Tp53rk cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Tp53rk
Entrez Gene ID	362272
Full Name	TP53 regulating kinase
Synonyms	Trp53rk
General protein information	Preferred Names TP53 regulating kinase Names TP53-regulating kinase
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 3 Map Location: 3q42

mRNA and Protein(s)

mRNA	Protein	Name
NM_001108606.1	NP_001102076.1	TP53-regulating kinase

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	TP53RK	XP_853966.2
Mus musculus (house mouse)	2810408M09Rik	NP_001007582.1
Mus musculus (house mouse)	Trp53rk	NP_076304.2
Kluyveromyces lactis	KLLA0A09625g	XP_451420.1
Magnaporthe oryzae (rice blast fungus)	MGG_01344	XP_003714269.1
Oryza sativa (rice)	Os10g0422300	NP_001064629.2
Xenopus tropicalis (tropical clawed frog)	tp53rk	XP_002933205.1
Homo sapiens (human)	TP53RK	NP_291028.3
Pan troglodytes (chimpanzee)	TP53RK	XP_514697.1
Bos taurus (cattle)	TP53RK	NP_001092650.1
Rattus norvegicus (Norway rat)	LOC685619	XP_002729296.1
Gallus gallus (chicken)	TP53RK	XP_425703.3
Drosophila melanogaster (fruit fly)	CG10673	NP_647948.1
Eremothecium gossypii	AGOS_AGR331C	NP_986997.1
Saccharomyces cerevisiae (baker's yeast)	BUD32	NP_011778.1
Neurospora crassa	NCU04595	XP_957863.2
Arabidopsis thaliana (thale cress)	AT5G26110	NP_568482.1
Danio rerio (zebrafish)	tp53rk	NP_001018386.1
Schizosaccharomyces pombe (fission yeast)	SPAP27G11.07c	NP_593411.1
Rattus norvegicus (Norway rat)	Tp53rk	NP_001102076.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP007476	XP_308396.4
Caenorhabditis elegans (roundworm)	F52C12.6	NP_001255237.1

Gene Ontology
Bibliography

Related articles in PubMed

Mutations in KEOPS-complex genes cause nephrotic syndrome with primary microcephaly.
Braun DA, Rao J, Mollet G, Schapiro D, Daugeron MC, Tan W, Gribouval O, Boyer O, Revy P, Jobst-Schwan T, Schmidt JM, Lawson JA, Schanze D, Ashraf S, Ullmann JFP, Hoogstraten CA, Boddaert N, Collinet B, Martin G, Liger D, Lovric S, Furlano M, Guerrera IC, Sanchez-Ferras O, Hu JF, Boschat AC, Sanquer S, Menten B, Vergult S, De Rocker N, Airik M, Hermle T, Shril S, Widmeier E, Gee HY, Choi WI, Sadowski CE, Pabst WL, Warejko JK, Daga A, Basta T, Matejas V, Scharmann K, Kienast SD, Behnam B, Beeson B, Begtrup A, Bruce M, Ch'ng GS, Lin SP, Chang JH, Chen CH, Cho MT, Gaffney PM, Gipson PE, Hsu CH, Kari JA, Ke YY, Kiraly-Borri C, Lai WM, Lemyre E, Littlejohn RO, Masri A, Moghtaderi M, Nakamura K, Ozaltin F, Praet M, Prasad C, Prytula A, Roeder ER, Rump P, Schnur RE, Shiihara T, Sinha MD, Soliman NA, Soulami K, Sweetser DA, Tsai WH, Tsai JD, Topaloglu R, Vester U, Viskochil DH, Vatanavicharn N, Waxler JL, Wierenga KJ, Wolf MTF, Wong SN, Leidel SA, Truglio G, Dedon PC, Poduri A, Mane S, Lifton RP, Bouchard M, Kannu P, Chitayat D, Magen D, Callewaert B, van Tilbeurgh H, Zenker M, Antignac C, Hildebrandt F
Nature genetics49(10)1529-1538(2017 Oct)

