hjv cDNA ORF clone, Danio rerio(zebrafish)

Gene
Clones
gRNAs

Summary

Gene Symbol	hjv
Entrez Gene ID	321932
Full Name	hemochromatosis type 2
Synonyms	DL-M,RGMC,RGMr,hjv,id:ibd3464,wu:fb38f10,zgc:136698
General protein information	Preferred Names hemochromatosis type 2 Names hemojuvelin RGM-like protein
Gene Type	protein-coding
Organism	Danio rerio(zebrafish)

mRNA and Protein(s)

mRNA	Protein	Name
XM_017351317.1	XP_017206806.1	hemojuvelin isoform X1
NM_001045281.1	NP_001038746.1	hemojuvelin precursor

Pathways from BioSystems

Homologies

Xenopus tropicalis (tropical clawed frog)	hfe2	XP_002938521.2
Homo sapiens (human)	HFE2	NP_998818.1
Canis lupus familiaris (dog)	HFE2	XP_859524.3
Bos taurus (cattle)	HFE2	NP_001193843.1
Mus musculus (house mouse)	Hfe2	NP_081402.3
Rattus norvegicus (Norway rat)	Hfe2	NP_001012080.1
Pan troglodytes (chimpanzee)	HFE2	XP_001163074.1
	HFE2	XP_001092987.1
Danio rerio (zebrafish)	hfe2	XP_005158349.1

Gene Ontology
Bibliography

Related articles in PubMed

Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database.
Pasquier J, Cabau C, Nguyen T, Jouanno E, Severac D, Braasch I, Journot L, Pontarotti P, Klopp C, Postlethwait JH, Guiguen Y, Bobe J
BMC genomics17368(2016 05)

RFX transcription factors are essential for hearing in mice.
Elkon R, Milon B, Morrison L, Shah M, Vijayakumar S, Racherla M, Leitch CC, Silipino L, Hadi S, Weiss-Gayet M, Barras E, Schmid CD, Ait-Lounis A, Barnes A, Song Y, Eisenman DJ, Eliyahu E, Frolenkov GI, Strome SE, Durand B, Zaghloul NA, Jones SM, Reith W, Hertzano R
Nature communications68549(2015 Oct)

The E3 ubiquitin ligase gp78 protects against ER stress in zebrafish liver.
Chen Z, Ballar P, Fu Y, Luo J, Du S, Fang S
Journal of genetics and genomics = Yi chuan xue bao41(7)357-68(2014 Jul)

Development of a transgenic zebrafish model expressing GFP in the notochord, somite and liver directed by the hfe2 gene promoter.
Bian YH, Xu C, Li J, Xu J, Zhang H, Du SJ
Transgenic research20(4)787-98(2011 Aug)

BMP signaling modulates hepcidin expression in zebrafish embryos independent of hemojuvelin.
Gibert Y, Lattanzi VJ, Zhen AW, Vedder L, Brunet F, Faasse SA, Babitt JL, Lin HY, Hammerschmidt M, Fraenkel PG
PloS one6(1)e14553(2011 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

data support an alternative mechanism for hepcidin regulation during zebrafish embryonic development, which is independent of hjv.
Title: BMP signaling modulates hepcidin expression in zebrafish embryos independent of hemojuvelin.

The following hjv gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the hjv cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ODa21871	NM_001045281.1 Latest version!	Danio rerio hemojuvelin BMP co-receptor (hjv), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$258.30 $369.00
ODa21871	XM_017351317.1 Latest version!	Danio rerio hemochromatosis type 2 (hfe2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$258.30 $369.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

hjv ( NM_001045281.1 ) cDNA ORF clone, Danio rerio(zebrafish) -> NP_001038746.1 Danio rerio hemojuvelin BMP co-receptor (hjv), mRNA.

