Lgr3 cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene
Clones
gRNAs

Summary

Gene Symbol	Lgr3
Entrez Gene ID	43098
Full Name	Leucine-rich repeat-containing G protein-coupled receptor 3
Synonyms	CG31096,CG5042,CG5046,CT16193,DLGR3,Dmel\CG31096,anon-WO0170980.25,anon-WO0170980.26,dLGR3,lgr3
General protein information	Preferred Names Leucine-rich repeat-containing G protein-coupled receptor 3 Names CG31096 gene product from transcript CG31096-RA CG31096-PA Lgr3-PA
Gene Type	protein-coding
Organism	Drosophila melanogaster(fruit fly)
Genome	Chromosome: 3R Map Location: 96E8-96E9

mRNA and Protein(s)

mRNA	Protein	Name
NM_170236.2	NP_733115.1	Leucine-rich repeat-containing G protein-coupled receptor 3

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	RXFP2	NP_001005870.1
Bos taurus (cattle)	RXFP2	XP_002691803.3
Mus musculus (house mouse)	Rxfp2	NP_536716.2
Rattus norvegicus (Norway rat)	Rxfp2	NP_001012493.1
Pan troglodytes (chimpanzee)	RXFP2	XP_001142347.1
Xenopus tropicalis (tropical clawed frog)	LOC100491657	XP_002934071.2
Homo sapiens (human)	RXFP2	NP_001159530.1
	RXFP2	XP_001118169.2
Drosophila melanogaster (fruit fly)	Lgr3	NP_733115.1

Gene Ontology
Bibliography

Related articles in PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
Matthews BB, Dos Santos G, Crosby MA, Emmert DB, St Pierre SE, Gramates LS, Zhou P, Schroeder AJ, Falls K, Strelets V, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
Crosby MA, Gramates LS, Dos Santos G, Matthews BB, St Pierre SE, Zhou P, Schroeder AJ, Falls K, Emmert DB, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Hoskins RA, Carlson JW, Kennedy C, Acevedo D, Evans-Holm M, Frise E, Wan KH, Park S, Mendez-Lago M, Rossi F, Villasante A, Dimitri P, Karpen GH, Celniker SE
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Smith CD, Shu S, Mungall CJ, Karpen GH
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)

Combined evidence annotation of transposable elements in genome sequences.
Quesneville H, Bergman CM, Andrieu O, Autard D, Nouaud D, Ashburner M, Anxolabehere D
PLoS computational biology1(2)166-75(2005 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Here we demonstrate that the Drosophila relaxin receptor homolog Lgr3, a leucine-rich repeat-containing G-protein-coupled receptor, is required for Dilp8-dependent growth coordination and developmental delay during the regeneration checkpoint; we demonstrate that Lgr3 activity in both the CNS and PG is necessary for NOS activation in the PG following damage
Title: Growth Coordination During Drosophila melanogaster Imaginal Disc Regeneration Is Mediated by Signaling Through the Relaxin Receptor Lgr3 in the Prothoracic Gland.

Coordinated regulation of Lgr3 by Fru and Dsx marks a point of convergence of the two branches of the sex-determination hierarchy
Title: Sex-specific regulation of Lgr3 in Drosophila neurons.

this study shows Lgr3 is a Dilp8 receptor
Title: A brain circuit that synchronizes growth and maturation revealed through Dilp8 binding to Lgr3.

Mutation of Lgr3 suppresses the delay in pupariation induced by imaginal disc growth perturbation or ectopic Dilp8 expression.
Title: Dilp8 requires the neuronal relaxin receptor Lgr3 to couple growth to developmental timing.

Leucine-rich repeat-containing G protein-coupled receptor 3 (Lgr3) mediates the checkpoint function of Dilp8 for entry into maturation. Two Lgr3-positive neurons in each brain lobe are required to induce a developmental delay upon overexpression of Dilp8.
Title: Drosophila Lgr3 Couples Organ Growth with Maturation and Ensures Developmental Stability.

The following Lgr3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Lgr3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OFa06115	NM_170236.2 Latest version!	Drosophila melanogaster Leucine-rich repeat-containing G protein-coupled receptor 3 (Lgr3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$426.30 $609.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Lgr3 ( NM_170236.2 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_733115.1 Drosophila melanogaster Leucine-rich repeat-containing G protein-coupled receptor 3 (Lgr3), mRNA.

