Mill1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Mill1
Entrez Gene ID	292671
Full Name	MHC I like leukocyte 1
General protein information	Preferred Names MHC I like leukocyte 1 Names MHC I like leukocyte 1 MHC class I-like located near the LRC, 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q21

mRNA and Protein(s)

mRNA	Protein	Name
XM_008758906.2	XP_008757128.1	MHC I like leukocyte 1 isoform X1
XM_008758907.2	XP_008757129.1	MHC I like leukocyte 1 isoform X1
NM_001011931.2	NP_001011931.1	MHC I like leukocyte 1 precursor

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Mill1	NP_001011931.1
Mus musculus (house mouse)	Mill1	NP_715630.3

Gene Ontology
Bibliography

Related articles in PubMed

Natural killer cell cytotoxicity is suppressed by exposure to the human NKG2D ligand MICA*008 that is shed by tumor cells in exosomes.
Ashiru O, Boutet P, Fern?ndez-Messina L, Ag?era-Gonz?lez S, Skepper JN, Val?s-G?mez M, Reyburn HT
Cancer research70(2)481-9(2010 Jan)

Tumor-associated MICA is shed by ADAM proteases.
Waldhauer I, Goehlsdorf D, Gieseke F, Weinschenk T, Wittenbrink M, Ludwig A, Stevanovic S, Rammensee HG, Steinle A
Cancer research68(15)6368-76(2008 Aug)

MHC class I-like MILL molecules are beta2-microglobulin-associated, GPI-anchored glycoproteins that do not require TAP for cell surface expression.
Kajikawa M, Baba T, Tomaru U, Watanabe Y, Koganei S, Tsuji-Kawahara S, Matsumoto N, Yamamoto K, Miyazawa M, Maenaka K, Ishizu A, Kasahara M
Journal of immunology (Baltimore, Md. : 1950)177(5)3108-15(2006 Sep)

Down-regulation of the NKG2D ligand MICA by the human cytomegalovirus glycoprotein UL142.
Chalupny NJ, Rein-Weston A, Dosch S, Cosman D
Biochemical and biophysical research communications346(1)175-81(2006 Jul)

The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor.
Gasser S, Orsulic S, Brown EJ, Raulet DH
Nature436(7054)1186-90(2005 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Mill1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mill1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa01571	NM_001011931.2 Latest version!	Rattus norvegicus MHC I like leukocyte 1 (Mill1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
ORa45049	XM_008758906.2 Latest version!	Rattus norvegicus MHC I like leukocyte 1 (Mill1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
ORa45049	XM_008758907.2 Latest version!	Rattus norvegicus MHC I like leukocyte 1 (Mill1), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Mill1 ( NM_001011931.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001011931.1 Rattus norvegicus MHC I like leukocyte 1 (Mill1), mRNA.

Price & Availability↑

CloneID	ORa01571
Clone ID Related Accession (Same CDS sequence)	NM_001011931.2
Accession Version	NM_001011931.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1215bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-18
Organism	Rattus norvegicus(Norway rat)
Product	MHC I like leukocyte 1 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AB113962.1 and AB113960.1. On Oct 8, 2005 this sequence version replaced NM_001011931.1. Sequence Note: This RefSeq record was created using sequences from two different strains, BN/SsN and WKAH/Hkm, because no single transcript from the same strain was available for the full length of the gene. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB113960.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2689601, SAMEA2689602 [ECO:0000350] ##Evidence-Data-END##

