Rxfp2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Rxfp2
Entrez Gene ID	363866
Full Name	relaxin/insulin-like family peptide receptor 2
Synonyms	Gpcr,Lgr8
General protein information	Preferred Names relaxin/insulin-like family peptide receptor 2 Names relaxin receptor 2 INSL3 receptor leucine-rich repeat-containing G protein-coupled receptor 8
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 12 Map Location: 12p12

mRNA and Protein(s)

mRNA	Protein	Name
NM_001012475.1	NP_001012493.1	relaxin receptor 2 precursor

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	RXFP2	NP_001005870.1
Bos taurus (cattle)	RXFP2	XP_002691803.3
Mus musculus (house mouse)	Rxfp2	NP_536716.2
Rattus norvegicus (Norway rat)	Rxfp2	NP_001012493.1
Pan troglodytes (chimpanzee)	RXFP2	XP_001142347.1
Xenopus tropicalis (tropical clawed frog)	LOC100491657	XP_002934071.2
Homo sapiens (human)	RXFP2	NP_001159530.1
	RXFP2	XP_001118169.2
Drosophila melanogaster (fruit fly)	Lgr3	NP_733115.1

Gene Ontology
Bibliography

Related articles in PubMed

Differential Ca
Chen YC, Chang YC, Chang HA, Lin YS, Tsao CW, Shen MR, Chiu WT
Cell calcium6731-39(2017 Nov)

Testosterone reduces knee passive range of motion and expression of relaxin receptor isoforms via 5?-dihydrotestosterone and androgen receptor binding.
Dehghan F, Muniandy S, Yusof A, Salleh N
International journal of molecular sciences15(3)4619-34(2014 Mar)

Sex-steroid regulation of relaxin receptor isoforms (RXFP1 & RXFP2) expression in the patellar tendon and lateral collateral ligament of female WKY rats.
Dehghan F, Muniandy S, Yusof A, Salleh N
International journal of medical sciences11(2)180-91(2014)

Examination of relaxin and its receptors expression in pig gametes and embryos.
Feugang JM, Rodriguez-Munoz JC, Willard ST, Bathgate RA, Ryan PL
Reproductive biology and endocrinology : RB&E910(2011 Jan)

Prenatal exposure to diaethylstilbestrol in the rat inhibits transabdominal testicular descent with involvement of the INSL3/LGR8 system and HOXA10.
Zhang L, Zheng XM, Hubert J, Zheng H, Yang ZW, Li SW
Chinese medical journal122(8)967-71(2009 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data indicate that knee passive range of motion (ROM), relaxin receptor isoforms Rxfp1 and Rxfp2 expression were significantly reduced following treatment with testosterone, and androgen antagonist flutamide antagonized the testosterone effect.
Title: Testosterone reduces knee passive range of motion and expression of relaxin receptor isoforms via 5?-dihydrotestosterone and androgen receptor binding.

RXFP1 & RXFP2 up-regulation by progesterone and estrogen could provide the basis for the reported increase in knee laxity while down-regulation of these receptor isoforms by testosterone could explain low incidence of non-contact knee injury in male.
Title: Sex-steroid regulation of relaxin receptor isoforms (RXFP1 & RXFP2) expression in the patellar tendon and lateral collateral ligament of female WKY rats.

These studies confirm the influence of midbrain dopamine systems on Pf neurons and suggest that LGR8 could be a useful marker for following changes in Pf neuron activity and adaptation under physiological modulatory and pathological conditions.
Title: Effect of unilateral lesion of the nigrostriatal dopamine pathway on survival and neurochemistry of parafascicular nucleus neurons in the rat--evaluation of time-course and LGR8 expression.

Prenatal exposure to diaethylstilbestrol can inhibit transabdominal testicular descent in a system that does not involve LGR8.
Title: Prenatal exposure to diaethylstilbestrol in the rat inhibits transabdominal testicular descent with involvement of the INSL3/LGR8 system and HOXA10.

The existence of a broadly distributed LGR8 signaling system in the rat involved in sensorimotor, limbic and cognitive functions.
Title: Leucine-rich repeat-containing G-protein-coupled receptor 8 in the rat brain: Enrichment in thalamic neurons and their efferent projections.

The following Rxfp2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Rxfp2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa02960	NM_001012475.1 Latest version!	Rattus norvegicus relaxin family peptide receptor 2 (Rxfp2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$433.30 $619.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Rxfp2 ( NM_001012475.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001012493.1 Rattus norvegicus relaxin family peptide receptor 2 (Rxfp2), mRNA.

