Hoxb13 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Hoxb13
Entrez Gene ID	303480
Full Name	homeo box B13
General protein information	Preferred Names homeo box B13 Names homeobox protein Hox-B13
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 10 Map Location: 10q26

mRNA and Protein(s)

mRNA	Protein	Name
NM_001107041.1	NP_001100511.1	homeobox protein Hox-B13

Pathways from BioSystems

Homologies

Homo sapiens (human)	HOXB13	NP_006352.2
Rattus norvegicus (Norway rat)	Hoxb13	NP_001100511.1
Bos taurus (cattle)	HOXB13	XP_003587468.1
Danio rerio (zebrafish)	hoxb13a	NP_001038377.1
Mus musculus (house mouse)	Hoxb13	NP_032293.1
Gallus gallus (chicken)	HOXB13	XP_001234927.1
Pan troglodytes (chimpanzee)	HOXB13	XP_523822.1
	HOXB13	XP_001089620.1
Canis lupus familiaris (dog)	HOXB13	XP_548180.2

Gene Ontology
Bibliography

Related articles in PubMed

Impact of cytosine methylation on DNA binding specificities of human transcription factors.
Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Sch?beler D, Vinson C, Taipale J
Science (New York, N.Y.)356(6337)(2017 05)

DNA-binding specificities of human transcription factors.
Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J
Cell152(1-2)327-39(2013 Jan)

HOX gene analysis of endothelial cell differentiation in human bone marrow-derived mesenchymal stem cells.
Chung N, Jee BK, Chae SW, Jeon YW, Lee KH, Rha HK
Molecular biology reports36(2)227-35(2009 Feb)

Methylation of homeobox genes is a frequent and early epigenetic event in breast cancer.
Tommasi S, Karm DL, Wu X, Yen Y, Pfeifer GP
Breast cancer research : BCR11(1)R14(2009)

Exploring the two-gene ratio in breast cancer--independent roles for HOXB13 and IL17BR in prediction of clinical outcome.
Jerevall PL, Brommesson S, Strand C, Gruvberger-Saal S, Malmstr?m P, Nordenskj?ld B, Wingren S, S?derkvist P, Fern? M, St?l O
Breast cancer research and treatment107(2)225-34(2008 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Hoxb13 functions to promote epidermal differentiation, a critical process for skin regeneration and for the maintenance of normal barrier function.
Title: Hoxb13 up-regulates transglutaminase activity and drives terminal differentiation in an epidermal organotypic model.

The following Hoxb13 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Hoxb13 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa41541	NM_001107041.1 Latest version!	Rattus norvegicus homeo box B13 (Hoxb13), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Hoxb13 ( NM_001107041.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001100511.1 Rattus norvegicus homeo box B13 (Hoxb13), mRNA.

Price & Availability↑

CloneID	ORa41541
Clone ID Related Accession (Same CDS sequence)	NM_001107041.1
Accession Version	NM_001107041.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 861bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-18
Organism	Rattus norvegicus(Norway rat)
Product	homeobox protein Hox-B13
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH473948.1. On or before Oct 4, 2007 this sequence version replaced XM_001081336.1, XM_220905.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMN02642693 [ECO:0000348] ##Evidence-Data-END##

ATGGAGCCCG GCAATTATGC CACCTTGGAC GGGGCCAAGG ATATCGAAGG CTTGCTGGGA 
GCTGGAGGGG GTCGGAATTT AGTCGCCCAC TCCTCCCCAC TGGCTAGCCA TCCCGCAGCT 
CCAACGCTGA TGCCGACTGT CAACTATGCC CCCTTGGATC TGCCAGGCTC TGCAGAGCCA 
CCAAAGCAGT GCCACCCTTG TCCTGGGGTG CCCCAGGGGG CATCTCCAGC TCCTGTGCCT 
TATGGCTACT TTGGAGGCGG GTACTACTCT TGCCGAGTAT CCAGGAGCTC ACTGAAACCC 
TGTGCCCAGA CGGCCACCCT GGCTACTTAC CCTTCGGAAA CCCCTGCACC TGGGGAGGAG 
TATCCTAGCC GTCCCACCGA GTTTGCCTTC TATCCGGGCT ACCCGGGACC TTACCAGCCT 
ATGGCCAGTT ACCTGGATGT GTCTGTGGTG CAGACCCTGG GGGCCCCTGG GGAGCCTCGC 
CACGACTCTC TGCTTCCCGT GGACAGTTAT CAGCCTTGGG CCCTGGCCGG TGGCTGGAAC 
AGCCAGATGT GCTGCCAAGG TGAACAGAAC CCACCAGGTC CATTCTGGAA AGCAGCATTT 
GCAGAGCCCA GTGTCCAGCA CCCTCCTCCC GACGGCTGCG CCTTCCGCCG CGGCCGCAAA 
AAACGCATTC CCTATAGCAA GGGGCAGTTG CGAGAGCTGG AGCGAGAGTA TGCGGCCAAC 
AAGTTTATCA CCAAGGACAA GAGGCGCAAG ATCTCGGCAG CCACCAGCCT CTCTGAACGC 
CAGATTACCA TCTGGTTTCA GAACCGCCGG GTCAAGGAGA AGAAGGTTCT TGCCAAGGTC 
AAGACCAGCA CTACTCCGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001100511.1
CDS	120..980
Translation	MEPGNYATLDGAKDIEGLLGAGGGRNLVAHSSPLASHPAAPTLMPTVNYAPLDLPGSAEPPKQCHPCPGVPQGASPAPVPYGYFGGGYYSCRVSRSSLKPCAQTATLATYPSETPAPGEEYPSRPTEFAFYPGYPGPYQPMASYLDVSVVQTLGAPGEPRHDSLLPVDSYQPWALAGGWNSQMCCQGEQNPPGPFWKAAFAEPSVQHPPPDGCAFRRGRKKRIPYSKGQLRELEREYAANKFITKDKRRKISAATSLSERQITIWFQNRRVKEKKVLAKVKTSTTP