Price & Availability↑

CloneID	OFa06115
Clone ID Related Accession (Same CDS sequence)	NM_170236.2
Accession Version	NM_170236.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2298bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-24
Organism	Drosophila melanogaster(fruit fly)
Product	Leucine-rich repeat-containing G protein-coupled receptor 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_033777). On Jan 16, 2013 this sequence version replaced NM_170236.1. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END##

ATGGTCTACG GCAGGAGCAT CGCCGTAGGC TTCTGTCTGA TGACCGTCGT CCTTCTGCTG 
GCCGCCGTGA TATTCTACTT GAGTTTGGGA CCCTGCCCCG CGGCCAGCTT CGCCTGCGAC 
AACGGCACGC TGTGCGTTCC AAGGCGCCAG ATGTGCGACA GTCGGAACGA TTGCGCCGAC 
AGCAGCGACG AGAATCCGGT GGAGTGCGGT CTCCTCTACG GCAGCAAGGA GATTGCCGAC 
AAGATTGTCC GTAATGCGAT TGAAAAGAAG CAACAGCGCC TAATCTCCGC CGTTTCAAAT 
GCGAGCGGTG CGGATTCAAC GACGTCGATG GTGCCAAGGA ATCAGAGCCT AACTTTAAAC 
ATGACTTGTG ATATCGTCAC ATATCCGAAG GCCTGTCAGT GCGGCCAGGG AACAATCCTC 
TACTGCGGTC GCTATGCCAA ATTGCGGCGA TTTCCGCGTC TCAGTTCGGA GGTCACCAAT 
CTGATCATCA TCCGCAACAA TCTGACCCTG CGCGACAATA TCTTTGCCAA TTTCACGCGT 
CTGCAGAAGC TGACGCTTAA GTACAACAAC ATATCACGTG TCCCGCTGGG CAGCTTCAGT 
GGCCTCTTTC ACCTGGAACG CCTGGAGCTG AGCCACAACA ACGTTAGCCA CCTGCCGCAC 
GGTGTCTTCC TGGGGCTGCA CAGCCTCCAG TGGCTGTTCT TGGTCAATAA CCATCTGCAC 
CACCTGCCCG TGGAGCAACT GCGATTCTTT AGACGATTGG AGTGGCTGGT GCTGAGCAGG 
AATCGTCTCA CACTGCGAAA TGTGCAGCTG CCGAAAATCC CGACGCTCTA CGAAGTTTAT 
TTGGATTTCA ATCGAATCGA ATACATTGGC GAGGAAACTT TTTCCCAATT GGATAATTTA 
CATTTGCTGG ATCTGCAGCA CAACCTCATA ACGCACATCC ATGGACGAGC CTTTGCGAAT 
CTAACAAATA TGCGAGATAT CCGCCTTGTC GGTAATCCCA TTAAGGAGTT ATCTGGCGAA 
ACATTTTTGC ACAACACTCG ACTGGAGGCA CTTTCGTTGG CCCTAATGCC GATTCACATC 
AGCAGCAGTT TAATGGAGCC ACTGAATATA TCGTTTTTGA ATCTCACGGG AATTCGGTAT 
GATCACATCG ACTTCGAGGC CATCAATTCA ATGCGCAACC TGACGTACAT CATCTACGAT 
CGATTCTTCT ACTGCTCAAT GACGCCGCGG GTGAGAATGT GCAAGCCGTC CACCGATGGA 
GTCAGCTCCT TTCAAGATCT TCTGAGCAAA CCAGTGTTAC GTTACTCCGC CTGGGTGATG 
