Rbp4 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Rbp4
Entrez Gene ID	25703
Full Name	retinol binding protein 4
Synonyms	RBPA
General protein information	Preferred Names retinol binding protein 4 Names retinol-binding protein 4 PRBP RBP plasma retinol-binding protein retinol binding protein 4, plasma
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q53
Summary	may play a role in vitamin A transport [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_013162.1	NP_037294.1	retinol-binding protein 4 precursor

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Rbp4	NP_037294.1
Danio rerio (zebrafish)	rbp4	NP_570995.1
Pan troglodytes (chimpanzee)	RBP4	NP_001038960.1
Homo sapiens (human)	RBP4	NP_006735.2
Mus musculus (house mouse)	Rbp4	NP_001152959.1
Xenopus tropicalis (tropical clawed frog)	rbp4	NP_001015748.1
Gallus gallus (chicken)	RBP4	NP_990569.1
Canis lupus familiaris (dog)	RBP4	XP_534969.2
Bos taurus (cattle)	RBP4	NP_001035565.2

Gene Ontology
Bibliography

Related articles in PubMed

High dietary fat-induced obesity in Wistar rats and type 2 diabetes in nonobese Goto-Kakizaki rats differentially affect retinol binding protein 4 expression and vitamin A metabolism.
Shirai T, Shichi Y, Sato M, Tanioka Y, Furusho T, Ota T, Tadokoro T, Suzuki T, Kobayashi K, Yamamoto Y
Nutrition research (New York, N.Y.)36(3)262-70(2016 Mar)

Involvement of RBP4 in hyperinsulinism-induced vascular smooth muscle cell proliferation.
Li F, Xia K, Sheikh SA, Cheng J, Li C, Yang T
Endocrine48(2)472-82(2015 Mar)

Retinol binding protein 4 promotes hyperinsulinism?induced proliferation of rat aortic smooth muscle cells.
Li F, Xia K, Sheikh MS, Cheng J, Li C, Yang T
Molecular medicine reports9(5)1634-40(2014 May)

Nitrofen interferes with trophoblastic expression of retinol-binding protein and transthyretin during lung morphogenesis in the nitrofen-induced congenital diaphragmatic hernia model.
Kutasy B, Gosemann JH, Doi T, Fujiwara N, Friedmacher F, Puri P
Pediatric surgery international28(2)143-8(2012 Feb)

Studies on the transport and cellular distribution of vitamin A in normal and vitamin A-deficient rats with special reference to the vitamin A-binding plasma protein.
Peterson PA, Rask L, Ostberg L, Andersson L, Kamwendo F, Pertoft H
The Journal of biological chemistry248(11)4009-22(1973 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

RBP4 levels increased by 2-fold in the serum of nonobese Goto-Kakizaki rats but not high-fat diet fed rats.
Title: High dietary fat-induced obesity in Wistar rats and type 2 diabetes in nonobese Goto-Kakizaki rats differentially affect retinol binding protein 4 expression and vitamin A metabolism.

plasma RBP4 concentrations were associated with cardiovascular disease. In addition, RBP4 increases the proliferation of vascular smooth muscle cells induced by hyperinsulinism via activation of MAPK signaling pathway
Title: Involvement of RBP4 in hyperinsulinism-induced vascular smooth muscle cell proliferation.

Retinol binding protein 4 promotes hyperinsulinisminduced proliferation of rat aortic smooth muscle cells.
Title: Retinol binding protein 4 promotes hyperinsulinism?induced proliferation of rat aortic smooth muscle cells.

Decreased trophoblast expression of retinol transport proteins suggest that nitrofen may interfere with the fetal retinol transport resulting in reduced pulmonary RBP and TTR levels and causing pulmonary hypoplasia in CDH.
Title: Nitrofen interferes with trophoblastic expression of retinol-binding protein and transthyretin during lung morphogenesis in the nitrofen-induced congenital diaphragmatic hernia model.

Steatotic liver grafts are more predisposed to down-regulate retinol-binding protein 4 and overexpress proliferator-activated receptor-gamma.
Title: Retinol-binding protein 4 and peroxisome proliferator-activated receptor-? in steatotic liver transplantation.

The following Rbp4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Rbp4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa02174	NM_013162.1 Latest version!	Rattus norvegicus retinol binding protein 4 (Rbp4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Rbp4 ( NM_013162.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_037294.1 Rattus norvegicus retinol binding protein 4 (Rbp4), mRNA.

