VNN1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	VNN1
Entrez Gene ID	8876
Full Name	vanin 1
Synonyms	HDLCQ8,Tiff66
General protein information	Preferred Names vanin 1 Names pantetheinase pantetheine hydrolase vannin 1 vascular non-inflammatory molecule 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6q23.2
Summary	This gene encodes a member of the vanin family of proteins, which share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. This protein, like its mouse homolog, is likely a GPI-anchored cell surface molecule. The mouse protein is expressed by the perivascular thymic stromal cells and regulates migration of T-cell progenitors to the thymus. This gene lies in close proximity to, and in the same transcriptional orientation as, two other vanin genes on chromosome 6q23-q24. [provided by RefSeq, Feb 2009].
Disorder MIM:	603570
Disorder Html:	[High density lipoprotein cholesterol level QTL 8] (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_004666.2	NP_004657.2	pantetheinase precursor
NM_004666.3	NP_004657.2	pantetheinase precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	VNN1	XP_001169280.1
Mus musculus (house mouse)	Vnn1	NP_035834.2
Xenopus tropicalis (tropical clawed frog)	vnn1	XP_004914646.1
Homo sapiens (human)	VNN1	NP_004657.2
Rattus norvegicus (Norway rat)	Vnn1	NP_001020794.1
Gallus gallus (chicken)	VNN1	NP_001034377.1
Canis lupus familiaris (dog)	VNN1	NP_001003372.1
Bos taurus (cattle)	VNN1	NP_001019727.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP012357	XP_320200.4
Xenopus tropicalis (tropical clawed frog)	vnn2	NP_001011263.1
	VNN1	XP_001102153.1

Gene Ontology
Bibliography

Related articles in PubMed

Metabolic pathway catalyzed by Vanin-1 pantetheinase plays a suppressive role in influenza virus replication in human alveolar epithelial A549 cells.
Yamashita N, Yashiro M, Ogawa H, Namba H, Nosaka N, Fujii Y, Morishima T, Tsukahara H, Yamada M
Biochemical and biophysical research communications489(4)466-471(2017 08)

Elevation of GPRC5A expression in colorectal cancer promotes tumor progression through VNN-1 induced oxidative stress.
Zhang L, Li L, Gao G, Wei G, Zheng Y, Wang C, Gao N, Zhao Y, Deng J, Chen H, Sun J, Li D, Zhang X, Liu M
International journal of cancer140(12)2734-2747(2017 06)

Early prediction of cisplatin-induced nephrotoxicity by urinary vanin-1 in patients with urothelial carcinoma.
Hosohata K, Washino S, Kubo T, Natsui S, Fujisaki A, Kurokawa S, Ando H, Fujimura A, Morita T
Toxicology359-36071-5(2016 06)

Serum pantetheinase/vanin levels regulate erythrocyte homeostasis and severity of malaria.
Rommelaere S, Millet V, Rihet P, Atwell S, Helfer E, Chasson L, Beaumont C, Chimini G, Sambo Mdo R, Viallat A, Penha-Gon?alves C, Galland F, Naquet P
The American journal of pathology185(11)3039-52(2015 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

findings suggest that the metabolic pathway catalyzed by VNN1 pantetheinase plays a suppressive role in IAV infection in the respiratory tract, especially in severe conditions under hypercytokinemia
Title: Metabolic pathway catalyzed by Vanin-1 pantetheinase plays a suppressive role in influenza virus replication in human alveolar epithelial A549 cells.

Data show that G protein-coupled receptor, family C, group 5, member A protein (GPRC5A) regulates oxidative stress through vanin 1 protein (VNN1).
Title: Elevation of GPRC5A expression in colorectal cancer promotes tumor progression through VNN-1 induced oxidative stress.

These data suggest that urinary vanin-1 is an early predictive biomarker for decline in eGFR in patients with urothelial carcinoma after dosing of cisplatin
Title: Early prediction of cisplatin-induced nephrotoxicity by urinary vanin-1 in patients with urothelial carcinoma.

serum pantetheinas, encoded by the VNN1 gene, level regulates erythrocyte life span and modulates the risk of developing complicated malaria.
Title: Serum pantetheinase/vanin levels regulate erythrocyte homeostasis and severity of malaria.