GCCACGTTGA CAATAGCTGG AAATGTGCTA GTCCTATGGG GACGCTTTAT CTACCGCGAT 
GAGAATGTGG CTGTGACAAT GGTGATTCGG AATCTGGCTC TGGCTGATAT GCTGATGGGC 
TTCTATTTGG TCACCATTGG AGTGCAGGAC TATCGCTACC GCAACGAGTA TTACAAGGTT 
GTGCTGGACT GGATAACCTC GTGGCAGTGC ACACTGATTG GAACGCTGGC CGTGAGCTCC 
TCGGAGGTTT CGATGCTTAT CCTGGCTTTT ATGTCGCTGG AGCGGTTTCT CTTGATCGCC 
GATCCCTTTC GCGGCCATCG CAGCATTGGA AATCGGGTGA TGTGGCTGGC TTTGATTTGC 
ATTTGGATTA CGGGCGTGGG CTTGGCTGTG GCACCGGTGC TCCTGTGGCG GACCAGTACC 
CTACCCTACT ACGGATCCTA TTCCGGAACC TGCTTTCCAT TGCACATCCA CGAGGCCTTC 
CCGATGGGCT GGCTTTACTC GGCTTTCGTG TTCCTGGGCG TCAATCTGCT GCTGCTGGTG 
ATGATTGCGA TGCTCTACAC GGCACTCCTT ATTTCGATAT GGCGAACGAG GAGCGCCACT 
CCGCTCACTC TGTTGGATTG CGAATTCGCT GTGCGATTCT TTTTCATCGT GCTGACCGAC 
TTCCTGTGCT GGGTGCCCAT CATCGTTATG AAGATCTGGG TTTTTTTCAA CTACAATATC 
TCCGATGACA TCTACGCCTG GTTGGTGGTC TTTGTGCTGC CACTTAACTC GGCGGTTAAT 
CCTCTCTTGT ACACCTTCAC CACGCCCAAG TACCGAAATC AAATCTTCCT TCGCGGCTGG 
AAGAAGATAA CTTCTAGAAA GCGAGCGGAG GCTGGCAATG GAAATGTGGC CACCACAACG 
ACGGGCACGG CAACTGGATC CTCTCAGCAT CCGGATGACT TCACGATCTT TGCCAAAGCC 
GCGATGAGAT GCCATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_733115.1
CDS	524..2821
Translation	MVYGRSIAVGFCLMTVVLLLAAVIFYLSLGPCPAASFACDNGTLCVPRRQMCDSRNDCADSSDENPVECGLLYGSKEIADKIVRNAIEKKQQRLISAVSNASGADSTTSMVPRNQSLTLNMTCDIVTYPKACQCGQGTILYCGRYAKLRRFPRLSSEVTNLIIIRNNLTLRDNIFANFTRLQKLTLKYNNISRVPLGSFSGLFHLERLELSHNNVSHLPHGVFLGLHSLQWLFLVNNHLHHLPVEQLRFFRRLEWLVLSRNRLTLRNVQLPKIPTLYEVYLDFNRIEYIGEETFSQLDNLHLLDLQHNLITHIHGRAFANLTNMRDIRLVGNPIKELSGETFLHNTRLEALSLALMPIHISSSLMEPLNISFLNLTGIRYDHIDFEAINSMRNLTYIIYDRFFYCSMTPRVRMCKPSTDGVSSFQDLLSKPVLRYSAWVMATLTIAGNVLVLWGRFIYRDENVAVTMVIRNLALADMLMGFYLVTIGVQDYRYRNEYYKVVLDWITSWQCTLIGTLAVSSSEVSMLILAFMSLERFLLIADPFRGHRSIGNRVMWLALICIWITGVGLAVAPVLLWRTSTLPYYGSYSGTCFPLHIHEAFPMGWLYSAFVFLGVNLLLLVMIAMLYTALLISIWRTRSATPLTLLDCEFAVRFFFIVLTDFLCWVPIIVMKIWVFFNYNISDDIYAWLVVFVLPLNSAVNPLLYTFTTPKYRNQIFLRGWKKITSRKRAEAGNGNVATTTTGTATGSSQHPDDFTIFAKAAMRCH

