Dhtkd1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Dhtkd1
Entrez Gene ID	361272
Full Name	dehydrogenase E1 and transketolase domain containing 1
General protein information	Preferred Names dehydrogenase E1 and transketolase domain containing 1 Names probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial dehydrogenase E1 and transketolase domain-containing protein 1 probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial-like
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 17 Map Location: 17q12.3

mRNA and Protein(s)

mRNA	Protein	Name
NM_001025720.1	NP_001020891.1	probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	DHTKD1	XP_001135864.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP000551	XP_310532.5
	LOC696445	XP_001085071.2
Mus musculus (house mouse)	Dhtkd1	NP_001074600.1
Bos taurus (cattle)	DHTKD1	NP_001192767.1
Rattus norvegicus (Norway rat)	Dhtkd1	NP_001020891.1
Danio rerio (zebrafish)	dhtkd1	NP_001008619.1
Homo sapiens (human)	DHTKD1	NP_061176.3
Canis lupus familiaris (dog)	DHTKD1	XP_535192.3
Gallus gallus (chicken)	DHTKD1	XP_004937543.1
Drosophila melanogaster (fruit fly)	CG1544	NP_651849.1
Caenorhabditis elegans (roundworm)	ZK836.2	NP_001256410.1
Xenopus tropicalis (tropical clawed frog)	dhtkd1	XP_002931921.1

Gene Ontology
Bibliography

Related articles in PubMed

Thiamine Induces Long-Term Changes in Amino Acid Profiles and Activities of 2-Oxoglutarate and 2-Oxoadipate Dehydrogenases in Rat Brain.
Tsepkova PM, Artiukhov AV, Boyko AI, Aleshin VA, Mkrtchyan GV, Zvyagintseva MA, Ryabov SI, Ksenofontov AL, Baratova LA, Graf AV, Bunik VI
Biochemistry. Biokhimiia82(6)723-736(2017 Jun)

Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7.
Nagamachi A, Matsui H, Asou H, Ozaki Y, Aki D, Kanai A, Takubo K, Suda T, Nakamura T, Wolff L, Honda H, Inaba T
Cancer cell24(3)305-17(2013 Sep)

A nonsense mutation in DHTKD1 causes Charcot-Marie-Tooth disease type 2 in a large Chinese pedigree.
Xu WY, Gu MM, Sun LH, Guo WT, Zhu HB, Ma JF, Yuan WT, Kuang Y, Ji BJ, Wu XL, Chen Y, Zhang HX, Sun FT, Huang W, Huang L, Chen SD, Wang ZG
American journal of human genetics91(6)1088-94(2012 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Thiamine Induces Long-Term Changes in Amino Acid Profiles and Activities of 2-Oxoglutarate and 2-Oxoadipate Dehydrogenases in Rat Brain
Title: Thiamine Induces Long-Term Changes in Amino Acid Profiles and Activities of 2-Oxoglutarate and 2-Oxoadipate Dehydrogenases in Rat Brain.

The following Dhtkd1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Dhtkd1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa42483	NM_001025720.1 Latest version!	Rattus norvegicus dehydrogenase E1 and transketolase domain containing 1 (Dhtkd1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$475.30 $679.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Dhtkd1 ( NM_001025720.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001020891.1 Rattus norvegicus dehydrogenase E1 and transketolase domain containing 1 (Dhtkd1), mRNA.

Price & Availability↑

CloneID	ORa42483
Clone ID Related Accession (Same CDS sequence)	NM_001025720.1
Accession Version	NM_001025720.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2763bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-09-14
Organism	Rattus norvegicus(Norway rat)
Product	probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC099075.1. On Jul 22, 2005 this sequence version replaced XM_341557.2. ##Evidence-Data-START## Transcript exon combination :: BC099075.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END##