VNN1 contributes to corticosteroid responsiveness, and changes in VNN1 nasal epithelial mRNA expression and VNN1 promoter methylation might be clinically useful biomarkers of treatment response in asthmatic children.
Title: Vanin-1 expression and methylation discriminate pediatric asthma corticosteroid treatment response.

The following VNN1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the VNN1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu23063	NM_004666.3 Latest version!	Homo sapiens vanin 1 (VNN1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$265.30 $379.00
View Old Accession Versions >>
OHu23063	NM_004666.2	Homo sapiens vanin 1 (VNN1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

VNN1 ( NM_004666.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_004657.2 Homo sapiens vanin 1 (VNN1), mRNA.

Price & Availability↑

CloneID	OHu23063
Clone ID Related Accession (Same CDS sequence)	NM_004666.2 , NM_004666.3
Accession Version	NM_004666.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1542bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	pantetheinase precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BJ995136.1, BC096266.3 and AL032821.2. This sequence is a reference standard in the RefSeqGene project. On Feb 14, 2009 this sequence version replaced NM_004666.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803614.177032.1, AJ132099.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACTACTC AGTTGCCAGC TTACGTGGCA ATTTTGCTTT TCTATGTCTC AAGAGCCAGC 
TGCCAGGACA CTTTCACTGC AGCTGTTTAT GAGCATGCAG CGATATTGCC CAATGCCACC 
CTAACACCAG TGTCTCGTGA GGAGGCTTTG GCATTAATGA ATCGGAATCT GGACATTTTG 
GAAGGAGCGA TCACATCAGC AGCAGATCAG GGTGCGCATA TTATTGTGAC TCCAGAAGAT 
GCTATTTATG GCTGGAACTT CAACAGGGAC TCTCTCTACC CATATTTGGA GGACATCCCA 
GACCCTGAAG TAAACTGGAT CCCCTGTAAT AATCGTAACA GATTTGGCCA GACCCCAGTA 