Price & Availability↑

CloneID	ORa02174
Clone ID Related Accession (Same CDS sequence)	NM_013162.1
Accession Version	NM_013162.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 606bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Rattus norvegicus(Norway rat)
Product	retinol-binding protein 4 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CO561550.1 and DV725071.1. On or before Oct 13, 2007 this sequence version replaced XM_001080229.1, XM_215285.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CF108847.1, BC167099.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01906347, SAMN01906349 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGTGGG TGTGGGCGCT CGTGCTGCTG GCGGCTCTGG GAGGCGGCAG CGCCGAGCGC 
GACTGCAGGG TGAGCAGCTT CAGAGTCAAG GAGAACTTCG ACAAGGCTCG TTTCTCTGGG 
CTCTGGTATG CCATCGCCAA AAAGGATCCC GAGGGTCTCT TTTTGCAAGA CAACATCATC 
GCTGAGTTTT CTGTGGACGA GAAGGGTCAT ATGAGCGCTA CAGCCAAGGG ACGAGTCCGT 
CTTCTGAGCA ACTGGGAAGT GTGTGCAGAC ATGGTGGGCA CTTTCACAGA CACAGAAGAT 
CCTGCCAAGT TCAAGATGAA GTACTGGGGT GTAGCCTCCT TTCTCCAGCG AGGAAACGAT 
GACCACTGGA TCATCGATAC GGACTACGAC ACCTTCGCTC TGCAGTATTC CTGCCGCCTG 
CAGAATCTGG ATGGCACCTG TGCAGACAGC TACTCCTTTG TGTTTTCTCG TGACCCCAAT 
GGCCTGACCC CGGAGACACG GAGGCTGGTG AGGCAGCGAC AGGAGGAGCT GTGCCTAGAG 
AGGCAGTACA GATGGATCGA GCACAATGGT TACTGTCAAA GCAGACCCTC AAGAAACAGT 
TTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_037294.1
CDS	51..656
Translation	MEWVWALVLLAALGGGSAERDCRVSSFRVKENFDKARFSGLWYAIAKKDPEGLFLQDNIIAEFSVDEKGHMSATAKGRVRLLSNWEVCADMVGTFTDTEDPAKFKMKYWGVASFLQRGNDDHWIIDTDYDTFALQYSCRLQNLDGTCADSYSFVFSRDPNGLTPETRRLVRQRQEELCLERQYRWIEHNGYCQSRPSRNSL

Target ORF information:

RefSeq Version	NM_013162.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus retinol binding protein 4 (Rbp4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013162.1

ORF Insert Sequence:

ATGGAGTGGG TGTGGGCGCT CGTGCTGCTG GCGGCTCTGG GAGGCGGCAG CGCCGAGCGC 
GACTGCAGGG TGAGCAGCTT CAGAGTCAAG GAGAACTTCG ACAAGGCTCG TTTCTCTGGG 
CTCTGGTATG CCATCGCCAA AAAGGATCCC GAGGGTCTCT TTTTGCAAGA CAACATCATC 
GCTGAGTTTT CTGTGGACGA GAAGGGTCAT ATGAGCGCTA CAGCCAAGGG ACGAGTCCGT 
CTTCTGAGCA ACTGGGAAGT GTGTGCAGAC ATGGTGGGCA CTTTCACAGA CACAGAAGAT 
CCTGCCAAGT TCAAGATGAA GTACTGGGGT GTAGCCTCCT TTCTCCAGCG AGGAAACGAT 
GACCACTGGA TCATCGATAC GGACTACGAC ACCTTCGCTC TGCAGTATTC CTGCCGCCTG 
CAGAATCTGG ATGGCACCTG TGCAGACAGC TACTCCTTTG TGTTTTCTCG TGACCCCAAT 
GGCCTGACCC CGGAGACACG GAGGCTGGTG AGGCAGCGAC AGGAGGAGCT GTGCCTAGAG 
AGGCAGTACA GATGGATCGA GCACAATGGT TACTGTCAAA GCAGACCCTC AAGAAACAGT 
TTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

High dietary fat-induced obesity in Wistar rats and type 2 diabetes in nonobese Goto-Kakizaki rats differentially affect retinol binding protein 4 expression and vitamin A metabolism.
Nutrition research (New York, N.Y.)36(3)262-70(2016 Mar)
Shirai T,Shichi Y,Sato M,Tanioka Y,Furusho T,Ota T,Tadokoro T,Suzuki T,Kobayashi K,Yamamoto Y

Involvement of RBP4 in hyperinsulinism-induced vascular smooth muscle cell proliferation.
Endocrine48(2)472-82(2015 Mar)
Li F,Xia K,Sheikh SA,Cheng J,Li C,Yang T

Retinol binding protein 4 promotes hyperinsulinism?induced proliferation of rat aortic smooth muscle cells.
Molecular medicine reports9(5)1634-40(2014 May)
Li F,Xia K,Sheikh MS,Cheng J,Li C,Yang T

Nitrofen interferes with trophoblastic expression of retinol-binding protein and transthyretin during lung morphogenesis in the nitrofen-induced congenital diaphragmatic hernia model.
Pediatric surgery international28(2)143-8(2012 Feb)
Kutasy B,Gosemann JH,Doi T,Fujiwara N,Friedmacher F,Puri P

Studies on the transport and cellular distribution of vitamin A in normal and vitamin A-deficient rats with special reference to the vitamin A-binding plasma protein.
The Journal of biological chemistry248(11)4009-22(1973 Jun)
Peterson PA,Rask L,Ostberg L,Andersson L,Kamwendo F,Pertoft H

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Rbp4 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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