Vnn1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Vnn1
Entrez Gene ID	29142
Full Name	vanin 1
Synonyms	Tiff66
General protein information	Preferred Names vanin 1 Names pantetheinase
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1p12

mRNA and Protein(s)

mRNA	Protein	Name
NM_001025623.1	NP_001020794.1	pantetheinase precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	VNN1	XP_001169280.1
Mus musculus (house mouse)	Vnn1	NP_035834.2
Xenopus tropicalis (tropical clawed frog)	vnn1	XP_004914646.1
Homo sapiens (human)	VNN1	NP_004657.2
Rattus norvegicus (Norway rat)	Vnn1	NP_001020794.1
Gallus gallus (chicken)	VNN1	NP_001034377.1
Canis lupus familiaris (dog)	VNN1	NP_001003372.1
Bos taurus (cattle)	VNN1	NP_001019727.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP012357	XP_320200.4
Xenopus tropicalis (tropical clawed frog)	vnn2	NP_001011263.1
	VNN1	XP_001102153.1

Gene Ontology
Bibliography

Related articles in PubMed

Pharmacological Inhibition of Vanin Activity Attenuates Transplant Vasculopathy in Rat Aortic Allografts.
Wedel J, Jansen PA, Botman PN, Rutjes FP, Schalkwijk J, Hillebrands JL
Transplantation100(8)1656-66(2016 08)

Genetic and pharmacological inhibition of vanin-1 activity in animal models of type 2 diabetes.
van Diepen JA, Jansen PA, Ballak DB, Hijmans A, Rutjes FP, Tack CJ, Netea MG, Schalkwijk J, Stienstra R
Scientific reports621906(2016 Mar)

The structure of vanin 1: a key enzyme linking metabolic disease and inflammation.
Boersma YL, Newman J, Adams TE, Cowieson N, Krippner G, Bozaoglu K, Peat TS
Acta crystallographica. Section D, Biological crystallography70(Pt 12)3320-9(2014 Dec)

Lipid-induced toxicity stimulates hepatocytes to release angiogenic microparticles that require Vanin-1 for uptake by endothelial cells.
Povero D, Eguchi A, Niesman IR, Andronikou N, de Mollerat du Jeu X, Mulya A, Berk M, Lazic M, Thapaliya S, Parola M, Patel HH, Feldstein AE
Science signaling6(296)ra88(2013 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Pharmacological inhibition of vanin activity attenuates development of transplant vasculopathy. This was accompanied by reduced macrophage infiltration and increased glutathione-synthesizing capacity.
Title: Pharmacological Inhibition of Vanin Activity Attenuates Transplant Vasculopathy in Rat Aortic Allografts.

absence of vanin-1 activity improves insulin sensitivity.
Title: Genetic and pharmacological inhibition of vanin-1 activity in animal models of type 2 diabetes.

Microparticle internalization required the interaction of the ectoenzyme Vanin-1 (VNN1), an abundant surface protein on the microparticles, with lipid raft domains of endothelial cells.
Title: Lipid-induced toxicity stimulates hepatocytes to release angiogenic microparticles that require Vanin-1 for uptake by endothelial cells.

Results suggest that, compared with urinary Kim-1 and neutrophil gelatinase-associated lipocalin, urinary vanin-1 is an earlier and equally sensitive biomarker for drug-induced acute kidney injury.
Title: Urinary vanin-1 as a novel biomarker for early detection of drug-induced acute kidney injury.

Proteomic-based study identifies vanin-1 as a marker of kidney damage in a rat model of type 1 diabetic nephropathy.
Title: Proteomic identification of vanin-1 as a marker of kidney damage in a rat model of type 1 diabetic nephropathy.

The following Vnn1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Vnn1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa13246	NM_001025623.1 Latest version!	Rattus norvegicus vanin 1 (Vnn1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$300.30 $429.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Vnn1 ( NM_001025623.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001020794.1 Rattus norvegicus vanin 1 (Vnn1), mRNA.

Price & Availability↑

CloneID	ORa13246
Clone ID Related Accession (Same CDS sequence)	NM_001025623.1
Accession Version	NM_001025623.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1539bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-01-26
Organism	Rattus norvegicus(Norway rat)
Product	pantetheinase precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC098934.1. On Jul 22, 2005 this sequence version replaced XM_215293.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC098934.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01906357 [ECO:0000348] ##Evidence-Data-END##