CAAGAAAGAC TCAGCTGCCT GGCCAAGAAC AACTCTATCT ATGTTGTGGC AAATATTGGG 
GACAAGAAGC CATGCGATAC CAGTGATCCT CAGTGTCCCC CTGATGGCCG TTACCAATAC 
AACACTGATG TGGTATTTGA TTCTCAAGGA AAACTGGTGG CACGCTACCA TAAGCAAAAC 
CTTTTCATGG GTGAAAATCA ATTCAATGTA CCCAAGGAGC CTGAGATTGT GACTTTCAAT 
ACCACCTTTG GAAGTTTTGG CATTTTCACA TGCTTTGATA TACTCTTCCA TGATCCTGCT 
GTTACCTTGG TGAAAGATTT CCACGTGGAC ACCATAGTAT TCCCAACAGC TTGGATGAAT 
GTTTTGCCAC ATTTGTCAGC TGTTGAATTC CACTCAGCTT GGGCTATGGG CATGAGGGTC 
AATTTCCTTG CATCCAACAT ACATTACCCC TCAAAGAAAA TGACAGGAAG TGGCATCTAT 
GCACCCAATT CTTCAAGAGC ATTTCATTAT GATATGAAGA CAGAAGAGGG AAAACTCCTC 
CTCTCGCAAC TGGATTCCCA CCCATCCCAT TCTGCAGTGG TGAACTGGAC TTCCTATGCC 
AGCAGTATAG AAGCGCTCTC ATCAGGAAAC AAGGAATTTA AAGGCACTGT CTTTTTCGAT 
GAATTCACTT TTGTGAAGCT CACAGGAGTT GCAGGAAATT ATACAGTTTG TCAGAAAGAT 
CTCTGCTGTC ATTTAAGCTA CAAAATGTCT GAGAACATAC CAAATGAAGT GTACGCTCTA 
GGGGCATTTG ACGGACTGCA CACTGTGGAA GGGCGCTATT ATCTACAGAT TTGTACCCTG 
TTGAAATGTA AAACGACTAA TTTAAACACT TGCGGTGACT CAGCTGAAAC AGCTTCTACC 
AGGTTTGAAA TGTTCTCCCT CAGTGGCACT TTCGGAACCC AGTATGTCTT TCCTGAGGTG 
TTGCTGAGTG AAAATCAGCT TGCACCTGGA GAATTTCAGG TGTCAACTGA CGGACGCTTG 
TTTAGTCTGA AGCCAACATC CGGACCTGTC TTAACAGTAA CTCTGTTTGG GAGGTTGTAT 
GAGAAGGACT GGGCATCAAA TGCTTCATCA GGCCTCACAG CACAAGCAAG AATAATAATG 
CTAATAGTTA TAGCACCTAT TGTATGCTCA TTAAGTTGGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004657.2
CDS	21..1562
Translation	MTTQLPAYVAILLFYVSRASCQDTFTAAVYEHAAILPNATLTPVSREEALALMNRNLDILEGAITSAADQGAHIIVTPEDAIYGWNFNRDSLYPYLEDIPDPEVNWIPCNNRNRFGQTPVQERLSCLAKNNSIYVVANIGDKKPCDTSDPQCPPDGRYQYNTDVVFDSQGKLVARYHKQNLFMGENQFNVPKEPEIVTFNTTFGSFGIFTCFDILFHDPAVTLVKDFHVDTIVFPTAWMNVLPHLSAVEFHSAWAMGMRVNFLASNIHYPSKKMTGSGIYAPNSSRAFHYDMKTEEGKLLLSQLDSHPSHSAVVNWTSYASSIEALSSGNKEFKGTVFFDEFTFVKLTGVAGNYTVCQKDLCCHLSYKMSENIPNEVYALGAFDGLHTVEGRYYLQICTLLKCKTTNLNTCGDSAETASTRFEMFSLSGTFGTQYVFPEVLLSENQLAPGEFQVSTDGRLFSLKPTSGPVLTVTLFGRLYEKDWASNASSGLTAQARIIMLIVIAPIVCSLSW

