Osm cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Osm
Entrez Gene ID	289747
Full Name	oncostatin M
General protein information	Preferred Names oncostatin M Names oncostatin-M
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 14 Map Location: 14q21
Summary	mouse homolog is a cytokine and an immediate early gene [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_006251200.2	XP_006251262.1	oncostatin-M isoform X1
NM_001006961.1	NP_001006962.1	oncostatin-M precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	OSM	NP_065391.1
Bos taurus (cattle)	OSM	NP_783644.3
Pan troglodytes (chimpanzee)	OSM	XP_001136178.1
Canis lupus familiaris (dog)	OSM	XP_005636497.1
	OSM	XP_001110148.1
Mus musculus (house mouse)	Osm	NP_001013383.1
Rattus norvegicus (Norway rat)	Osm	NP_001006962.1

Gene Ontology
Bibliography

Related articles in PubMed

MicroRNA-20a-5p suppresses IL-17 production by targeting OSM and CCL1 in patients with Vogt-Koyanagi-Harada disease.
Chang R, Yi S, Tan X, Huang Y, Wang Q, Su G, Zhou C, Cao Q, Yuan G, Kijlstra A, Yang P
The British journal of ophthalmology(2017 Sep)

Oncostatin M-dependent Mcl-1 induction mediated by JAK1/2-STAT1/3 and CREB contributes to bioenergetic improvements and protective effects against mitochondrial dysfunction in cortical neurons.
Chang SH, Hwang CS, Yin JH, Chen SD, Yang DI
Biochimica et biophysica acta1853(10 Pt A)2306-25(2015 Oct)

Cross-talk between KLF4 and STAT3 regulates axon regeneration.
Qin S, Zou Y, Zhang CL
Nature communications42633(2013)

CNTF mediates neurotrophic factor secretion and fluid absorption in human retinal pigment epithelium.
Li R, Wen R, Banzon T, Maminishkis A, Miller SS
PloS one6(9)e23148(2011)

Long term oncostatin M treatment induces an osteocyte-like differentiation on osteosarcoma and calvaria cells.
Brounais B, David E, Chipoy C, Trichet V, Ferr? V, Charrier C, Duplomb L, Berreur M, R?dini F, Heymann D, Blanchard F
Bone44(5)830-9(2009 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

findings indicated that OSM induces Mcl-1 expression via activation of ERK1/2, JAK1/2, STAT1/3, and CREB; furthermore, OSM-mediated Mcl-1 induction contributes to bioenergetic improvements
Title: Oncostatin M-dependent Mcl-1 induction mediated by JAK1/2-STAT1/3 and CREB contributes to bioenergetic improvements and protective effects against mitochondrial dysfunction in cortical neurons.

Results indicate that osteosarcoma cells stably producing OSM do not develop resistance to this cytokine and thus could be a valuable new tool to study the anti-cancer effect of OSM in vivo.
Title: Long term oncostatin M treatment induces an osteocyte-like differentiation on osteosarcoma and calvaria cells.

OSM may not only play a role in the regulation of Sertoli cell proliferation and the initiation of spermatogenesis but may also play a role in the regulation of Leydig cell progenitor formation.
Title: Oncostatin-M inhibits luteinizing hormone stimulated Leydig cell progenitor formation in vitro.

In the immortalized mouse and primary cultured proliferative rat hepatocytes, treatment with OSM markedly increased mRNA and protein of claudin-2 together with formation of developed networks of TJ strands.
Title: Oncostatin M induces upregulation of claudin-2 in rodent hepatocytes coinciding with changes in morphology and function of tight junctions.

OSM is a key mediator for inducing differentiation of OC15-5 cells into hepatocytes
Title: Oncostatin M inhibits proliferation of rat oval cells, OC15-5, inducing differentiation into hepatocytes.

The following Osm gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Osm cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa10893	NM_001006961.1 Latest version!	Rattus norvegicus oncostatin M (Osm), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00
ORa36237	XM_006251200.2 Latest version!	Rattus norvegicus oncostatin M (Osm), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Osm ( NM_001006961.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001006962.1 Rattus norvegicus oncostatin M (Osm), mRNA.