Proteomic analysis of the human KEOPS complex identifies C14ORF142 as a core subunit homologous to yeast Gon7.
Wan LC, Maisonneuve P, Szilard RK, Lambert JP, Ng TF, Manczyk N, Huang H, Laister R, Caudy AA, Gingras AC, Durocher D, Sicheri F
Nucleic acids research45(2)805-817(2017 Jan)

Cloning and characterization of a p53-related protein kinase expressed in interleukin-2-activated cytotoxic T-cells, epithelial tumor cell lines, and the testes.
Abe Y, Matsumoto S, Wei S, Nezu K, Miyoshi A, Kito K, Ueda N, Shigemoto K, Hitsumoto Y, Nikawa J, Enomoto Y
The Journal of biological chemistry276(47)44003-11(2001 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Tp53rk gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Tp53rk cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa07907	NM_001108606.1 Latest version!	Rattus norvegicus TP53 regulating kinase (Tp53rk), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Tp53rk ( NM_001108606.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001102076.1 Rattus norvegicus TP53 regulating kinase (Tp53rk), mRNA.

Price & Availability↑

CloneID	ORa07907
Clone ID Related Accession (Same CDS sequence)	NM_001108606.1
Accession Version	NM_001108606.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 735bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-18
Organism	Rattus norvegicus(Norway rat)
Product	TP53-regulating kinase
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH474005.2. On Oct 4, 2007 this sequence version replaced XM_342580.3. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGGCTGGCG CGTCTTCGGA GGCGGAGGCG GAGGCGCTGG CCGCGGCGCG CGAGCGGAGC 
CGCCTCTTCC TGAGCGGCCT GGAGCTGGTG CAGCAGGGCG CCGAGGCTCG AGTGTTCCGT 
GGCCGCTTCC AGGGCCGAGC GGCCGTGGTG AAGCACCGCT TCCCTAAGGG CTACCGGCAC 
CCGGAGCTGG AGGCGCGGCT CGGCCGGCGG CGGACGGTTC AGGAGGCTCG CGCGCTGTTG 
CGCTGCCGCC GTGCGGGAAT AGCTGCCCCC GTCGTCTTCT TTGTGGACTA TGCTTCTAAC 
TGCCTATATA TGGAAGAAAT CGAAGACTCG GTGACTGTTC GAGATTATAT TCAATCCACT 
ATGGAGACTA AACAAGACCC CCAATGCCTC TTGGACTTGG CCAGGAAGAT CGGGCAGGTT 
CTGGCCAGAC TGCATGACGA GGACCTCATT CACGGGGACC TCACCACCTC CAACATGCTC 
CTGACACGGC CCCTGGAGCA GCTGCACATC GTGCTCATCG ACTTCGGGCT GAGTTTTGTC 
TCAGGACTGC CAGAAGACAA AGGCGTAGAC CTCTATGTCC TGGAGAAAGC CTTCCTCAGC 
ACGCACCCCC ACACTGAGAC TGTGTTTGAA GCCTTTCTGA AGAGTTACGG TGCCTCATCC 
AAGAAGTCCG ATCCAGTGCT GAAGAAGTTA GATGAGGTGC GCCTGAGAGG GCGAAAGCGG 
TCCATGGTTG GGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001102076.1
CDS	633..1367
Translation	MAGASSEAEAEALAAARERSRLFLSGLELVQQGAEARVFRGRFQGRAAVVKHRFPKGYRHPELEARLGRRRTVQEARALLRCRRAGIAAPVVFFVDYASNCLYMEEIEDSVTVRDYIQSTMETKQDPQCLLDLARKIGQVLARLHDEDLIHGDLTTSNMLLTRPLEQLHIVLIDFGLSFVSGLPEDKGVDLYVLEKAFLSTHPHTETVFEAFLKSYGASSKKSDPVLKKLDEVRLRGRKRSMVG

Target ORF information:

RefSeq Version	NM_001108606.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus TP53 regulating kinase (Tp53rk), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001108606.1

ORF Insert Sequence:

ATGGCTGGCG CGTCTTCGGA GGCGGAGGCG GAGGCGCTGG CCGCGGCGCG CGAGCGGAGC 
CGCCTCTTCC TGAGCGGCCT GGAGCTGGTG CAGCAGGGCG CCGAGGCTCG AGTGTTCCGT 
GGCCGCTTCC AGGGCCGAGC GGCCGTGGTG AAGCACCGCT TCCCTAAGGG CTACCGGCAC 
CCGGAGCTGG AGGCGCGGCT CGGCCGGCGG CGGACGGTTC AGGAGGCTCG CGCGCTGTTG 
CGCTGCCGCC GTGCGGGAAT AGCTGCCCCC GTCGTCTTCT TTGTGGACTA TGCTTCTAAC 
TGCCTATATA TGGAAGAAAT CGAAGACTCG GTGACTGTTC GAGATTATAT TCAATCCACT 
ATGGAGACTA AACAAGACCC CCAATGCCTC TTGGACTTGG CCAGGAAGAT CGGGCAGGTT 
CTGGCCAGAC TGCATGACGA GGACCTCATT CACGGGGACC TCACCACCTC CAACATGCTC 
CTGACACGGC CCCTGGAGCA GCTGCACATC GTGCTCATCG ACTTCGGGCT GAGTTTTGTC 
TCAGGACTGC CAGAAGACAA AGGCGTAGAC CTCTATGTCC TGGAGAAAGC CTTCCTCAGC 
ACGCACCCCC ACACTGAGAC TGTGTTTGAA GCCTTTCTGA AGAGTTACGG TGCCTCATCC 
AAGAAGTCCG ATCCAGTGCT GAAGAAGTTA GATGAGGTGC GCCTGAGAGG GCGAAAGCGG 
TCCATGGTTG GGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Mutations in KEOPS-complex genes cause nephrotic syndrome with primary microcephaly.
Nature genetics49(10)1529-1538(2017 Oct)
Braun DA,Rao J,Mollet G,Schapiro D,Daugeron MC,Tan W,Gribouval O,Boyer O,Revy P,Jobst-Schwan T,Schmidt JM,Lawson JA,Schanze D,Ashraf S,Ullmann JFP,Hoogstraten CA,Boddaert N,Collinet B,Martin G,Liger D,Lovric S,Furlano M,Guerrera IC,Sanchez-Ferras O,Hu JF,Boschat AC,Sanquer S,Menten B,Vergult S,De Rocker N,Airik M,Hermle T,Shril S,Widmeier E,Gee HY,Choi WI,Sadowski CE,Pabst WL,Warejko JK,Daga A,Basta T,Matejas V,Scharmann K,Kienast SD,Behnam B,Beeson B,Begtrup A,Bruce M,Ch'ng GS,Lin SP,Chang JH,Chen CH,Cho MT,Gaffney PM,Gipson PE,Hsu CH,Kari JA,Ke YY,Kiraly-Borri C,Lai WM,Lemyre E,Littlejohn RO,Masri A,Moghtaderi M,Nakamura K,Ozaltin F,Praet M,Prasad C,Prytula A,Roeder ER,Rump P,Schnur RE,Shiihara T,Sinha MD,Soliman NA,Soulami K,Sweetser DA,Tsai WH,Tsai JD,Topaloglu R,Vester U,Viskochil DH,Vatanavicharn N,Waxler JL,Wierenga KJ,Wolf MTF,Wong SN,Leidel SA,Truglio G,Dedon PC,Poduri A,Mane S,Lifton RP,Bouchard M,Kannu P,Chitayat D,Magen D,Callewaert B,van Tilbeurgh H,Zenker M,Antignac C,Hildebrandt F

Proteomic analysis of the human KEOPS complex identifies C14ORF142 as a core subunit homologous to yeast Gon7.
Nucleic acids research45(2)805-817(2017 Jan)
Wan LC,Maisonneuve P,Szilard RK,Lambert JP,Ng TF,Manczyk N,Huang H,Laister R,Caudy AA,Gingras AC,Durocher D,Sicheri F

Cloning and characterization of a p53-related protein kinase expressed in interleukin-2-activated cytotoxic T-cells, epithelial tumor cell lines, and the testes.
The Journal of biological chemistry276(47)44003-11(2001 Nov)
Abe Y,Matsumoto S,Wei S,Nezu K,Miyoshi A,Kito K,Ueda N,Shigemoto K,Hitsumoto Y,Nikawa J,Enomoto Y