Price & Availability↑

CloneID	ORa02960
Clone ID Related Accession (Same CDS sequence)	NM_001012475.1
Accession Version	NM_001012475.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2214bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Rattus norvegicus(Norway rat)
Product	relaxin receptor 2 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY906861.1. On Apr 20, 2005 this sequence version replaced XM_344073.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY906861.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGTGGCTTC TACTTCATGT CGTCCTTCTG ATGGAGGTCA AAGATTTCAC ACTGGCTGGC 
AGCAATATGG TGGCTCCTCT GTGCCCAAAA GGGTATTTCC CCTGTGGGAA TCTCACCAAG 
TGCTTACCCC GAGCCTTTCA CTGCGACGGC GTGGATGATT GCGGGAATGG TGCGGATGAG 
GACAACTGTG GTGACACTAG TGGATGGACG ACCATATTTG GCACAGTCCA TGGAAATGTC 
AATAAAGTGA CATTAACAGA GGAGTGCTTT CTCAGCCGGT ACCCACAGCA CTGTTACTGC 
AGAGAAAATG AACTAGAATG CGTAAACGCC GACTTAAAAG CTGTGCCAAA GGTTTCCAGC 
AACGTAACAT TACTATCTCT TAAGAAAAAC AAAATTCACA GACTTCCAGT CAAGGTTTTC 
AGCAAATACG CAGAACTCAG AAAGATATTC CTCCAGCACA ACTGCATCAC ACACATCTCC 
AGGAGAGCGT TCCTTGGATT ACATAACCTA CAGATACTGT ATCTCAGCCA TAACTGCATT 
ACCTCTCTCA GGCCTGGGAT ATTCAAAGAC TTGCATCAGC TCGCTTGGCT AATTTTAGAT 
GACAACCCAA TCACCAGAAT CTCACAGAGG TCCTTTACTG GATTAAACTC CTTGTTTTTC 
TTGTCCATGG TGAGTAACCG GCTGGAGGCC CTTCCTGAAA GGCTGTGCGC CCAGATGCCT 
CAACTCAACT GGGTGGATCT GGCAAACAAT GGGATAAAGT TCATAACGAA CTCCACCTTC 
CTGACGTGCG ACTCGCTCAC GGTTCTGTTT CTGCCTAGAA ATCAAATTGG TTTTGTTCCA 
GAGAAGACAT TTTCTTCATT AAAAAATTTA GGAGAACTGG ACCTGTCTAG CAATGTGATA 
GCAAAACTAC CAGCCCACCT TTTCAGCGAC CTTCACCTTC TCCAAAAGCT GAACCTGTCG 
TCCAACCCTC TTCTGTATGT CCACAAGAAC CAGTTTGGAA GTCTCAAACA ACTTCAGTCT 
CTAGACCTGG AAAGGATAGA GATTCCAAAC ATAAACACCG GAATGTTCCG GCCCATGAAG 
AACCTTTCTC ACATATATTT GAAAACCTTT CGGTACTGCT CCTATGTTCC CCATGTCCGA 
ATCTGTATGC CCTCGACTGA TGGTATATCT TCATCTGAGG ACCTCTTGGC TAACAGTATC 
CTCAGAGTGT CTGTCTGGGT TATAGCTTTC ATTACCTGCG CTGGGAATTT CCTCGTCATA 