Price & Availability↑

CloneID	ORa10893
Clone ID Related Accession (Same CDS sequence)	NM_001006961.1
Accession Version	NM_001006961.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 720bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-22
Organism	Rattus norvegicus(Norway rat)
Product	oncostatin-M precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB167521.1. On Nov 22, 2004 this sequence version replaced XM_223567.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB167521.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689594, SAMEA2689599 [ECO:0000348] ##Evidence-Data-END##

ATGCGGGCTC AGCCTCCACC GAGAACACTG CTTAGTTTGG CCCTTGCGCT CCTGTTCCTG 
AGCATGTCAT GGGCCAAGCG TGGCTGCTCC AGCTCTTCCC CGAAGCTCCT CAGCCAGTTG 
AAGAGTCAGG CGAACATCAC GGGGAACACG GCATCGCTCT TGGAGCCCTA TATCCTCCAC 
CAAAACCTGA ACACGCTCAC CCTGAGAGCT GCCTGCACAG AGCACCCTGT GGCCTTCCCC 
AGTGAGGACA TGCTCCGGCA GCTGAGTAAG CCTGACTTCC TGAGCACTGT GCACGCCACG 
CTGGGCAGAG TCTGGCACCA ACTGGGTGCT TTCAGACAGC AATTTCCCAA GATTCAGGAT 
TTTCCAGAGC TGGAGAGGGC CAGGCAGAAC ATCCAAGGGA TCAGGAACAA TGTTTACTGC 
ATGGCTCGGC TGCTCCACCC ACCCCTGGAG ATCCCTGAGC CCACACAGGC AGACTCTGGG 
ACCTCACGAC CCACTACCAC AGCACCAGGC ATCTTTCAGA TCAAGATAGA CAGCTGCCGC 
TTCCTCTGGG GCTACCATCG CTTCATGGGT TCAGTGGGGA GAGTCTTCGA GGAGTGGGGG 
GATGGCTCCA GGCGCAGCCG GAGACACAGC CCACTCTGGG CCTGGCTCAA GGGAGACCAC 
AGAATCAGAC CCTCCCGGAG CAGCCAGAGC GCCATGCTCA GGTCCCTGGT GCCCCGGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001006962.1
CDS	1..720
Translation	MRAQPPPRTLLSLALALLFLSMSWAKRGCSSSSPKLLSQLKSQANITGNTASLLEPYILHQNLNTLTLRAACTEHPVAFPSEDMLRQLSKPDFLSTVHATLGRVWHQLGAFRQQFPKIQDFPELERARQNIQGIRNNVYCMARLLHPPLEIPEPTQADSGTSRPTTTAPGIFQIKIDSCRFLWGYHRFMGSVGRVFEEWGDGSRRSRRHSPLWAWLKGDHRIRPSRSSQSAMLRSLVPR

Target ORF information:

RefSeq Version	NM_001006961.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus oncostatin M (Osm), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001006961.1

ORF Insert Sequence:

ATGCGGGCTC AGCCTCCACC GAGAACACTG CTTAGTTTGG CCCTTGCGCT CCTGTTCCTG 
AGCATGTCAT GGGCCAAGCG TGGCTGCTCC AGCTCTTCCC CGAAGCTCCT CAGCCAGTTG 
AAGAGTCAGG CGAACATCAC GGGGAACACG GCATCGCTCT TGGAGCCCTA TATCCTCCAC 
CAAAACCTGA ACACGCTCAC CCTGAGAGCT GCCTGCACAG AGCACCCTGT GGCCTTCCCC 
AGTGAGGACA TGCTCCGGCA GCTGAGTAAG CCTGACTTCC TGAGCACTGT GCACGCCACG 
CTGGGCAGAG TCTGGCACCA ACTGGGTGCT TTCAGACAGC AATTTCCCAA GATTCAGGAT 
TTTCCAGAGC TGGAGAGGGC CAGGCAGAAC ATCCAAGGGA TCAGGAACAA TGTTTACTGC 
ATGGCTCGGC TGCTCCACCC ACCCCTGGAG ATCCCTGAGC CCACACAGGC AGACTCTGGG 
ACCTCACGAC CCACTACCAC AGCACCAGGC ATCTTTCAGA TCAAGATAGA CAGCTGCCGC 
TTCCTCTGGG GCTACCATCG CTTCATGGGT TCAGTGGGGA GAGTCTTCGA GGAGTGGGGG 
GATGGCTCCA GGCGCAGCCG GAGACACAGC CCACTCTGGG CCTGGCTCAA GGGAGACCAC 
AGAATCAGAC CCTCCCGGAG CAGCCAGAGC GCCATGCTCA GGTCCCTGGT GCCCCGGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Osm ( XM_006251200.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006251262.1 Rattus norvegicus oncostatin M (Osm), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa36237
Clone ID Related Accession (Same CDS sequence)	XM_006251200.2
Accession Version	XM_006251200.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 921bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	oncostatin-M isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005113.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 7, 2014 this sequence version replaced XM_006251200.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGACACGGA CCCCCATGCT GCCTGCTCAC CCCAAGAAGG CTGAGGCTGC GGTTTACATC 
ATCCTTGGGC GTGGGGCTGA CCTCGAAGAA CGAATTCGAA GAAAACGGGA GGAGGAGCGG 
GCATGTCATG GCGCCTGGCG CCCATTGGCC GCCTGGGGAG ACTTTGGTTT TTGGGGTCAT 
GTTCCCAGAA GGCCTGCCCT CCCCCCTCCC CCTCCCCCCC CACCTCACGA GGTGTTGGCC 
AATCGCCCCG TCGGGCATAA AGTGGCTGCC AGCCCGCAGG ACACCCAGCC AAGCCGTGTC 
ACCCCTGAGA GGCACGGGCC GAATCACCAG GACCCAGCAT GCGGGCTCAG CCTCCACCGA 
GAACACTGCT TAATCCTCCA CCAAAACCTG AACACGCTCA CCCTGAGAGC TGCCTGCACA 
GAGCACCCTG TGGCCTTCCC CAGTGAGGAC ATGCTCCGGC AGCTGAGTAA GCCTGACTTC 
CTGAGCACTG TGCACGCCAC GCTGGGCAGA GTCTGGCACC AACTGGGTGC TTTCAGACAG 
CAATTTCCCA AGATTCAGGA TTTTCCAGAG CTGGAGAGGG CCAGGCAGAA CATCCAAGGG 
ATCAGGAACA ATGTTTACTG CATGGCTCGG CTGCTCCACC CACCCCTGGA GATCCCTGAG 
CCCACACAGG CAGACTCTGG GACCTCACGA CCCACTACCA CAGCACCAGG CATCTTTCAG 
ATCAAGATAG ACAGCTGCCG CTTCCTCTGG GGCTACCATC GCTTCATGGG TTCAGTGGGG 
AGAGTCTTCG AGGAGTGGGG GGATGGCTCC AGGCGCAGCC GGAGACACAG CCCACTCTGG 
GCCTGGCTCA AGGGAGACCA CAGAATCAGA CCCTCCCGGA GCAGCCAGAG CGCCATGCTC 
AGGTCCCTGG TGCCCCGGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006251262.1
CDS	716..1636
Translation	MTRTPMLPAHPKKAEAAVYIILGRGADLEERIRRKREEERACHGAWRPLAAWGDFGFWGHVPRRPALPPPPPPPPHEVLANRPVGHKVAASPQDTQPSRVTPERHGPNHQDPACGLSLHREHCLILHQNLNTLTLRAACTEHPVAFPSEDMLRQLSKPDFLSTVHATLGRVWHQLGAFRQQFPKIQDFPELERARQNIQGIRNNVYCMARLLHPPLEIPEPTQADSGTSRPTTTAPGIFQIKIDSCRFLWGYHRFMGSVGRVFEEWGDGSRRSRRHSPLWAWLKGDHRIRPSRSSQSAMLRSLVPR

