FGF18 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	FGF18
Entrez Gene ID	8817
Full Name	fibroblast growth factor 18
Synonyms	FGF-18,ZFGF5
General protein information	Preferred Names fibroblast growth factor 18 Names fibroblast growth factor 18
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 5 Map Location: 5q35.1
Summary	The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. It has been shown in vitro that this protein is able to induce neurite outgrowth in PC12 cells. Studies of the similar proteins in mouse and chick suggested that this protein is a pleiotropic growth factor that stimulates proliferation in a number of tissues, most notably the liver and small intestine. Knockout studies of the similar gene in mice implied the role of this protein in regulating proliferation and differentiation of midline cerebellar structures. [provided by RefSeq, Jul 2008].
Disorder MIM:	603726

mRNA and Protein(s)

mRNA	Protein	Name
NM_003862.2	NP_003853.1	fibroblast growth factor 18 precursor
NM_003862.3	NP_003853.1	fibroblast growth factor 18 precursor

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	FGF18	XP_854425.1
Gallus gallus (chicken)	FGF18	NP_990045.1
Mus musculus (house mouse)	Fgf18	NP_032031.1
Rattus norvegicus (Norway rat)	Fgf18	NP_062072.1
Homo sapiens (human)	FGF18	NP_003853.1
Bos taurus (cattle)	FGF18	NP_001069475.1
Danio rerio (zebrafish)	fgf18a	NP_001013282.1
Danio rerio (zebrafish)	fgf18b	NP_001012379.1

Gene Ontology
Bibliography

Related articles in PubMed

Association study of FGF18 with developmental dyslexia in Chinese population.
Chen H, Zhou Y, Ge Z, Li Q, Sun Q, Zheng L, Lv H, Tan LH, Sun Y
Psychiatric genetics28(1)8-11(2018 02)

Ribosomal protein S15a promotes tumor angiogenesis via enhancing Wnt/?-catenin-induced FGF18 expression in hepatocellular carcinoma.
Guo P, Wang Y, Dai C, Tao C, Wu F, Xie X, Yu H, Zhu Q, Li J, Ye L, Yu F, Shan Y, Yu Z, Dhanasekaran R, Zheng R, Chen G
Oncogene(2017 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

FGF18 serves an essential role in the growth and migration of non-small cell lung cancer cells by regulating the ERK, p38 signaling pathways and MMP26 protein levels.
Title: Fibroblast growth factor 18 promotes proliferation and migration of H460 cells via the ERK and p38 signaling pathways.

significantly increased in endometrioid adenocarinoma
Title: Endometrial Cancer-Associated FGF18 Expression Is Reduced by Bazedoxifene in Human Endometrial Stromal Cells In Vitro and in Murine Endometrium.

FGF9 and FGF18 increased the migratory capacities of human lung fibroblasts, and FGF9 actively modulated matrix metalloproteinase activity in idiopathic pulmonary fibrosis.
Title: FGF9 and FGF18 in idiopathic pulmonary fibrosis promote survival and migration and inhibit myofibroblast differentiation of human lung fibroblasts in vitro.

Data suggest that the combination of FIGO stage, ovarian carcinoma type, and/or fibroblast growth factor 18 (FGF18) score could predict poor prognosis among ovarian carcinoma patients.
Title: FGF18 as a potential biomarker in serous and mucinous ovarian tumors.

The position of sulfate ions bound to FGF18 provides insight into the putative HS-binding site and allows comparison with the prototypical FGFs, FGF1, and FGF2.
Title: The crystal structure of fibroblast growth factor 18 (FGF18).

The following FGF18 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FGF18 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu19120	NM_003862.3 Latest version!	Homo sapiens fibroblast growth factor 18 (FGF18), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu19120	NM_003862.2	Homo sapiens fibroblast growth factor 18 (FGF18), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

FGF18 ( NM_003862.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_003853.1 Homo sapiens fibroblast growth factor 18 (FGF18), mRNA.