Target ORF information:

RefSeq Version	NM_004666.2
Organism	Homo sapiens(human)
Definition	Homo sapiens vanin 1 (VNN1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004666.2

ORF Insert Sequence:

ATGACTACTC AGTTGCCAGC TTACGTGGCA ATTTTGCTTT TCTATGTCTC AAGAGCCAGC 
TGCCAGGACA CTTTCACTGC AGCTGTTTAT GAGCATGCAG CGATATTGCC CAATGCCACC 
CTAACACCAG TGTCTCGTGA GGAGGCTTTG GCATTAATGA ATCGGAATCT GGACATTTTG 
GAAGGAGCGA TCACATCAGC AGCAGATCAG GGTGCGCATA TTATTGTGAC TCCAGAAGAT 
GCTATTTATG GCTGGAACTT CAACAGGGAC TCTCTCTACC CATATTTGGA GGACATCCCA 
GACCCTGAAG TAAACTGGAT CCCCTGTAAT AATCGTAACA GATTTGGCCA GACCCCAGTA 
CAAGAAAGAC TCAGCTGCCT GGCCAAGAAC AACTCTATCT ATGTTGTGGC AAATATTGGG 
GACAAGAAGC CATGCGATAC CAGTGATCCT CAGTGTCCCC CTGATGGCCG TTACCAATAC 
AACACTGATG TGGTATTTGA TTCTCAAGGA AAACTGGTGG CACGCTACCA TAAGCAAAAC 
CTTTTCATGG GTGAAAATCA ATTCAATGTA CCCAAGGAGC CTGAGATTGT GACTTTCAAT 
ACCACCTTTG GAAGTTTTGG CATTTTCACA TGCTTTGATA TACTCTTCCA TGATCCTGCT 
GTTACCTTGG TGAAAGATTT CCACGTGGAC ACCATAGTAT TCCCAACAGC TTGGATGAAT 
GTTTTGCCAC ATTTGTCAGC TGTTGAATTC CACTCAGCTT GGGCTATGGG CATGAGGGTC 
AATTTCCTTG CATCCAACAT ACATTACCCC TCAAAGAAAA TGACAGGAAG TGGCATCTAT 
GCACCCAATT CTTCAAGAGC ATTTCATTAT GATATGAAGA CAGAAGAGGG AAAACTCCTC 
CTCTCGCAAC TGGATTCCCA CCCATCCCAT TCTGCAGTGG TGAACTGGAC TTCCTATGCC 
AGCAGTATAG AAGCGCTCTC ATCAGGAAAC AAGGAATTTA AAGGCACTGT CTTTTTCGAT 
GAATTCACTT TTGTGAAGCT CACAGGAGTT GCAGGAAATT ATACAGTTTG TCAGAAAGAT 
CTCTGCTGTC ATTTAAGCTA CAAAATGTCT GAGAACATAC CAAATGAAGT GTACGCTCTA 
GGGGCATTTG ACGGACTGCA CACTGTGGAA GGGCGCTATT ATCTACAGAT TTGTACCCTG 
TTGAAATGTA AAACGACTAA TTTAAACACT TGCGGTGACT CAGCTGAAAC AGCTTCTACC 
AGGTTTGAAA TGTTCTCCCT CAGTGGCACT TTCGGAACCC AGTATGTCTT TCCTGAGGTG 
TTGCTGAGTG AAAATCAGCT TGCACCTGGA GAATTTCAGG TGTCAACTGA CGGACGCTTG 
TTTAGTCTGA AGCCAACATC CGGACCTGTC TTAACAGTAA CTCTGTTTGG GAGGTTGTAT 
GAGAAGGACT GGGCATCAAA TGCTTCATCA GGCCTCACAG CACAAGCAAG AATAATAATG 
CTAATAGTTA TAGCACCTAT TGTATGCTCA TTAAGTTGGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