ATGGCATCGG CTACTGTGGC AGCTGCAGGG AGAGCTCTCC GCCGAGCGGT CCCGCTTCTC 
AGGCGCAGTT ACCAGACGGA GAGGGGCGTC TATGGATACC GGCCTAGGAA AGCCGGGAGC 
GGCGAGCCCC GAGGCGACCG TGCACGCCCC TCAGTTGACC ATGGCCTTGC CAGGCTGGTG 
ACAGTGTATT GTGAGCATGG CCACAAAGCT GCCCAGATCA ACCCTCTCTT CCCCGGACAA 
GCCCTCCTGG ATACTGTGCC TGAAATCCAA GCTCTTGTGC AGACACTCCA GGGACCCTTC 
ACTACCACAG GACTGTTAAA CATGGGCAAA GAAGAGGCTT CTCTTGAGGA AGTGTTGGCC 
TATTTGAACC ATATCTACTG TGGGCCAATT TCTATTGAAA CCGCCCAGCT GCAGAGCCAG 
GAGGAGAAAG ACTGGTTTGC CAGAAGGTTT GAGGAACTGA AAAAGGAGAC ATTTACCACA 
GAAGAGCGAA AACACCTGTC GAAACTACTG CTAGAATCTC AGGAGTTTGA CCACTTTTTG 
GCCACCAAGT TTGCCACAGT GAAGAGATAC GGAGGTGAAG GGGCAGAGAG CATGATGGGC 
TTTTTTCACG AGTTGCTGAA ATTGTCAGCC TATGGCGGTA TAACGGACAT CATTATCGGG 
ATGCCCCACA GAGGGAGGCT GAATCTGTTG ACAGGCCTTC TGCAGTTACC TCCAGAGCTG 
ATGTTCCGTA AAATGCGAGG CTTAAGTGAG TTTCCAGAAA ACGTTGCTGC CATTGGTGAC 
GTCCTGTCCC ATCTGACCTC CTCAGTGGAC CTAGACTTTG GGGCCCATCG ACCCCTCCAT 
GTGACAATGC TACCCAACCC CTCACACCTG GAAGCTATTA ACCCCGTGGC TGTAGGGAAA 
ACTCGTGGCA GGCAGCAGTC TCAGGAAGAC GGGGACTACT CACCAAATGG TTCTGCTCAG 
CCTGGGGACA AAGTCATATG CCTGCAGGTT CATGGCGACG CTTCCTTCTG CGGTCAAGGG 
ATTGTTCTGG AGACGTTCAC GCTCTCTAAT CTCCCACATT TCAGAATCGG TGGGAGCATC 
CATCTCATAG TCAATAACCA GTTGGGTTAC ACCACGCCTG CTGAGAGAGG AAGGTCGTCC 
TTATACAGCA GTGACATTGG AAAGCTAGTA GGCTGTGCCA TCATCCATGT CAACGGAGAC 
AGTCCAGAGG AAGTGGTCCG AGCGACACGA CTTGCTTTTG AGTATCAGCG CCAGTTCCGC 
AAGGACGTGA TTATTGATTT GTTATGCTAT AGGCAGTGGG GTCACAATGA GCTGGACGAA 
CCTTTCTTCA CCAACCCGGT CATGTACAAA ATCATCAGAG CTCGAAAGAG CATTCCTGAT 
ACCTACGCAG AGCACCTCAT CGCCAGCGGA CTCATGACGC AGGAGGAGGT CTCCGACATA 
AAAGCCTCCT ACTACGCCAA GTTAAATGGC CACTTGGCCA ATGTGGCCCA CTACAGCCCC 
CCGGCCCCGC ACCTGCAGGC CCGCTGGCAG GGCCTGGTGC AGCCAGCAGC CTGCGTCACC 
ACCTGGGACA CGGGCGTGCC GCTGGAGCTG CTACGGTTCG TTGGCGTGAA GTCCGTGGAG 
GTTCCAGAGG AGCTGCAGTT ACACAGCCAC CTGCTAAAGA TGTATGTTCA GTCAAGAATG 
GAGAAGGTGA AGAATGGAAC CAATCTTGAC TGGGCCACCG CAGAAACACT TGCCTTGGGC 
TCCTTACTTG CTCAAGGTTT CAATGTTCGT CTGAGTGGCC AAGATGTTGG CCGTGGAACT 
TTCAGTCAAA GGCATGCAAT GGTGGTTTGC CAGAACACTG ATGATGTCTA CATTCCTCTG 
