Clk1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Clk1
Entrez Gene ID	301434
Full Name	CDC-like kinase 1
General protein information	Preferred Names CDC-like kinase 1 Names dual specificity protein kinase CLK1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 9 Map Location: 9q31

mRNA and Protein(s)

mRNA	Protein	Name
XM_008767083.2	XP_008765305.1	dual specificity protein kinase CLK1 isoform X1
NM_001106913.2	NP_001100383.2	dual specificity protein kinase CLK1

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	CLK1	XP_003641631.1
Homo sapiens (human)	CLK1	NP_001155879.1
Canis lupus familiaris (dog)	CLK1	XP_858089.3
Rattus norvegicus (Norway rat)	Clk1	NP_001100383.2
Pan troglodytes (chimpanzee)	CLK1	XP_001170743.2
	CLK1	XP_001093219.1
Mus musculus (house mouse)	Clk1	NP_001036099.1
Xenopus tropicalis (tropical clawed frog)	clk1	NP_001016921.1

Gene Ontology
Bibliography

Related articles in PubMed

Cdc2-like kinases and DNA topoisomerase I regulate alternative splicing of tissue factor in human endothelial cells.
Eisenreich A, Bogdanov VY, Zakrzewicz A, Pries A, Antoniak S, Poller W, Schultheiss HP, Rauch U
Circulation research104(5)589-99(2009 Mar)

Biochemical characterization and localization of the dual specificity kinase CLK1.
Menegay HJ, Myers MP, Moeslein FM, Landreth GE
Journal of cell science113 ( Pt 18)3241-53(2000 Sep)

The CLK family kinases, CLK1 and CLK2, phosphorylate and activate the tyrosine phosphatase, PTP-1B.
Moeslein FM, Myers MP, Landreth GE
The Journal of biological chemistry274(38)26697-704(1999 Sep)

Characterization and comparison of four serine- and arginine-rich (SR) protein kinases.
Nayler O, Stamm S, Ullrich A
The Biochemical journal326 ( Pt 3)693-700(1997 Sep)

STY, a tyrosine-phosphorylating enzyme with sequence homology to serine/threonine kinases.
Howell BW, Afar DE, Lew J, Douville EM, Icely PL, Gray DA, Bell JC
Molecular and cellular biology11(1)568-72(1991 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Clk1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Clk1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa02477	NM_001106913.2 Latest version!	Rattus norvegicus CDC-like kinase 1 (Clk1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00
ORa45863	XM_008767083.2 Latest version!	Rattus norvegicus CDC-like kinase 1 (Clk1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Clk1 ( NM_001106913.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001100383.2 Rattus norvegicus CDC-like kinase 1 (Clk1), mRNA.

