C5ar2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	C5ar2
Entrez Gene ID	445269
Full Name	complement component 5a receptor 2
Synonyms	C5L2,Gpr77
General protein information	Preferred Names complement component 5a receptor 2 Names C5a anaphylatoxin chemotactic receptor 2 C5A receptor beta C5a anaphylatoxin chemotactic receptor C5L2 G protein-coupled receptor 77 complement 5A receptor beta
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q21
Summary	binds C5a anaphylatoxin, a potent inflammatory mediator, as a ligand [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_006228352.3	XP_006228414.1	C5a anaphylatoxin chemotactic receptor 2 isoform X1
XM_006228353.3	XP_006228415.1	C5a anaphylatoxin chemotactic receptor 2 isoform X2
NM_001003710.2	NP_001003710.2	C5a anaphylatoxin chemotactic receptor 2

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	C5ar2	NP_001003710.2
Mus musculus (house mouse)	C5ar2	NP_795886.2
	GPR77	XP_001112956.1
Bos taurus (cattle)	GPR77	NP_001071415.1
Homo sapiens (human)	C5AR2	NP_001258678.1
Pan troglodytes (chimpanzee)	GPR77	XP_003953593.1
Canis lupus familiaris (dog)	C5AR2	XP_005616452.1

Gene Ontology
Bibliography

Related articles in PubMed

Novel insights in localization and expression levels of C5aR and C5L2 under native and post-transplant conditions in the kidney.
van Werkhoven MB, Damman J, Daha MR, Krikke C, van Goor H, van Son WJ, Hillebrands JL, van Dijk MC, Seelen MA
Molecular immunology53(3)237-45(2013 Mar)

Human colonic epithelial cells detect and respond to C5a via apically expressed C5aR through the ERK pathway.
Cao Q, McIsaac SM, Stadnyk AW
American journal of physiology. Cell physiology302(12)C1731-40(2012 Jun)

Expression of receptors for anaphylatoxins C3a and C5a on rat islet preparations.
Tokodai K, Goto M, Inagaki A, Imura T, Nakanishi W, Satomi S
Transplantation proceedings43(9)3179-80(2011 Nov)

Complement C5a receptors in the pituitary gland: expression and function.
Francis K, Lewis BM, Monk PN, Ham J
The Journal of endocrinology199(3)417-24(2008 Dec)

The role of the N-terminal domain of the complement fragment receptor C5L2 in ligand binding.
Scola AM, Higginbottom A, Partridge LJ, Reid RC, Woodruff T, Taylor SM, Fairlie DP, Monk PN
The Journal of biological chemistry282(6)3664-71(2007 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

C5aR and C5L2, but not C3aR, are expressed on CD11b-positive leukocytes in islet preparations
Title: Expression of receptors for anaphylatoxins C3a and C5a on rat islet preparations.

C5a receptors and C5L2 were demonstrated in the rat anterior pituitary gland and they may play a role in dampening down inflammation by inhibiting the release of MIF and stimulating the release of ACTH.
Title: Complement C5a receptors in the pituitary gland: expression and function.

C5L2 appears to bind complement factor C5a and its C-terminal cleavage product C5a des Arg by different mechanisms, and, unlike C5a receptor (C5aR), C5L2 uses critical residues in its N-terminal domain for binding only to C5a des Arg.
Title: The role of the N-terminal domain of the complement fragment receptor C5L2 in ligand binding.

C5L2 is a highly regulated scavenger receptor for C5a and C5a-des-Arg(74)
Title: Ligand specificity of the anaphylatoxin C5L2 receptor and its regulation on myeloid and epithelial cell lines.

data provide the first evidence for a role for C5a receptor C5L2 in balancing the biological responses to Complement 5a
Title: Evidence for a functional role of the second C5a receptor C5L2.

The following C5ar2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the C5ar2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa09884	NM_001003710.2 Latest version!	Rattus norvegicus complement component 5a receptor 2 (C5ar2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
ORa22363	XM_006228352.3 Latest version!	Rattus norvegicus complement component 5a receptor 2 (C5ar2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
ORa22364	XM_006228353.3 Latest version!	Rattus norvegicus complement component 5a receptor 2 (C5ar2), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

C5ar2 ( NM_001003710.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001003710.2 Rattus norvegicus complement component 5a receptor 2 (C5ar2), mRNA.

