Igfbp1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Igfbp1
Entrez Gene ID	25685
Full Name	insulin-like growth factor binding protein 1
Synonyms	IBP1,IGF-BP25,IGFBA
General protein information	Preferred Names insulin-like growth factor binding protein 1 Names insulin-like growth factor-binding protein 1 IBP-1 IGF-binding protein 1 IGFBP-1 placental protein 12
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 14 Map Location: 14q21
Summary	a modulator of a Insulin growth factor (IGF) bioavailability [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_013144.1	NP_037276.1	insulin-like growth factor-binding protein 1 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	IGFBP1	NP_000587.1
Bos taurus (cattle)	IGFBP1	NP_776979.2
Canis lupus familiaris (dog)	IGFBP1	XP_005629556.1
Mus musculus (house mouse)	Igfbp1	NP_032367.3
Danio rerio (zebrafish)	igfbp1a	NP_775390.2
Xenopus tropicalis (tropical clawed frog)	igfbp1	NP_001029118.1
Pan troglodytes (chimpanzee)	IGFBP1	XP_519083.3
	IGFBP1	XP_001085935.2
Rattus norvegicus (Norway rat)	Igfbp1	NP_037276.1
Gallus gallus (chicken)	IGFBP1	NP_001001294.1
Danio rerio (zebrafish)	igfbp1b	NP_001091727.1

Gene Ontology
Bibliography

Related articles in PubMed

[Study on intermittent hypoxia in children sleep apnea hypopnea syndrome model and insulin-like growth factor-1 and insulin-like growth factor binding protein-3 levels in serum].
Hou J, Yan J, Kang QQ
Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery47(3)218-22(2012 Mar)

Neutrophil-derived azurocidin cleaves insulin-like growth factor-binding protein-1, -2 and -4.
Brandt K, Lundell K, Brismar K
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society21(3)167-73(2011 Jun)

Insulin-like growth factor binding protein-1 activates integrin-mediated intracellular signaling and migration in oligodendrocytes.
Chesik D, De Keyser J, Bron R, Fuhler GM
Journal of neurochemistry113(5)1319-30(2010 Jun)

Regulation of insulin-like growth factor binding protein-1 expression during aging.
Rutkute K, Nikolova-Karakashian MN
Biochemical and biophysical research communications361(2)263-9(2007 Sep)

Growth hormone-binding protein is directly and IGFBP-3 is inversely associated with risk of female breast cancer.
Pazaitou-Panayiotou K, Kelesidis T, Kelesidis I, Kaprara A, Blakeman J, Vainas I, Mpousoulegas A, Williams CJ, Mantzoros C
European journal of endocrinology156(2)187-94(2007 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

In simulated sleep apnea hypopnea syndrome, intermittent hypoxia in young rats does not cause physical growth retardation, but serum IGF-1 and IGFBP-3 levels decreased with the increase of hypoxia and decline of oxygen saturation.
Title: [Study on intermittent hypoxia in children sleep apnea hypopnea syndrome model and insulin-like growth factor-1 and insulin-like growth factor binding protein-3 levels in serum].

up-regulation of IGFBP-1 in oligodendrocytes in multiple sclerosis may serve two functions: (i) regulate IGF-1 actions, (ii) exert IGF-independent effects through its RGD sequence
Title: Insulin-like growth factor binding protein-1 activates integrin-mediated intracellular signaling and migration in oligodendrocytes.

Age-related oxidative stress underlies the upregulated JNK activation and IGFBP-1 expression.
Title: Regulation of insulin-like growth factor binding protein-1 expression during aging.

Activation of the mTOR pathway, without activation of its upstream regulator PI 3-kinase, reduces IGFBP1 expression.
Title: A temporal switch in the insulin-signalling pathway that regulates hepatic IGF-binding protein-1 gene expression.

insulin inhibition of IGFBP-1 mRNA levels can occur in the absence of the phosphorylation of Foxo1/Foxo3, whereas activation of the mTOR pathway is both necessary and sufficient
Title: Regulation of hepatic insulin-like growth factor-binding protein-1 gene expression by insulin: central role for mammalian target of rapamycin independent of forkhead box O proteins.

The following Igfbp1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Igfbp1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa02118	NM_013144.1 Latest version!	Rattus norvegicus insulin-like growth factor binding protein 1 (Igfbp1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Igfbp1 ( NM_013144.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_037276.1 Rattus norvegicus insulin-like growth factor binding protein 1 (Igfbp1), mRNA.

Price & Availability↑

CloneID	ORa02118
Clone ID Related Accession (Same CDS sequence)	NM_013144.1
Accession Version	NM_013144.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 819bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	insulin-like growth factor-binding protein 1 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from M58634.1. On Jun 25, 2006 this sequence version replaced XM_001053362.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M58634.1, BC078889.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689597, SAMEA2689598 [ECO:0000348] ##Evidence-Data-END##