Target ORF information:

RefSeq Version	XM_006251200.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus oncostatin M (Osm), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006251200.2

ORF Insert Sequence:

ATGACACGGA CCCCCATGCT GCCTGCTCAC CCCAAGAAGG CTGAGGCTGC GGTTTACATC 
ATCCTTGGGC GTGGGGCTGA CCTCGAAGAA CGAATTCGAA GAAAACGGGA GGAGGAGCGG 
GCATGTCATG GCGCCTGGCG CCCATTGGCC GCCTGGGGAG ACTTTGGTTT TTGGGGTCAT 
GTTCCCAGAA GGCCTGCCCT CCCCCCTCCC CCTCCCCCCC CACCTCACGA GGTGTTGGCC 
AATCGCCCCG TCGGGCATAA AGTGGCTGCC AGCCCGCAGG ACACCCAGCC AAGCCGTGTC 
ACCCCTGAGA GGCACGGGCC GAATCACCAG GACCCAGCAT GCGGGCTCAG CCTCCACCGA 
GAACACTGCT TAATCCTCCA CCAAAACCTG AACACGCTCA CCCTGAGAGC TGCCTGCACA 
GAGCACCCTG TGGCCTTCCC CAGTGAGGAC ATGCTCCGGC AGCTGAGTAA GCCTGACTTC 
CTGAGCACTG TGCACGCCAC GCTGGGCAGA GTCTGGCACC AACTGGGTGC TTTCAGACAG 
CAATTTCCCA AGATTCAGGA TTTTCCAGAG CTGGAGAGGG CCAGGCAGAA CATCCAAGGG 
ATCAGGAACA ATGTTTACTG CATGGCTCGG CTGCTCCACC CACCCCTGGA GATCCCTGAG 
CCCACACAGG CAGACTCTGG GACCTCACGA CCCACTACCA CAGCACCAGG CATCTTTCAG 
ATCAAGATAG ACAGCTGCCG CTTCCTCTGG GGCTACCATC GCTTCATGGG TTCAGTGGGG 
AGAGTCTTCG AGGAGTGGGG GGATGGCTCC AGGCGCAGCC GGAGACACAG CCCACTCTGG 
GCCTGGCTCA AGGGAGACCA CAGAATCAGA CCCTCCCGGA GCAGCCAGAG CGCCATGCTC 
AGGTCCCTGG TGCCCCGGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

MicroRNA-20a-5p suppresses IL-17 production by targeting OSM and CCL1 in patients with Vogt-Koyanagi-Harada disease.
The British journal of ophthalmology(2017 Sep)
Chang R,Yi S,Tan X,Huang Y,Wang Q,Su G,Zhou C,Cao Q,Yuan G,Kijlstra A,Yang P

Oncostatin M-dependent Mcl-1 induction mediated by JAK1/2-STAT1/3 and CREB contributes to bioenergetic improvements and protective effects against mitochondrial dysfunction in cortical neurons.
Biochimica et biophysica acta1853(10 Pt A)2306-25(2015 Oct)
Chang SH,Hwang CS,Yin JH,Chen SD,Yang DI

Cross-talk between KLF4 and STAT3 regulates axon regeneration.
Nature communications42633(2013)
Qin S,Zou Y,Zhang CL

CNTF mediates neurotrophic factor secretion and fluid absorption in human retinal pigment epithelium.
PloS one6(9)e23148(2011)
Li R,Wen R,Banzon T,Maminishkis A,Miller SS

Long term oncostatin M treatment induces an osteocyte-like differentiation on osteosarcoma and calvaria cells.
Bone44(5)830-9(2009 May)
Brounais B,David E,Chipoy C,Trichet V,Ferr? V,Charrier C,Duplomb L,Berreur M,R?dini F,Heymann D,Blanchard F

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Osm cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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