Price & Availability↑

CloneID	ORa09884
Clone ID Related Accession (Same CDS sequence)	NM_001003710.2
Accession Version	NM_001003710.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1032bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Rattus norvegicus(Norway rat)
Product	C5a anaphylatoxin chemotactic receptor 2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY741660.1. On Oct 17, 2004 this sequence version replaced NM_001003710.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY741660.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052297, SAMEA2689594 [ECO:0000348] ##Evidence-Data-END##

ATGCTGAACG ACACCACCAG CAAGGATTAT GAGTATGAGT ATGATCAGGA ACAGTATAGT 
GACCTTCTGA ACGTCCCCGT AGACTGCCCA GCTGGCAACT GCTTCTCTAA TGATGCCTAC 
CTCATAGTCC TGCTTGGCCT GTATTCAGTC ATCTTCCTGG TGGGTGTGCC AGGCAACACC 
CTGTTGGCGT GGGTGACCTG GAAAGAGTCT CGCCACAGGC TCGGGGCCTC TTGGTTCCTG 
CACTTGACCA TGGCGGACTT GCTTTGCTGT GTGTCTCTGC CCTTCCTGGC TGTGCCCATC 
GCCCAAAAGG GCCACTGGCC ATACGGGACA GCAGGCTGCT GGCTGTTGTC CTCCATCACC 
GTTCTGTCTA TGTATGCCAG TGTGCTGCTC CTGACGGGCC TCAGTGGCGA CCTCTTCCTA 
TTGGCTTTCA GGCCCTCCTG GAAGAATGCA GATCAACGAA CATGTGGGGT GCGTGTGGTC 
CAGGTCTCCT CCTGGATGCT GGCCCTGTTG CTGACTGTGC CTGGTGCTGT CTATCGTAAG 
CTGCTTCAGG AGCACTATCC TCCCCGGCTT GTGTGTGGCA CAAACTATGG GGGATCGGTC 
ACCGCGGAAG TTACCATCAC CACTGTTCGA TTCCTCTTTG GCTTCCTGGT GCCATTGGTG 
TTCATGGCCA GTTGCCACGG CATCCTCCAA CGGCAGATGG CTCGCCGCCA CTGGCCCCTG 
GGCACAGCTG TTGTGGTGGG GTTTTTCATT TGCTGGACCC CTTTTCACCT CCTGCGGGTC 
ATCATTGCAG TGGCTTTTTC ACACTCCCCG CTCCTTGCCT GGGCCCTGGA GGCTGAGCCT 
TTGGTTACGG GCCTGGCCCT TGCTCACAGT GCTCTCAATC CTATTATGTT TTTGAATTTC 
GGAAGAAAAC AACTCTGCAA GTCACTCCAG GCTGCATGTC ACTGGGCCCT GAGGGATCTA 
CAGGATGAAG AGGAAAGTGC CGTGACCAAG GTATCCACCA GCCAGGAAAT GGTGTCTGAG 
ATGCCGGTGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001003710.2
CDS	135..1166
Translation	MLNDTTSKDYEYEYDQEQYSDLLNVPVDCPAGNCFSNDAYLIVLLGLYSVIFLVGVPGNTLLAWVTWKESRHRLGASWFLHLTMADLLCCVSLPFLAVPIAQKGHWPYGTAGCWLLSSITVLSMYASVLLLTGLSGDLFLLAFRPSWKNADQRTCGVRVVQVSSWMLALLLTVPGAVYRKLLQEHYPPRLVCGTNYGGSVTAEVTITTVRFLFGFLVPLVFMASCHGILQRQMARRHWPLGTAVVVGFFICWTPFHLLRVIIAVAFSHSPLLAWALEAEPLVTGLALAHSALNPIMFLNFGRKQLCKSLQAACHWALRDLQDEEESAVTKVSTSQEMVSEMPV

Target ORF information:

RefSeq Version	NM_001003710.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus complement component 5a receptor 2 (C5ar2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001003710.2

ORF Insert Sequence:

ATGCTGAACG ACACCACCAG CAAGGATTAT GAGTATGAGT ATGATCAGGA ACAGTATAGT 
GACCTTCTGA ACGTCCCCGT AGACTGCCCA GCTGGCAACT GCTTCTCTAA TGATGCCTAC 
CTCATAGTCC TGCTTGGCCT GTATTCAGTC ATCTTCCTGG TGGGTGTGCC AGGCAACACC 
CTGTTGGCGT GGGTGACCTG GAAAGAGTCT CGCCACAGGC TCGGGGCCTC TTGGTTCCTG 
CACTTGACCA TGGCGGACTT GCTTTGCTGT GTGTCTCTGC CCTTCCTGGC TGTGCCCATC 
GCCCAAAAGG GCCACTGGCC ATACGGGACA GCAGGCTGCT GGCTGTTGTC CTCCATCACC 
GTTCTGTCTA TGTATGCCAG TGTGCTGCTC CTGACGGGCC TCAGTGGCGA CCTCTTCCTA 
TTGGCTTTCA GGCCCTCCTG GAAGAATGCA GATCAACGAA CATGTGGGGT GCGTGTGGTC 
CAGGTCTCCT CCTGGATGCT GGCCCTGTTG CTGACTGTGC CTGGTGCTGT CTATCGTAAG 
CTGCTTCAGG AGCACTATCC TCCCCGGCTT GTGTGTGGCA CAAACTATGG GGGATCGGTC 
ACCGCGGAAG TTACCATCAC CACTGTTCGA TTCCTCTTTG GCTTCCTGGT GCCATTGGTG 
TTCATGGCCA GTTGCCACGG CATCCTCCAA CGGCAGATGG CTCGCCGCCA CTGGCCCCTG 
GGCACAGCTG TTGTGGTGGG GTTTTTCATT TGCTGGACCC CTTTTCACCT CCTGCGGGTC 
ATCATTGCAG TGGCTTTTTC ACACTCCCCG CTCCTTGCCT GGGCCCTGGA GGCTGAGCCT 
TTGGTTACGG GCCTGGCCCT TGCTCACAGT GCTCTCAATC CTATTATGTT TTTGAATTTC 
GGAAGAAAAC AACTCTGCAA GTCACTCCAG GCTGCATGTC ACTGGGCCCT GAGGGATCTA 
CAGGATGAAG AGGAAAGTGC CGTGACCAAG GTATCCACCA GCCAGGAAAT GGTGTCTGAG 
ATGCCGGTGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