Price & Availability↑

CloneID	ORa02477
Clone ID Related Accession (Same CDS sequence)	NM_001106913.2
Accession Version	NM_001106913.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1452bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Rattus norvegicus(Norway rat)
Product	dual specificity protein kinase CLK1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC081942.1, CV127206.1 and AA923848.1. On Jun 23, 2009 this sequence version replaced NM_001106913.1. ##Evidence-Data-START## Transcript exon combination :: FQ232068.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGACATT CAAAGAGAAC TTACTGTCCT GACTGGGATG AAAGAGATTG GGATTATGGA 
ACATGGAGAA GCAGCAGCAG TCATAAAAGA AGGAAGAGAT CACATAGCAG TGCCCGTGAT 
TATAAGCGAT GCAAATACAA TCACTCCAAA ACAACGGACA GCTATTATCT GGAAAGTAGA 
TCCATACATG AGAAAGCCTA TCACAGCCGA CGCTATGTTG ATGAATACAG GAATGACTAC 
ATGACCTACG AGCCAGGGTA TCCCTATGGA GAACCTGGAA GCAGATACCA GAATCATAGT 
AGCAAGTCCT CTGGTAGGAG TGGAAGAAGC AGTTACAAAA GCAAACATAG GAGTCACCAC 
CACACGTCAC ATCGTCGTTC ACATGGGAAG AGTCACCGAA GGAAAAGATC GAGGAGTGTA 
GAGGATGATG AGGAGGGTCA CCTGATCTGT CAGAGTGGAG ACGTACTAAG TGCAAGATAT 
GAAATTGTTG ATACTTTAGG TGAAGGTGCT TTTGGAAAAG TGGTGGAGTG TATCGATCAT 
AAAGTGGGAG GTAGACATGT AGCGGTAAAA ATAGTTAAAA ATGTGGATAG ATACTGTGAA 
GCTGCTCAAT CGGAAATACA AGTTTTGGAA CACTTAAATG CAACAGACCC CCATAGTACT 
TTCCGTTGTG TCCAGATGTT GGAATGGTTT GAGCACCGAG GTCACATTTG CATTGTGTTT 
GAACTTCTGG GGCTTAGTAC TTACGATTTC ATTAAGGAAA ACAGCTTTCT GCCGTTTCGA 
ATGGATCATA TCAGGAAGAT GGCATATCAA ATATGCAAAT CTGTAAACTT TTTGCATAGT 
AATAAATTGA CTCACACAGA CTTGAAGCCT GAAAACATCT TATTTGTGAA GTCTGACTAC 
ACAGAGGCTT ATAATCCCAA AATGAAACGT GATGAACGCA CTATAGTAAA TCCCGATATT 
AAAGTGGTGG ACTTTGGGAG TGCAACATAT GATGACGAAC ATCACAGCAC ATTGGTATCT 
ACAAGACATT ACAGAGCACC AGAAGTCATT CTAGCCCTAG GGTGGTCACA ACCATGTGAT 
GTCTGGAGTA TAGGATGTAT TCTTATCGAG TATTATCTTG GATTTACAGT TTTTCCGACT 
CATGATAGCA GGGAACATTT AGCAATGATG GAAAGGATTC TTGGACCACT GCCAAAGCAC 
ATGATTGAGA AAACCAGGAA ACGCACATAC TTCCATCACG ATCGATTGGA TTGGGATGAG 
CACAGTTCTG CTGGCAGATA TGTTTCTCGG CGCTGTAAGC CTCTGAAGGA GTTTATGCTG 
TCTCAGGATG CCGAGCATGA GCTTCTCTTT GACCTCATTG GGAAAATGTT GGAGTATGAT 
CCAGCCAAAA GAATCACTCT CAAAGAAGCC CTAAAGCATC CTTTCTTTTA CCCGCTTAAA 
AAGCATACAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001100383.2
CDS	134..1585
Translation	MRHSKRTYCPDWDERDWDYGTWRSSSSHKRRKRSHSSARDYKRCKYNHSKTTDSYYLESRSIHEKAYHSRRYVDEYRNDYMTYEPGYPYGEPGSRYQNHSSKSSGRSGRSSYKSKHRSHHHTSHRRSHGKSHRRKRSRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKVGGRHVAVKIVKNVDRYCEAAQSEIQVLEHLNATDPHSTFRCVQMLEWFEHRGHICIVFELLGLSTYDFIKENSFLPFRMDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVKSDYTEAYNPKMKRDERTIVNPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSREHLAMMERILGPLPKHMIEKTRKRTYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDAEHELLFDLIGKMLEYDPAKRITLKEALKHPFFYPLKKHT

Target ORF information:

RefSeq Version	NM_001106913.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus CDC-like kinase 1 (Clk1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001106913.2

ORF Insert Sequence:

ATGAGACATT CAAAGAGAAC TTACTGTCCT GACTGGGATG AAAGAGATTG GGATTATGGA 
ACATGGAGAA GCAGCAGCAG TCATAAAAGA AGGAAGAGAT CACATAGCAG TGCCCGTGAT 
TATAAGCGAT GCAAATACAA TCACTCCAAA ACAACGGACA GCTATTATCT GGAAAGTAGA 
TCCATACATG AGAAAGCCTA TCACAGCCGA CGCTATGTTG ATGAATACAG GAATGACTAC 
ATGACCTACG AGCCAGGGTA TCCCTATGGA GAACCTGGAA GCAGATACCA GAATCATAGT 
AGCAAGTCCT CTGGTAGGAG TGGAAGAAGC AGTTACAAAA GCAAACATAG GAGTCACCAC 
CACACGTCAC ATCGTCGTTC ACATGGGAAG AGTCACCGAA GGAAAAGATC GAGGAGTGTA 
GAGGATGATG AGGAGGGTCA CCTGATCTGT CAGAGTGGAG ACGTACTAAG TGCAAGATAT 
GAAATTGTTG ATACTTTAGG TGAAGGTGCT TTTGGAAAAG TGGTGGAGTG TATCGATCAT 
AAAGTGGGAG GTAGACATGT AGCGGTAAAA ATAGTTAAAA ATGTGGATAG ATACTGTGAA 
GCTGCTCAAT CGGAAATACA AGTTTTGGAA CACTTAAATG CAACAGACCC CCATAGTACT 
TTCCGTTGTG TCCAGATGTT GGAATGGTTT GAGCACCGAG GTCACATTTG CATTGTGTTT 
GAACTTCTGG GGCTTAGTAC TTACGATTTC ATTAAGGAAA ACAGCTTTCT GCCGTTTCGA 
ATGGATCATA TCAGGAAGAT GGCATATCAA ATATGCAAAT CTGTAAACTT TTTGCATAGT 
AATAAATTGA CTCACACAGA CTTGAAGCCT GAAAACATCT TATTTGTGAA GTCTGACTAC 
ACAGAGGCTT ATAATCCCAA AATGAAACGT GATGAACGCA CTATAGTAAA TCCCGATATT 
AAAGTGGTGG ACTTTGGGAG TGCAACATAT GATGACGAAC ATCACAGCAC ATTGGTATCT 
ACAAGACATT ACAGAGCACC AGAAGTCATT CTAGCCCTAG GGTGGTCACA ACCATGTGAT 
GTCTGGAGTA TAGGATGTAT TCTTATCGAG TATTATCTTG GATTTACAGT TTTTCCGACT 
CATGATAGCA GGGAACATTT AGCAATGATG GAAAGGATTC TTGGACCACT GCCAAAGCAC 
ATGATTGAGA AAACCAGGAA ACGCACATAC TTCCATCACG ATCGATTGGA TTGGGATGAG 
CACAGTTCTG CTGGCAGATA TGTTTCTCGG CGCTGTAAGC CTCTGAAGGA GTTTATGCTG 
TCTCAGGATG CCGAGCATGA GCTTCTCTTT GACCTCATTG GGAAAATGTT GGAGTATGAT 
CCAGCCAAAA GAATCACTCT CAAAGAAGCC CTAAAGCATC CTTTCTTTTA CCCGCTTAAA 
AAGCATACAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Clk1 ( XM_008767083.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008765305.1 Rattus norvegicus CDC-like kinase 1 (Clk1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa45863
Clone ID Related Accession (Same CDS sequence)	XM_008767083.2
Accession Version	XM_008767083.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 777bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	dual specificity protein kinase CLK1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005108.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008767083.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTTGGAAT GGTTTGAGCA CCGAGGTCAC ATTTGCATTG TGTTTGAACT TCTGGGGCTT 
AGTACTTACG ATTTCATTAA GGAAAACAGC TTTCTGCCGT TTCGAATGGA TCATATCAGG 
AAGATGGCAT ATCAAATATG CAAATCTGTA AACTTTTTGC ATAGTAATAA ATTGACTCAC 
ACAGACTTGA AGCCTGAAAA CATCTTATTT GTGAAGTCTG ACTACACAGA GGCTTATAAT 
CCCAAAATGA AACGTGATGA ACGCACTATA GTAAATCCCG ATATTAAAGT GGTGGACTTT 
GGGAGTGCAA CATATGATGA CGAACATCAC AGCACATTGG TATCTACAAG ACATTACAGA 
GCACCAGAAG TCATTCTAGC CCTAGGGTGG TCACAACCAT GTGATGTCTG GAGTATAGGA 
TGTATTCTTA TCGAGTATTA TCTTGGATTT ACAGTTTTTC CGACTCATGA TAGCAGGGAA 
CATTTAGCAA TGATGGAAAG GATTCTTGGA CCACTGCCAA AGCACATGAT TGAGAAAACC 
AGGAAACGCA CATACTTCCA TCACGATCGA TTGGATTGGG ATGAGCACAG TTCTGCTGGC 
AGATATGTTT CTCGGCGCTG TAAGCCTCTG AAGGAGTTTA TGCTGTCTCA GGATGCCGAG 
CATGAGCTTC TCTTTGACCT CATTGGGAAA ATGTTGGAGT ATGATCCAGC CAAAAGAATC 
ACTCTCAAAG AAGCCCTAAA GCATCCTTTC TTTTACCCGC TTAAAAAGCA TACATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008765305.1
CDS	740..1516
Translation	MLEWFEHRGHICIVFELLGLSTYDFIKENSFLPFRMDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVKSDYTEAYNPKMKRDERTIVNPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSREHLAMMERILGPLPKHMIEKTRKRTYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDAEHELLFDLIGKMLEYDPAKRITLKEALKHPFFYPLKKHT

