C5AR2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	C5AR2
Entrez Gene ID	27202
Full Name	complement component 5a receptor 2
Synonyms	C5L2,GPF77,GPR77
General protein information	Preferred Names complement component 5a receptor 2 Names C5a anaphylatoxin chemotactic receptor 2 C5a anaphylatoxin chemotactic receptor C5L2 G protein-coupled receptor 77 G protein-coupled receptor C5L2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19q13.32
Summary	This gene encodes a G-protein coupled receptor 1 family member involved in the complement system of the innate immune response. Unlike classical G-protein coupled receptors, the encoded protein does not associate with intracellular G-proteins. It may instead modulate signal transduction through the beta-arrestin pathway, and may alternatively act as a decoy receptor. This gene may be involved in coronary artery disease and in the pathogenesis of sepsis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012].
Disorder MIM:	609949

mRNA and Protein(s)

mRNA	Protein	Name
XM_011526736.1	XP_011525038.1	C5a anaphylatoxin chemotactic receptor 2 isoform X1
NM_001271750.1	NP_001258679.1	C5a anaphylatoxin chemotactic receptor 2
NM_018485.2	NP_060955.1	C5a anaphylatoxin chemotactic receptor 2
XM_011526737.1	XP_011525039.1	C5a anaphylatoxin chemotactic receptor 2 isoform X1
NM_001271749.1	NP_001258678.1	C5a anaphylatoxin chemotactic receptor 2
NM_018485.3	NP_060955.1	C5a anaphylatoxin chemotactic receptor 2
XM_011526736.2	XP_011525038.1	C5a anaphylatoxin chemotactic receptor 2 isoform X1
NM_001271749.2	NP_001258678.1	C5a anaphylatoxin chemotactic receptor 2

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	C5ar2	NP_001003710.2
Mus musculus (house mouse)	C5ar2	NP_795886.2
	GPR77	XP_001112956.1
Bos taurus (cattle)	GPR77	NP_001071415.1
Homo sapiens (human)	C5AR2	NP_001258678.1
Pan troglodytes (chimpanzee)	GPR77	XP_003953593.1
Canis lupus familiaris (dog)	C5AR2	XP_005616452.1

Gene Ontology
Bibliography

Related articles in PubMed

New concepts on the therapeutic control of complement anaphylatoxin receptors.
Hawksworth OA, Li XX, Coulthard LG, Wolvetang EJ, Woodruff TM
Molecular immunology8936-43(2017 Sep)

C5L2 Receptor Represses Brain-Derived Neurotrophic Factor Secretion in Lipoteichoic Acid-Stimulated Pulp Fibroblasts.
Chmilewsky F, About I, Chung SH
Journal of dental research96(1)92-99(2017 Jan)

Association of C5L2 genetic polymorphisms with coronary artery disease in a Han population in Xinjiang, China.
Zheng YY, Xie X, Ma YT, Fu ZY, Ma X, Yang YN, Li XM, Pan S, Adi D, Chen BD, Liu F
Oncotarget8(5)8590-8596(2017 Jan)

The Novel Receptor C5aR2 Is Required for C5a-Mediated Human Mast Cell Adhesion, Migration, and Proinflammatory Mediator Production.
Pundir P, MacDonald CA, Kulka M
Journal of immunology (Baltimore, Md. : 1950)195(6)2774-87(2015 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Studies indicate that the complement response lie the active fragments, C3a and C5a, acting through their specific receptors, C3aR, C5aR1 and C5aR2 to direct the cellular response to inflammation.
Title: New concepts on the therapeutic control of complement anaphylatoxin receptors.

negative regulator of BDNF secretion by pulp fibroblasts under carious teeth
Title: C5L2 Receptor Represses Brain-Derived Neurotrophic Factor Secretion in Lipoteichoic Acid-Stimulated Pulp Fibroblasts.

C5AR and C5L2-mediated neutrophil dysfunction is associated with a poor outcome in sepsis.
Title: Complement 5a receptor-mediated neutrophil dysfunction is associated with a poor outcome in sepsis.

this study reveals a novel role for C5aR2 in C5a-mediated activation of mast cells and demonstrates that C5aR2 ligation initiates a beta-arrestin-2-, PI3K-, and ERK-dependent signaling pathway in these cells.
Title: The Novel Receptor C5aR2 Is Required for C5a-Mediated Human Mast Cell Adhesion, Migration, and Proinflammatory Mediator Production.

All the C698T genotypes and allele frequencies in C5L2 were almost similar in both the cases and controls.
Title: Genetic polymorphisms in paraoxonase 1 and G protein-coupled receptor 77, and the risk of glucose-6-phosphate dehydrogenase deficiency in a Saudi population.

The following C5AR2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the C5AR2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu00455	NM_018485.3 Latest version!	Homo sapiens complement component 5a receptor 2 (C5AR2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu00455	NM_001271750.1 Latest version!	Homo sapiens complement component 5a receptor 2 (C5AR2), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu00455	NM_001271749.2 Latest version!	Homo sapiens complement component 5a receptor 2 (C5AR2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu00455	XM_011526736.2 Latest version!	Homo sapiens complement component 5a receptor 2 (C5AR2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu00455	XM_011526737.1 Latest version!	Homo sapiens complement component 5a receptor 2 (C5AR2), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
View Old Accession Versions >>
OHu00455	NM_018485.2	Homo sapiens complement component 5a receptor 2 (C5AR2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu00455	XM_011526736.1	Homo sapiens complement component 5a receptor 2 (C5AR2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu00455	NM_001271749.1	Homo sapiens complement component 5a receptor 2 (C5AR2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

C5AR2 ( NM_001271750.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001258679.1 Homo sapiens complement component 5a receptor 2 (C5AR2), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu00455
Clone ID Related Accession (Same CDS sequence)	XM_011526736.1 , NM_001271750.1 , NM_018485.2 , XM_011526737.1 , NM_001271749.1 , NM_018485.3 , XM_011526736.2 , NM_001271749.2
Accession Version	NM_001271750.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1014bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-07
Organism	Homo sapiens(human)
Product	C5a anaphylatoxin chemotactic receptor 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP370117.1, AC008754.8 and AB038237.1. Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BP370117.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03465414 [ECO:0000348] ##Evidence-Data-END##