Price & Availability↑

CloneID	ODa21871
Clone ID Related Accession (Same CDS sequence)	XM_017351317.1 , NM_001045281.1
Accession Version	NM_001045281.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1233bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-11-23
Organism	Danio rerio(zebrafish)
Product	hemojuvelin precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC112964.1. On or before Aug 31, 2013 this sequence version replaced XM_005158292.1, NM_213643.1. ##Evidence-Data-START## Transcript exon combination :: BC112964.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END##

ATGGGAATGG CAGCATCAGC TGGTGGTGGG AATCACTCAC ACACAACATG GAGACACATT 
GTGATCATTG TTTTAATGGT CCTGCTCTTT AGTGCTCCAT CAGTATGTGC GCAGTGTCGA 
ATCTTGCGAT GCAACTCAGA CTTCGTGGCT GCGACTTTGG AGAGCGGTGT CATTGGAGGA 
GGCAATAAAG AGGGTGTAAA TACGGGATAC TGCAGCGCCC TGCGATCCTA CGCCCTCTGC 
ACCCAGCGGA CGGCCCGAGC CTGCAGGGGA GACCTTGCGT ATCACTCTGC TGTACAGGGC 
ATCGAGGACC TGCTCATACA ATACCGCTGC CCAAAAGCAG GCCCCACGGC TCAGCCTCAG 
CCTCGGCCCC TGCCCCAAGC CCCTCTCTCC GGGGATGGAT GCTTCTACGA GAAGGGTTTT 
ATACAGAGGG AGGGCCGGGC CCCAGAATAT CTACACTGTG GGGTGTTTGG AGACCCGCAT 
ATCCGTACCT TCAACGAGGA GTTCCAGACG TGTGCAGTGC AGGGCGCCTG GCCTCTCATA 
GATAACCAGT ATCTGTACAT CCAGGCCACC AGCAGTCCCA CCAGGGAGAG CTCTGACACC 
ACCATACTCA CAGAGGTCAC GGTGATCTTC CAGAACTGGC GTGAGTGCGC TGAACAGCAG 
GTTTATCAAG CAAAACTGGG CAACGTTCCT CCAGCGTTTG CGGACGGCTC TGTGACTGGC 
GGGGACCGCA GAGGGCATCA GAGTCTGCGT ATTCACTCAC AAGACCCAGG CCGGCATGCT 
GAAATCTGGG CTACTCATAT TGGGACCATG ATAATAGTGC GGCAGGTTGG CCAGTCGCTG 
AGCCTGTCCG TCCGCTCTCC TCGTGCCATC GTGGAGTCCT ATACGCCGGA ACAGGACCTG 
CAGTTGTGTG TGTGGGGGTG TCCCATTTCA CAACGTTTAG AGATGCTGCA TGCACATCCA 
TTCGACCCCG CATACACACA CTGTTCCTCG CTGTTTCCGG GGAGAGATGT GTATTTCCAG 
GCCTGCCTGT TTGATGTGCA GGTGACCGGG GATGTGAACT CCAGCGCTTC AGCTGTGGCT 
GCGTTAGAGG ACGCTCGAGC CATGATTTCT GACCCCGCGA GTGTTCATTT GGTGACTGGT 
GGGACGGGTA ATAACTCCCC GTCATTGCTG GTGGTTCTAG GTTTCAGTTT CCTTACAGAG 
ACCCTCAGAC ACAGTTTTTT GGGGTCAGCG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001038746.1
CDS	198..1430
Translation	MGMAASAGGGNHSHTTWRHIVIIVLMVLLFSAPSVCAQCRILRCNSDFVAATLESGVIGGGNKEGVNTGYCSALRSYALCTQRTARACRGDLAYHSAVQGIEDLLIQYRCPKAGPTAQPQPRPLPQAPLSGDGCFYEKGFIQREGRAPEYLHCGVFGDPHIRTFNEEFQTCAVQGAWPLIDNQYLYIQATSSPTRESSDTTILTEVTVIFQNWRECAEQQVYQAKLGNVPPAFADGSVTGGDRRGHQSLRIHSQDPGRHAEIWATHIGTMIIVRQVGQSLSLSVRSPRAIVESYTPEQDLQLCVWGCPISQRLEMLHAHPFDPAYTHCSSLFPGRDVYFQACLFDVQVTGDVNSSASAVAALEDARAMISDPASVHLVTGGTGNNSPSLLVVLGFSFLTETLRHSFLGSA

Target ORF information:

RefSeq Version	NM_001045281.1
Organism	Danio rerio(zebrafish)
Definition	Danio rerio hemojuvelin BMP co-receptor (hjv), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001045281.1

ORF Insert Sequence:

ATGGGAATGG CAGCATCAGC TGGTGGTGGG AATCACTCAC ACACAACATG GAGACACATT 
GTGATCATTG TTTTAATGGT CCTGCTCTTT AGTGCTCCAT CAGTATGTGC GCAGTGTCGA 
ATCTTGCGAT GCAACTCAGA CTTCGTGGCT GCGACTTTGG AGAGCGGTGT CATTGGAGGA 
GGCAATAAAG AGGGTGTAAA TACGGGATAC TGCAGCGCCC TGCGATCCTA CGCCCTCTGC 
ACCCAGCGGA CGGCCCGAGC CTGCAGGGGA GACCTTGCGT ATCACTCTGC TGTACAGGGC 
ATCGAGGACC TGCTCATACA ATACCGCTGC CCAAAAGCAG GCCCCACGGC TCAGCCTCAG 
CCTCGGCCCC TGCCCCAAGC CCCTCTCTCC GGGGATGGAT GCTTCTACGA GAAGGGTTTT 
ATACAGAGGG AGGGCCGGGC CCCAGAATAT CTACACTGTG GGGTGTTTGG AGACCCGCAT 
ATCCGTACCT TCAACGAGGA GTTCCAGACG TGTGCAGTGC AGGGCGCCTG GCCTCTCATA 
GATAACCAGT ATCTGTACAT CCAGGCCACC AGCAGTCCCA CCAGGGAGAG CTCTGACACC 
ACCATACTCA CAGAGGTCAC GGTGATCTTC CAGAACTGGC GTGAGTGCGC TGAACAGCAG 
GTTTATCAAG CAAAACTGGG CAACGTTCCT CCAGCGTTTG CGGACGGCTC TGTGACTGGC 
GGGGACCGCA GAGGGCATCA GAGTCTGCGT ATTCACTCAC AAGACCCAGG CCGGCATGCT 
GAAATCTGGG CTACTCATAT TGGGACCATG ATAATAGTGC GGCAGGTTGG CCAGTCGCTG 
AGCCTGTCCG TCCGCTCTCC TCGTGCCATC GTGGAGTCCT ATACGCCGGA ACAGGACCTG 
CAGTTGTGTG TGTGGGGGTG TCCCATTTCA CAACGTTTAG AGATGCTGCA TGCACATCCA 
TTCGACCCCG CATACACACA CTGTTCCTCG CTGTTTCCGG GGAGAGATGT GTATTTCCAG 
GCCTGCCTGT TTGATGTGCA GGTGACCGGG GATGTGAACT CCAGCGCTTC AGCTGTGGCT 
GCGTTAGAGG ACGCTCGAGC CATGATTTCT GACCCCGCGA GTGTTCATTT GGTGACTGGT 
GGGACGGGTA ATAACTCCCC GTCATTGCTG GTGGTTCTAG GTTTCAGTTT CCTTACAGAG 
ACCCTCAGAC ACAGTTTTTT GGGGTCAGCG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

