATG TTTGTTGGTG GCTGTCTTGC TTTCATACTG 
GACAACACAG TACCAGGGAG CCCAGAGGAA AGAGGTCTGA TACAGTGGAA AGCCGGGGCA 
CACGCCAACA GTGAGACGCT GGCCAGTCTC AAGAGCTACG ATTTCCCGTT CGGGATGGGC 
ATGGTAAAAA GGACCACCTT TTTTAGATAC ATCCCCATCT GCCCAGTCTT CAGAGGATTC 
TCTAAGACAG AAAATCAGCC TGCAGTTCTA GAAGACGCTC CAGACAACAC AGAAACTGGG 
TCTGTGTGTA CCAAGGTCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006254664.1
CDS	183..2183
Translation	MKQLPSWKAMLPVGPWLSLCPCAPDGTRAQQLRMKELTHAAPEGRCDSAYTNTEISQTRVSEMKAQEDPGSSKQHECPDSAGTSTRDQQAPLPAEPKFDMLYKIEDVPPWYLCILLGFQHYLTCFSGTIAVPFLLAEALCVGRDQHMISQLIGTIFTCVGITTLIQTTVGIRLPLFQASAFAFLVPAKAILALERWKCPPEEEIYGNWSMPLNTSHIWHPRIREVQGAIMVSSVVEVVIGLLGLPGALLSYIGPLTVTPTVSLIGLSVFQAAGDRAGSHWGISACSILLIVLFSQYLRNLTFLLPVYRWGKGLTLFRIQIFKMFPIVLAIMTVWLLCYVLTLTDVLPADPTVYGFQARTDARGDIMAISPWIRIPYPCQWGLPTVTVAAVLGMFSATLAGIIESIGDYYACARLAGAPPPPVHAINRGIFTEGVCCIIAGLLGTGNGSTSSSPNIGVLGITKVGSRRVVQYGAGIMLILGAIGKFTALFASLPDPILGGMFCTLFGMITAVGLSNLQFVDMNSSRNLFVLGFSMFFGLTLPNYLDSNPGAINTGVPEVDQILTVLLTTEMFVGGCLAFILDNTVPGSPEERGLIQWKAGAHANSETLASLKSYDFPFGMGMVKRTTFFRYIPICPVFRGFSKTENQPAVLEDAPDNTETGSVCTKV

Target ORF information:

RefSeq Version	XM_006254602.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus solute carrier family 23 member 1 (Slc23a1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006254602.3

ORF Insert Sequence:

ATGAAGCAGC TGCCTAGCTG GAAAGCCATG CTGCCCGTGG GCCCTTGGCT TAGCCTGTGC 
CCCTGTGCCC CAGACGGGAC ACGGGCGCAG CAACTCAGAA TGAAAGAGTT AACACATGCA 
GCCCCAGAGG GTAGATGTGA CAGCGCATAT ACAAATACAG AGATTTCTCA AACCCGTGTC 
TCAGAGATGA AAGCTCAGGA GGACCCCGGG AGCTCAAAGC AGCATGAATG CCCAGATTCA 
GCAGGGACTT CCACCAGGGA CCAGCAGGCA CCTTTGCCCG CGGAGCCCAA GTTTGACATG 
TTGTACAAGA TTGAGGACGT GCCACCATGG TACCTGTGTA TCCTGCTGGG CTTCCAGCAT 
TACCTGACAT GCTTCAGTGG TACCATTGCT GTGCCCTTCC TCCTGGCTGA GGCGCTGTGT 
GTGGGCCGCG ACCAGCACAT GATCAGTCAG CTCATTGGTA CCATCTTCAC CTGCGTGGGT 
ATCACCACTC TCATTCAGAC TACAGTGGGC ATCCGGCTGC CGCTGTTCCA GGCCAGTGCC 
TTTGCGTTTC TGGTTCCAGC CAAGGCTATC CTGGCCTTGG AGAGGTGGAA GTGTCCTCCA 
GAAGAGGAGA TCTACGGTAA CTGGAGTATG CCCCTGAACA CCTCTCATAT CTGGCATCCT 
CGGATTCGGG AGGTCCAGGG TGCAATCATG GTGTCCAGCG TGGTAGAGGT GGTGATTGGG 
CTGTTGGGGC TGCCTGGGGC CCTGCTCAGC TACATTGGAC CTCTCACAGT CACCCCCACT 
GTCTCCCTTA TCGGTCTCTC TGTTTTCCAA GCTGCTGGCG ACCGAGCTGG CTCCCATTGG 
GGCATTTCGG CTTGCTCCAT TCTACTGATC GTCCTGTTCT CCCAGTATCT ACGCAACCTC 
ACCTTCCTGT TGCCTGTTTA CCGATGGGGC AAGGGTCTTA CTCTCTTCCG CATCCAGATC 
TTTAAGATGT TTCCGATCGT GCTGGCCATC ATGACCGTGT GGCTACTCTG CTATGTGCTG 
ACTCTGACAG ACGTGCTGCC CGCAGATCCC ACAGTCTACG GTTTCCAGGC TCGAACTGAT 
GCCCGAGGGG ACATCATGGC TATCTCTCCC TGGATCCGGA TCCCCTACCC ATGTCAATGG 
GGCCTACCCA CAGTGACCGT GGCTGCAGTT CTGGGAATGT TCAGCGCCAC ACTGGCGGGC 
ATCATCGAGT CCATCGGTGA TTACTATGCC TGCGCCCGGT TGGCTGGAGC ACCACCCCCT 
CCAGTCCATG CTATCAACAG GGGGATTTTC ACCGAAGGCG TCTGCTGCAT CATCGCTGGG 
CTACTGGGCA CAGGCAACGG GTCCACCTCT TCCAGCCCCA ACATCGGGGT CCTAGGGATT 
ACCAAGGTGG GCAGCCGAAG AGTCGTGCAG TATGGTGCAG GTATCATGCT AATCCTGGGG 
GCCATTGGCA AATTCACAGC TCTCTTCGCC TCACTGCCGG ACCCCATCCT GGGAGGGATG 
TTCTGCACTC TTTTCGGTAT GATCACCGCT GTGGGACTGT CCAATCTGCA GTTTGTGGAC 
ATGAACTCCT CCCGCAACCT CTTTGTATTG GGATTCTCCA TGTTCTTCGG CCTCACGCTA 
CCCAACTACC TGGATTCCAA CCCAGGTGCC ATCAACACAG GCGTTCCTGA AGTGGATCAG 
ATCCTAACTG TGCTGCTGAC CACAGAGATG TTTGTTGGTG GCTGTCTTGC TTTCATACTG 
GACAACACAG TACCAGGGAG CCCAGAGGAA AGAGGTCTGA TACAGTGGAA AGCCGGGGCA 
CACGCCAACA GTGAGACGCT GGCCAGTCTC AAGAGCTACG ATTTCCCGTT CGGGATGGGC 
ATGGTAAAAA GGACCACCTT TTTTAGATAC ATCCCCATCT GCCCAGTCTT CAGAGGATTC 
TCTAAGACAG AAAATCAGCC TGCAGTTCTA GAAGACGCTC CAGACAACAC AGAAACTGGG 
TCTGTGTGTA CCAAGGTCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Liver metabolic/oxidative stress induces hepatic and extrahepatic changes in the expression of the vitamin C transporters SVCT1 and SVCT2.
European journal of nutrition53(2)401-12(2014)
Hierro C,Monte MJ,Lozano E,Gonzalez-Sanchez E,Marin JJ,Macias RI

Essential role of intracellular glutathione in controlling ascorbic acid transporter expression and function in rat hepatocytes and hepatoma cells.
Free radical biology & medicine52(9)1874-87(2012 May)
Mardones L,Z??iga FA,Villagr?n M,Sotomayor K,Mendoza P,Escobar D,Gonz?lez M,Ormazabal V,Maldonado M,O?ate G,Angulo C,Concha II,Reyes AM,C?rcamo JG,Barra V,Vera JC,Rivas CI

Hepatic expression of sodium-dependent vitamin C transporters: ontogeny, subtissular distribution and effect of chronic liver diseases.
The British journal of nutrition106(12)1814-25(2011 Dec)
Macias RI,Hierro C,de Juan SC,Jimenez F,Gonzalez-San Martin F,Marin JJ

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Large-scale proteomics and phosphoproteomics of urinary exosomes.
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Slc23a1 cDNA ORF clone, Rattus norvegicus(Norway rat)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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