Fgf18 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Fgf18
Entrez Gene ID	29369
Full Name	fibroblast growth factor 18
General protein information	Preferred Names fibroblast growth factor 18 Names fibroblast growth factor 18 FGF-18
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 10 Map Location: 10q12
Summary	fibroblast growth factor; may be a secreted signalling molecule in the adult lung [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_019199.1	NP_062072.1	fibroblast growth factor 18 precursor

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	FGF18	XP_854425.1
Gallus gallus (chicken)	FGF18	NP_990045.1
Mus musculus (house mouse)	Fgf18	NP_032031.1
Rattus norvegicus (Norway rat)	Fgf18	NP_062072.1
Homo sapiens (human)	FGF18	NP_003853.1
Bos taurus (cattle)	FGF18	NP_001069475.1
Danio rerio (zebrafish)	fgf18a	NP_001013282.1
Danio rerio (zebrafish)	fgf18b	NP_001012379.1

Gene Ontology
Bibliography

Related articles in PubMed

MicroRNA-505 identified from patients with essential hypertension impairs endothelial cell migration and tube formation.
Yang Q, Jia C, Wang P, Xiong M, Cui J, Li L, Wang W, Wu Q, Chen Y, Zhang T
International journal of cardiology177(3)925-34(2014 Dec)

Pulmonary FGF-18 gene expression is downregulated during the canalicular-saccular stages in nitrofen-induced hypoplastic lungs.
Takahashi H, Friedmacher F, Fujiwara N, Hofmann A, Kutasy B, Gosemann JH, Puri P
Pediatric surgery international29(11)1199-203(2013 Nov)

FGF18 is required for early chondrocyte proliferation, hypertrophy and vascular invasion of the growth plate.
Liu Z, Lavine KJ, Hung IH, Ornitz DM
Developmental biology302(1)80-91(2007 Feb)

Fibroblast growth factor 16 and 18 are expressed in human cardiovascular tissues and induce on endothelial cells migration but not proliferation.
Antoine M, Wirz W, Tag CG, Gressner AM, Wycislo M, M?ller R, Kiefer P
Biochemical and biophysical research communications346(1)224-33(2006 Jul)

Structural basis by which alternative splicing modulates the organizer activity of FGF8 in the brain.
Olsen SK, Li JY, Bromleigh C, Eliseenkova AV, Ibrahimi OA, Lao Z, Zhang F, Linhardt RJ, Joyner AL, Mohammadi M
Genes & development20(2)185-98(2006 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Downregulation of FGF-18 gene expression in nitrofen-induced hypoplastic lungs suggests that decreased FGF-18 expression during the canalicular-saccular stages
Title: Pulmonary FGF-18 gene expression is downregulated during the canalicular-saccular stages in nitrofen-induced hypoplastic lungs.

analysis of FGF18 and FGFR5 expression in primary endothelial cells and vascular smooth muscle cells
Title: Expression pattern of fibroblast growth factors (FGFs), their receptors and antagonists in primary endothelial cells and vascular smooth muscle cells.

FGF-18 is involved in postnatal lung development through stimulating myofibroblast proliferation and differentiation.
Title: FGF-18 is upregulated in the postnatal rat lung and enhances elastogenesis in myofibroblasts.

FGF18 represses noggin expression and is induced by calcineurin
Title: FGF18 represses noggin expression and is induced by calcineurin.

FGF18 is an effective neuroprotective agent in a rat model of transient middle cerebral artery occlusion
Title: Fibroblast growth factor-18 reduced infarct volumes and behavioral deficits after transient occlusion of the middle cerebral artery in rats.

The following Fgf18 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Fgf18 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa04007	NM_019199.1 Latest version!	Rattus norvegicus fibroblast growth factor 18 (Fgf18), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Fgf18 ( NM_019199.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_062072.1 Rattus norvegicus fibroblast growth factor 18 (Fgf18), mRNA.

Price & Availability↑

CloneID	ORa04007
Clone ID Related Accession (Same CDS sequence)	NM_019199.1
Accession Version	NM_019199.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 624bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	fibroblast growth factor 18 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB004638.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB004638.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMEA2689602 [ECO:0000348] ##Evidence-Data-END##