VNN1 ( NM_004666.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_004657.2 Homo sapiens vanin 1 (VNN1), mRNA.

Price & Availability↑

CloneID	OHu23063
Clone ID Related Accession (Same CDS sequence)	NM_004666.2 , NM_004666.3
Accession Version	NM_004666.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1542bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-26
Organism	Homo sapiens(human)
Product	pantetheinase precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BJ995136.1, BC096266.3 and AL032821.2. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_004666.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803614.177032.1, AJ132099.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000367928.5/ ENSP00000356905.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGACTACTC AGTTGCCAGC TTACGTGGCA ATTTTGCTTT TCTATGTCTC AAGAGCCAGC 
TGCCAGGACA CTTTCACTGC AGCTGTTTAT GAGCATGCAG CGATATTGCC CAATGCCACC 
CTAACACCAG TGTCTCGTGA GGAGGCTTTG GCATTAATGA ATCGGAATCT GGACATTTTG 
GAAGGAGCGA TCACATCAGC AGCAGATCAG GGTGCGCATA TTATTGTGAC TCCAGAAGAT 
GCTATTTATG GCTGGAACTT CAACAGGGAC TCTCTCTACC CATATTTGGA GGACATCCCA 
GACCCTGAAG TAAACTGGAT CCCCTGTAAT AATCGTAACA GATTTGGCCA GACCCCAGTA 
CAAGAAAGAC TCAGCTGCCT GGCCAAGAAC AACTCTATCT ATGTTGTGGC AAATATTGGG 
GACAAGAAGC CATGCGATAC CAGTGATCCT CAGTGTCCCC CTGATGGCCG TTACCAATAC 
AACACTGATG TGGTATTTGA TTCTCAAGGA AAACTGGTGG CACGCTACCA TAAGCAAAAC 
CTTTTCATGG GTGAAAATCA ATTCAATGTA CCCAAGGAGC CTGAGATTGT GACTTTCAAT 
ACCACCTTTG GAAGTTTTGG CATTTTCACA TGCTTTGATA TACTCTTCCA TGATCCTGCT 
GTTACCTTGG TGAAAGATTT CCACGTGGAC ACCATAGTAT TCCCAACAGC TTGGATGAAT 
GTTTTGCCAC ATTTGTCAGC TGTTGAATTC CACTCAGCTT GGGCTATGGG CATGAGGGTC 
AATTTCCTTG CATCCAACAT ACATTACCCC TCAAAGAAAA TGACAGGAAG TGGCATCTAT 
GCACCCAATT CTTCAAGAGC ATTTCATTAT GATATGAAGA CAGAAGAGGG AAAACTCCTC 
CTCTCGCAAC TGGATTCCCA CCCATCCCAT TCTGCAGTGG TGAACTGGAC TTCCTATGCC 
AGCAGTATAG AAGCGCTCTC ATCAGGAAAC AAGGAATTTA AAGGCACTGT CTTTTTCGAT 
GAATTCACTT TTGTGAAGCT CACAGGAGTT GCAGGAAATT ATACAGTTTG TCAGAAAGAT 
CTCTGCTGTC ATTTAAGCTA CAAAATGTCT GAGAACATAC CAAATGAAGT GTACGCTCTA 
GGGGCATTTG ACGGACTGCA CACTGTGGAA GGGCGCTATT ATCTACAGAT TTGTACCCTG 
TTGAAATGTA AAACGACTAA TTTAAACACT TGCGGTGACT CAGCTGAAAC AGCTTCTACC 
AGGTTTGAAA TGTTCTCCCT CAGTGGCACT TTCGGAACCC AGTATGTCTT TCCTGAGGTG 
TTGCTGAGTG AAAATCAGCT TGCACCTGGA GAATTTCAGG TGTCAACTGA CGGACGCTTG 
TTTAGTCTGA AGCCAACATC CGGACCTGTC TTAACAGTAA CTCTGTTTGG GAGGTTGTAT 
GAGAAGGACT GGGCATCAAA TGCTTCATCA GGCCTCACAG CACAAGCAAG AATAATAATG 
CTAATAGTTA TAGCACCTAT TGTATGCTCA TTAAGTTGGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004657.2
CDS	21..1562
Translation	MTTQLPAYVAILLFYVSRASCQDTFTAAVYEHAAILPNATLTPVSREEALALMNRNLDILEGAITSAADQGAHIIVTPEDAIYGWNFNRDSLYPYLEDIPDPEVNWIPCNNRNRFGQTPVQERLSCLAKNNSIYVVANIGDKKPCDTSDPQCPPDGRYQYNTDVVFDSQGKLVARYHKQNLFMGENQFNVPKEPEIVTFNTTFGSFGIFTCFDILFHDPAVTLVKDFHVDTIVFPTAWMNVLPHLSAVEFHSAWAMGMRVNFLASNIHYPSKKMTGSGIYAPNSSRAFHYDMKTEEGKLLLSQLDSHPSHSAVVNWTSYASSIEALSSGNKEFKGTVFFDEFTFVKLTGVAGNYTVCQKDLCCHLSYKMSENIPNEVYALGAFDGLHTVEGRYYLQICTLLKCKTTNLNTCGDSAETASTRFEMFSLSGTFGTQYVFPEVLLSENQLAPGEFQVSTDGRLFSLKPTSGPVLTVTLFGRLYEKDWASNASSGLTAQARIIMLIVIAPIVCSLSW

Target ORF information:

RefSeq Version	NM_004666.3
Organism	Homo sapiens(human)
Definition	Homo sapiens vanin 1 (VNN1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004666.3

ORF Insert Sequence:

ATGACTACTC AGTTGCCAGC TTACGTGGCA ATTTTGCTTT TCTATGTCTC AAGAGCCAGC 
TGCCAGGACA CTTTCACTGC AGCTGTTTAT GAGCATGCAG CGATATTGCC CAATGCCACC 
CTAACACCAG TGTCTCGTGA GGAGGCTTTG GCATTAATGA ATCGGAATCT GGACATTTTG 
GAAGGAGCGA TCACATCAGC AGCAGATCAG GGTGCGCATA TTATTGTGAC TCCAGAAGAT 
GCTATTTATG GCTGGAACTT CAACAGGGAC TCTCTCTACC CATATTTGGA GGACATCCCA 
GACCCTGAAG TAAACTGGAT CCCCTGTAAT AATCGTAACA GATTTGGCCA GACCCCAGTA 
CAAGAAAGAC TCAGCTGCCT GGCCAAGAAC AACTCTATCT ATGTTGTGGC AAATATTGGG 
GACAAGAAGC CATGCGATAC CAGTGATCCT CAGTGTCCCC CTGATGGCCG TTACCAATAC 
AACACTGATG TGGTATTTGA TTCTCAAGGA AAACTGGTGG CACGCTACCA TAAGCAAAAC 
CTTTTCATGG GTGAAAATCA ATTCAATGTA CCCAAGGAGC CTGAGATTGT GACTTTCAAT 
ACCACCTTTG GAAGTTTTGG CATTTTCACA TGCTTTGATA TACTCTTCCA TGATCCTGCT 
GTTACCTTGG TGAAAGATTT CCACGTGGAC ACCATAGTAT TCCCAACAGC TTGGATGAAT 
GTTTTGCCAC ATTTGTCAGC TGTTGAATTC CACTCAGCTT GGGCTATGGG CATGAGGGTC 
AATTTCCTTG CATCCAACAT ACATTACCCC TCAAAGAAAA TGACAGGAAG TGGCATCTAT 
GCACCCAATT CTTCAAGAGC ATTTCATTAT GATATGAAGA CAGAAGAGGG AAAACTCCTC 
CTCTCGCAAC TGGATTCCCA CCCATCCCAT TCTGCAGTGG TGAACTGGAC TTCCTATGCC 
AGCAGTATAG AAGCGCTCTC ATCAGGAAAC AAGGAATTTA AAGGCACTGT CTTTTTCGAT 
GAATTCACTT TTGTGAAGCT CACAGGAGTT GCAGGAAATT ATACAGTTTG TCAGAAAGAT 
CTCTGCTGTC ATTTAAGCTA CAAAATGTCT GAGAACATAC CAAATGAAGT GTACGCTCTA 
GGGGCATTTG ACGGACTGCA CACTGTGGAA GGGCGCTATT ATCTACAGAT TTGTACCCTG 
TTGAAATGTA AAACGACTAA TTTAAACACT TGCGGTGACT CAGCTGAAAC AGCTTCTACC 
AGGTTTGAAA TGTTCTCCCT CAGTGGCACT TTCGGAACCC AGTATGTCTT TCCTGAGGTG 
TTGCTGAGTG AAAATCAGCT TGCACCTGGA GAATTTCAGG TGTCAACTGA CGGACGCTTG 
TTTAGTCTGA AGCCAACATC CGGACCTGTC TTAACAGTAA CTCTGTTTGG GAGGTTGTAT 
GAGAAGGACT GGGCATCAAA TGCTTCATCA GGCCTCACAG CACAAGCAAG AATAATAATG 
CTAATAGTTA TAGCACCTAT TGTATGCTCA TTAAGTTGGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Metabolic pathway catalyzed by Vanin-1 pantetheinase plays a suppressive role in influenza virus replication in human alveolar epithelial A549 cells.
Biochemical and biophysical research communications489(4)466-471(2017 08)
Yamashita N,Yashiro M,Ogawa H,Namba H,Nosaka N,Fujii Y,Morishima T,Tsukahara H,Yamada M

Elevation of GPRC5A expression in colorectal cancer promotes tumor progression through VNN-1 induced oxidative stress.
International journal of cancer140(12)2734-2747(2017 06)
Zhang L,Li L,Gao G,Wei G,Zheng Y,Wang C,Gao N,Zhao Y,Deng J,Chen H,Sun J,Li D,Zhang X,Liu M

Early prediction of cisplatin-induced nephrotoxicity by urinary vanin-1 in patients with urothelial carcinoma.
Toxicology359-36071-5(2016 06)
Hosohata K,Washino S,Kubo T,Natsui S,Fujisaki A,Kurokawa S,Ando H,Fujimura A,Morita T

Serum pantetheinase/vanin levels regulate erythrocyte homeostasis and severity of malaria.
The American journal of pathology185(11)3039-52(2015 Nov)
Rommelaere S,Millet V,Rihet P,Atwell S,Helfer E,Chasson L,Beaumont C,Chimini G,Sambo Mdo R,Viallat A,Penha-Gon?alves C,Galland F,Naquet P

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VNN1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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