Hjv cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Hjv
Entrez Gene ID	310681
Full Name	hemochromatosis type 2 (juvenile)
Synonyms	Rgmc
General protein information	Preferred Names hemochromatosis type 2 (juvenile) Names hemojuvelin RGM domain family member C hemochromatosis type 2 (juvenile) (human homolog) hemochromatosis type 2 protein homolog
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 2 Map Location: 2q34

mRNA and Protein(s)

mRNA	Protein	Name
NM_001012080.1	NP_001012080.1	hemojuvelin precursor

Pathways from BioSystems

Homologies

Xenopus tropicalis (tropical clawed frog)	hfe2	XP_002938521.2
Homo sapiens (human)	HFE2	NP_998818.1
Canis lupus familiaris (dog)	HFE2	XP_859524.3
Bos taurus (cattle)	HFE2	NP_001193843.1
Mus musculus (house mouse)	Hfe2	NP_081402.3
Rattus norvegicus (Norway rat)	Hfe2	NP_001012080.1
Pan troglodytes (chimpanzee)	HFE2	XP_001163074.1
	HFE2	XP_001092987.1
Danio rerio (zebrafish)	hfe2	XP_005158349.1

Gene Ontology
Bibliography

Related articles in PubMed

Anti-hemojuvelin antibody corrects anemia caused by inappropriately high hepcidin levels.
Kovac S, B?ser P, Cui Y, Ferring-Appel D, Casarrubea D, Huang L, Fung E, Popp A, Mueller BK, Hentze MW
Haematologica101(5)e173-6(2016 05)

Bmp6 expression in murine liver non parenchymal cells: a mechanism to control their high iron exporter activity and protect hepatocytes from iron overload?
Rausa M, Pagani A, Nai A, Campanella A, Gilberti ME, Apostoli P, Camaschella C, Silvestri L
PloS one10(4)e0122696(2015)

Functional and clinical impact of novel TMPRSS6 variants in iron-refractory iron-deficiency anemia patients and genotype-phenotype studies.
De Falco L, Silvestri L, Kannengiesser C, Mor?n E, Oudin C, Rausa M, Bruno M, Aranda J, Argiles B, Yenicesu I, Falcon-Rodriguez M, Yilmaz-Keskin E, Kocak U, Beaumont C, Camaschella C, Iolascon A, Grandchamp B, Sanchez M
Human mutation35(11)1321-9(2014 Nov)

The role of hepcidin and its related genes (BMP6, GDF-15, and HJV) in rats exposed to ischemia and reperfusion.
Dokuyucu R, Demir T, Yumruta? Onder, Erba?ci AB, Orkmez M, Bahar AY, Bayraktar R, Bozgeyik I, Kaplan DS, Cengiz B, Ba?ci BC
Turkish journal of medical sciences44(4)576-81(2014)

Iron-dependent regulation of hepcidin in Hjv-/- mice: evidence that hemojuvelin is dispensable for sensing body iron levels.
Gkouvatsos K, Fillebeen C, Daba A, Wagner J, Sebastiani G, Pantopoulos K
PloS one9(1)e85530(2014)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Expression levels of GDF-15, BMP6, and HJV genes increased in rats exposed to ischemia and reperfusion, but this increase was not statistically significant.
Title: The role of hepcidin and its related genes (BMP6, GDF-15, and HJV) in rats exposed to ischemia and reperfusion.

Matriptase-2- and proprotein convertase-cleaved forms of hemojuvelin have different roles in the down-regulation of hepcidin expression
Title: Matriptase-2- and proprotein convertase-cleaved forms of hemojuvelin have different roles in the down-regulation of hepcidin expression.

Phagocytosis upregulates hepcidin-gene expression and downregulates Hjv- and Fpn-1-gene expression within the liver.
Title: Phagocytosis of gadolinium chloride or zymosan induces simultaneous upregulation of hepcidin- and downregulation of hemojuvelin- and Fpn-1-gene expression in murine liver.

The results suggest that the HJV-neogenin interaction is required for the BMP-mediated induction of hepcidin expression when HJV is expressed.
Title: Hemojuvelin-neogenin interaction is required for bone morphogenic protein-4-induced hepcidin expression.

hemojuvelin(HFE2)& transferrin receptor type 2 were predominantly localized to hepatocyte basolateral membrane domain; localization of HFE2 & TfR2 at the same membrane domain renders a functional interaction of these proteins in iron homeostasis possible
Title: Localization of the iron-regulatory proteins hemojuvelin and transferrin receptor 2 to the basolateral membrane domain of hepatocytes.

The following Hjv gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Hjv cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa02207	NM_001012080.1 Latest version!	Rattus norvegicus hemojuvelin BMP co-receptor (Hjv), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$188.30 $269.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Hjv ( NM_001012080.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001012080.1 Rattus norvegicus hemojuvelin BMP co-receptor (Hjv), mRNA.