ATGGGGAACG ATTCTGTCAG CTACGAGTAT GGGGATTACA GCGACCTCTC GGACCGCCCT 
GTGGACTGCC TGGATGGCGC CTGCCTGGCC ATCGACCCGC TGCGCGTGGC CCCGCTCCCA 
CTGTATGCCG CCATCTTCCT GGTGGGGGTG CCGGGCAATG CCATGGTGGC CTGGGTGGCT 
GGGAAGGTGG CCCGCCGGAG GGTGGGTGCC ACCTGGTTGC TCCACCTGGC CGTGGCGGAT 
TTGCTGTGCT GTTTGTCTCT GCCCATCCTG GCAGTGCCCA TTGCCCGTGG AGGCCACTGG 
CCGTATGGTG CAGTGGGCTG TCGGGCGCTG CCCTCCATCA TCCTGCTGAC CATGTATGCC 
AGCGTCCTGC TCCTGGCAGC TCTCAGTGCC GACCTCTGCT TCCTGGCTCT CGGGCCTGCC 
TGGTGGTCTA CGGTTCAGCG GGCGTGCGGG GTGCAGGTGG CCTGTGGGGC AGCCTGGACA 
CTGGCCTTGC TGCTCACCGT GCCCTCCGCC ATCTACCGCC GGCTGCACCA GGAGCACTTC 
CCAGCCCGGC TGCAGTGTGT GGTGGACTAC GGCGGCTCCT CCAGCACCGA GAATGCGGTG 
ACTGCCATCC GGTTTCTTTT TGGCTTCCTG GGGCCCCTGG TGGCCGTGGC CAGCTGCCAC 
AGTGCCCTCC TGTGCTGGGC AGCCCGACGC TGCCGGCCGC TGGGCACAGC CATTGTGGTG 
GGGTTTTTTG TCTGCTGGGC ACCCTACCAC CTGCTGGGGC TGGTGCTCAC TGTGGCGGCC 
CCGAACTCCG CACTCCTGGC CAGGGCCCTG CGGGCTGAAC CCCTCATCGT GGGCCTTGCC 
CTCGCTCACA GCTGCCTCAA TCCCATGCTC TTCCTGTATT TTGGGAGGGC TCAACTCCGC 
CGGTCACTGC CAGCTGCCTG TCACTGGGCC CTGAGGGAGT CCCAGGGCCA GGACGAAAGT 
GTGGACAGCA AGAAATCCAC CAGCCATGAC CTGGTCTCGG AGATGGAGGT GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001258679.1
CDS	142..1155
Translation	MGNDSVSYEYGDYSDLSDRPVDCLDGACLAIDPLRVAPLPLYAAIFLVGVPGNAMVAWVAGKVARRRVGATWLLHLAVADLLCCLSLPILAVPIARGGHWPYGAVGCRALPSIILLTMYASVLLLAALSADLCFLALGPAWWSTVQRACGVQVACGAAWTLALLLTVPSAIYRRLHQEHFPARLQCVVDYGGSSSTENAVTAIRFLFGFLGPLVAVASCHSALLCWAARRCRPLGTAIVVGFFVCWAPYHLLGLVLTVAAPNSALLARALRAEPLIVGLALAHSCLNPMLFLYFGRAQLRRSLPAACHWALRESQGQDESVDSKKSTSHDLVSEMEV

Target ORF information:

RefSeq Version	NM_001271750.1
Organism	Homo sapiens(human)
Definition	Homo sapiens complement component 5a receptor 2 (C5AR2), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001271750.1

ORF Insert Sequence:

ATGGGGAACG ATTCTGTCAG CTACGAGTAT GGGGATTACA GCGACCTCTC GGACCGCCCT 
GTGGACTGCC TGGATGGCGC CTGCCTGGCC ATCGACCCGC TGCGCGTGGC CCCGCTCCCA 
CTGTATGCCG CCATCTTCCT GGTGGGGGTG CCGGGCAATG CCATGGTGGC CTGGGTGGCT 
GGGAAGGTGG CCCGCCGGAG GGTGGGTGCC ACCTGGTTGC TCCACCTGGC CGTGGCGGAT 
TTGCTGTGCT GTTTGTCTCT GCCCATCCTG GCAGTGCCCA TTGCCCGTGG AGGCCACTGG 
CCGTATGGTG CAGTGGGCTG TCGGGCGCTG CCCTCCATCA TCCTGCTGAC CATGTATGCC 
AGCGTCCTGC TCCTGGCAGC TCTCAGTGCC GACCTCTGCT TCCTGGCTCT CGGGCCTGCC 
TGGTGGTCTA CGGTTCAGCG GGCGTGCGGG GTGCAGGTGG CCTGTGGGGC AGCCTGGACA 
CTGGCCTTGC TGCTCACCGT GCCCTCCGCC ATCTACCGCC GGCTGCACCA GGAGCACTTC 
CCAGCCCGGC TGCAGTGTGT GGTGGACTAC GGCGGCTCCT CCAGCACCGA GAATGCGGTG 
ACTGCCATCC GGTTTCTTTT TGGCTTCCTG GGGCCCCTGG TGGCCGTGGC CAGCTGCCAC 
AGTGCCCTCC TGTGCTGGGC AGCCCGACGC TGCCGGCCGC TGGGCACAGC CATTGTGGTG 
GGGTTTTTTG TCTGCTGGGC ACCCTACCAC CTGCTGGGGC TGGTGCTCAC TGTGGCGGCC 
CCGAACTCCG CACTCCTGGC CAGGGCCCTG CGGGCTGAAC CCCTCATCGT GGGCCTTGCC 
CTCGCTCACA GCTGCCTCAA TCCCATGCTC TTCCTGTATT TTGGGAGGGC TCAACTCCGC 
CGGTCACTGC CAGCTGCCTG TCACTGGGCC CTGAGGGAGT CCCAGGGCCA GGACGAAAGT 
GTGGACAGCA AGAAATCCAC CAGCCATGAC CTGGTCTCGG AGATGGAGGT GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

C5AR2 ( NM_018485.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_060955.1 Homo sapiens complement component 5a receptor 2 (C5AR2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu00455
Clone ID Related Accession (Same CDS sequence)	XM_011526736.1 , NM_001271750.1 , NM_018485.2 , XM_011526737.1 , NM_001271749.1 , NM_018485.3 , XM_011526736.2 , NM_001271749.2
Accession Version	NM_018485.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1014bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-22
Organism	Homo sapiens(human)
Product	C5a anaphylatoxin chemotactic receptor 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA673976.1, AC099491.2 and AB038237.1. On Nov 15, 2012 this sequence version replaced NM_018485.1. Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB038237.1, BP298450.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END##

ATGGGGAACG ATTCTGTCAG CTACGAGTAT GGGGATTACA GCGACCTCTC GGACCGCCCT 
GTGGACTGCC TGGATGGCGC CTGCCTGGCC ATCGACCCGC TGCGCGTGGC CCCGCTCCCA 
CTGTATGCCG CCATCTTCCT GGTGGGGGTG CCGGGCAATG CCATGGTGGC CTGGGTGGCT 
GGGAAGGTGG CCCGCCGGAG GGTGGGTGCC ACCTGGTTGC TCCACCTGGC CGTGGCGGAT 
TTGCTGTGCT GTTTGTCTCT GCCCATCCTG GCAGTGCCCA TTGCCCGTGG AGGCCACTGG 
CCGTATGGTG CAGTGGGCTG TCGGGCGCTG CCCTCCATCA TCCTGCTGAC CATGTATGCC 
AGCGTCCTGC TCCTGGCAGC TCTCAGTGCC GACCTCTGCT TCCTGGCTCT CGGGCCTGCC 
TGGTGGTCTA CGGTTCAGCG GGCGTGCGGG GTGCAGGTGG CCTGTGGGGC AGCCTGGACA 
CTGGCCTTGC TGCTCACCGT GCCCTCCGCC ATCTACCGCC GGCTGCACCA GGAGCACTTC 
CCAGCCCGGC TGCAGTGTGT GGTGGACTAC GGCGGCTCCT CCAGCACCGA GAATGCGGTG 
ACTGCCATCC GGTTTCTTTT TGGCTTCCTG GGGCCCCTGG TGGCCGTGGC CAGCTGCCAC 
AGTGCCCTCC TGTGCTGGGC AGCCCGACGC TGCCGGCCGC TGGGCACAGC CATTGTGGTG 
GGGTTTTTTG TCTGCTGGGC ACCCTACCAC CTGCTGGGGC TGGTGCTCAC TGTGGCGGCC 
CCGAACTCCG CACTCCTGGC CAGGGCCCTG CGGGCTGAAC CCCTCATCGT GGGCCTTGCC 
CTCGCTCACA GCTGCCTCAA TCCCATGCTC TTCCTGTATT TTGGGAGGGC TCAACTCCGC 
CGGTCACTGC CAGCTGCCTG TCACTGGGCC CTGAGGGAGT CCCAGGGCCA GGACGAAAGT 
GTGGACAGCA AGAAATCCAC CAGCCATGAC CTGGTCTCGG AGATGGAGGT GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_060955.1
CDS	181..1194
Translation	MGNDSVSYEYGDYSDLSDRPVDCLDGACLAIDPLRVAPLPLYAAIFLVGVPGNAMVAWVAGKVARRRVGATWLLHLAVADLLCCLSLPILAVPIARGGHWPYGAVGCRALPSIILLTMYASVLLLAALSADLCFLALGPAWWSTVQRACGVQVACGAAWTLALLLTVPSAIYRRLHQEHFPARLQCVVDYGGSSSTENAVTAIRFLFGFLGPLVAVASCHSALLCWAARRCRPLGTAIVVGFFVCWAPYHLLGLVLTVAAPNSALLARALRAEPLIVGLALAHSCLNPMLFLYFGRAQLRRSLPAACHWALRESQGQDESVDSKKSTSHDLVSEMEV