AACCACATGG ACCCTAACCA GAAGGGCTTT CTGGAGGTTA GCAACAGCCC GCTGTCAGAA 
GAGGCTGTCT TGGGATTTGA ATACGGGATG AGCATCGAAA GCCCAAAGTT GCTGCCCCTC 
TGGGAAGCTC AGTTTGGCGA TTTCTTCAAT GGAGCCCAGA TCATCTTTGA CACATTCATC 
TCTGGAGGCG AGGCCAAGTG GCTCCTGCAG AGTGGCCTTG TCATCCTCCT TCCACACGGC 
TATGATGGAG CCGGGCCTGA CCACTCATCC TGTCGGATAG AGCGCTTCTT GCAGATGTGC 
GACAGTGCGG AAGAAGGCGT GGACAGCGAC ACTGTGAACA TGTTTGTGGT TCACCCGACT 
ACGCCTGCTC AGTACTTCCA CTTGCTTAGA AGACAGATGA TGCGGAACTT CAGAAAGCCT 
CTCATCGTTG CATCTCCCAA AATGTTACTC AGGTACCCTG TAGCTGTGTC AACGCTTGAG 
GAGATGGCGC CAGGAACAGC ATTCAAACCT GTCATTGGTG ATTCGTCGGT AGACCCCAAA 
AATGTCAAAA CCCTCATATT CTGCTCCGGC AAACATTTTT ATGCCCTGCT GAAGCAAAGA 
GAGTCTCTGG GGGCTAAGAA GCGTGATTTT GCCATCATTC GACTAGAGGA ACTCTGCCCT 
TTCCCGCTGG ATTCATTACA ACAAGAGATG GGCAAATACA AACACGTTCA AGATATCATC 
TGGAGTCAGG AGGAGCCTCA GAACATGGGT CCGTGGTCTT TTGTTTATCC AAGGTTTGAA 
AAGCAACTTG CTTGCAAGCT CCGTCTCGTA AGTCGACCCC CTTTGCCAGC GCCCGCGGTG 
GGAATTGGCA CAGTGCACCA GCAGCAGCAT GAAGCCATCC TCTTCAAGAC CTTCACTTCC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001020891.1
CDS	70..2832
Translation	MASATVAAAGRALRRAVPLLRRSYQTERGVYGYRPRKAGSGEPRGDRARPSVDHGLARLVTVYCEHGHKAAQINPLFPGQALLDTVPEIQALVQTLQGPFTTTGLLNMGKEEASLEEVLAYLNHIYCGPISIETAQLQSQEEKDWFARRFEELKKETFTTEERKHLSKLLLESQEFDHFLATKFATVKRYGGEGAESMMGFFHELLKLSAYGGITDIIIGMPHRGRLNLLTGLLQLPPELMFRKMRGLSEFPENVAAIGDVLSHLTSSVDLDFGAHRPLHVTMLPNPSHLEAINPVAVGKTRGRQQSQEDGDYSPNGSAQPGDKVICLQVHGDASFCGQGIVLETFTLSNLPHFRIGGSIHLIVNNQLGYTTPAERGRSSLYSSDIGKLVGCAIIHVNGDSPEEVVRATRLAFEYQRQFRKDVIIDLLCYRQWGHNELDEPFFTNPVMYKIIRARKSIPDTYAEHLIASGLMTQEEVSDIKASYYAKLNGHLANVAHYSPPAPHLQARWQGLVQPAACVTTWDTGVPLELLRFVGVKSVEVPEELQLHSHLLKMYVQSRMEKVKNGTNLDWATAETLALGSLLAQGFNVRLSGQDVGRGTFSQRHAMVVCQNTDDVYIPLNHMDPNQKGFLEVSNSPLSEEAVLGFEYGMSIESPKLLPLWEAQFGDFFNGAQIIFDTFISGGEAKWLLQSGLVILLPHGYDGAGPDHSSCRIERFLQMCDSAEEGVDSDTVNMFVVHPTTPAQYFHLLRRQMMRNFRKPLIVASPKMLLRYPVAVSTLEEMAPGTAFKPVIGDSSVDPKNVKTLIFCSGKHFYALLKQRESLGAKKRDFAIIRLEELCPFPLDSLQQEMGKYKHVQDIIWSQEEPQNMGPWSFVYPRFEKQLACKLRLVSRPPLPAPAVGIGTVHQQQHEAILFKTFTS