GCCGTGAGAT CTCTCATTAA GGCTGAGAAT ACGACTCACG CTATGTCCAT CAAAATCCTT 
TGTTGTGCCG ACTGCCTGAT GGGGGTGTAC CTGTTCTCCG TGGGCGTCTT TGACATCAAG 
TACCGAGGGC AGTATCAGAA GTATGCGCTG CTGTGGATGG AGAGTGTACC CTGCCGCCTG 
CTGGGCTTCC TGGCCACGCT GTCCACAGAG GTCTCGGTGC TGCTGCTGAC ATTCCTGACC 
CTGGAGAAGT TCCTGGTCAT CGTATTCCCT TTCAGCAACC TGCGCCTGGG CAAGCGTCAG 
ACGGCCGTGG TCCTCGCCAG CATCTGGGTG GCGGGATTTC TCATAGCGGC CGTTCCCTTC 
ACCAGCGAGG ATTATTTTGG CAACTTTTAT GGGAAAAACG GAGTCTGCTT CCCACTTCAT 
TACGACCAAG CAGAAGATTT TGGAAGTAGA GGGTACTCCC TTGGGATTTT CCTAGGCGTG 
AACTTGCTGG CTTTCCTCGT CATCACGTTC TCCTATGTCA CCATGTTCTG CTCCATTCAG 
AAAACAGCCC TCCAGACTGC AGAAGTGAGG AGCCACATCG GGAAGGAGGT GGCTGTCGCC 
AACCGGTTCT TTTTCATCGT GTTCTCTGAC GCCATCTGCT GGATTCCTGT GTTTGTCGTT 
AAAATCCTGT CTCTCCTTCA AGTAGAGATA CCAGGCACAA TCACTTCCTG GATCGTGGTT 
TTTTTCCTTC CGGTAAACAG CGCCTTAAAC CCCATCCTCT ACACTCTCAC CACCTCCCTT 
TTTAAGGACA AGTTGAAACA GTTGCTGCAC AAACATCGGA GGAAATCCAT TTTCAAAGTT 
AAGAAGAAAA GTCTATCTGC TTCCATTGTG TGGACAGATG ACTCTTCACT TAAACTTGGA 
GTGTTGAACA AAATAGCCCT TGGGGACAGT ATAATGAAGC CGGTCTCCCC GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001012493.1
CDS	1..2214
Translation	MWLLLHVVLLMEVKDFTLAGSNMVAPLCPKGYFPCGNLTKCLPRAFHCDGVDDCGNGADEDNCGDTSGWTTIFGTVHGNVNKVTLTEECFLSRYPQHCYCRENELECVNADLKAVPKVSSNVTLLSLKKNKIHRLPVKVFSKYAELRKIFLQHNCITHISRRAFLGLHNLQILYLSHNCITSLRPGIFKDLHQLAWLILDDNPITRISQRSFTGLNSLFFLSMVSNRLEALPERLCAQMPQLNWVDLANNGIKFITNSTFLTCDSLTVLFLPRNQIGFVPEKTFSSLKNLGELDLSSNVIAKLPAHLFSDLHLLQKLNLSSNPLLYVHKNQFGSLKQLQSLDLERIEIPNINTGMFRPMKNLSHIYLKTFRYCSYVPHVRICMPSTDGISSSEDLLANSILRVSVWVIAFITCAGNFLVIAVRSLIKAENTTHAMSIKILCCADCLMGVYLFSVGVFDIKYRGQYQKYALLWMESVPCRLLGFLATLSTEVSVLLLTFLTLEKFLVIVFPFSNLRLGKRQTAVVLASIWVAGFLIAAVPFTSEDYFGNFYGKNGVCFPLHYDQAEDFGSRGYSLGIFLGVNLLAFLVITFSYVTMFCSIQKTALQTAEVRSHIGKEVAVANRFFFIVFSDAICWIPVFVVKILSLLQVEIPGTITSWIVVFFLPVNSALNPILYTLTTSLFKDKLKQLLHKHRRKSIFKVKKKSLSASIVWTDDSSLKLGVLNKIALGDSIMKPVSP