hjv ( XM_017351317.1 ) cDNA ORF clone, Danio rerio(zebrafish) -> XP_017206806.1 Danio rerio hemochromatosis type 2 (hfe2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ODa21871
Clone ID Related Accession (Same CDS sequence)	XM_017351317.1 , NM_001045281.1
Accession Version	XM_017351317.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1233bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-23
Organism	Danio rerio(Zebrafish)
Product	hemojuvelin isoform X1
Comment	MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_007127.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Danio rerio Annotation Release 105 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGAATGG CAGCATCAGC TGGTGGTGGG AATCACTCAC ACACAACATG GAGACACATT 
GTGATCATTG TTTTAATGGT CCTGCTCTTT AGTGCTCCAT CAGTATGTGC GCAGTGTCGA 
ATCTTGCGAT GCAACTCAGA CTTCGTGGCT GCGACTTTGG AGAGCGGTGT CATTGGAGGA 
GGCAATAAAG AGGGTGTAAA TACGGGATAC TGCAGCGCCC TGCGATCCTA CGCCCTCTGC 
ACCCAGCGGA CGGCCCGAGC CTGCAGGGGA GACCTTGCGT ATCACTCTGC TGTACAGGGC 
ATCGAGGACC TGCTCATACA ATACCGCTGC CCAAAAGCAG GCCCCACGGC TCAGCCTCAG 
CCTCGGCCCC TGCCCCAAGC CCCTCTCTCC GGGGATGGAT GCTTCTACGA GAAGGGTTTT 
ATACAGAGGG AGGGCCGGGC CCCAGAATAT CTACACTGTG GGGTGTTTGG AGACCCGCAT 
ATCCGTACCT TCAACGAGGA GTTCCAGACG TGTGCAGTGC AGGGCGCCTG GCCTCTCATA 
GATAACCAGT ATCTGTACAT CCAGGCCACC AGCAGTCCCA CCAGGGAGAG CTCTGACACC 
ACCATACTCA CAGAGGTCAC GGTGATCTTC CAGAACTGGC GTGAGTGCGC TGAACAGCAG 
GTTTATCAAG CAAAACTGGG CAACGTTCCT CCAGCGTTTG CGGACGGCTC TGTGACTGGC 
GGGGACCGCA GAGGGCATCA GAGTCTGCGT ATTCACTCAC AAGACCCAGG CCGGCATGCT 
GAAATCTGGG CTACTCATAT TGGGACCATG ATAATAGTGC GGCAGGTTGG CCAGTCGCTG 
AGCCTGTCCG TCCGCTCTCC TCGTGCCATC GTGGAGTCCT ATACGCCGGA ACAGGACCTG 
CAGTTGTGTG TGTGGGGGTG TCCCATTTCA CAACGTTTAG AGATGCTGCA TGCACATCCA 
TTCGACCCCG CATACACACA CTGTTCCTCG CTGTTTCCGG GGAGAGATGT GTATTTCCAG 
GCCTGCCTGT TTGATGTGCA GGTGACCGGG GATGTGAACT CCAGCGCTTC AGCTGTGGCT 
GCGTTAGAGG ACGCTCGAGC CATGATTTCT GACCCCGCGA GTGTTCATTT GGTGACTGGT 
GGGACGGGTA ATAACTCCCC GTCATTGCTG GTGGTTCTAG GTTTCAGTTT CCTTACAGAG 
ACCCTCAGAC ACAGTTTTTT GGGGTCAGCG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017206806.1
CDS	183..1415
Translation	MGMAASAGGGNHSHTTWRHIVIIVLMVLLFSAPSVCAQCRILRCNSDFVAATLESGVIGGGNKEGVNTGYCSALRSYALCTQRTARACRGDLAYHSAVQGIEDLLIQYRCPKAGPTAQPQPRPLPQAPLSGDGCFYEKGFIQREGRAPEYLHCGVFGDPHIRTFNEEFQTCAVQGAWPLIDNQYLYIQATSSPTRESSDTTILTEVTVIFQNWRECAEQQVYQAKLGNVPPAFADGSVTGGDRRGHQSLRIHSQDPGRHAEIWATHIGTMIIVRQVGQSLSLSVRSPRAIVESYTPEQDLQLCVWGCPISQRLEMLHAHPFDPAYTHCSSLFPGRDVYFQACLFDVQVTGDVNSSASAVAALEDARAMISDPASVHLVTGGTGNNSPSLLVVLGFSFLTETLRHSFLGSA

Target ORF information:

RefSeq Version	XM_017351317.1
Organism	Danio rerio(Zebrafish)
Definition	Danio rerio hemochromatosis type 2 (hfe2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017351317.1

ORF Insert Sequence:

ATGGGAATGG CAGCATCAGC TGGTGGTGGG AATCACTCAC ACACAACATG GAGACACATT 
GTGATCATTG TTTTAATGGT CCTGCTCTTT AGTGCTCCAT CAGTATGTGC GCAGTGTCGA 
ATCTTGCGAT GCAACTCAGA CTTCGTGGCT GCGACTTTGG AGAGCGGTGT CATTGGAGGA 
GGCAATAAAG AGGGTGTAAA TACGGGATAC TGCAGCGCCC TGCGATCCTA CGCCCTCTGC 
ACCCAGCGGA CGGCCCGAGC CTGCAGGGGA GACCTTGCGT ATCACTCTGC TGTACAGGGC 
ATCGAGGACC TGCTCATACA ATACCGCTGC CCAAAAGCAG GCCCCACGGC TCAGCCTCAG 
CCTCGGCCCC TGCCCCAAGC CCCTCTCTCC GGGGATGGAT GCTTCTACGA GAAGGGTTTT 
ATACAGAGGG AGGGCCGGGC CCCAGAATAT CTACACTGTG GGGTGTTTGG AGACCCGCAT 
ATCCGTACCT TCAACGAGGA GTTCCAGACG TGTGCAGTGC AGGGCGCCTG GCCTCTCATA 
GATAACCAGT ATCTGTACAT CCAGGCCACC AGCAGTCCCA CCAGGGAGAG CTCTGACACC 
ACCATACTCA CAGAGGTCAC GGTGATCTTC CAGAACTGGC GTGAGTGCGC TGAACAGCAG 
GTTTATCAAG CAAAACTGGG CAACGTTCCT CCAGCGTTTG CGGACGGCTC TGTGACTGGC 
GGGGACCGCA GAGGGCATCA GAGTCTGCGT ATTCACTCAC AAGACCCAGG CCGGCATGCT 
GAAATCTGGG CTACTCATAT TGGGACCATG ATAATAGTGC GGCAGGTTGG CCAGTCGCTG 
AGCCTGTCCG TCCGCTCTCC TCGTGCCATC GTGGAGTCCT ATACGCCGGA ACAGGACCTG 
CAGTTGTGTG TGTGGGGGTG TCCCATTTCA CAACGTTTAG AGATGCTGCA TGCACATCCA 
TTCGACCCCG CATACACACA CTGTTCCTCG CTGTTTCCGG GGAGAGATGT GTATTTCCAG 
GCCTGCCTGT TTGATGTGCA GGTGACCGGG GATGTGAACT CCAGCGCTTC AGCTGTGGCT 
GCGTTAGAGG ACGCTCGAGC CATGATTTCT GACCCCGCGA GTGTTCATTT GGTGACTGGT 
GGGACGGGTA ATAACTCCCC GTCATTGCTG GTGGTTCTAG GTTTCAGTTT CCTTACAGAG 
ACCCTCAGAC ACAGTTTTTT GGGGTCAGCG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database.
BMC genomics17368(2016 05)
Pasquier J,Cabau C,Nguyen T,Jouanno E,Severac D,Braasch I,Journot L,Pontarotti P,Klopp C,Postlethwait JH,Guiguen Y,Bobe J

RFX transcription factors are essential for hearing in mice.
Nature communications68549(2015 Oct)
Elkon R,Milon B,Morrison L,Shah M,Vijayakumar S,Racherla M,Leitch CC,Silipino L,Hadi S,Weiss-Gayet M,Barras E,Schmid CD,Ait-Lounis A,Barnes A,Song Y,Eisenman DJ,Eliyahu E,Frolenkov GI,Strome SE,Durand B,Zaghloul NA,Jones SM,Reith W,Hertzano R

The E3 ubiquitin ligase gp78 protects against ER stress in zebrafish liver.
Journal of genetics and genomics = Yi chuan xue bao41(7)357-68(2014 Jul)
Chen Z,Ballar P,Fu Y,Luo J,Du S,Fang S

Development of a transgenic zebrafish model expressing GFP in the notochord, somite and liver directed by the hfe2 gene promoter.
Transgenic research20(4)787-98(2011 Aug)
Bian YH,Xu C,Li J,Xu J,Zhang H,Du SJ

BMP signaling modulates hepcidin expression in zebrafish embryos independent of hemojuvelin.
PloS one6(1)e14553(2011 Jan)
Gibert Y,Lattanzi VJ,Zhen AW,Vedder L,Brunet F,Faasse SA,Babitt JL,Lin HY,Hammerschmidt M,Fraenkel PG

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hjv cDNA ORF clone, Danio rerio(zebrafish)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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