Price & Availability↑

CloneID	OHu19120
Clone ID Related Accession (Same CDS sequence)	NM_003862.2 , NM_003862.3
Accession Version	NM_003862.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 624bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-27
Organism	Homo sapiens(human)
Product	fibroblast growth factor 18 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF075292.1 and BQ018759.1. This sequence is a reference standard in the RefSeqGene project. On Jul 17, 2010 this sequence version replaced NM_003862.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF075292.1, BC006245.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTATTCAG CGCCCTCCGC CTGCACTTGC CTGTGTTTAC ACTTCCTGCT GCTGTGCTTC 
CAGGTACAGG TGCTGGTTGC CGAGGAGAAC GTGGACTTCC GCATCCACGT GGAGAACCAG 
ACGCGGGCTC GGGACGATGT GAGCCGTAAG CAGCTGCGGC TGTACCAGCT CTACAGCCGG 
ACCAGTGGGA AACACATCCA GGTCCTGGGC CGCAGGATCA GTGCCCGCGG CGAGGATGGG 
GACAAGTATG CCCAGCTCCT AGTGGAGACA GACACCTTCG GTAGTCAAGT CCGGATCAAG 
GGCAAGGAGA CGGAATTCTA CCTGTGCATG AACCGCAAAG GCAAGCTCGT GGGGAAGCCC 
GATGGCACCA GCAAGGAGTG TGTGTTCATC GAGAAGGTTC TGGAGAACAA CTACACGGCC 
CTGATGTCGG CTAAGTACTC CGGCTGGTAC GTGGGCTTCA CCAAGAAGGG GCGGCCGCGG 
AAGGGCCCCA AGACCCGGGA GAACCAGCAG GACGTGCATT TCATGAAGCG CTACCCCAAG 
GGGCAGCCGG AGCTTCAGAA GCCCTTCAAG TACACGACGG TGACCAAGAG GTCCCGTCGG 
ATCCGGCCCA CACACCCTGC CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003853.1
CDS	538..1161
Translation	MYSAPSACTCLCLHFLLLCFQVQVLVAEENVDFRIHVENQTRARDDVSRKQLRLYQLYSRTSGKHIQVLGRRISARGEDGDKYAQLLVETDTFGSQVRIKGKETEFYLCMNRKGKLVGKPDGTSKECVFIEKVLENNYTALMSAKYSGWYVGFTKKGRPRKGPKTRENQQDVHFMKRYPKGQPELQKPFKYTTVTKRSRRIRPTHPA

Target ORF information:

RefSeq Version	NM_003862.2
Organism	Homo sapiens(human)
Definition	Homo sapiens fibroblast growth factor 18 (FGF18), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003862.2

ORF Insert Sequence:

ATGTATTCAG CGCCCTCCGC CTGCACTTGC CTGTGTTTAC ACTTCCTGCT GCTGTGCTTC 
CAGGTACAGG TGCTGGTTGC CGAGGAGAAC GTGGACTTCC GCATCCACGT GGAGAACCAG 
ACGCGGGCTC GGGACGATGT GAGCCGTAAG CAGCTGCGGC TGTACCAGCT CTACAGCCGG 
ACCAGTGGGA AACACATCCA GGTCCTGGGC CGCAGGATCA GTGCCCGCGG CGAGGATGGG 
GACAAGTATG CCCAGCTCCT AGTGGAGACA GACACCTTCG GTAGTCAAGT CCGGATCAAG 
GGCAAGGAGA CGGAATTCTA CCTGTGCATG AACCGCAAAG GCAAGCTCGT GGGGAAGCCC 
GATGGCACCA GCAAGGAGTG TGTGTTCATC GAGAAGGTTC TGGAGAACAA CTACACGGCC 
CTGATGTCGG CTAAGTACTC CGGCTGGTAC GTGGGCTTCA CCAAGAAGGG GCGGCCGCGG 
AAGGGCCCCA AGACCCGGGA GAACCAGCAG GACGTGCATT TCATGAAGCG CTACCCCAAG 
GGGCAGCCGG AGCTTCAGAA GCCCTTCAAG TACACGACGG TGACCAAGAG GTCCCGTCGG 
ATCCGGCCCA CACACCCTGC CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FGF18 ( NM_003862.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_003853.1 Homo sapiens fibroblast growth factor 18 (FGF18), mRNA.