Target ORF information:

RefSeq Version	NM_001107041.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus homeo box B13 (Hoxb13), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001107041.1

ORF Insert Sequence:

ATGGAGCCCG GCAATTATGC CACCTTGGAC GGGGCCAAGG ATATCGAAGG CTTGCTGGGA 
GCTGGAGGGG GTCGGAATTT AGTCGCCCAC TCCTCCCCAC TGGCTAGCCA TCCCGCAGCT 
CCAACGCTGA TGCCGACTGT CAACTATGCC CCCTTGGATC TGCCAGGCTC TGCAGAGCCA 
CCAAAGCAGT GCCACCCTTG TCCTGGGGTG CCCCAGGGGG CATCTCCAGC TCCTGTGCCT 
TATGGCTACT TTGGAGGCGG GTACTACTCT TGCCGAGTAT CCAGGAGCTC ACTGAAACCC 
TGTGCCCAGA CGGCCACCCT GGCTACTTAC CCTTCGGAAA CCCCTGCACC TGGGGAGGAG 
TATCCTAGCC GTCCCACCGA GTTTGCCTTC TATCCGGGCT ACCCGGGACC TTACCAGCCT 
ATGGCCAGTT ACCTGGATGT GTCTGTGGTG CAGACCCTGG GGGCCCCTGG GGAGCCTCGC 
CACGACTCTC TGCTTCCCGT GGACAGTTAT CAGCCTTGGG CCCTGGCCGG TGGCTGGAAC 
AGCCAGATGT GCTGCCAAGG TGAACAGAAC CCACCAGGTC CATTCTGGAA AGCAGCATTT 
GCAGAGCCCA GTGTCCAGCA CCCTCCTCCC GACGGCTGCG CCTTCCGCCG CGGCCGCAAA 
AAACGCATTC CCTATAGCAA GGGGCAGTTG CGAGAGCTGG AGCGAGAGTA TGCGGCCAAC 
AAGTTTATCA CCAAGGACAA GAGGCGCAAG ATCTCGGCAG CCACCAGCCT CTCTGAACGC 
CAGATTACCA TCTGGTTTCA GAACCGCCGG GTCAAGGAGA AGAAGGTTCT TGCCAAGGTC 
AAGACCAGCA CTACTCCGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Impact of cytosine methylation on DNA binding specificities of human transcription factors.
Science (New York, N.Y.)356(6337)(2017 05)
Yin Y,Morgunova E,Jolma A,Kaasinen E,Sahu B,Khund-Sayeed S,Das PK,Kivioja T,Dave K,Zhong F,Nitta KR,Taipale M,Popov A,Ginno PA,Domcke S,Yan J,Sch?beler D,Vinson C,Taipale J

DNA-binding specificities of human transcription factors.
Cell152(1-2)327-39(2013 Jan)
Jolma A,Yan J,Whitington T,Toivonen J,Nitta KR,Rastas P,Morgunova E,Enge M,Taipale M,Wei G,Palin K,Vaquerizas JM,Vincentelli R,Luscombe NM,Hughes TR,Lemaire P,Ukkonen E,Kivioja T,Taipale J

HOX gene analysis of endothelial cell differentiation in human bone marrow-derived mesenchymal stem cells.
Molecular biology reports36(2)227-35(2009 Feb)
Chung N,Jee BK,Chae SW,Jeon YW,Lee KH,Rha HK

Methylation of homeobox genes is a frequent and early epigenetic event in breast cancer.
Breast cancer research : BCR11(1)R14(2009)
Tommasi S,Karm DL,Wu X,Yen Y,Pfeifer GP

Exploring the two-gene ratio in breast cancer--independent roles for HOXB13 and IL17BR in prediction of clinical outcome.
Breast cancer research and treatment107(2)225-34(2008 Jan)
Jerevall PL,Brommesson S,Strand C,Gruvberger-Saal S,Malmstr?m P,Nordenskj?ld B,Wingren S,S?derkvist P,Fern? M,St?l O