C5ar2 ( XM_006228352.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006228414.1 Rattus norvegicus complement component 5a receptor 2 (C5ar2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa22363
Clone ID Related Accession (Same CDS sequence)	XM_006228352.3
Accession Version	XM_006228352.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1161bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	C5a anaphylatoxin chemotactic receptor 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006228352.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAACTATG AGGGGCTGGG AGACGGTTCA GTGAGTAAAG TGTTTGCTAT TCAAACAGAA 
GGGCATGACT TCCAGCCCCA GGACGTGGAT ATGTCCAGCA CAGAGCTACG CACGGTGTCT 
GGGGCCAGGA TGCTGAACGA CACCACCAGC AAGGATTATG AGTATGAGTA TGATCAGGAA 
CAGTATAGTG ACCTTCTGAA CGTCCCCGTA GACTGCCCAG CTGGCAACTG CTTCTCTAAT 
GATGCCTACC TCATAGTCCT GCTTGGCCTG TATTCAGTCA TCTTCCTGGT GGGTGTGCCA 
GGCAACACCC TGTTGGCGTG GGTGACCTGG AAAGAGTCTC GCCACAGGCT CGGGGCCTCT 
TGGTTCCTGC ACTTGACCAT GGCGGACTTG CTTTGCTGTG TGTCTCTGCC CTTCCTGGCT 
GTGCCCATCG CCCAAAAGGG CCACTGGCCA TACGGGACAG CAGGCTGCTG GCTGTTGTCC 
TCCATCACCG TTCTGTCTAT GTATGCCAGT GTGCTGCTCC TGACGGGCCT CAGTGGCGAC 
CTCTTCCTAT TGGCTTTCAG GCCCTCCTGG AAGAATGCAG ATCAACGAAC ATGTGGGGTG 
CGTGTGGTCC AGGTCTCCTC CTGGATGCTG GCCCTGTTGC TGACTGTGCC TGGTGCTGTC 
TATCGTAAGC TGCTTCAGGA GCACTATCCT CCCCGGCTTG TGTGTGGCAC AAACTATGGG 
GGATCGGTCA CCGCGGAAGT TACCATCACC ACTGTTCGAT TCCTCTTTGG CTTCCTGGTG 
CCATTGGTGT TCATGGCCAG TTGCCACGGC ATCCTCCAAC GGCAGATGGC TCGCCGCCAC 
TGGCCCCTGG GCACAGCTGT TGTGGTGGGG TTTTTCATTT GCTGGACCCC TTTTCACCTC 
CTGCGGGTCA TCATTGCAGT GGCTTCTTCA CACTCCCCGC TCCTTGCCTG GGCCCTGGAG 
GCTGAGCCTT TGGTTACGGG CCTGGCCCTT GCTCACAGTG CTCTCAATCC TATTATGTTT 
TTGTATTTCG GAAGAAAACA ACTCTGCAAG TCACTCCAGG CTGCATGTCA CTGGGCCCTG 
AGGGATCTAC AGGATGAGGA GGAAAGTGCC GTGACCAAGG TATCCACCAG CCAGGAAATG 
GTGTCTGAGA TGCCGGTGTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006228414.1
CDS	401..1561
Translation	MNYEGLGDGSVSKVFAIQTEGHDFQPQDVDMSSTELRTVSGARMLNDTTSKDYEYEYDQEQYSDLLNVPVDCPAGNCFSNDAYLIVLLGLYSVIFLVGVPGNTLLAWVTWKESRHRLGASWFLHLTMADLLCCVSLPFLAVPIAQKGHWPYGTAGCWLLSSITVLSMYASVLLLTGLSGDLFLLAFRPSWKNADQRTCGVRVVQVSSWMLALLLTVPGAVYRKLLQEHYPPRLVCGTNYGGSVTAEVTITTVRFLFGFLVPLVFMASCHGILQRQMARRHWPLGTAVVVGFFICWTPFHLLRVIIAVASSHSPLLAWALEAEPLVTGLALAHSALNPIMFLYFGRKQLCKSLQAACHWALRDLQDEEESAVTKVSTSQEMVSEMPV

Target ORF information:

RefSeq Version	XM_006228352.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus complement component 5a receptor 2 (C5ar2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006228352.3

ORF Insert Sequence:

ATGAACTATG AGGGGCTGGG AGACGGTTCA GTGAGTAAAG TGTTTGCTAT TCAAACAGAA 
GGGCATGACT TCCAGCCCCA GGACGTGGAT ATGTCCAGCA CAGAGCTACG CACGGTGTCT 
GGGGCCAGGA TGCTGAACGA CACCACCAGC AAGGATTATG AGTATGAGTA TGATCAGGAA 
CAGTATAGTG ACCTTCTGAA CGTCCCCGTA GACTGCCCAG CTGGCAACTG CTTCTCTAAT 
GATGCCTACC TCATAGTCCT GCTTGGCCTG TATTCAGTCA TCTTCCTGGT GGGTGTGCCA 
GGCAACACCC TGTTGGCGTG GGTGACCTGG AAAGAGTCTC GCCACAGGCT CGGGGCCTCT 
TGGTTCCTGC ACTTGACCAT GGCGGACTTG CTTTGCTGTG TGTCTCTGCC CTTCCTGGCT 
GTGCCCATCG CCCAAAAGGG CCACTGGCCA TACGGGACAG CAGGCTGCTG GCTGTTGTCC 
TCCATCACCG TTCTGTCTAT GTATGCCAGT GTGCTGCTCC TGACGGGCCT CAGTGGCGAC 
CTCTTCCTAT TGGCTTTCAG GCCCTCCTGG AAGAATGCAG ATCAACGAAC ATGTGGGGTG 
CGTGTGGTCC AGGTCTCCTC CTGGATGCTG GCCCTGTTGC TGACTGTGCC TGGTGCTGTC 
TATCGTAAGC TGCTTCAGGA GCACTATCCT CCCCGGCTTG TGTGTGGCAC AAACTATGGG 
GGATCGGTCA CCGCGGAAGT TACCATCACC ACTGTTCGAT TCCTCTTTGG CTTCCTGGTG 
CCATTGGTGT TCATGGCCAG TTGCCACGGC ATCCTCCAAC GGCAGATGGC TCGCCGCCAC 
TGGCCCCTGG GCACAGCTGT TGTGGTGGGG TTTTTCATTT GCTGGACCCC TTTTCACCTC 
CTGCGGGTCA TCATTGCAGT GGCTTCTTCA CACTCCCCGC TCCTTGCCTG GGCCCTGGAG 
GCTGAGCCTT TGGTTACGGG CCTGGCCCTT GCTCACAGTG CTCTCAATCC TATTATGTTT 
TTGTATTTCG GAAGAAAACA ACTCTGCAAG TCACTCCAGG CTGCATGTCA CTGGGCCCTG 
AGGGATCTAC AGGATGAGGA GGAAAGTGCC GTGACCAAGG TATCCACCAG CCAGGAAATG 
GTGTCTGAGA TGCCGGTGTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