Target ORF information:

RefSeq Version	NM_018485.2
Organism	Homo sapiens(human)
Definition	Homo sapiens complement component 5a receptor 2 (C5AR2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_018485.2

ORF Insert Sequence:

ATGGGGAACG ATTCTGTCAG CTACGAGTAT GGGGATTACA GCGACCTCTC GGACCGCCCT 
GTGGACTGCC TGGATGGCGC CTGCCTGGCC ATCGACCCGC TGCGCGTGGC CCCGCTCCCA 
CTGTATGCCG CCATCTTCCT GGTGGGGGTG CCGGGCAATG CCATGGTGGC CTGGGTGGCT 
GGGAAGGTGG CCCGCCGGAG GGTGGGTGCC ACCTGGTTGC TCCACCTGGC CGTGGCGGAT 
TTGCTGTGCT GTTTGTCTCT GCCCATCCTG GCAGTGCCCA TTGCCCGTGG AGGCCACTGG 
CCGTATGGTG CAGTGGGCTG TCGGGCGCTG CCCTCCATCA TCCTGCTGAC CATGTATGCC 
AGCGTCCTGC TCCTGGCAGC TCTCAGTGCC GACCTCTGCT TCCTGGCTCT CGGGCCTGCC 
TGGTGGTCTA CGGTTCAGCG GGCGTGCGGG GTGCAGGTGG CCTGTGGGGC AGCCTGGACA 
CTGGCCTTGC TGCTCACCGT GCCCTCCGCC ATCTACCGCC GGCTGCACCA GGAGCACTTC 
CCAGCCCGGC TGCAGTGTGT GGTGGACTAC GGCGGCTCCT CCAGCACCGA GAATGCGGTG 
ACTGCCATCC GGTTTCTTTT TGGCTTCCTG GGGCCCCTGG TGGCCGTGGC CAGCTGCCAC 
AGTGCCCTCC TGTGCTGGGC AGCCCGACGC TGCCGGCCGC TGGGCACAGC CATTGTGGTG 
GGGTTTTTTG TCTGCTGGGC ACCCTACCAC CTGCTGGGGC TGGTGCTCAC TGTGGCGGCC 
CCGAACTCCG CACTCCTGGC CAGGGCCCTG CGGGCTGAAC CCCTCATCGT GGGCCTTGCC 
CTCGCTCACA GCTGCCTCAA TCCCATGCTC TTCCTGTATT TTGGGAGGGC TCAACTCCGC 
CGGTCACTGC CAGCTGCCTG TCACTGGGCC CTGAGGGAGT CCCAGGGCCA GGACGAAAGT 
GTGGACAGCA AGAAATCCAC CAGCCATGAC CTGGTCTCGG AGATGGAGGT GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

C5AR2 ( NM_001271749.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001258678.1 Homo sapiens complement component 5a receptor 2 (C5AR2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu00455
Clone ID Related Accession (Same CDS sequence)	XM_011526736.1 , NM_001271750.1 , NM_018485.2 , XM_011526737.1 , NM_001271749.1 , NM_018485.3 , XM_011526736.2 , NM_001271749.2
Accession Version	NM_001271749.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1014bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-22
Organism	Homo sapiens(human)
Product	C5a anaphylatoxin chemotactic receptor 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK313994.1 and AB038237.1. Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK313994.1, BP214414.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END##

ATGGGGAACG ATTCTGTCAG CTACGAGTAT GGGGATTACA GCGACCTCTC GGACCGCCCT 
GTGGACTGCC TGGATGGCGC CTGCCTGGCC ATCGACCCGC TGCGCGTGGC CCCGCTCCCA 
CTGTATGCCG CCATCTTCCT GGTGGGGGTG CCGGGCAATG CCATGGTGGC CTGGGTGGCT 
GGGAAGGTGG CCCGCCGGAG GGTGGGTGCC ACCTGGTTGC TCCACCTGGC CGTGGCGGAT 
TTGCTGTGCT GTTTGTCTCT GCCCATCCTG GCAGTGCCCA TTGCCCGTGG AGGCCACTGG 
CCGTATGGTG CAGTGGGCTG TCGGGCGCTG CCCTCCATCA TCCTGCTGAC CATGTATGCC 
AGCGTCCTGC TCCTGGCAGC TCTCAGTGCC GACCTCTGCT TCCTGGCTCT CGGGCCTGCC 
TGGTGGTCTA CGGTTCAGCG GGCGTGCGGG GTGCAGGTGG CCTGTGGGGC AGCCTGGACA 
CTGGCCTTGC TGCTCACCGT GCCCTCCGCC ATCTACCGCC GGCTGCACCA GGAGCACTTC 
CCAGCCCGGC TGCAGTGTGT GGTGGACTAC GGCGGCTCCT CCAGCACCGA GAATGCGGTG 
ACTGCCATCC GGTTTCTTTT TGGCTTCCTG GGGCCCCTGG TGGCCGTGGC CAGCTGCCAC 
AGTGCCCTCC TGTGCTGGGC AGCCCGACGC TGCCGGCCGC TGGGCACAGC CATTGTGGTG 
GGGTTTTTTG TCTGCTGGGC ACCCTACCAC CTGCTGGGGC TGGTGCTCAC TGTGGCGGCC 
CCGAACTCCG CACTCCTGGC CAGGGCCCTG CGGGCTGAAC CCCTCATCGT GGGCCTTGCC 
CTCGCTCACA GCTGCCTCAA TCCCATGCTC TTCCTGTATT TTGGGAGGGC TCAACTCCGC 
CGGTCACTGC CAGCTGCCTG TCACTGGGCC CTGAGGGAGT CCCAGGGCCA GGACGAAAGT 
GTGGACAGCA AGAAATCCAC CAGCCATGAC CTGGTCTCGG AGATGGAGGT GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001258678.1
CDS	219..1232
Translation	MGNDSVSYEYGDYSDLSDRPVDCLDGACLAIDPLRVAPLPLYAAIFLVGVPGNAMVAWVAGKVARRRVGATWLLHLAVADLLCCLSLPILAVPIARGGHWPYGAVGCRALPSIILLTMYASVLLLAALSADLCFLALGPAWWSTVQRACGVQVACGAAWTLALLLTVPSAIYRRLHQEHFPARLQCVVDYGGSSSTENAVTAIRFLFGFLGPLVAVASCHSALLCWAARRCRPLGTAIVVGFFVCWAPYHLLGLVLTVAAPNSALLARALRAEPLIVGLALAHSCLNPMLFLYFGRAQLRRSLPAACHWALRESQGQDESVDSKKSTSHDLVSEMEV

