The following Large1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Large1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | ORa11717 | |
| Clone ID Related Accession (Same CDS sequence) | NM_001108439.1 | |
| Accession Version | NM_001108439.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1158bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2017-10-01 | |
| Organism | Rattus norvegicus(Norway rat) | |
| Product | glycosyltransferase-like protein LARGE1 | |
| Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH474006.1. On or before Oct 4, 2007 this sequence version replaced XM_001060350.1, XM_341645.3. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END## | |
1 | ATGCTGGGAA TCTGCCGAGG GAGACGGAAA TTCCTGGCTG CCTCTCTGAC TCTACTCTGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001101909.1 |
| CDS | 468..1625 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_001108439.1 |
1 | ATGCTGGGAA TCTGCCGAGG GAGACGGAAA TTCCTGGCTG CCTCTCTGAC TCTACTCTGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | ORa38629 | |
| Clone ID Related Accession (Same CDS sequence) | XM_006255140.3 , XM_017601309.1 | |
| Accession Version | XM_006255140.3 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 2271bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2016-07-25 | |
| Organism | Rattus norvegicus(Norway rat) | |
| Product | glycosyltransferase-like protein LARGE1 isoform X1 | |
| Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005118.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006255140.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGCTGGGAA TCTGCCGAGG GAGACGGAAA TTCCTGGCTG CCTCTCTGAC TCTACTCTGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_006255202.1 |
| CDS | 1138..3408 |
| Translation |
Target ORF information:
Target ORF information:
|
XM_006255140.3 |
1 | ATGCTGGGAA TCTGCCGAGG GAGACGGAAA TTCCTGGCTG CCTCTCTGAC TCTACTCTGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | ORa38629 | |
| Clone ID Related Accession (Same CDS sequence) | XM_006255140.3 , XM_017601309.1 | |
| Accession Version | XM_017601309.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 2271bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2016-07-25 | |
| Organism | Rattus norvegicus(Norway rat) | |
| Product | glycosyltransferase-like protein LARGE1 isoform X1 | |
| Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005118.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGCTGGGAA TCTGCCGAGG GAGACGGAAA TTCCTGGCTG CCTCTCTGAC TCTACTCTGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_017456798.1 |
| CDS | 338..2608 |
| Translation |
Target ORF information:
Target ORF information:
|
XM_017601309.1 |
1 | ATGCTGGGAA TCTGCCGAGG GAGACGGAAA TTCCTGGCTG CCTCTCTGAC TCTACTCTGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Endogenous glucuronyltransferase activity of LARGE or LARGE2 required for functional modification of ?-dystroglycan in cells and tissues. |
B4GAT1 is the priming enzyme for the LARGE-dependent functional glycosylation of ?-dystroglycan. |
The glucuronyltransferase B4GAT1 is required for initiation of LARGE-mediated ?-dystroglycan functional glycosylation. |
LARGE glycans on dystroglycan function as a tunable matrix scaffold to prevent dystrophy. |
LARGE2 generates the same xylose- and glucuronic acid-containing glycan structures as LARGE. |