ATGTATTCAG CGCCCTCCGC CTGCACTTGC CTGTGTTTAC ACTTTCTACT GCTGTGCTTC 
CAGGTTCAGG TGTTGGCAGC CGAGGAGAAC GTGGACTTCC GCATCCATGT GGAGAACCAG 
ACTCGGGCTC GCGATGATGT GAGTCGGAAG CAGCTGCGCT TGTACCAGCT CTACAGCAGG 
ACCAGTGGGA AGCACATTCA AGTCCTGGGC CGTAGGATCA GTGCCCGTGG CGAGGACGGG 
GACAAGTATG CCCAGCTCCT AGTGGAGACG GATACCTTCG GGAGTCAAGT CCGGATCAAG 
GGCAAAGAGA CAGAGTTCTA CCTGTGTATG AACCGAAAAG GCAAGCTCGT GGGGAAGCCT 
GATGGTACTA GCAAGGAGTG CGTGTTCATT GAGAAGGTTC TGGAAAACAA CTACACGGCC 
CTGATGTCAG CCAAGTACTC AGGCTGGTAC GTGGGCTTCA CCAAGAAGGG GCGGCCTCGC 
AAGGGTCCCA AGACCCGCGA AAACCAGCAA GATGTGCACT TCATGAAGCG TTACCCCAAG 
GGACAGACTG AGCTGCAGAA GCCCTTCAAG TACACCACAG TTACTAAGCG ATCCCGGCGG 
ATCCGCCCCA CTCACCCCGG CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_062072.1
CDS	1..624
Translation	MYSAPSACTCLCLHFLLLCFQVQVLAAEENVDFRIHVENQTRARDDVSRKQLRLYQLYSRTSGKHIQVLGRRISARGEDGDKYAQLLVETDTFGSQVRIKGKETEFYLCMNRKGKLVGKPDGTSKECVFIEKVLENNYTALMSAKYSGWYVGFTKKGRPRKGPKTRENQQDVHFMKRYPKGQTELQKPFKYTTVTKRSRRIRPTHPG

Target ORF information:

RefSeq Version	NM_019199.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus fibroblast growth factor 18 (Fgf18), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_019199.1

ORF Insert Sequence:

ATGTATTCAG CGCCCTCCGC CTGCACTTGC CTGTGTTTAC ACTTTCTACT GCTGTGCTTC 
CAGGTTCAGG TGTTGGCAGC CGAGGAGAAC GTGGACTTCC GCATCCATGT GGAGAACCAG 
ACTCGGGCTC GCGATGATGT GAGTCGGAAG CAGCTGCGCT TGTACCAGCT CTACAGCAGG 
ACCAGTGGGA AGCACATTCA AGTCCTGGGC CGTAGGATCA GTGCCCGTGG CGAGGACGGG 
GACAAGTATG CCCAGCTCCT AGTGGAGACG GATACCTTCG GGAGTCAAGT CCGGATCAAG 
GGCAAAGAGA CAGAGTTCTA CCTGTGTATG AACCGAAAAG GCAAGCTCGT GGGGAAGCCT 
GATGGTACTA GCAAGGAGTG CGTGTTCATT GAGAAGGTTC TGGAAAACAA CTACACGGCC 
CTGATGTCAG CCAAGTACTC AGGCTGGTAC GTGGGCTTCA CCAAGAAGGG GCGGCCTCGC 
AAGGGTCCCA AGACCCGCGA AAACCAGCAA GATGTGCACT TCATGAAGCG TTACCCCAAG 
GGACAGACTG AGCTGCAGAA GCCCTTCAAG TACACCACAG TTACTAAGCG ATCCCGGCGG 
ATCCGCCCCA CTCACCCCGG CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

MicroRNA-505 identified from patients with essential hypertension impairs endothelial cell migration and tube formation.
International journal of cardiology177(3)925-34(2014 Dec)
Yang Q,Jia C,Wang P,Xiong M,Cui J,Li L,Wang W,Wu Q,Chen Y,Zhang T

Pulmonary FGF-18 gene expression is downregulated during the canalicular-saccular stages in nitrofen-induced hypoplastic lungs.
Pediatric surgery international29(11)1199-203(2013 Nov)
Takahashi H,Friedmacher F,Fujiwara N,Hofmann A,Kutasy B,Gosemann JH,Puri P

FGF18 is required for early chondrocyte proliferation, hypertrophy and vascular invasion of the growth plate.
Developmental biology302(1)80-91(2007 Feb)
Liu Z,Lavine KJ,Hung IH,Ornitz DM

Fibroblast growth factor 16 and 18 are expressed in human cardiovascular tissues and induce on endothelial cells migration but not proliferation.
Biochemical and biophysical research communications346(1)224-33(2006 Jul)
Antoine M,Wirz W,Tag CG,Gressner AM,Wycislo M,M?ller R,Kiefer P

Structural basis by which alternative splicing modulates the organizer activity of FGF8 in the brain.
Genes & development20(2)185-98(2006 Jan)
Olsen SK,Li JY,Bromleigh C,Eliseenkova AV,Ibrahimi OA,Lao Z,Zhang F,Linhardt RJ,Joyner AL,Mohammadi M

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Fgf18 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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