C5ar2 ( XM_006228353.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006228415.1 Rattus norvegicus complement component 5a receptor 2 (C5ar2), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa22364
Clone ID Related Accession (Same CDS sequence)	XM_006228353.3
Accession Version	XM_006228353.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1032bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	C5a anaphylatoxin chemotactic receptor 2 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006228353.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTGAACG ACACCACCAG CAAGGATTAT GAGTATGAGT ATGATCAGGA ACAGTATAGT 
GACCTTCTGA ACGTCCCCGT AGACTGCCCA GCTGGCAACT GCTTCTCTAA TGATGCCTAC 
CTCATAGTCC TGCTTGGCCT GTATTCAGTC ATCTTCCTGG TGGGTGTGCC AGGCAACACC 
CTGTTGGCGT GGGTGACCTG GAAAGAGTCT CGCCACAGGC TCGGGGCCTC TTGGTTCCTG 
CACTTGACCA TGGCGGACTT GCTTTGCTGT GTGTCTCTGC CCTTCCTGGC TGTGCCCATC 
GCCCAAAAGG GCCACTGGCC ATACGGGACA GCAGGCTGCT GGCTGTTGTC CTCCATCACC 
GTTCTGTCTA TGTATGCCAG TGTGCTGCTC CTGACGGGCC TCAGTGGCGA CCTCTTCCTA 
TTGGCTTTCA GGCCCTCCTG GAAGAATGCA GATCAACGAA CATGTGGGGT GCGTGTGGTC 
CAGGTCTCCT CCTGGATGCT GGCCCTGTTG CTGACTGTGC CTGGTGCTGT CTATCGTAAG 
CTGCTTCAGG AGCACTATCC TCCCCGGCTT GTGTGTGGCA CAAACTATGG GGGATCGGTC 
ACCGCGGAAG TTACCATCAC CACTGTTCGA TTCCTCTTTG GCTTCCTGGT GCCATTGGTG 
TTCATGGCCA GTTGCCACGG CATCCTCCAA CGGCAGATGG CTCGCCGCCA CTGGCCCCTG 
GGCACAGCTG TTGTGGTGGG GTTTTTCATT TGCTGGACCC CTTTTCACCT CCTGCGGGTC 
ATCATTGCAG TGGCTTCTTC ACACTCCCCG CTCCTTGCCT GGGCCCTGGA GGCTGAGCCT 
TTGGTTACGG GCCTGGCCCT TGCTCACAGT GCTCTCAATC CTATTATGTT TTTGTATTTC 
GGAAGAAAAC AACTCTGCAA GTCACTCCAG GCTGCATGTC ACTGGGCCCT GAGGGATCTA 
CAGGATGAGG AGGAAAGTGC CGTGACCAAG GTATCCACCA GCCAGGAAAT GGTGTCTGAG 
ATGCCGGTGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006228415.1
CDS	297..1328
Translation	MLNDTTSKDYEYEYDQEQYSDLLNVPVDCPAGNCFSNDAYLIVLLGLYSVIFLVGVPGNTLLAWVTWKESRHRLGASWFLHLTMADLLCCVSLPFLAVPIAQKGHWPYGTAGCWLLSSITVLSMYASVLLLTGLSGDLFLLAFRPSWKNADQRTCGVRVVQVSSWMLALLLTVPGAVYRKLLQEHYPPRLVCGTNYGGSVTAEVTITTVRFLFGFLVPLVFMASCHGILQRQMARRHWPLGTAVVVGFFICWTPFHLLRVIIAVASSHSPLLAWALEAEPLVTGLALAHSALNPIMFLYFGRKQLCKSLQAACHWALRDLQDEEESAVTKVSTSQEMVSEMPV