Target ORF information:

RefSeq Version	NM_170236.2
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster Leucine-rich repeat-containing G protein-coupled receptor 3 (Lgr3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_170236.2

ORF Insert Sequence:

ATGGTCTACG GCAGGAGCAT CGCCGTAGGC TTCTGTCTGA TGACCGTCGT CCTTCTGCTG 
GCCGCCGTGA TATTCTACTT GAGTTTGGGA CCCTGCCCCG CGGCCAGCTT CGCCTGCGAC 
AACGGCACGC TGTGCGTTCC AAGGCGCCAG ATGTGCGACA GTCGGAACGA TTGCGCCGAC 
AGCAGCGACG AGAATCCGGT GGAGTGCGGT CTCCTCTACG GCAGCAAGGA GATTGCCGAC 
AAGATTGTCC GTAATGCGAT TGAAAAGAAG CAACAGCGCC TAATCTCCGC CGTTTCAAAT 
GCGAGCGGTG CGGATTCAAC GACGTCGATG GTGCCAAGGA ATCAGAGCCT AACTTTAAAC 
ATGACTTGTG ATATCGTCAC ATATCCGAAG GCCTGTCAGT GCGGCCAGGG AACAATCCTC 
TACTGCGGTC GCTATGCCAA ATTGCGGCGA TTTCCGCGTC TCAGTTCGGA GGTCACCAAT 
CTGATCATCA TCCGCAACAA TCTGACCCTG CGCGACAATA TCTTTGCCAA TTTCACGCGT 
CTGCAGAAGC TGACGCTTAA GTACAACAAC ATATCACGTG TCCCGCTGGG CAGCTTCAGT 
GGCCTCTTTC ACCTGGAACG CCTGGAGCTG AGCCACAACA ACGTTAGCCA CCTGCCGCAC 
GGTGTCTTCC TGGGGCTGCA CAGCCTCCAG TGGCTGTTCT TGGTCAATAA CCATCTGCAC 
CACCTGCCCG TGGAGCAACT GCGATTCTTT AGACGATTGG AGTGGCTGGT GCTGAGCAGG 
AATCGTCTCA CACTGCGAAA TGTGCAGCTG CCGAAAATCC CGACGCTCTA CGAAGTTTAT 
TTGGATTTCA ATCGAATCGA ATACATTGGC GAGGAAACTT TTTCCCAATT GGATAATTTA 
CATTTGCTGG ATCTGCAGCA CAACCTCATA ACGCACATCC ATGGACGAGC CTTTGCGAAT 
CTAACAAATA TGCGAGATAT CCGCCTTGTC GGTAATCCCA TTAAGGAGTT ATCTGGCGAA 
ACATTTTTGC ACAACACTCG ACTGGAGGCA CTTTCGTTGG CCCTAATGCC GATTCACATC 
AGCAGCAGTT TAATGGAGCC ACTGAATATA TCGTTTTTGA ATCTCACGGG AATTCGGTAT 
GATCACATCG ACTTCGAGGC CATCAATTCA ATGCGCAACC TGACGTACAT CATCTACGAT 
CGATTCTTCT ACTGCTCAAT GACGCCGCGG GTGAGAATGT GCAAGCCGTC CACCGATGGA 
GTCAGCTCCT TTCAAGATCT TCTGAGCAAA CCAGTGTTAC GTTACTCCGC CTGGGTGATG 
GCCACGTTGA CAATAGCTGG AAATGTGCTA GTCCTATGGG GACGCTTTAT CTACCGCGAT 
GAGAATGTGG CTGTGACAAT GGTGATTCGG AATCTGGCTC TGGCTGATAT GCTGATGGGC 
TTCTATTTGG TCACCATTGG AGTGCAGGAC TATCGCTACC GCAACGAGTA TTACAAGGTT 
GTGCTGGACT GGATAACCTC GTGGCAGTGC ACACTGATTG GAACGCTGGC CGTGAGCTCC 
TCGGAGGTTT CGATGCTTAT CCTGGCTTTT ATGTCGCTGG AGCGGTTTCT CTTGATCGCC 
GATCCCTTTC GCGGCCATCG CAGCATTGGA AATCGGGTGA TGTGGCTGGC TTTGATTTGC 
ATTTGGATTA CGGGCGTGGG CTTGGCTGTG GCACCGGTGC TCCTGTGGCG GACCAGTACC 
CTACCCTACT ACGGATCCTA TTCCGGAACC TGCTTTCCAT TGCACATCCA CGAGGCCTTC 
CCGATGGGCT GGCTTTACTC GGCTTTCGTG TTCCTGGGCG TCAATCTGCT GCTGCTGGTG 
ATGATTGCGA TGCTCTACAC GGCACTCCTT ATTTCGATAT GGCGAACGAG GAGCGCCACT 
CCGCTCACTC TGTTGGATTG CGAATTCGCT GTGCGATTCT TTTTCATCGT GCTGACCGAC 
TTCCTGTGCT GGGTGCCCAT CATCGTTATG AAGATCTGGG TTTTTTTCAA CTACAATATC 
TCCGATGACA TCTACGCCTG GTTGGTGGTC TTTGTGCTGC CACTTAACTC GGCGGTTAAT 
CCTCTCTTGT ACACCTTCAC CACGCCCAAG TACCGAAATC AAATCTTCCT TCGCGGCTGG 
AAGAAGATAA CTTCTAGAAA GCGAGCGGAG GCTGGCAATG GAAATGTGGC CACCACAACG 
ACGGGCACGG CAACTGGATC CTCTCAGCAT CCGGATGACT TCACGATCTT TGCCAAAGCC 
GCGATGAGAT GCCATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)
Matthews BB,Dos Santos G,Crosby MA,Emmert DB,St Pierre SE,Gramates LS,Zhou P,Schroeder AJ,Falls K,Strelets V,Russo SM,Gelbart WM,

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)
Crosby MA,Gramates LS,Dos Santos G,Matthews BB,St Pierre SE,Zhou P,Schroeder AJ,Falls K,Emmert DB,Russo SM,Gelbart WM,

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)
Hoskins RA,Carlson JW,Kennedy C,Acevedo D,Evans-Holm M,Frise E,Wan KH,Park S,Mendez-Lago M,Rossi F,Villasante A,Dimitri P,Karpen GH,Celniker SE

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)
Smith CD,Shu S,Mungall CJ,Karpen GH

Combined evidence annotation of transposable elements in genome sequences.
PLoS computational biology1(2)166-75(2005 Jul)
Quesneville H,Bergman CM,Andrieu O,Autard D,Nouaud D,Ashburner M,Anxolabehere D

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Lgr3 cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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