Target ORF information:

RefSeq Version	NM_001271749.1
Organism	Homo sapiens(human)
Definition	Homo sapiens complement component 5a receptor 2 (C5AR2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001271749.1

ORF Insert Sequence:

ATGGGGAACG ATTCTGTCAG CTACGAGTAT GGGGATTACA GCGACCTCTC GGACCGCCCT 
GTGGACTGCC TGGATGGCGC CTGCCTGGCC ATCGACCCGC TGCGCGTGGC CCCGCTCCCA 
CTGTATGCCG CCATCTTCCT GGTGGGGGTG CCGGGCAATG CCATGGTGGC CTGGGTGGCT 
GGGAAGGTGG CCCGCCGGAG GGTGGGTGCC ACCTGGTTGC TCCACCTGGC CGTGGCGGAT 
TTGCTGTGCT GTTTGTCTCT GCCCATCCTG GCAGTGCCCA TTGCCCGTGG AGGCCACTGG 
CCGTATGGTG CAGTGGGCTG TCGGGCGCTG CCCTCCATCA TCCTGCTGAC CATGTATGCC 
AGCGTCCTGC TCCTGGCAGC TCTCAGTGCC GACCTCTGCT TCCTGGCTCT CGGGCCTGCC 
TGGTGGTCTA CGGTTCAGCG GGCGTGCGGG GTGCAGGTGG CCTGTGGGGC AGCCTGGACA 
CTGGCCTTGC TGCTCACCGT GCCCTCCGCC ATCTACCGCC GGCTGCACCA GGAGCACTTC 
CCAGCCCGGC TGCAGTGTGT GGTGGACTAC GGCGGCTCCT CCAGCACCGA GAATGCGGTG 
ACTGCCATCC GGTTTCTTTT TGGCTTCCTG GGGCCCCTGG TGGCCGTGGC CAGCTGCCAC 
AGTGCCCTCC TGTGCTGGGC AGCCCGACGC TGCCGGCCGC TGGGCACAGC CATTGTGGTG 
GGGTTTTTTG TCTGCTGGGC ACCCTACCAC CTGCTGGGGC TGGTGCTCAC TGTGGCGGCC 
CCGAACTCCG CACTCCTGGC CAGGGCCCTG CGGGCTGAAC CCCTCATCGT GGGCCTTGCC 
CTCGCTCACA GCTGCCTCAA TCCCATGCTC TTCCTGTATT TTGGGAGGGC TCAACTCCGC 
CGGTCACTGC CAGCTGCCTG TCACTGGGCC CTGAGGGAGT CCCAGGGCCA GGACGAAAGT 
GTGGACAGCA AGAAATCCAC CAGCCATGAC CTGGTCTCGG AGATGGAGGT GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

C5AR2 ( NM_018485.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_060955.1 Homo sapiens complement component 5a receptor 2 (C5AR2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu00455
Clone ID Related Accession (Same CDS sequence)	XM_011526736.1 , NM_001271750.1 , NM_018485.2 , XM_011526737.1 , NM_001271749.1 , NM_018485.3 , XM_011526736.2 , NM_001271749.2
Accession Version	NM_018485.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1014bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-07
Organism	Homo sapiens(human)
Product	C5a anaphylatoxin chemotactic receptor 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA673976.1, AB038237.1 and AC008754.8. On May 31, 2019 this sequence version replaced NM_018485.2. Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB038237.1, DA464037.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END##

ATGGGGAACG ATTCTGTCAG CTACGAGTAT GGGGATTACA GCGACCTCTC GGACCGCCCT 
GTGGACTGCC TGGATGGCGC CTGCCTGGCC ATCGACCCGC TGCGCGTGGC CCCGCTCCCA 
CTGTATGCCG CCATCTTCCT GGTGGGGGTG CCGGGCAATG CCATGGTGGC CTGGGTGGCT 
GGGAAGGTGG CCCGCCGGAG GGTGGGTGCC ACCTGGTTGC TCCACCTGGC CGTGGCGGAT 
TTGCTGTGCT GTTTGTCTCT GCCCATCCTG GCAGTGCCCA TTGCCCGTGG AGGCCACTGG 
CCGTATGGTG CAGTGGGCTG TCGGGCGCTG CCCTCCATCA TCCTGCTGAC CATGTATGCC 
AGCGTCCTGC TCCTGGCAGC TCTCAGTGCC GACCTCTGCT TCCTGGCTCT CGGGCCTGCC 
TGGTGGTCTA CGGTTCAGCG GGCGTGCGGG GTGCAGGTGG CCTGTGGGGC AGCCTGGACA 
CTGGCCTTGC TGCTCACCGT GCCCTCCGCC ATCTACCGCC GGCTGCACCA GGAGCACTTC 
CCAGCCCGGC TGCAGTGTGT GGTGGACTAC GGCGGCTCCT CCAGCACCGA GAATGCGGTG 
ACTGCCATCC GGTTTCTTTT TGGCTTCCTG GGGCCCCTGG TGGCCGTGGC CAGCTGCCAC 
AGTGCCCTCC TGTGCTGGGC AGCCCGACGC TGCCGGCCGC TGGGCACAGC CATTGTGGTG 
GGGTTTTTTG TCTGCTGGGC ACCCTACCAC CTGCTGGGGC TGGTGCTCAC TGTGGCGGCC 
CCGAACTCCG CACTCCTGGC CAGGGCCCTG CGGGCTGAAC CCCTCATCGT GGGCCTTGCC 
CTCGCTCACA GCTGCCTCAA TCCCATGCTC TTCCTGTATT TTGGGAGGGC TCAACTCCGC 
CGGTCACTGC CAGCTGCCTG TCACTGGGCC CTGAGGGAGT CCCAGGGCCA GGACGAAAGT 
GTGGACAGCA AGAAATCCAC CAGCCATGAC CTGGTCTCGG AGATGGAGGT GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_060955.1
CDS	91..1104
Translation	MGNDSVSYEYGDYSDLSDRPVDCLDGACLAIDPLRVAPLPLYAAIFLVGVPGNAMVAWVAGKVARRRVGATWLLHLAVADLLCCLSLPILAVPIARGGHWPYGAVGCRALPSIILLTMYASVLLLAALSADLCFLALGPAWWSTVQRACGVQVACGAAWTLALLLTVPSAIYRRLHQEHFPARLQCVVDYGGSSSTENAVTAIRFLFGFLGPLVAVASCHSALLCWAARRCRPLGTAIVVGFFVCWAPYHLLGLVLTVAAPNSALLARALRAEPLIVGLALAHSCLNPMLFLYFGRAQLRRSLPAACHWALRESQGQDESVDSKKSTSHDLVSEMEV

Target ORF information:

RefSeq Version	NM_018485.3
Organism	Homo sapiens(human)
Definition	Homo sapiens complement component 5a receptor 2 (C5AR2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_018485.3

ORF Insert Sequence:

ATGGGGAACG ATTCTGTCAG CTACGAGTAT GGGGATTACA GCGACCTCTC GGACCGCCCT 
GTGGACTGCC TGGATGGCGC CTGCCTGGCC ATCGACCCGC TGCGCGTGGC CCCGCTCCCA 
CTGTATGCCG CCATCTTCCT GGTGGGGGTG CCGGGCAATG CCATGGTGGC CTGGGTGGCT 
GGGAAGGTGG CCCGCCGGAG GGTGGGTGCC ACCTGGTTGC TCCACCTGGC CGTGGCGGAT 
TTGCTGTGCT GTTTGTCTCT GCCCATCCTG GCAGTGCCCA TTGCCCGTGG AGGCCACTGG 
CCGTATGGTG CAGTGGGCTG TCGGGCGCTG CCCTCCATCA TCCTGCTGAC CATGTATGCC 
AGCGTCCTGC TCCTGGCAGC TCTCAGTGCC GACCTCTGCT TCCTGGCTCT CGGGCCTGCC 
TGGTGGTCTA CGGTTCAGCG GGCGTGCGGG GTGCAGGTGG CCTGTGGGGC AGCCTGGACA 
CTGGCCTTGC TGCTCACCGT GCCCTCCGCC ATCTACCGCC GGCTGCACCA GGAGCACTTC 
CCAGCCCGGC TGCAGTGTGT GGTGGACTAC GGCGGCTCCT CCAGCACCGA GAATGCGGTG 
ACTGCCATCC GGTTTCTTTT TGGCTTCCTG GGGCCCCTGG TGGCCGTGGC CAGCTGCCAC 
AGTGCCCTCC TGTGCTGGGC AGCCCGACGC TGCCGGCCGC TGGGCACAGC CATTGTGGTG 
GGGTTTTTTG TCTGCTGGGC ACCCTACCAC CTGCTGGGGC TGGTGCTCAC TGTGGCGGCC 
CCGAACTCCG CACTCCTGGC CAGGGCCCTG CGGGCTGAAC CCCTCATCGT GGGCCTTGCC 
CTCGCTCACA GCTGCCTCAA TCCCATGCTC TTCCTGTATT TTGGGAGGGC TCAACTCCGC 
CGGTCACTGC CAGCTGCCTG TCACTGGGCC CTGAGGGAGT CCCAGGGCCA GGACGAAAGT 
GTGGACAGCA AGAAATCCAC CAGCCATGAC CTGGTCTCGG AGATGGAGGT GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

C5AR2 ( NM_001271749.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001258678.1 Homo sapiens complement component 5a receptor 2 (C5AR2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu00455
Clone ID Related Accession (Same CDS sequence)	XM_011526736.1 , NM_001271750.1 , NM_018485.2 , XM_011526737.1 , NM_001271749.1 , NM_018485.3 , XM_011526736.2 , NM_001271749.2
Accession Version	NM_001271749.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1014bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	C5a anaphylatoxin chemotactic receptor 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK313994.1, AB038237.1 and AC008754.8. On May 17, 2019 this sequence version replaced NM_001271749.1. Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK313994.1, DA980912.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000595464.3/ ENSP00000472620.1 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END##

ATGGGGAACG ATTCTGTCAG CTACGAGTAT GGGGATTACA GCGACCTCTC GGACCGCCCT 
GTGGACTGCC TGGATGGCGC CTGCCTGGCC ATCGACCCGC TGCGCGTGGC CCCGCTCCCA 
CTGTATGCCG CCATCTTCCT GGTGGGGGTG CCGGGCAATG CCATGGTGGC CTGGGTGGCT 
GGGAAGGTGG CCCGCCGGAG GGTGGGTGCC ACCTGGTTGC TCCACCTGGC CGTGGCGGAT 
TTGCTGTGCT GTTTGTCTCT GCCCATCCTG GCAGTGCCCA TTGCCCGTGG AGGCCACTGG 
CCGTATGGTG CAGTGGGCTG TCGGGCGCTG CCCTCCATCA TCCTGCTGAC CATGTATGCC 
AGCGTCCTGC TCCTGGCAGC TCTCAGTGCC GACCTCTGCT TCCTGGCTCT CGGGCCTGCC 
TGGTGGTCTA CGGTTCAGCG GGCGTGCGGG GTGCAGGTGG CCTGTGGGGC AGCCTGGACA 
CTGGCCTTGC TGCTCACCGT GCCCTCCGCC ATCTACCGCC GGCTGCACCA GGAGCACTTC 
CCAGCCCGGC TGCAGTGTGT GGTGGACTAC GGCGGCTCCT CCAGCACCGA GAATGCGGTG 
ACTGCCATCC GGTTTCTTTT TGGCTTCCTG GGGCCCCTGG TGGCCGTGGC CAGCTGCCAC 
AGTGCCCTCC TGTGCTGGGC AGCCCGACGC TGCCGGCCGC TGGGCACAGC CATTGTGGTG 
GGGTTTTTTG TCTGCTGGGC ACCCTACCAC CTGCTGGGGC TGGTGCTCAC TGTGGCGGCC 
CCGAACTCCG CACTCCTGGC CAGGGCCCTG CGGGCTGAAC CCCTCATCGT GGGCCTTGCC 
CTCGCTCACA GCTGCCTCAA TCCCATGCTC TTCCTGTATT TTGGGAGGGC TCAACTCCGC 
CGGTCACTGC CAGCTGCCTG TCACTGGGCC CTGAGGGAGT CCCAGGGCCA GGACGAAAGT 
GTGGACAGCA AGAAATCCAC CAGCCATGAC CTGGTCTCGG AGATGGAGGT GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001258678.1
CDS	191..1204
Translation	MGNDSVSYEYGDYSDLSDRPVDCLDGACLAIDPLRVAPLPLYAAIFLVGVPGNAMVAWVAGKVARRRVGATWLLHLAVADLLCCLSLPILAVPIARGGHWPYGAVGCRALPSIILLTMYASVLLLAALSADLCFLALGPAWWSTVQRACGVQVACGAAWTLALLLTVPSAIYRRLHQEHFPARLQCVVDYGGSSSTENAVTAIRFLFGFLGPLVAVASCHSALLCWAARRCRPLGTAIVVGFFVCWAPYHLLGLVLTVAAPNSALLARALRAEPLIVGLALAHSCLNPMLFLYFGRAQLRRSLPAACHWALRESQGQDESVDSKKSTSHDLVSEMEV

Target ORF information:

RefSeq Version	NM_001271749.2
Organism	Homo sapiens(human)
Definition	Homo sapiens complement component 5a receptor 2 (C5AR2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001271749.2

ORF Insert Sequence:

ATGGGGAACG ATTCTGTCAG CTACGAGTAT GGGGATTACA GCGACCTCTC GGACCGCCCT 
GTGGACTGCC TGGATGGCGC CTGCCTGGCC ATCGACCCGC TGCGCGTGGC CCCGCTCCCA 
CTGTATGCCG CCATCTTCCT GGTGGGGGTG CCGGGCAATG CCATGGTGGC CTGGGTGGCT 
GGGAAGGTGG CCCGCCGGAG GGTGGGTGCC ACCTGGTTGC TCCACCTGGC CGTGGCGGAT 
TTGCTGTGCT GTTTGTCTCT GCCCATCCTG GCAGTGCCCA TTGCCCGTGG AGGCCACTGG 
CCGTATGGTG CAGTGGGCTG TCGGGCGCTG CCCTCCATCA TCCTGCTGAC CATGTATGCC 
AGCGTCCTGC TCCTGGCAGC TCTCAGTGCC GACCTCTGCT TCCTGGCTCT CGGGCCTGCC 
TGGTGGTCTA CGGTTCAGCG GGCGTGCGGG GTGCAGGTGG CCTGTGGGGC AGCCTGGACA 
CTGGCCTTGC TGCTCACCGT GCCCTCCGCC ATCTACCGCC GGCTGCACCA GGAGCACTTC 
CCAGCCCGGC TGCAGTGTGT GGTGGACTAC GGCGGCTCCT CCAGCACCGA GAATGCGGTG 
ACTGCCATCC GGTTTCTTTT TGGCTTCCTG GGGCCCCTGG TGGCCGTGGC CAGCTGCCAC 
AGTGCCCTCC TGTGCTGGGC AGCCCGACGC TGCCGGCCGC TGGGCACAGC CATTGTGGTG 
GGGTTTTTTG TCTGCTGGGC ACCCTACCAC CTGCTGGGGC TGGTGCTCAC TGTGGCGGCC 
CCGAACTCCG CACTCCTGGC CAGGGCCCTG CGGGCTGAAC CCCTCATCGT GGGCCTTGCC 
CTCGCTCACA GCTGCCTCAA TCCCATGCTC TTCCTGTATT TTGGGAGGGC TCAACTCCGC 
CGGTCACTGC CAGCTGCCTG TCACTGGGCC CTGAGGGAGT CCCAGGGCCA GGACGAAAGT 
GTGGACAGCA AGAAATCCAC CAGCCATGAC CTGGTCTCGG AGATGGAGGT GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

C5AR2 ( XM_011526736.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011525038.1 Homo sapiens complement component 5a receptor 2 (C5AR2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu00455
Clone ID Related Accession (Same CDS sequence)	XM_011526736.1 , NM_001271750.1 , NM_018485.2 , XM_011526737.1 , NM_001271749.1 , NM_018485.3 , XM_011526736.2 , NM_001271749.2
Accession Version	XM_011526736.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1014bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-11
Organism	Homo sapiens(Human)
Product	C5a anaphylatoxin chemotactic receptor 2 isoform X1
Comment

ATGGGGAACG ATTCTGTCAG CTACGAGTAT GGGGATTACA GCGACCTCTC GGACCGCCCT 
GTGGACTGCC TGGATGGCGC CTGCCTGGCC ATCGACCCGC TGCGCGTGGC CCCGCTCCCA 
CTGTATGCCG CCATCTTCCT GGTGGGGGTG CCGGGCAATG CCATGGTGGC CTGGGTGGCT 
GGGAAGGTGG CCCGCCGGAG GGTGGGTGCC ACCTGGTTGC TCCACCTGGC CGTGGCGGAT 
TTGCTGTGCT GTTTGTCTCT GCCCATCCTG GCAGTGCCCA TTGCCCGTGG AGGCCACTGG 
CCGTATGGTG CAGTGGGCTG TCGGGCGCTG CCCTCCATCA TCCTGCTGAC CATGTATGCC 
AGCGTCCTGC TCCTGGCAGC TCTCAGTGCC GACCTCTGCT TCCTGGCTCT CGGGCCTGCC 
TGGTGGTCTA CGGTTCAGCG GGCGTGCGGG GTGCAGGTGG CCTGTGGGGC AGCCTGGACA 
CTGGCCTTGC TGCTCACCGT GCCCTCCGCC ATCTACCGCC GGCTGCACCA GGAGCACTTC 
CCAGCCCGGC TGCAGTGTGT GGTGGACTAC GGCGGCTCCT CCAGCACCGA GAATGCGGTG 
ACTGCCATCC GGTTTCTTTT TGGCTTCCTG GGGCCCCTGG TGGCCGTGGC CAGCTGCCAC 
AGTGCCCTCC TGTGCTGGGC AGCCCGACGC TGCCGGCCGC TGGGCACAGC CATTGTGGTG 
GGGTTTTTTG TCTGCTGGGC ACCCTACCAC CTGCTGGGGC TGGTGCTCAC TGTGGCGGCC 
CCGAACTCCG CACTCCTGGC CAGGGCCCTG CGGGCTGAAC CCCTCATCGT GGGCCTTGCC 
CTCGCTCACA GCTGCCTCAA TCCCATGCTC TTCCTGTATT TTGGGAGGGC TCAACTCCGC 
CGGTCACTGC CAGCTGCCTG TCACTGGGCC CTGAGGGAGT CCCAGGGCCA GGACGAAAGT 
GTGGACAGCA AGAAATCCAC CAGCCATGAC CTGGTCTCGG AGATGGAGGT GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011525038.1
Translation	MGNDSVSYEYGDYSDLSDRPVDCLDGACLAIDPLRVAPLPLYAAIFLVGVPGNAMVAWVAGKVARRRVGATWLLHLAVADLLCCLSLPILAVPIARGGHWPYGAVGCRALPSIILLTMYASVLLLAALSADLCFLALGPAWWSTVQRACGVQVACGAAWTLALLLTVPSAIYRRLHQEHFPARLQCVVDYGGSSSTENAVTAIRFLFGFLGPLVAVASCHSALLCWAARRCRPLGTAIVVGFFVCWAPYHLLGLVLTVAAPNSALLARALRAEPLIVGLALAHSCLNPMLFLYFGRAQLRRSLPAACHWALRESQGQDESVDSKKSTSHDLVSEMEV

Target ORF information:

RefSeq Version	XM_011526736.1
Organism	Homo sapiens(Human)
Definition	Homo sapiens complement component 5a receptor 2 (C5AR2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011526736.1

ORF Insert Sequence:

ATGGGGAACG ATTCTGTCAG CTACGAGTAT GGGGATTACA GCGACCTCTC GGACCGCCCT 
GTGGACTGCC TGGATGGCGC CTGCCTGGCC ATCGACCCGC TGCGCGTGGC CCCGCTCCCA 
CTGTATGCCG CCATCTTCCT GGTGGGGGTG CCGGGCAATG CCATGGTGGC CTGGGTGGCT 
GGGAAGGTGG CCCGCCGGAG GGTGGGTGCC ACCTGGTTGC TCCACCTGGC CGTGGCGGAT 
TTGCTGTGCT GTTTGTCTCT GCCCATCCTG GCAGTGCCCA TTGCCCGTGG AGGCCACTGG 
CCGTATGGTG CAGTGGGCTG TCGGGCGCTG CCCTCCATCA TCCTGCTGAC CATGTATGCC 
AGCGTCCTGC TCCTGGCAGC TCTCAGTGCC GACCTCTGCT TCCTGGCTCT CGGGCCTGCC 
TGGTGGTCTA CGGTTCAGCG GGCGTGCGGG GTGCAGGTGG CCTGTGGGGC AGCCTGGACA 
CTGGCCTTGC TGCTCACCGT GCCCTCCGCC ATCTACCGCC GGCTGCACCA GGAGCACTTC 
CCAGCCCGGC TGCAGTGTGT GGTGGACTAC GGCGGCTCCT CCAGCACCGA GAATGCGGTG 
ACTGCCATCC GGTTTCTTTT TGGCTTCCTG GGGCCCCTGG TGGCCGTGGC CAGCTGCCAC 
AGTGCCCTCC TGTGCTGGGC AGCCCGACGC TGCCGGCCGC TGGGCACAGC CATTGTGGTG 
GGGTTTTTTG TCTGCTGGGC ACCCTACCAC CTGCTGGGGC TGGTGCTCAC TGTGGCGGCC 
CCGAACTCCG CACTCCTGGC CAGGGCCCTG CGGGCTGAAC CCCTCATCGT GGGCCTTGCC 
CTCGCTCACA GCTGCCTCAA TCCCATGCTC TTCCTGTATT TTGGGAGGGC TCAACTCCGC 
CGGTCACTGC CAGCTGCCTG TCACTGGGCC CTGAGGGAGT CCCAGGGCCA GGACGAAAGT 
GTGGACAGCA AGAAATCCAC CAGCCATGAC CTGGTCTCGG AGATGGAGGT GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