ATGATGTTGT CCAGGGACCT CAGAGCTGAA GCTGCAGTTC GGCTGTGGAT AATGTTCTTG 
CTCCTGGAGG ATTTACTGGG CGCTTGTGCA GTGGGTGACT ACCAAAGACG AGTGCCTTCT 
GCCCCCAACA CAGACATCAG GAACACTCTA GAGAAGCCTA GAGTAACCAC ACAGGAGGTA 
GCAGGACCCC ACACTCTGCG CTATGACCTC ATGGCCTTGT CTCTGAAGTT GCCTGAGTTG 
CCCCAGGTCC TGATCTGGAG ATACTTTGAT GATGAGCCCT TCCTACATTA TAATGAAAGC 
AGCAACAGAA CAGACTCCTG GGAACCTAGG ATCAAGAGAC ATTGGAGAGC TATGACTTGG 
GCAAGAGAGA CTGAGGATCT GCAGGAAATG GTGGAGCAAC TCAAAAGGAT GCTAGCTGAG 
GTCACAGGCC AGAAAGGCCA AGATAAGGGC CTTCACATCC TCCAGGCAAC CCTGGGCTGT 
GAGCTTCAAA GAAATGGAAG CACTAGAGGC TTCTGGCACC TGGGCTATGA CGGGCGGAAC 
CTCCTCACCT TCGACCAGAA GACTCTCACA TGGACAATGG ATATGCCCTT CACCCAGCAG 
AAGAAGACGT TCTGGGAGCC ACGTGCACCC AGGGCTGACC TAGTTAAGAC GTTCTTGGAT 
GACACATGTC CTGCTCAGCT CCAGAGACAT CTGGCTTCCT TGAGAAGTGA ACCACTTGAC 
ACAGGTTCCC CGATGGTGAT CGTGACCTTC AGGAATTATC CACTGGGCAG GGTCACACTG 
ACATGCCGGG CTTTTAATCT GTATCCCCAT ATGGCCACCA GGGGCACCCT GGCCTGGCTT 
CAGGATAGGA AGCTGGTAAA GCAGAAAGCT TTTGAGCCAG GGACCATCTT GCCCAGTGGG 
GACAGGACCT ACCAGATCTG GGTGTCCATT TGGGTTCTTC CTGGACAGGA ACCACAGTTC 
ACCTGTAATC TGAGTTACCA TGGTGGCAAC ATAGAGAAGC GTGCTGTTAT TGTGAACACT 
GTCTCTGGTG AGAAAACAAG ACAACCTTCC ACCTCAGGTG TGGGAGGCAG GGTCAAGAAA 
AGCCTGTGGA CTACAATGAC CACAGCTTTT ATGGTGACCT CCTGGACCAG GAAAACTGGT 
GGGGACTCCA CTCTGCTTCT GCTCTGGTGG CTTCTGTTCT TTTCTACAGT GTTGGCAGTT 
CTGACCCTCG TCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001011931.1
CDS	28..1242
Translation	MMLSRDLRAEAAVRLWIMFLLLEDLLGACAVGDYQRRVPSAPNTDIRNTLEKPRVTTQEVAGPHTLRYDLMALSLKLPELPQVLIWRYFDDEPFLHYNESSNRTDSWEPRIKRHWRAMTWARETEDLQEMVEQLKRMLAEVTGQKGQDKGLHILQATLGCELQRNGSTRGFWHLGYDGRNLLTFDQKTLTWTMDMPFTQQKKTFWEPRAPRADLVKTFLDDTCPAQLQRHLASLRSEPLDTGSPMVIVTFRNYPLGRVTLTCRAFNLYPHMATRGTLAWLQDRKLVKQKAFEPGTILPSGDRTYQIWVSIWVLPGQEPQFTCNLSYHGGNIEKRAVIVNTVSGEKTRQPSTSGVGGRVKKSLWTTMTTAFMVTSWTRKTGGDSTLLLLWWLLFFSTVLAVLTLV

Target ORF information:

RefSeq Version	NM_001011931.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus MHC I like leukocyte 1 (Mill1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001011931.2

ORF Insert Sequence:

ATGATGTTGT CCAGGGACCT CAGAGCTGAA GCTGCAGTTC GGCTGTGGAT AATGTTCTTG 
CTCCTGGAGG ATTTACTGGG CGCTTGTGCA GTGGGTGACT ACCAAAGACG AGTGCCTTCT 
GCCCCCAACA CAGACATCAG GAACACTCTA GAGAAGCCTA GAGTAACCAC ACAGGAGGTA 
GCAGGACCCC ACACTCTGCG CTATGACCTC ATGGCCTTGT CTCTGAAGTT GCCTGAGTTG 
CCCCAGGTCC TGATCTGGAG ATACTTTGAT GATGAGCCCT TCCTACATTA TAATGAAAGC 
AGCAACAGAA CAGACTCCTG GGAACCTAGG ATCAAGAGAC ATTGGAGAGC TATGACTTGG 
GCAAGAGAGA CTGAGGATCT GCAGGAAATG GTGGAGCAAC TCAAAAGGAT GCTAGCTGAG 
GTCACAGGCC AGAAAGGCCA AGATAAGGGC CTTCACATCC TCCAGGCAAC CCTGGGCTGT 
GAGCTTCAAA GAAATGGAAG CACTAGAGGC TTCTGGCACC TGGGCTATGA CGGGCGGAAC 
CTCCTCACCT TCGACCAGAA GACTCTCACA TGGACAATGG ATATGCCCTT CACCCAGCAG 
AAGAAGACGT TCTGGGAGCC ACGTGCACCC AGGGCTGACC TAGTTAAGAC GTTCTTGGAT 
GACACATGTC CTGCTCAGCT CCAGAGACAT CTGGCTTCCT TGAGAAGTGA ACCACTTGAC 
ACAGGTTCCC CGATGGTGAT CGTGACCTTC AGGAATTATC CACTGGGCAG GGTCACACTG 
ACATGCCGGG CTTTTAATCT GTATCCCCAT ATGGCCACCA GGGGCACCCT GGCCTGGCTT 
CAGGATAGGA AGCTGGTAAA GCAGAAAGCT TTTGAGCCAG GGACCATCTT GCCCAGTGGG 
GACAGGACCT ACCAGATCTG GGTGTCCATT TGGGTTCTTC CTGGACAGGA ACCACAGTTC 
ACCTGTAATC TGAGTTACCA TGGTGGCAAC ATAGAGAAGC GTGCTGTTAT TGTGAACACT 
GTCTCTGGTG AGAAAACAAG ACAACCTTCC ACCTCAGGTG TGGGAGGCAG GGTCAAGAAA 
AGCCTGTGGA CTACAATGAC CACAGCTTTT ATGGTGACCT CCTGGACCAG GAAAACTGGT 
GGGGACTCCA CTCTGCTTCT GCTCTGGTGG CTTCTGTTCT TTTCTACAGT GTTGGCAGTT 
CTGACCCTCG TCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Mill1 ( XM_008758906.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008757128.1 Rattus norvegicus MHC I like leukocyte 1 (Mill1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa45049
Clone ID Related Accession (Same CDS sequence)	XM_008758906.2 , XM_008758907.2
Accession Version	XM_008758906.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1215bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	MHC I like leukocyte 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008758906.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGATGTTGT CCAGGGACCT CAGAGCTGAA GCTGCAGTTC GGCTGTGGAT AATGTTCTTG 
CTCCTGGAGG ATTTACTGGG CGCTTGTGCA GTGGGTGACT ACCAAAGACG AGTGCCTTCT 
GCCCCCAACA CAGACATCAG GAACACTCTA GAGAAGCCTA GAGTAACCAC ACAGGAGGTA 
GCAGGACCCC ACACTCTGCG CTATGACCTC ATGGCCTTGT CTCTGAAGTT GCCTGAGTTG 
CCCCAGGTCC TGATCTGGAG ATACTTTGAT GATGAGCCCT TCCTACATTA TAATGAAAGC 
AGCAACAGAA CAGACTCCTG GGAACCTAGG ATCAAGAGAC ATTGGAGAGC TATGACTTGG 
GCAAGAGAGA CTGAGGATCT GCAGGAAATG GTGGAGCAAC TCAAAAGGAT GCTAGCTGAG 
GTCACAGGCC AGAAAGGCCA AGATAAGGGC CTTCACATCC TCCAGGCAAC CCTGGGCTGT 
GAGCTTCAAA GAAATGGAAG CACTAGAGGC TTCTGGCACC TGGGCTATGA CGGGCGGAAC 
CTCCTCACCT TCGACCAGAA GACTCTCACA TGGACAATGG ATATGCCCTT CACCCAGCAG 
AAGAAGACGT TCTGGGAGCC ACGTGCACCC AGGGCTGACC TAGTTAAGAC GTTCTTGGAT 
GACACATGTC CTGCTCAGCT CCAGAGACAT CTGGCTTCCT TGAGAAGTGA ACCACTTGAC 
ACAGGTTCCC CGATGGTGAT CGTGACCTTC AGGAATTATC CACTGGGCAG GGTCACACTG 
ACATGCCGGG CTTTTAATCT GTATCCCCAT ATGGCCACCA GGGGCACCCT GGCCTGGCTT 
CAGGATAGGA AGCTGGTAAA GCAGAAAGCT TTTGAACCAG GGACCATCTT GCCCAGTGGG 
GACAGGACCT ACCAGATCTG GGTGTCCATT TGGGTTCTTC CTGGACAGGA ACCACAGTTC 
ACCTGTAATC TGAGTTACCA TGGTGGCAAC ATAGAGAAGC GTGCTGTTAT TGTGAACACT 
GTCTCTGGTG AGAAAACAAG ACAACCTTCC ACCTCAGGTG TGGGAGGCAG GGTCAAGAAA 
AGCCTGTGGA CTACAATGAC CACAGCTTTT ATGGTGACCT CCTGGACCAG GAAAACTGGT 
GGGGACTCCA CTCTGCTTCT GCTCTGGTGG CTTCTGTTCT TTTCTACAGT GTTGGCAGTT 
CTGACCCTCG TCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008757128.1
CDS	98..1312
Translation	MMLSRDLRAEAAVRLWIMFLLLEDLLGACAVGDYQRRVPSAPNTDIRNTLEKPRVTTQEVAGPHTLRYDLMALSLKLPELPQVLIWRYFDDEPFLHYNESSNRTDSWEPRIKRHWRAMTWARETEDLQEMVEQLKRMLAEVTGQKGQDKGLHILQATLGCELQRNGSTRGFWHLGYDGRNLLTFDQKTLTWTMDMPFTQQKKTFWEPRAPRADLVKTFLDDTCPAQLQRHLASLRSEPLDTGSPMVIVTFRNYPLGRVTLTCRAFNLYPHMATRGTLAWLQDRKLVKQKAFEPGTILPSGDRTYQIWVSIWVLPGQEPQFTCNLSYHGGNIEKRAVIVNTVSGEKTRQPSTSGVGGRVKKSLWTTMTTAFMVTSWTRKTGGDSTLLLLWWLLFFSTVLAVLTLV