ATGAGCCTGT CTCGGTGGCT GGCGTGGGCT GCAGCGTTTT CCGTCTTCTG TGTCTTAAAA 
GTCAGCTCTC TGGACACTTT CCTCGCAGCT GTTTACGAGC ATGCTGTGAT CCTGCCTAAA 
GTCACCCTGT TACCTGTGTC TCACAGTGAG GCACTGGCAT TAATGAACCA GAATCTGGAC 
CTTCTGGAAG GAGCGATCTT ATCAGCAGCT AAGCAGGGTG CGCACATTAT TGTGACTCCA 
GAAGATGGTA TATACGGTGT GCAGTTCACC AGGGATACCA TCTACCCATA CCTGGAGGAT 
ATCCCAGACC CTCAAGTAAA CTGGATACCC TGTGATAATC CGGAAAGATT TGGCTCTACC 
CCGGTGCAGG AGAGACTCAG CTGCTTGGCC AAGAACAACT CAATCTATGT CGTGGCGAAC 
ATGGGAGACA AGAAGCCATG CAACACCAGC GACTCTCACT GTCCACCTGA CGGCCGATTC 
CAATACAACA CTGATGTGGT GTTTGATTCC CGGGGTAAAT TGGTTGCCAG ATACCATAAG 
CAAAACCTTT TCATGGGAGA AGAGCAATTC AATGCCCCCC CGGAGCCTGA GGTCGTGACT 
TTTGACACCC CCTTTGGAAA GTTTGGCATC TTCACCTGTT TCGATATTCT CTTCCATGAT 
CCTGCTGTCA CCCTAGTGAC AGAGTTCCAG GTGGACACCA TACTGTTCCC AACTGCCTGG 
ATGGACGTGC TTCCTCATTT GGCAGCCATT GAATTCCACT CAGCTTGGGC TATAGGCATG 
GGAGTCAATT TCCTAGCAGC TAATCTACAT ATTCCCTTGA GGAGAATGAC AGGAAGTGGT 
ATCTATGCAC CCGATTCTCC ACGGGCCTTT CATTATGACA GGAAGACACA GGAAGGAAAG 
CTCCTCCTTG CACAGCTGGA CTCTCACCCG AGTCACTCCC CAGTGAACTG GACTTCCTAT 
GCCAGCAGTG TAGAAGCACC CCCAACTGAA AAGGAGGAAT TTCGGAGTTT TGTTTTCTTT 
GATGAGTTTA CCTTTGTGGA GCTCAAAGGG ATCACAGGAA ATTACACTGT TTGCCAGAAC 
GACCTCTGCT GTCATCTAAG CTACCAGATG TCTGAGAAGC GAGCTGATGA AGTTTATGCT 
CTTGGGGCTT TTGACGGGTT GCACACCGTG GAAGGGCAGT ATCACCTGCA GATTTGCATT 
CTGCTAAAGT GTAAAACTAC CAATTTACGC ACCTGTGGTA GTTCAGTGGA CACAGCTTCT 
ACCAGGTTTG AAATGTTCTC CCTCAGTGGC ACTTTTGGAA CGCGGTATGT CTTCCCTGAG 
GTGTTGCTGA GTGAAGTCAA GCTTGCTCCT GGGGAGTTTC AGGTGTTGAG TGACGGGCGC 
CTGGTTAGCC TGAAGCCAAC GTCTGGACCT GTGTTAACAG TCGGTCTCTT TGGGAGGTTG 
TATGAGAAGG ACTGGGCATC AAATGCTTCC TCAGACCTCA TAGCACACTC ACTGATAATA 
ATGCTGATCC TAGCTCCTAT TATACATTAC TTGTGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001020794.1
CDS	131..1669
Translation	MSLSRWLAWAAAFSVFCVLKVSSLDTFLAAVYEHAVILPKVTLLPVSHSEALALMNQNLDLLEGAILSAAKQGAHIIVTPEDGIYGVQFTRDTIYPYLEDIPDPQVNWIPCDNPERFGSTPVQERLSCLAKNNSIYVVANMGDKKPCNTSDSHCPPDGRFQYNTDVVFDSRGKLVARYHKQNLFMGEEQFNAPPEPEVVTFDTPFGKFGIFTCFDILFHDPAVTLVTEFQVDTILFPTAWMDVLPHLAAIEFHSAWAIGMGVNFLAANLHIPLRRMTGSGIYAPDSPRAFHYDRKTQEGKLLLAQLDSHPSHSPVNWTSYASSVEAPPTEKEEFRSFVFFDEFTFVELKGITGNYTVCQNDLCCHLSYQMSEKRADEVYALGAFDGLHTVEGQYHLQICILLKCKTTNLRTCGSSVDTASTRFEMFSLSGTFGTRYVFPEVLLSEVKLAPGEFQVLSDGRLVSLKPTSGPVLTVGLFGRLYEKDWASNASSDLIAHSLIIMLILAPIIHYLC

Target ORF information:

RefSeq Version	NM_001025623.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus vanin 1 (Vnn1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001025623.1

ORF Insert Sequence:

ATGAGCCTGT CTCGGTGGCT GGCGTGGGCT GCAGCGTTTT CCGTCTTCTG TGTCTTAAAA 
GTCAGCTCTC TGGACACTTT CCTCGCAGCT GTTTACGAGC ATGCTGTGAT CCTGCCTAAA 
GTCACCCTGT TACCTGTGTC TCACAGTGAG GCACTGGCAT TAATGAACCA GAATCTGGAC 
CTTCTGGAAG GAGCGATCTT ATCAGCAGCT AAGCAGGGTG CGCACATTAT TGTGACTCCA 
GAAGATGGTA TATACGGTGT GCAGTTCACC AGGGATACCA TCTACCCATA CCTGGAGGAT 
ATCCCAGACC CTCAAGTAAA CTGGATACCC TGTGATAATC CGGAAAGATT TGGCTCTACC 
CCGGTGCAGG AGAGACTCAG CTGCTTGGCC AAGAACAACT CAATCTATGT CGTGGCGAAC 
ATGGGAGACA AGAAGCCATG CAACACCAGC GACTCTCACT GTCCACCTGA CGGCCGATTC 
CAATACAACA CTGATGTGGT GTTTGATTCC CGGGGTAAAT TGGTTGCCAG ATACCATAAG 
CAAAACCTTT TCATGGGAGA AGAGCAATTC AATGCCCCCC CGGAGCCTGA GGTCGTGACT 
TTTGACACCC CCTTTGGAAA GTTTGGCATC TTCACCTGTT TCGATATTCT CTTCCATGAT 
CCTGCTGTCA CCCTAGTGAC AGAGTTCCAG GTGGACACCA TACTGTTCCC AACTGCCTGG 
ATGGACGTGC TTCCTCATTT GGCAGCCATT GAATTCCACT CAGCTTGGGC TATAGGCATG 
GGAGTCAATT TCCTAGCAGC TAATCTACAT ATTCCCTTGA GGAGAATGAC AGGAAGTGGT 
ATCTATGCAC CCGATTCTCC ACGGGCCTTT CATTATGACA GGAAGACACA GGAAGGAAAG 
CTCCTCCTTG CACAGCTGGA CTCTCACCCG AGTCACTCCC CAGTGAACTG GACTTCCTAT 
GCCAGCAGTG TAGAAGCACC CCCAACTGAA AAGGAGGAAT TTCGGAGTTT TGTTTTCTTT 
GATGAGTTTA CCTTTGTGGA GCTCAAAGGG ATCACAGGAA ATTACACTGT TTGCCAGAAC 
GACCTCTGCT GTCATCTAAG CTACCAGATG TCTGAGAAGC GAGCTGATGA AGTTTATGCT 
CTTGGGGCTT TTGACGGGTT GCACACCGTG GAAGGGCAGT ATCACCTGCA GATTTGCATT 
CTGCTAAAGT GTAAAACTAC CAATTTACGC ACCTGTGGTA GTTCAGTGGA CACAGCTTCT 
ACCAGGTTTG AAATGTTCTC CCTCAGTGGC ACTTTTGGAA CGCGGTATGT CTTCCCTGAG 
GTGTTGCTGA GTGAAGTCAA GCTTGCTCCT GGGGAGTTTC AGGTGTTGAG TGACGGGCGC 
CTGGTTAGCC TGAAGCCAAC GTCTGGACCT GTGTTAACAG TCGGTCTCTT TGGGAGGTTG 
TATGAGAAGG ACTGGGCATC AAATGCTTCC TCAGACCTCA TAGCACACTC ACTGATAATA 
ATGCTGATCC TAGCTCCTAT TATACATTAC TTGTGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Pharmacological Inhibition of Vanin Activity Attenuates Transplant Vasculopathy in Rat Aortic Allografts.
Transplantation100(8)1656-66(2016 08)
Wedel J,Jansen PA,Botman PN,Rutjes FP,Schalkwijk J,Hillebrands JL

Genetic and pharmacological inhibition of vanin-1 activity in animal models of type 2 diabetes.
Scientific reports621906(2016 Mar)
van Diepen JA,Jansen PA,Ballak DB,Hijmans A,Rutjes FP,Tack CJ,Netea MG,Schalkwijk J,Stienstra R

The structure of vanin 1: a key enzyme linking metabolic disease and inflammation.
Acta crystallographica. Section D, Biological crystallography70(Pt 12)3320-9(2014 Dec)
Boersma YL,Newman J,Adams TE,Cowieson N,Krippner G,Bozaoglu K,Peat TS

Lipid-induced toxicity stimulates hepatocytes to release angiogenic microparticles that require Vanin-1 for uptake by endothelial cells.
Science signaling6(296)ra88(2013 Oct)
Povero D,Eguchi A,Niesman IR,Andronikou N,de Mollerat du Jeu X,Mulya A,Berk M,Lazic M,Thapaliya S,Parola M,Patel HH,Feldstein AE

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Vnn1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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