C5AR2 ( XM_011526737.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011525039.1 Homo sapiens complement component 5a receptor 2 (C5AR2), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu00455
Clone ID Related Accession (Same CDS sequence)	XM_011526736.1 , NM_001271750.1 , NM_018485.2 , XM_011526737.1 , NM_001271749.1 , NM_018485.3 , XM_011526736.2 , NM_001271749.2
Accession Version	XM_011526737.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1014bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-11
Organism	Homo sapiens(Human)
Product	C5a anaphylatoxin chemotactic receptor 2 isoform X1
Comment

ATGGGGAACG ATTCTGTCAG CTACGAGTAT GGGGATTACA GCGACCTCTC GGACCGCCCT 
GTGGACTGCC TGGATGGCGC CTGCCTGGCC ATCGACCCGC TGCGCGTGGC CCCGCTCCCA 
CTGTATGCCG CCATCTTCCT GGTGGGGGTG CCGGGCAATG CCATGGTGGC CTGGGTGGCT 
GGGAAGGTGG CCCGCCGGAG GGTGGGTGCC ACCTGGTTGC TCCACCTGGC CGTGGCGGAT 
TTGCTGTGCT GTTTGTCTCT GCCCATCCTG GCAGTGCCCA TTGCCCGTGG AGGCCACTGG 
CCGTATGGTG CAGTGGGCTG TCGGGCGCTG CCCTCCATCA TCCTGCTGAC CATGTATGCC 
AGCGTCCTGC TCCTGGCAGC TCTCAGTGCC GACCTCTGCT TCCTGGCTCT CGGGCCTGCC 
TGGTGGTCTA CGGTTCAGCG GGCGTGCGGG GTGCAGGTGG CCTGTGGGGC AGCCTGGACA 
CTGGCCTTGC TGCTCACCGT GCCCTCCGCC ATCTACCGCC GGCTGCACCA GGAGCACTTC 
CCAGCCCGGC TGCAGTGTGT GGTGGACTAC GGCGGCTCCT CCAGCACCGA GAATGCGGTG 
ACTGCCATCC GGTTTCTTTT TGGCTTCCTG GGGCCCCTGG TGGCCGTGGC CAGCTGCCAC 
AGTGCCCTCC TGTGCTGGGC AGCCCGACGC TGCCGGCCGC TGGGCACAGC CATTGTGGTG 
GGGTTTTTTG TCTGCTGGGC ACCCTACCAC CTGCTGGGGC TGGTGCTCAC TGTGGCGGCC 
CCGAACTCCG CACTCCTGGC CAGGGCCCTG CGGGCTGAAC CCCTCATCGT GGGCCTTGCC 
CTCGCTCACA GCTGCCTCAA TCCCATGCTC TTCCTGTATT TTGGGAGGGC TCAACTCCGC 
CGGTCACTGC CAGCTGCCTG TCACTGGGCC CTGAGGGAGT CCCAGGGCCA GGACGAAAGT 
GTGGACAGCA AGAAATCCAC CAGCCATGAC CTGGTCTCGG AGATGGAGGT GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011525039.1
Translation	MGNDSVSYEYGDYSDLSDRPVDCLDGACLAIDPLRVAPLPLYAAIFLVGVPGNAMVAWVAGKVARRRVGATWLLHLAVADLLCCLSLPILAVPIARGGHWPYGAVGCRALPSIILLTMYASVLLLAALSADLCFLALGPAWWSTVQRACGVQVACGAAWTLALLLTVPSAIYRRLHQEHFPARLQCVVDYGGSSSTENAVTAIRFLFGFLGPLVAVASCHSALLCWAARRCRPLGTAIVVGFFVCWAPYHLLGLVLTVAAPNSALLARALRAEPLIVGLALAHSCLNPMLFLYFGRAQLRRSLPAACHWALRESQGQDESVDSKKSTSHDLVSEMEV

Target ORF information:

RefSeq Version	XM_011526737.1
Organism	Homo sapiens(Human)
Definition	Homo sapiens complement component 5a receptor 2 (C5AR2), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011526737.1

ORF Insert Sequence:

ATGGGGAACG ATTCTGTCAG CTACGAGTAT GGGGATTACA GCGACCTCTC GGACCGCCCT 
GTGGACTGCC TGGATGGCGC CTGCCTGGCC ATCGACCCGC TGCGCGTGGC CCCGCTCCCA 
CTGTATGCCG CCATCTTCCT GGTGGGGGTG CCGGGCAATG CCATGGTGGC CTGGGTGGCT 
GGGAAGGTGG CCCGCCGGAG GGTGGGTGCC ACCTGGTTGC TCCACCTGGC CGTGGCGGAT 
TTGCTGTGCT GTTTGTCTCT GCCCATCCTG GCAGTGCCCA TTGCCCGTGG AGGCCACTGG 
CCGTATGGTG CAGTGGGCTG TCGGGCGCTG CCCTCCATCA TCCTGCTGAC CATGTATGCC 
AGCGTCCTGC TCCTGGCAGC TCTCAGTGCC GACCTCTGCT TCCTGGCTCT CGGGCCTGCC 
TGGTGGTCTA CGGTTCAGCG GGCGTGCGGG GTGCAGGTGG CCTGTGGGGC AGCCTGGACA 
CTGGCCTTGC TGCTCACCGT GCCCTCCGCC ATCTACCGCC GGCTGCACCA GGAGCACTTC 
CCAGCCCGGC TGCAGTGTGT GGTGGACTAC GGCGGCTCCT CCAGCACCGA GAATGCGGTG 
ACTGCCATCC GGTTTCTTTT TGGCTTCCTG GGGCCCCTGG TGGCCGTGGC CAGCTGCCAC 
AGTGCCCTCC TGTGCTGGGC AGCCCGACGC TGCCGGCCGC TGGGCACAGC CATTGTGGTG 
GGGTTTTTTG TCTGCTGGGC ACCCTACCAC CTGCTGGGGC TGGTGCTCAC TGTGGCGGCC 
CCGAACTCCG CACTCCTGGC CAGGGCCCTG CGGGCTGAAC CCCTCATCGT GGGCCTTGCC 
CTCGCTCACA GCTGCCTCAA TCCCATGCTC TTCCTGTATT TTGGGAGGGC TCAACTCCGC 
CGGTCACTGC CAGCTGCCTG TCACTGGGCC CTGAGGGAGT CCCAGGGCCA GGACGAAAGT 
GTGGACAGCA AGAAATCCAC CAGCCATGAC CTGGTCTCGG AGATGGAGGT GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