Target ORF information:

RefSeq Version	XM_008758906.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus MHC I like leukocyte 1 (Mill1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008758906.2

ORF Insert Sequence:

ATGATGTTGT CCAGGGACCT CAGAGCTGAA GCTGCAGTTC GGCTGTGGAT AATGTTCTTG 
CTCCTGGAGG ATTTACTGGG CGCTTGTGCA GTGGGTGACT ACCAAAGACG AGTGCCTTCT 
GCCCCCAACA CAGACATCAG GAACACTCTA GAGAAGCCTA GAGTAACCAC ACAGGAGGTA 
GCAGGACCCC ACACTCTGCG CTATGACCTC ATGGCCTTGT CTCTGAAGTT GCCTGAGTTG 
CCCCAGGTCC TGATCTGGAG ATACTTTGAT GATGAGCCCT TCCTACATTA TAATGAAAGC 
AGCAACAGAA CAGACTCCTG GGAACCTAGG ATCAAGAGAC ATTGGAGAGC TATGACTTGG 
GCAAGAGAGA CTGAGGATCT GCAGGAAATG GTGGAGCAAC TCAAAAGGAT GCTAGCTGAG 
GTCACAGGCC AGAAAGGCCA AGATAAGGGC CTTCACATCC TCCAGGCAAC CCTGGGCTGT 
GAGCTTCAAA GAAATGGAAG CACTAGAGGC TTCTGGCACC TGGGCTATGA CGGGCGGAAC 
CTCCTCACCT TCGACCAGAA GACTCTCACA TGGACAATGG ATATGCCCTT CACCCAGCAG 
AAGAAGACGT TCTGGGAGCC ACGTGCACCC AGGGCTGACC TAGTTAAGAC GTTCTTGGAT 
GACACATGTC CTGCTCAGCT CCAGAGACAT CTGGCTTCCT TGAGAAGTGA ACCACTTGAC 
ACAGGTTCCC CGATGGTGAT CGTGACCTTC AGGAATTATC CACTGGGCAG GGTCACACTG 
ACATGCCGGG CTTTTAATCT GTATCCCCAT ATGGCCACCA GGGGCACCCT GGCCTGGCTT 
CAGGATAGGA AGCTGGTAAA GCAGAAAGCT TTTGAACCAG GGACCATCTT GCCCAGTGGG 
GACAGGACCT ACCAGATCTG GGTGTCCATT TGGGTTCTTC CTGGACAGGA ACCACAGTTC 
ACCTGTAATC TGAGTTACCA TGGTGGCAAC ATAGAGAAGC GTGCTGTTAT TGTGAACACT 
GTCTCTGGTG AGAAAACAAG ACAACCTTCC ACCTCAGGTG TGGGAGGCAG GGTCAAGAAA 
AGCCTGTGGA CTACAATGAC CACAGCTTTT ATGGTGACCT CCTGGACCAG GAAAACTGGT 
GGGGACTCCA CTCTGCTTCT GCTCTGGTGG CTTCTGTTCT TTTCTACAGT GTTGGCAGTT 
CTGACCCTCG TCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Mill1 ( XM_008758907.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008757129.1 Rattus norvegicus MHC I like leukocyte 1 (Mill1), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa45049
Clone ID Related Accession (Same CDS sequence)	XM_008758906.2 , XM_008758907.2
Accession Version	XM_008758907.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1215bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	MHC I like leukocyte 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008758907.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGATGTTGT CCAGGGACCT CAGAGCTGAA GCTGCAGTTC GGCTGTGGAT AATGTTCTTG 