Target ORF information:

RefSeq Version	NM_001025720.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus dehydrogenase E1 and transketolase domain containing 1 (Dhtkd1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001025720.1

ORF Insert Sequence:

ATGGCATCGG CTACTGTGGC AGCTGCAGGG AGAGCTCTCC GCCGAGCGGT CCCGCTTCTC 
AGGCGCAGTT ACCAGACGGA GAGGGGCGTC TATGGATACC GGCCTAGGAA AGCCGGGAGC 
GGCGAGCCCC GAGGCGACCG TGCACGCCCC TCAGTTGACC ATGGCCTTGC CAGGCTGGTG 
ACAGTGTATT GTGAGCATGG CCACAAAGCT GCCCAGATCA ACCCTCTCTT CCCCGGACAA 
GCCCTCCTGG ATACTGTGCC TGAAATCCAA GCTCTTGTGC AGACACTCCA GGGACCCTTC 
ACTACCACAG GACTGTTAAA CATGGGCAAA GAAGAGGCTT CTCTTGAGGA AGTGTTGGCC 
TATTTGAACC ATATCTACTG TGGGCCAATT TCTATTGAAA CCGCCCAGCT GCAGAGCCAG 
GAGGAGAAAG ACTGGTTTGC CAGAAGGTTT GAGGAACTGA AAAAGGAGAC ATTTACCACA 
GAAGAGCGAA AACACCTGTC GAAACTACTG CTAGAATCTC AGGAGTTTGA CCACTTTTTG 
GCCACCAAGT TTGCCACAGT GAAGAGATAC GGAGGTGAAG GGGCAGAGAG CATGATGGGC 
TTTTTTCACG AGTTGCTGAA ATTGTCAGCC TATGGCGGTA TAACGGACAT CATTATCGGG 
ATGCCCCACA GAGGGAGGCT GAATCTGTTG ACAGGCCTTC TGCAGTTACC TCCAGAGCTG 
ATGTTCCGTA AAATGCGAGG CTTAAGTGAG TTTCCAGAAA ACGTTGCTGC CATTGGTGAC 
GTCCTGTCCC ATCTGACCTC CTCAGTGGAC CTAGACTTTG GGGCCCATCG ACCCCTCCAT 
GTGACAATGC TACCCAACCC CTCACACCTG GAAGCTATTA ACCCCGTGGC TGTAGGGAAA 
ACTCGTGGCA GGCAGCAGTC TCAGGAAGAC GGGGACTACT CACCAAATGG TTCTGCTCAG 
CCTGGGGACA AAGTCATATG CCTGCAGGTT CATGGCGACG CTTCCTTCTG CGGTCAAGGG 
ATTGTTCTGG AGACGTTCAC GCTCTCTAAT CTCCCACATT TCAGAATCGG TGGGAGCATC 
CATCTCATAG TCAATAACCA GTTGGGTTAC ACCACGCCTG CTGAGAGAGG AAGGTCGTCC 
TTATACAGCA GTGACATTGG AAAGCTAGTA GGCTGTGCCA TCATCCATGT CAACGGAGAC 
AGTCCAGAGG AAGTGGTCCG AGCGACACGA CTTGCTTTTG AGTATCAGCG CCAGTTCCGC 
AAGGACGTGA TTATTGATTT GTTATGCTAT AGGCAGTGGG GTCACAATGA GCTGGACGAA 
CCTTTCTTCA CCAACCCGGT CATGTACAAA ATCATCAGAG CTCGAAAGAG CATTCCTGAT 
ACCTACGCAG AGCACCTCAT CGCCAGCGGA CTCATGACGC AGGAGGAGGT CTCCGACATA 
AAAGCCTCCT ACTACGCCAA GTTAAATGGC CACTTGGCCA ATGTGGCCCA CTACAGCCCC 
CCGGCCCCGC ACCTGCAGGC CCGCTGGCAG GGCCTGGTGC AGCCAGCAGC CTGCGTCACC 
ACCTGGGACA CGGGCGTGCC GCTGGAGCTG CTACGGTTCG TTGGCGTGAA GTCCGTGGAG 
GTTCCAGAGG AGCTGCAGTT ACACAGCCAC CTGCTAAAGA TGTATGTTCA GTCAAGAATG 
GAGAAGGTGA AGAATGGAAC CAATCTTGAC TGGGCCACCG CAGAAACACT TGCCTTGGGC 