Target ORF information:

RefSeq Version	XM_008767083.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus CDC-like kinase 1 (Clk1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008767083.2

ORF Insert Sequence:

ATGTTGGAAT GGTTTGAGCA CCGAGGTCAC ATTTGCATTG TGTTTGAACT TCTGGGGCTT 
AGTACTTACG ATTTCATTAA GGAAAACAGC TTTCTGCCGT TTCGAATGGA TCATATCAGG 
AAGATGGCAT ATCAAATATG CAAATCTGTA AACTTTTTGC ATAGTAATAA ATTGACTCAC 
ACAGACTTGA AGCCTGAAAA CATCTTATTT GTGAAGTCTG ACTACACAGA GGCTTATAAT 
CCCAAAATGA AACGTGATGA ACGCACTATA GTAAATCCCG ATATTAAAGT GGTGGACTTT 
GGGAGTGCAA CATATGATGA CGAACATCAC AGCACATTGG TATCTACAAG ACATTACAGA 
GCACCAGAAG TCATTCTAGC CCTAGGGTGG TCACAACCAT GTGATGTCTG GAGTATAGGA 
TGTATTCTTA TCGAGTATTA TCTTGGATTT ACAGTTTTTC CGACTCATGA TAGCAGGGAA 
CATTTAGCAA TGATGGAAAG GATTCTTGGA CCACTGCCAA AGCACATGAT TGAGAAAACC 
AGGAAACGCA CATACTTCCA TCACGATCGA TTGGATTGGG ATGAGCACAG TTCTGCTGGC 
AGATATGTTT CTCGGCGCTG TAAGCCTCTG AAGGAGTTTA TGCTGTCTCA GGATGCCGAG 
CATGAGCTTC TCTTTGACCT CATTGGGAAA ATGTTGGAGT ATGATCCAGC CAAAAGAATC 
ACTCTCAAAG AAGCCCTAAA GCATCCTTTC TTTTACCCGC TTAAAAAGCA TACATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Cdc2-like kinases and DNA topoisomerase I regulate alternative splicing of tissue factor in human endothelial cells.
Circulation research104(5)589-99(2009 Mar)
Eisenreich A,Bogdanov VY,Zakrzewicz A,Pries A,Antoniak S,Poller W,Schultheiss HP,Rauch U

Biochemical characterization and localization of the dual specificity kinase CLK1.
Journal of cell science113 ( Pt 18)3241-53(2000 Sep)
Menegay HJ,Myers MP,Moeslein FM,Landreth GE

The CLK family kinases, CLK1 and CLK2, phosphorylate and activate the tyrosine phosphatase, PTP-1B.
The Journal of biological chemistry274(38)26697-704(1999 Sep)
Moeslein FM,Myers MP,Landreth GE

Characterization and comparison of four serine- and arginine-rich (SR) protein kinases.
The Biochemical journal326 ( Pt 3)693-700(1997 Sep)
Nayler O,Stamm S,Ullrich A

STY, a tyrosine-phosphorylating enzyme with sequence homology to serine/threonine kinases.
Molecular and cellular biology11(1)568-72(1991 Jan)
Howell BW,Afar DE,Lew J,Douville EM,Icely PL,Gray DA,Bell JC