CTCCTGGAGG ATTTACTGGG CGCTTGTGCA GTGGGTGACT ACCAAAGACG AGTGCCTTCT 
GCCCCCAACA CAGACATCAG GAACACTCTA GAGAAGCCTA GAGTAACCAC ACAGGAGGTA 
GCAGGACCCC ACACTCTGCG CTATGACCTC ATGGCCTTGT CTCTGAAGTT GCCTGAGTTG 
CCCCAGGTCC TGATCTGGAG ATACTTTGAT GATGAGCCCT TCCTACATTA TAATGAAAGC 
AGCAACAGAA CAGACTCCTG GGAACCTAGG ATCAAGAGAC ATTGGAGAGC TATGACTTGG 
GCAAGAGAGA CTGAGGATCT GCAGGAAATG GTGGAGCAAC TCAAAAGGAT GCTAGCTGAG 
GTCACAGGCC AGAAAGGCCA AGATAAGGGC CTTCACATCC TCCAGGCAAC CCTGGGCTGT 
GAGCTTCAAA GAAATGGAAG CACTAGAGGC TTCTGGCACC TGGGCTATGA CGGGCGGAAC 
CTCCTCACCT TCGACCAGAA GACTCTCACA TGGACAATGG ATATGCCCTT CACCCAGCAG 
AAGAAGACGT TCTGGGAGCC ACGTGCACCC AGGGCTGACC TAGTTAAGAC GTTCTTGGAT 
GACACATGTC CTGCTCAGCT CCAGAGACAT CTGGCTTCCT TGAGAAGTGA ACCACTTGAC 
ACAGGTTCCC CGATGGTGAT CGTGACCTTC AGGAATTATC CACTGGGCAG GGTCACACTG 
ACATGCCGGG CTTTTAATCT GTATCCCCAT ATGGCCACCA GGGGCACCCT GGCCTGGCTT 
CAGGATAGGA AGCTGGTAAA GCAGAAAGCT TTTGAACCAG GGACCATCTT GCCCAGTGGG 
GACAGGACCT ACCAGATCTG GGTGTCCATT TGGGTTCTTC CTGGACAGGA ACCACAGTTC 
ACCTGTAATC TGAGTTACCA TGGTGGCAAC ATAGAGAAGC GTGCTGTTAT TGTGAACACT 
GTCTCTGGTG AGAAAACAAG ACAACCTTCC ACCTCAGGTG TGGGAGGCAG GGTCAAGAAA 
AGCCTGTGGA CTACAATGAC CACAGCTTTT ATGGTGACCT CCTGGACCAG GAAAACTGGT 
GGGGACTCCA CTCTGCTTCT GCTCTGGTGG CTTCTGTTCT TTTCTACAGT GTTGGCAGTT 
CTGACCCTCG TCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008757129.1
CDS	116..1330
Translation	MMLSRDLRAEAAVRLWIMFLLLEDLLGACAVGDYQRRVPSAPNTDIRNTLEKPRVTTQEVAGPHTLRYDLMALSLKLPELPQVLIWRYFDDEPFLHYNESSNRTDSWEPRIKRHWRAMTWARETEDLQEMVEQLKRMLAEVTGQKGQDKGLHILQATLGCELQRNGSTRGFWHLGYDGRNLLTFDQKTLTWTMDMPFTQQKKTFWEPRAPRADLVKTFLDDTCPAQLQRHLASLRSEPLDTGSPMVIVTFRNYPLGRVTLTCRAFNLYPHMATRGTLAWLQDRKLVKQKAFEPGTILPSGDRTYQIWVSIWVLPGQEPQFTCNLSYHGGNIEKRAVIVNTVSGEKTRQPSTSGVGGRVKKSLWTTMTTAFMVTSWTRKTGGDSTLLLLWWLLFFSTVLAVLTLV

Target ORF information:

RefSeq Version	XM_008758907.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus MHC I like leukocyte 1 (Mill1), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008758907.2

ORF Insert Sequence:

ATGATGTTGT CCAGGGACCT CAGAGCTGAA GCTGCAGTTC GGCTGTGGAT AATGTTCTTG 
CTCCTGGAGG ATTTACTGGG CGCTTGTGCA GTGGGTGACT ACCAAAGACG AGTGCCTTCT 
GCCCCCAACA CAGACATCAG GAACACTCTA GAGAAGCCTA GAGTAACCAC ACAGGAGGTA 
GCAGGACCCC ACACTCTGCG CTATGACCTC ATGGCCTTGT CTCTGAAGTT GCCTGAGTTG 
CCCCAGGTCC TGATCTGGAG ATACTTTGAT GATGAGCCCT TCCTACATTA TAATGAAAGC 
AGCAACAGAA CAGACTCCTG GGAACCTAGG ATCAAGAGAC ATTGGAGAGC TATGACTTGG 
GCAAGAGAGA CTGAGGATCT GCAGGAAATG GTGGAGCAAC TCAAAAGGAT GCTAGCTGAG 
GTCACAGGCC AGAAAGGCCA AGATAAGGGC CTTCACATCC TCCAGGCAAC CCTGGGCTGT 
GAGCTTCAAA GAAATGGAAG CACTAGAGGC TTCTGGCACC TGGGCTATGA CGGGCGGAAC 
CTCCTCACCT TCGACCAGAA GACTCTCACA TGGACAATGG ATATGCCCTT CACCCAGCAG 
AAGAAGACGT TCTGGGAGCC ACGTGCACCC AGGGCTGACC TAGTTAAGAC GTTCTTGGAT 
GACACATGTC CTGCTCAGCT CCAGAGACAT CTGGCTTCCT TGAGAAGTGA ACCACTTGAC 
ACAGGTTCCC CGATGGTGAT CGTGACCTTC AGGAATTATC CACTGGGCAG GGTCACACTG 
ACATGCCGGG CTTTTAATCT GTATCCCCAT ATGGCCACCA GGGGCACCCT GGCCTGGCTT 
CAGGATAGGA AGCTGGTAAA GCAGAAAGCT TTTGAACCAG GGACCATCTT GCCCAGTGGG 
GACAGGACCT ACCAGATCTG GGTGTCCATT TGGGTTCTTC CTGGACAGGA ACCACAGTTC 
ACCTGTAATC TGAGTTACCA TGGTGGCAAC ATAGAGAAGC GTGCTGTTAT TGTGAACACT 
GTCTCTGGTG AGAAAACAAG ACAACCTTCC ACCTCAGGTG TGGGAGGCAG GGTCAAGAAA 
AGCCTGTGGA CTACAATGAC CACAGCTTTT ATGGTGACCT CCTGGACCAG GAAAACTGGT 
GGGGACTCCA CTCTGCTTCT GCTCTGGTGG CTTCTGTTCT TTTCTACAGT GTTGGCAGTT 
CTGACCCTCG TCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Natural killer cell cytotoxicity is suppressed by exposure to the human NKG2D ligand MICA*008 that is shed by tumor cells in exosomes.
Cancer research70(2)481-9(2010 Jan)
Ashiru O,Boutet P,Fern?ndez-Messina L,Ag?era-Gonz?lez S,Skepper JN,Val?s-G?mez M,Reyburn HT

Tumor-associated MICA is shed by ADAM proteases.
Cancer research68(15)6368-76(2008 Aug)
Waldhauer I,Goehlsdorf D,Gieseke F,Weinschenk T,Wittenbrink M,Ludwig A,Stevanovic S,Rammensee HG,Steinle A

MHC class I-like MILL molecules are beta2-microglobulin-associated, GPI-anchored glycoproteins that do not require TAP for cell surface expression.
Journal of immunology (Baltimore, Md. : 1950)177(5)3108-15(2006 Sep)
Kajikawa M,Baba T,Tomaru U,Watanabe Y,Koganei S,Tsuji-Kawahara S,Matsumoto N,Yamamoto K,Miyazawa M,Maenaka K,Ishizu A,Kasahara M

Down-regulation of the NKG2D ligand MICA by the human cytomegalovirus glycoprotein UL142.
Biochemical and biophysical research communications346(1)175-81(2006 Jul)
Chalupny NJ,Rein-Weston A,Dosch S,Cosman D

The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor.
Nature436(7054)1186-90(2005 Aug)
Gasser S,Orsulic S,Brown EJ,Raulet DH

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Mill1 cDNA ORF clone, Rattus norvegicus(Norway rat)

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