TCCTTACTTG CTCAAGGTTT CAATGTTCGT CTGAGTGGCC AAGATGTTGG CCGTGGAACT 
TTCAGTCAAA GGCATGCAAT GGTGGTTTGC CAGAACACTG ATGATGTCTA CATTCCTCTG 
AACCACATGG ACCCTAACCA GAAGGGCTTT CTGGAGGTTA GCAACAGCCC GCTGTCAGAA 
GAGGCTGTCT TGGGATTTGA ATACGGGATG AGCATCGAAA GCCCAAAGTT GCTGCCCCTC 
TGGGAAGCTC AGTTTGGCGA TTTCTTCAAT GGAGCCCAGA TCATCTTTGA CACATTCATC 
TCTGGAGGCG AGGCCAAGTG GCTCCTGCAG AGTGGCCTTG TCATCCTCCT TCCACACGGC 
TATGATGGAG CCGGGCCTGA CCACTCATCC TGTCGGATAG AGCGCTTCTT GCAGATGTGC 
GACAGTGCGG AAGAAGGCGT GGACAGCGAC ACTGTGAACA TGTTTGTGGT TCACCCGACT 
ACGCCTGCTC AGTACTTCCA CTTGCTTAGA AGACAGATGA TGCGGAACTT CAGAAAGCCT 
CTCATCGTTG CATCTCCCAA AATGTTACTC AGGTACCCTG TAGCTGTGTC AACGCTTGAG 
GAGATGGCGC CAGGAACAGC ATTCAAACCT GTCATTGGTG ATTCGTCGGT AGACCCCAAA 
AATGTCAAAA CCCTCATATT CTGCTCCGGC AAACATTTTT ATGCCCTGCT GAAGCAAAGA 
GAGTCTCTGG GGGCTAAGAA GCGTGATTTT GCCATCATTC GACTAGAGGA ACTCTGCCCT 
TTCCCGCTGG ATTCATTACA ACAAGAGATG GGCAAATACA AACACGTTCA AGATATCATC 
TGGAGTCAGG AGGAGCCTCA GAACATGGGT CCGTGGTCTT TTGTTTATCC AAGGTTTGAA 
AAGCAACTTG CTTGCAAGCT CCGTCTCGTA AGTCGACCCC CTTTGCCAGC GCCCGCGGTG 
GGAATTGGCA CAGTGCACCA GCAGCAGCAT GAAGCCATCC TCTTCAAGAC CTTCACTTCC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Thiamine Induces Long-Term Changes in Amino Acid Profiles and Activities of 2-Oxoglutarate and 2-Oxoadipate Dehydrogenases in Rat Brain.
Biochemistry. Biokhimiia82(6)723-736(2017 Jun)
Tsepkova PM,Artiukhov AV,Boyko AI,Aleshin VA,Mkrtchyan GV,Zvyagintseva MA,Ryabov SI,Ksenofontov AL,Baratova LA,Graf AV,Bunik VI

Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7.
Cancer cell24(3)305-17(2013 Sep)
Nagamachi A,Matsui H,Asou H,Ozaki Y,Aki D,Kanai A,Takubo K,Suda T,Nakamura T,Wolff L,Honda H,Inaba T

A nonsense mutation in DHTKD1 causes Charcot-Marie-Tooth disease type 2 in a large Chinese pedigree.
American journal of human genetics91(6)1088-94(2012 Dec)
Xu WY,Gu MM,Sun LH,Guo WT,Zhu HB,Ma JF,Yuan WT,Kuang Y,Ji BJ,Wu XL,Chen Y,Zhang HX,Sun FT,Huang W,Huang L,Chen SD,Wang ZG

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Dhtkd1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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