Target ORF information:

RefSeq Version	NM_001012475.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus relaxin family peptide receptor 2 (Rxfp2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001012475.1

ORF Insert Sequence:

ATGTGGCTTC TACTTCATGT CGTCCTTCTG ATGGAGGTCA AAGATTTCAC ACTGGCTGGC 
AGCAATATGG TGGCTCCTCT GTGCCCAAAA GGGTATTTCC CCTGTGGGAA TCTCACCAAG 
TGCTTACCCC GAGCCTTTCA CTGCGACGGC GTGGATGATT GCGGGAATGG TGCGGATGAG 
GACAACTGTG GTGACACTAG TGGATGGACG ACCATATTTG GCACAGTCCA TGGAAATGTC 
AATAAAGTGA CATTAACAGA GGAGTGCTTT CTCAGCCGGT ACCCACAGCA CTGTTACTGC 
AGAGAAAATG AACTAGAATG CGTAAACGCC GACTTAAAAG CTGTGCCAAA GGTTTCCAGC 
AACGTAACAT TACTATCTCT TAAGAAAAAC AAAATTCACA GACTTCCAGT CAAGGTTTTC 
AGCAAATACG CAGAACTCAG AAAGATATTC CTCCAGCACA ACTGCATCAC ACACATCTCC 
AGGAGAGCGT TCCTTGGATT ACATAACCTA CAGATACTGT ATCTCAGCCA TAACTGCATT 
ACCTCTCTCA GGCCTGGGAT ATTCAAAGAC TTGCATCAGC TCGCTTGGCT AATTTTAGAT 
GACAACCCAA TCACCAGAAT CTCACAGAGG TCCTTTACTG GATTAAACTC CTTGTTTTTC 
TTGTCCATGG TGAGTAACCG GCTGGAGGCC CTTCCTGAAA GGCTGTGCGC CCAGATGCCT 
CAACTCAACT GGGTGGATCT GGCAAACAAT GGGATAAAGT TCATAACGAA CTCCACCTTC 
CTGACGTGCG ACTCGCTCAC GGTTCTGTTT CTGCCTAGAA ATCAAATTGG TTTTGTTCCA 
GAGAAGACAT TTTCTTCATT AAAAAATTTA GGAGAACTGG ACCTGTCTAG CAATGTGATA 
GCAAAACTAC CAGCCCACCT TTTCAGCGAC CTTCACCTTC TCCAAAAGCT GAACCTGTCG 
TCCAACCCTC TTCTGTATGT CCACAAGAAC CAGTTTGGAA GTCTCAAACA ACTTCAGTCT 
CTAGACCTGG AAAGGATAGA GATTCCAAAC ATAAACACCG GAATGTTCCG GCCCATGAAG 
AACCTTTCTC ACATATATTT GAAAACCTTT CGGTACTGCT CCTATGTTCC CCATGTCCGA 
ATCTGTATGC CCTCGACTGA TGGTATATCT TCATCTGAGG ACCTCTTGGC TAACAGTATC 
CTCAGAGTGT CTGTCTGGGT TATAGCTTTC ATTACCTGCG CTGGGAATTT CCTCGTCATA 
GCCGTGAGAT CTCTCATTAA GGCTGAGAAT ACGACTCACG CTATGTCCAT CAAAATCCTT 
TGTTGTGCCG ACTGCCTGAT GGGGGTGTAC CTGTTCTCCG TGGGCGTCTT TGACATCAAG 
TACCGAGGGC AGTATCAGAA GTATGCGCTG CTGTGGATGG AGAGTGTACC CTGCCGCCTG 
CTGGGCTTCC TGGCCACGCT GTCCACAGAG GTCTCGGTGC TGCTGCTGAC ATTCCTGACC 
CTGGAGAAGT TCCTGGTCAT CGTATTCCCT TTCAGCAACC TGCGCCTGGG CAAGCGTCAG 
ACGGCCGTGG TCCTCGCCAG CATCTGGGTG GCGGGATTTC TCATAGCGGC CGTTCCCTTC 
ACCAGCGAGG ATTATTTTGG CAACTTTTAT GGGAAAAACG GAGTCTGCTT CCCACTTCAT 
TACGACCAAG CAGAAGATTT TGGAAGTAGA GGGTACTCCC TTGGGATTTT CCTAGGCGTG 
AACTTGCTGG CTTTCCTCGT CATCACGTTC TCCTATGTCA CCATGTTCTG CTCCATTCAG 
AAAACAGCCC TCCAGACTGC AGAAGTGAGG AGCCACATCG GGAAGGAGGT GGCTGTCGCC 
AACCGGTTCT TTTTCATCGT GTTCTCTGAC GCCATCTGCT GGATTCCTGT GTTTGTCGTT 
AAAATCCTGT CTCTCCTTCA AGTAGAGATA CCAGGCACAA TCACTTCCTG GATCGTGGTT 
TTTTTCCTTC CGGTAAACAG CGCCTTAAAC CCCATCCTCT ACACTCTCAC CACCTCCCTT 
TTTAAGGACA AGTTGAAACA GTTGCTGCAC AAACATCGGA GGAAATCCAT TTTCAAAGTT 
AAGAAGAAAA GTCTATCTGC TTCCATTGTG TGGACAGATG ACTCTTCACT TAAACTTGGA 
GTGTTGAACA AAATAGCCCT TGGGGACAGT ATAATGAAGC CGGTCTCCCC GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Differential Ca
Cell calcium6731-39(2017 Nov)
Chen YC,Chang YC,Chang HA,Lin YS,Tsao CW,Shen MR,Chiu WT

Testosterone reduces knee passive range of motion and expression of relaxin receptor isoforms via 5?-dihydrotestosterone and androgen receptor binding.
International journal of molecular sciences15(3)4619-34(2014 Mar)
Dehghan F,Muniandy S,Yusof A,Salleh N

Sex-steroid regulation of relaxin receptor isoforms (RXFP1 & RXFP2) expression in the patellar tendon and lateral collateral ligament of female WKY rats.
International journal of medical sciences11(2)180-91(2014)
Dehghan F,Muniandy S,Yusof A,Salleh N

Examination of relaxin and its receptors expression in pig gametes and embryos.
Reproductive biology and endocrinology : RB&E910(2011 Jan)
Feugang JM,Rodriguez-Munoz JC,Willard ST,Bathgate RA,Ryan PL

Prenatal exposure to diaethylstilbestrol in the rat inhibits transabdominal testicular descent with involvement of the INSL3/LGR8 system and HOXA10.
Chinese medical journal122(8)967-71(2009 Apr)
Zhang L,Zheng XM,Hubert J,Zheng H,Yang ZW,Li SW

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Rxfp2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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