C5AR2 ( XM_011526736.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011525038.1 Homo sapiens complement component 5a receptor 2 (C5AR2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu00455
Clone ID Related Accession (Same CDS sequence)	XM_011526736.1 , NM_001271750.1 , NM_018485.2 , XM_011526737.1 , NM_001271749.1 , NM_018485.3 , XM_011526736.2 , NM_001271749.2
Accession Version	XM_011526736.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1014bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	C5a anaphylatoxin chemotactic receptor 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011526736.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGGAACG ATTCTGTCAG CTACGAGTAT GGGGATTACA GCGACCTCTC GGACCGCCCT 
GTGGACTGCC TGGATGGCGC CTGCCTGGCC ATCGACCCGC TGCGCGTGGC CCCGCTCCCA 
CTGTATGCCG CCATCTTCCT GGTGGGGGTG CCGGGCAATG CCATGGTGGC CTGGGTGGCT 
GGGAAGGTGG CCCGCCGGAG GGTGGGTGCC ACCTGGTTGC TCCACCTGGC CGTGGCGGAT 
TTGCTGTGCT GTTTGTCTCT GCCCATCCTG GCAGTGCCCA TTGCCCGTGG AGGCCACTGG 
CCGTATGGTG CAGTGGGCTG TCGGGCGCTG CCCTCCATCA TCCTGCTGAC CATGTATGCC 
AGCGTCCTGC TCCTGGCAGC TCTCAGTGCC GACCTCTGCT TCCTGGCTCT CGGGCCTGCC 
TGGTGGTCTA CGGTTCAGCG GGCGTGCGGG GTGCAGGTGG CCTGTGGGGC AGCCTGGACA 
CTGGCCTTGC TGCTCACCGT GCCCTCCGCC ATCTACCGCC GGCTGCACCA GGAGCACTTC 
CCAGCCCGGC TGCAGTGTGT GGTGGACTAC GGCGGCTCCT CCAGCACCGA GAATGCGGTG 
ACTGCCATCC GGTTTCTTTT TGGCTTCCTG GGGCCCCTGG TGGCCGTGGC CAGCTGCCAC 
AGTGCCCTCC TGTGCTGGGC AGCCCGACGC TGCCGGCCGC TGGGCACAGC CATTGTGGTG 
GGGTTTTTTG TCTGCTGGGC ACCCTACCAC CTGCTGGGGC TGGTGCTCAC TGTGGCGGCC 
CCGAACTCCG CACTCCTGGC CAGGGCCCTG CGGGCTGAAC CCCTCATCGT GGGCCTTGCC 
CTCGCTCACA GCTGCCTCAA TCCCATGCTC TTCCTGTATT TTGGGAGGGC TCAACTCCGC 
CGGTCACTGC CAGCTGCCTG TCACTGGGCC CTGAGGGAGT CCCAGGGCCA GGACGAAAGT 
GTGGACAGCA AGAAATCCAC CAGCCATGAC CTGGTCTCGG AGATGGAGGT GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011525038.1
CDS	856..1869
Translation	MGNDSVSYEYGDYSDLSDRPVDCLDGACLAIDPLRVAPLPLYAAIFLVGVPGNAMVAWVAGKVARRRVGATWLLHLAVADLLCCLSLPILAVPIARGGHWPYGAVGCRALPSIILLTMYASVLLLAALSADLCFLALGPAWWSTVQRACGVQVACGAAWTLALLLTVPSAIYRRLHQEHFPARLQCVVDYGGSSSTENAVTAIRFLFGFLGPLVAVASCHSALLCWAARRCRPLGTAIVVGFFVCWAPYHLLGLVLTVAAPNSALLARALRAEPLIVGLALAHSCLNPMLFLYFGRAQLRRSLPAACHWALRESQGQDESVDSKKSTSHDLVSEMEV

Target ORF information:

RefSeq Version	XM_011526736.2
Organism	Homo sapiens(human)
Definition	Homo sapiens complement component 5a receptor 2 (C5AR2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011526736.2

ORF Insert Sequence:

ATGGGGAACG ATTCTGTCAG CTACGAGTAT GGGGATTACA GCGACCTCTC GGACCGCCCT 
GTGGACTGCC TGGATGGCGC CTGCCTGGCC ATCGACCCGC TGCGCGTGGC CCCGCTCCCA 
CTGTATGCCG CCATCTTCCT GGTGGGGGTG CCGGGCAATG CCATGGTGGC CTGGGTGGCT 
GGGAAGGTGG CCCGCCGGAG GGTGGGTGCC ACCTGGTTGC TCCACCTGGC CGTGGCGGAT 
TTGCTGTGCT GTTTGTCTCT GCCCATCCTG GCAGTGCCCA TTGCCCGTGG AGGCCACTGG 
CCGTATGGTG CAGTGGGCTG TCGGGCGCTG CCCTCCATCA TCCTGCTGAC CATGTATGCC 
AGCGTCCTGC TCCTGGCAGC TCTCAGTGCC GACCTCTGCT TCCTGGCTCT CGGGCCTGCC 
TGGTGGTCTA CGGTTCAGCG GGCGTGCGGG GTGCAGGTGG CCTGTGGGGC AGCCTGGACA 
CTGGCCTTGC TGCTCACCGT GCCCTCCGCC ATCTACCGCC GGCTGCACCA GGAGCACTTC 
CCAGCCCGGC TGCAGTGTGT GGTGGACTAC GGCGGCTCCT CCAGCACCGA GAATGCGGTG 
ACTGCCATCC GGTTTCTTTT TGGCTTCCTG GGGCCCCTGG TGGCCGTGGC CAGCTGCCAC 
AGTGCCCTCC TGTGCTGGGC AGCCCGACGC TGCCGGCCGC TGGGCACAGC CATTGTGGTG 
GGGTTTTTTG TCTGCTGGGC ACCCTACCAC CTGCTGGGGC TGGTGCTCAC TGTGGCGGCC 
CCGAACTCCG CACTCCTGGC CAGGGCCCTG CGGGCTGAAC CCCTCATCGT GGGCCTTGCC 
CTCGCTCACA GCTGCCTCAA TCCCATGCTC TTCCTGTATT TTGGGAGGGC TCAACTCCGC 
CGGTCACTGC CAGCTGCCTG TCACTGGGCC CTGAGGGAGT CCCAGGGCCA GGACGAAAGT 
GTGGACAGCA AGAAATCCAC CAGCCATGAC CTGGTCTCGG AGATGGAGGT GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

New concepts on the therapeutic control of complement anaphylatoxin receptors.
Molecular immunology8936-43(2017 Sep)
Hawksworth OA,Li XX,Coulthard LG,Wolvetang EJ,Woodruff TM

C5L2 Receptor Represses Brain-Derived Neurotrophic Factor Secretion in Lipoteichoic Acid-Stimulated Pulp Fibroblasts.
Journal of dental research96(1)92-99(2017 Jan)
Chmilewsky F,About I,Chung SH

Association of C5L2 genetic polymorphisms with coronary artery disease in a Han population in Xinjiang, China.
Oncotarget8(5)8590-8596(2017 Jan)
Zheng YY,Xie X,Ma YT,Fu ZY,Ma X,Yang YN,Li XM,Pan S,Adi D,Chen BD,Liu F

The Novel Receptor C5aR2 Is Required for C5a-Mediated Human Mast Cell Adhesion, Migration, and Proinflammatory Mediator Production.
Journal of immunology (Baltimore, Md. : 1950)195(6)2774-87(2015 Sep)
Pundir P,MacDonald CA,Kulka M

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C5AR2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

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Target ORF information:

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ORF Insert Sequence:

Target ORF information:

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ORF Insert Sequence:

Target ORF information:

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ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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