Price & Availability↑

CloneID	ORa02207
Clone ID Related Accession (Same CDS sequence)	NM_001012080.1
Accession Version	NM_001012080.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1269bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Rattus norvegicus(Norway rat)
Product	hemojuvelin precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC089203.1. On Feb 11, 2005 this sequence version replaced XM_227467.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC089203.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689596, SAMEA2689597 [ECO:0000348] ##Evidence-Data-END##

ATGGGGGATC GAGGCCGGTC CCCTAGTCTC CGGTCCCCCC ATGGCAGTCC TCCAACTCTA 
AGCACCCTCA CTCTCCTGCT GCTCCTCTGT GGACAGGCTC ACTCCCAGTG CAAGATCCTC 
CGCTGCAATG CCGAGTACGT CTCGTCCACT CTGAGCCTTC GGGGAGGGGG CTCACCGGAC 
ACGCCACATG GAGGCGGCCG TGGTGGGCCG GCCTCAGGTG GCTTGTGTCG CGCCCTGCGC 
TCCTACGCTC TCTGCACGCG GCGCACCGCC CGCACCTGCC GCGGGGACCT CGCTTTCCAC 
TCCGCGGTGC ATGGCATAGA GGACCTGATG ATCCAGCACA ACTGCTCACG CCAGGGTCCC 
ACGGCCTCGC CCCCGGCCCG GGGTCCTGCC CTGCCCGGGG CCGGCCCAGC GCCCCTGACC 
CCAGATCCCT GTGACTATGA AGCCCGGTTT TCCAGGCTGC ACGGTCGAAC CCCGGGTTTC 
TTGCATTGTG CTTCCTTTGG AGACCCCCAT GTGCGCAGCT TCCACAATCA CTTTCACACA 
TGCCGCGTCC AAGGAGCTTG GCCCCTACTA GATAACGACT TCCTCTTTGT CCAAGCCACC 
AGCTCCCCGG TAGCATCGGG AGCCAACGCT ACCACCATCC GGAAGATCAC TATCATATTT 
AAAAACATGC AGGAATGCAT TGACCAGAAA GTCTACCAGG CTGAGGTAGA CAATCTTCCT 
GCAGCCTTTG AAGATGGTTC TGTCAATGGG GGCGACCGAC CTGGGGGCTC GAGTTTGTCC 
ATTCAAACTG CTAACCTTGG GAGCCACGTG GAGATTCGAG CTGCCTACAT TGGAACAACT 
ATAATCGTTC GTCAGACAGC TGGACAGCTC TCCTTCTCCA TCAGGGTAGC GGAGGATGTG 
GCACGGGCCT TCTCTGCTGA GCAGGATCTA CAGCTGTGTG TTGGGGGATG CCCTCCGAGC 
CAGCGACTCT CTCGCTCAGA GCGCAATCGC CGTGGGGCGA TAGCCATAGA TACTGCCAGA 
AGGTTGTGTA AGGAAGGGCT TCCGGTTGAA GATGCCTACT TCCAATCCTG CGTCTTTGAT 
GTTTCAGTCT CCGGTGACCC CAACTTTACT GTGGCAGCTC AGTCAGCTCT GGACGATGCC 
CGAGTCTTCT TGACCGATTT GGAGAACTTG CACCTTTTCC CAGTAGATGC GGGGCCTCCC 
CTCTCTCCAG CCACCTGCCT AGTCCGGCTT CTTTCGGTCC TCTTTGTTCT GTGGTTTTGC 
ATTCAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001012080.1
CDS	222..1490
Translation	MGDRGRSPSLRSPHGSPPTLSTLTLLLLLCGQAHSQCKILRCNAEYVSSTLSLRGGGSPDTPHGGGRGGPASGGLCRALRSYALCTRRTARTCRGDLAFHSAVHGIEDLMIQHNCSRQGPTASPPARGPALPGAGPAPLTPDPCDYEARFSRLHGRTPGFLHCASFGDPHVRSFHNHFHTCRVQGAWPLLDNDFLFVQATSSPVASGANATTIRKITIIFKNMQECIDQKVYQAEVDNLPAAFEDGSVNGGDRPGGSSLSIQTANLGSHVEIRAAYIGTTIIVRQTAGQLSFSIRVAEDVARAFSAEQDLQLCVGGCPPSQRLSRSERNRRGAIAIDTARRLCKEGLPVEDAYFQSCVFDVSVSGDPNFTVAAQSALDDARVFLTDLENLHLFPVDAGPPLSPATCLVRLLSVLFVLWFCIQ

Target ORF information:

RefSeq Version	NM_001012080.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus hemojuvelin BMP co-receptor (Hjv), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001012080.1

ORF Insert Sequence:

ATGGGGGATC GAGGCCGGTC CCCTAGTCTC CGGTCCCCCC ATGGCAGTCC TCCAACTCTA 
AGCACCCTCA CTCTCCTGCT GCTCCTCTGT GGACAGGCTC ACTCCCAGTG CAAGATCCTC 
CGCTGCAATG CCGAGTACGT CTCGTCCACT CTGAGCCTTC GGGGAGGGGG CTCACCGGAC 
ACGCCACATG GAGGCGGCCG TGGTGGGCCG GCCTCAGGTG GCTTGTGTCG CGCCCTGCGC 
TCCTACGCTC TCTGCACGCG GCGCACCGCC CGCACCTGCC GCGGGGACCT CGCTTTCCAC 
TCCGCGGTGC ATGGCATAGA GGACCTGATG ATCCAGCACA ACTGCTCACG CCAGGGTCCC 
ACGGCCTCGC CCCCGGCCCG GGGTCCTGCC CTGCCCGGGG CCGGCCCAGC GCCCCTGACC 
CCAGATCCCT GTGACTATGA AGCCCGGTTT TCCAGGCTGC ACGGTCGAAC CCCGGGTTTC 
TTGCATTGTG CTTCCTTTGG AGACCCCCAT GTGCGCAGCT TCCACAATCA CTTTCACACA 
TGCCGCGTCC AAGGAGCTTG GCCCCTACTA GATAACGACT TCCTCTTTGT CCAAGCCACC 
AGCTCCCCGG TAGCATCGGG AGCCAACGCT ACCACCATCC GGAAGATCAC TATCATATTT 
AAAAACATGC AGGAATGCAT TGACCAGAAA GTCTACCAGG CTGAGGTAGA CAATCTTCCT 
GCAGCCTTTG AAGATGGTTC TGTCAATGGG GGCGACCGAC CTGGGGGCTC GAGTTTGTCC 
ATTCAAACTG CTAACCTTGG GAGCCACGTG GAGATTCGAG CTGCCTACAT TGGAACAACT 
ATAATCGTTC GTCAGACAGC TGGACAGCTC TCCTTCTCCA TCAGGGTAGC GGAGGATGTG 
GCACGGGCCT TCTCTGCTGA GCAGGATCTA CAGCTGTGTG TTGGGGGATG CCCTCCGAGC 
CAGCGACTCT CTCGCTCAGA GCGCAATCGC CGTGGGGCGA TAGCCATAGA TACTGCCAGA 
AGGTTGTGTA AGGAAGGGCT TCCGGTTGAA GATGCCTACT TCCAATCCTG CGTCTTTGAT 
GTTTCAGTCT CCGGTGACCC CAACTTTACT GTGGCAGCTC AGTCAGCTCT GGACGATGCC 
CGAGTCTTCT TGACCGATTT GGAGAACTTG CACCTTTTCC CAGTAGATGC GGGGCCTCCC 
CTCTCTCCAG CCACCTGCCT AGTCCGGCTT CTTTCGGTCC TCTTTGTTCT GTGGTTTTGC 
ATTCAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Anti-hemojuvelin antibody corrects anemia caused by inappropriately high hepcidin levels.
Haematologica101(5)e173-6(2016 05)
Kovac S,B?ser P,Cui Y,Ferring-Appel D,Casarrubea D,Huang L,Fung E,Popp A,Mueller BK,Hentze MW

Bmp6 expression in murine liver non parenchymal cells: a mechanism to control their high iron exporter activity and protect hepatocytes from iron overload?
PloS one10(4)e0122696(2015)
Rausa M,Pagani A,Nai A,Campanella A,Gilberti ME,Apostoli P,Camaschella C,Silvestri L

Functional and clinical impact of novel TMPRSS6 variants in iron-refractory iron-deficiency anemia patients and genotype-phenotype studies.
Human mutation35(11)1321-9(2014 Nov)
De Falco L,Silvestri L,Kannengiesser C,Mor?n E,Oudin C,Rausa M,Bruno M,Aranda J,Argiles B,Yenicesu I,Falcon-Rodriguez M,Yilmaz-Keskin E,Kocak U,Beaumont C,Camaschella C,Iolascon A,Grandchamp B,Sanchez M

The role of hepcidin and its related genes (BMP6, GDF-15, and HJV) in rats exposed to ischemia and reperfusion.
Turkish journal of medical sciences44(4)576-81(2014)
Dokuyucu R,Demir T,Yumruta? Onder,Erba?ci AB,Orkmez M,Bahar AY,Bayraktar R,Bozgeyik I,Kaplan DS,Cengiz B,Ba?ci BC

Iron-dependent regulation of hepcidin in Hjv-/- mice: evidence that hemojuvelin is dispensable for sensing body iron levels.
PloS one9(1)e85530(2014)
Gkouvatsos K,Fillebeen C,Daba A,Wagner J,Sebastiani G,Pantopoulos K

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Hjv cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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