ATGCCGGAGT TCCTAACTGT TGTTTCTTGG CCGTTCCTGA TCCTCCTGTC CTTCCAGGTT 
CGCGTAGTCG CTGGAGCCCC CCAGCCATGG CACTGTGCTC CCTGCACTGC TGAGAGGCTG 
GAGCTCTGTC CACCCGTGCC TGCTTCGTGC CCCGAGATTT CTCGGCCTGC GGGCTGTGGC 
TGCTGCCCGA CATGTGCCTT GCCACTGGGT GCTGCCTGTG GTGTGGCCAC TGCGCGCTGC 
GCTCAGGGAC TCAGCTGCCG TGCGCTGCCA GGGGAGCCTC GACCTCTGCA TGCCCTCACC 
CGTGGCCAGG GAGCCTGTGT ACTAGAACCT GCCGCACCCG CCACGAGCAG CTTGTCCGGT 
TCTCAGCATG AAGAGGCAAA GGCTGCTGTG GCCTCTGAGG ATGAGCTTGC CGAGAGCCCA 
GAGATGACAG AGGAACAGCT GCTGGATAGC TTCCACCTCA TGGCCCCATC CCGTGAGGAC 
CAGCCCATCC TGTGGAATGC CATTAGCACC TACAGCAGCA TGCGGGCCCG GGAGATCACT 
GACCTCAAGA AATGGAAGGA GCCCTGCCAA CGGGAACTCT ATAAAGTGTT AGAGAGATTA 
GCTGCCGCTC AACAGAAAGC AGGAGATGAG ATCTACAAAT TTTATCTGCC AAACTGCAAC 
AAGAATGGAT TTTATCACAG CAAACAGTGC GAGACATCTC TGGATGGAGA AGCTGGGCTC 
TGCTGGTGTG TCTACCCATG GAGTGGGAAG AAGATCCCTG GATCTCTGGA GACCAGAGGG 
GACCCCAACT GCCACCAGTA TTTTAATGTG CAAAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_037276.1
CDS	160..978
Translation	MPEFLTVVSWPFLILLSFQVRVVAGAPQPWHCAPCTAERLELCPPVPASCPEISRPAGCGCCPTCALPLGAACGVATARCAQGLSCRALPGEPRPLHALTRGQGACVLEPAAPATSSLSGSQHEEAKAAVASEDELAESPEMTEEQLLDSFHLMAPSREDQPILWNAISTYSSMRAREITDLKKWKEPCQRELYKVLERLAAAQQKAGDEIYKFYLPNCNKNGFYHSKQCETSLDGEAGLCWCVYPWSGKKIPGSLETRGDPNCHQYFNVQN

Target ORF information:

RefSeq Version	NM_013144.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus insulin-like growth factor binding protein 1 (Igfbp1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013144.1

ORF Insert Sequence:

ATGCCGGAGT TCCTAACTGT TGTTTCTTGG CCGTTCCTGA TCCTCCTGTC CTTCCAGGTT 
CGCGTAGTCG CTGGAGCCCC CCAGCCATGG CACTGTGCTC CCTGCACTGC TGAGAGGCTG 
GAGCTCTGTC CACCCGTGCC TGCTTCGTGC CCCGAGATTT CTCGGCCTGC GGGCTGTGGC 
TGCTGCCCGA CATGTGCCTT GCCACTGGGT GCTGCCTGTG GTGTGGCCAC TGCGCGCTGC 
GCTCAGGGAC TCAGCTGCCG TGCGCTGCCA GGGGAGCCTC GACCTCTGCA TGCCCTCACC 
CGTGGCCAGG GAGCCTGTGT ACTAGAACCT GCCGCACCCG CCACGAGCAG CTTGTCCGGT 
TCTCAGCATG AAGAGGCAAA GGCTGCTGTG GCCTCTGAGG ATGAGCTTGC CGAGAGCCCA 
GAGATGACAG AGGAACAGCT GCTGGATAGC TTCCACCTCA TGGCCCCATC CCGTGAGGAC 
CAGCCCATCC TGTGGAATGC CATTAGCACC TACAGCAGCA TGCGGGCCCG GGAGATCACT 
GACCTCAAGA AATGGAAGGA GCCCTGCCAA CGGGAACTCT ATAAAGTGTT AGAGAGATTA 
GCTGCCGCTC AACAGAAAGC AGGAGATGAG ATCTACAAAT TTTATCTGCC AAACTGCAAC 
AAGAATGGAT TTTATCACAG CAAACAGTGC GAGACATCTC TGGATGGAGA AGCTGGGCTC 
TGCTGGTGTG TCTACCCATG GAGTGGGAAG AAGATCCCTG GATCTCTGGA GACCAGAGGG 
GACCCCAACT GCCACCAGTA TTTTAATGTG CAAAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

[Study on intermittent hypoxia in children sleep apnea hypopnea syndrome model and insulin-like growth factor-1 and insulin-like growth factor binding protein-3 levels in serum].
Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery47(3)218-22(2012 Mar)
Hou J,Yan J,Kang QQ

Neutrophil-derived azurocidin cleaves insulin-like growth factor-binding protein-1, -2 and -4.
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society21(3)167-73(2011 Jun)
Brandt K,Lundell K,Brismar K

Insulin-like growth factor binding protein-1 activates integrin-mediated intracellular signaling and migration in oligodendrocytes.
Journal of neurochemistry113(5)1319-30(2010 Jun)
Chesik D,De Keyser J,Bron R,Fuhler GM

Regulation of insulin-like growth factor binding protein-1 expression during aging.
Biochemical and biophysical research communications361(2)263-9(2007 Sep)
Rutkute K,Nikolova-Karakashian MN

Growth hormone-binding protein is directly and IGFBP-3 is inversely associated with risk of female breast cancer.
European journal of endocrinology156(2)187-94(2007 Feb)
Pazaitou-Panayiotou K,Kelesidis T,Kelesidis I,Kaprara A,Blakeman J,Vainas I,Mpousoulegas A,Williams CJ,Mantzoros C

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Igfbp1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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