Target ORF information:

RefSeq Version	XM_006228353.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus complement component 5a receptor 2 (C5ar2), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006228353.3

ORF Insert Sequence:

ATGCTGAACG ACACCACCAG CAAGGATTAT GAGTATGAGT ATGATCAGGA ACAGTATAGT 
GACCTTCTGA ACGTCCCCGT AGACTGCCCA GCTGGCAACT GCTTCTCTAA TGATGCCTAC 
CTCATAGTCC TGCTTGGCCT GTATTCAGTC ATCTTCCTGG TGGGTGTGCC AGGCAACACC 
CTGTTGGCGT GGGTGACCTG GAAAGAGTCT CGCCACAGGC TCGGGGCCTC TTGGTTCCTG 
CACTTGACCA TGGCGGACTT GCTTTGCTGT GTGTCTCTGC CCTTCCTGGC TGTGCCCATC 
GCCCAAAAGG GCCACTGGCC ATACGGGACA GCAGGCTGCT GGCTGTTGTC CTCCATCACC 
GTTCTGTCTA TGTATGCCAG TGTGCTGCTC CTGACGGGCC TCAGTGGCGA CCTCTTCCTA 
TTGGCTTTCA GGCCCTCCTG GAAGAATGCA GATCAACGAA CATGTGGGGT GCGTGTGGTC 
CAGGTCTCCT CCTGGATGCT GGCCCTGTTG CTGACTGTGC CTGGTGCTGT CTATCGTAAG 
CTGCTTCAGG AGCACTATCC TCCCCGGCTT GTGTGTGGCA CAAACTATGG GGGATCGGTC 
ACCGCGGAAG TTACCATCAC CACTGTTCGA TTCCTCTTTG GCTTCCTGGT GCCATTGGTG 
TTCATGGCCA GTTGCCACGG CATCCTCCAA CGGCAGATGG CTCGCCGCCA CTGGCCCCTG 
GGCACAGCTG TTGTGGTGGG GTTTTTCATT TGCTGGACCC CTTTTCACCT CCTGCGGGTC 
ATCATTGCAG TGGCTTCTTC ACACTCCCCG CTCCTTGCCT GGGCCCTGGA GGCTGAGCCT 
TTGGTTACGG GCCTGGCCCT TGCTCACAGT GCTCTCAATC CTATTATGTT TTTGTATTTC 
GGAAGAAAAC AACTCTGCAA GTCACTCCAG GCTGCATGTC ACTGGGCCCT GAGGGATCTA 
CAGGATGAGG AGGAAAGTGC CGTGACCAAG GTATCCACCA GCCAGGAAAT GGTGTCTGAG 
ATGCCGGTGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Novel insights in localization and expression levels of C5aR and C5L2 under native and post-transplant conditions in the kidney.
Molecular immunology53(3)237-45(2013 Mar)
van Werkhoven MB,Damman J,Daha MR,Krikke C,van Goor H,van Son WJ,Hillebrands JL,van Dijk MC,Seelen MA

Human colonic epithelial cells detect and respond to C5a via apically expressed C5aR through the ERK pathway.
American journal of physiology. Cell physiology302(12)C1731-40(2012 Jun)
Cao Q,McIsaac SM,Stadnyk AW

Expression of receptors for anaphylatoxins C3a and C5a on rat islet preparations.
Transplantation proceedings43(9)3179-80(2011 Nov)
Tokodai K,Goto M,Inagaki A,Imura T,Nakanishi W,Satomi S

Complement C5a receptors in the pituitary gland: expression and function.
The Journal of endocrinology199(3)417-24(2008 Dec)
Francis K,Lewis BM,Monk PN,Ham J

The role of the N-terminal domain of the complement fragment receptor C5L2 in ligand binding.
The Journal of biological chemistry282(6)3664-71(2007 Feb)
Scola AM,Higginbottom A,Partridge LJ,Reid RC,Woodruff T,Taylor SM,Fairlie DP,Monk PN

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C5ar2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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