Price & Availability↑

CloneID	OHu19120
Clone ID Related Accession (Same CDS sequence)	NM_003862.2 , NM_003862.3
Accession Version	NM_003862.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 624bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-21
Organism	Homo sapiens(human)
Product	fibroblast growth factor 18 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC093246.3, AF075292.1 and BQ018759.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_003862.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF075292.1, BC006245.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000274625.6/ ENSP00000274625.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTATTCAG CGCCCTCCGC CTGCACTTGC CTGTGTTTAC ACTTCCTGCT GCTGTGCTTC 
CAGGTACAGG TGCTGGTTGC CGAGGAGAAC GTGGACTTCC GCATCCACGT GGAGAACCAG 
ACGCGGGCTC GGGACGATGT GAGCCGTAAG CAGCTGCGGC TGTACCAGCT CTACAGCCGG 
ACCAGTGGGA AACACATCCA GGTCCTGGGC CGCAGGATCA GTGCCCGCGG CGAGGATGGG 
GACAAGTATG CCCAGCTCCT AGTGGAGACA GACACCTTCG GTAGTCAAGT CCGGATCAAG 
GGCAAGGAGA CGGAATTCTA CCTGTGCATG AACCGCAAAG GCAAGCTCGT GGGGAAGCCC 
GATGGCACCA GCAAGGAGTG TGTGTTCATC GAGAAGGTTC TGGAGAACAA CTACACGGCC 
CTGATGTCGG CTAAGTACTC CGGCTGGTAC GTGGGCTTCA CCAAGAAGGG GCGGCCGCGG 
AAGGGCCCCA AGACCCGGGA GAACCAGCAG GACGTGCATT TCATGAAGCG CTACCCCAAG 
GGGCAGCCGG AGCTTCAGAA GCCCTTCAAG TACACGACGG TGACCAAGAG GTCCCGTCGG 
ATCCGGCCCA CACACCCTGC CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003853.1
CDS	554..1177
Translation	MYSAPSACTCLCLHFLLLCFQVQVLVAEENVDFRIHVENQTRARDDVSRKQLRLYQLYSRTSGKHIQVLGRRISARGEDGDKYAQLLVETDTFGSQVRIKGKETEFYLCMNRKGKLVGKPDGTSKECVFIEKVLENNYTALMSAKYSGWYVGFTKKGRPRKGPKTRENQQDVHFMKRYPKGQPELQKPFKYTTVTKRSRRIRPTHPA

Target ORF information:

RefSeq Version	NM_003862.3
Organism	Homo sapiens(human)
Definition	Homo sapiens fibroblast growth factor 18 (FGF18), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003862.3

ORF Insert Sequence:

ATGTATTCAG CGCCCTCCGC CTGCACTTGC CTGTGTTTAC ACTTCCTGCT GCTGTGCTTC 
CAGGTACAGG TGCTGGTTGC CGAGGAGAAC GTGGACTTCC GCATCCACGT GGAGAACCAG 
ACGCGGGCTC GGGACGATGT GAGCCGTAAG CAGCTGCGGC TGTACCAGCT CTACAGCCGG 
ACCAGTGGGA AACACATCCA GGTCCTGGGC CGCAGGATCA GTGCCCGCGG CGAGGATGGG 
GACAAGTATG CCCAGCTCCT AGTGGAGACA GACACCTTCG GTAGTCAAGT CCGGATCAAG 
GGCAAGGAGA CGGAATTCTA CCTGTGCATG AACCGCAAAG GCAAGCTCGT GGGGAAGCCC 
GATGGCACCA GCAAGGAGTG TGTGTTCATC GAGAAGGTTC TGGAGAACAA CTACACGGCC 
CTGATGTCGG CTAAGTACTC CGGCTGGTAC GTGGGCTTCA CCAAGAAGGG GCGGCCGCGG 
AAGGGCCCCA AGACCCGGGA GAACCAGCAG GACGTGCATT TCATGAAGCG CTACCCCAAG 
GGGCAGCCGG AGCTTCAGAA GCCCTTCAAG TACACGACGG TGACCAAGAG GTCCCGTCGG 
ATCCGGCCCA CACACCCTGC CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Association study of FGF18 with developmental dyslexia in Chinese population.
Psychiatric genetics28(1)8-11(2018 02)
Chen H,Zhou Y,Ge Z,Li Q,Sun Q,Zheng L,Lv H,Tan LH,Sun Y

Ribosomal protein S15a promotes tumor angiogenesis via enhancing Wnt/?-catenin-induced FGF18 expression in hepatocellular carcinoma.
Oncogene(2017 Dec)
Guo P,Wang Y,Dai C,Tao C,Wu F,Xie X,Yu H,Zhu Q,Li J,Ye L,Yu F,Shan Y,Yu Z,Dhanasekaran R,Zheng R,Chen G

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FGF18 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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