Gys2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Gys2
Entrez Gene ID	25623
Full Name	glycogen synthase 2
Synonyms	GLYSN
General protein information	Preferred Names glycogen synthase 2 Names glycogen [starch] synthase, liver Glycogen synthase 2 (liver)
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 4 Map Location: 4q44
Summary	catalyzes the formation of 1,4-a-linked glucose chains in glycogen, the primary storage form of glucose [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_013089.2	NP_037221.2	glycogen [starch] synthase, liver

Pathways from BioSystems

Homologies

Bos taurus (cattle)	GYS2	NP_001179834.1
Mus musculus (house mouse)	Gys2	NP_663547.2
Danio rerio (zebrafish)	gys2	NP_001018199.1
Pan troglodytes (chimpanzee)	GYS2	XP_520790.2
Gallus gallus (chicken)	GYS2	XP_004938048.1
Canis lupus familiaris (dog)	GYS2	XP_534869.2
Homo sapiens (human)	GYS2	NP_068776.2
	GYS2	XP_001098578.1
Rattus norvegicus (Norway rat)	Gys2	NP_037221.1

Gene Ontology
Bibliography

Related articles in PubMed

Hepatic overexpression of a constitutively active form of liver glycogen synthase improves glucose homeostasis.
Ros S, Zafra D, Valles-Ortega J, Garc?a-Rocha M, Forrow S, Dom?nguez J, Calb? J, Guinovart JJ
The Journal of biological chemistry285(48)37170-7(2010 Nov)

Control of liver glycogen synthase activity and intracellular distribution by phosphorylation.
Ros S, Garc?a-Rocha M, Dom?nguez J, Ferrer JC, Guinovart JJ
The Journal of biological chemistry284(10)6370-8(2009 Mar)

Metabolic impact of overexpression of liver glycogen synthase with serine-to-alanine substitutions in rat primary hepatocytes.
Kadotani A, Fujimura M, Nakamura T, Ohyama S, Harada N, Maruki H, Tamai Y, Kanatani A, Eiki J, Nagata Y
Archives of biochemistry and biophysics466(2)283-9(2007 Oct)

Conjugated bile acids regulate hepatocyte glycogen synthase activity in vitro and in vivo via Galphai signaling.
Fang Y, Studer E, Mitchell C, Grant S, Pandak WM, Hylemon PB, Dent P
Molecular pharmacology71(4)1122-8(2007 Apr)

Defect in glucokinase translocation in Zucker diabetic fatty rats.
Fujimoto Y, Donahue EP, Shiota M
American journal of physiology. Endocrinology and metabolism287(3)E414-23(2004 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Transgenic LGS rat showed enhanced glycogen storage and an mproved glucose tolerance.
Title: Hepatic overexpression of a constitutively active form of liver glycogen synthase improves glucose homeostasis.

LGS translocation is strictly dependent on glycogen synthesis.
Title: Control of liver glycogen synthase activity and intracellular distribution by phosphorylation.

elevation of glycogen synthase activity has an inhibitory effect on glucose production in hepatocytes by shunting gluconeogenic precursors into glycogen.
Title: Metabolic impact of overexpression of liver glycogen synthase with serine-to-alanine substitutions in rat primary hepatocytes.

bile acids are physiological regulators of glycogen synthase in rat liver and conjugated bile acids use a Galpha(i)-coupled G protein-coupled receptor to regulate GS activity in vitro and in vivo
Title: Conjugated bile acids regulate hepatocyte glycogen synthase activity in vitro and in vivo via Galphai signaling.

glycogen synthase is activated by glucose-6-phosphate, which also controls its subcellular distribution in the hepatocyte
Title: Glucose 6-phosphate produced by gluconeogenesis and by glucokinase is equally effective in activating hepatic glycogen synthase.

The following Gys2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Gys2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa43179	NM_013089.2 Latest version!	Rattus norvegicus glycogen synthase 2 (Gys2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$412.30 $589.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Gys2 ( NM_013089.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_037221.2 Rattus norvegicus glycogen synthase 2 (Gys2), mRNA.

Price & Availability↑

CloneID	ORa43179
Clone ID Related Accession (Same CDS sequence)	NM_013089.2
Accession Version	NM_013089.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2115bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-01
Organism	Rattus norvegicus(Norway rat)
Product	glycogen [starch] synthase, liver
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC130778.4. On Feb 5, 2015 this sequence version replaced NM_013089.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: J05446.1, AF346902.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2689598, SAMEA2689601 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTCAGGG GCCGCTCCTT GTCTGTGACG TCCCTTGGTG GGCTCCCTGC ATGGGAAGCT 
GAAAGACTCC CCGTGGAAGA CTTATTGCTT TTTGAAGTTT CCTGGGAAGT GACCAACAAA 
GTTGGGGGCA TCTGTACTGT GATCCAGAGC AAAGCCAAAA CCACAGCCAA TGAATGGGGA 
GAGAATTACT TCCTGATAGG TCCGTATTTT GAGCATAATG TGAAGACTCA AGTAGAGCCA 
TGCGAGCCCG CCAACGATGC CGTCAGAAAA GCTGTGGATG CCATGAACAA ACATGGCTGC 
CAGGTGCATT TTGGAAGATG GCTGATAGAA GGGAGTCCGT ATGTGGTGCT TTTTGACATC 
AGCTCCTCAG CGTGGAACCT GGACAGGTGG AAGGGAGACT TCTGGGAAGC ATGTGGCGTT 
GGCATCCCTC ACGACGACCG AGAAGCCAAT GACATGCTCA TATTTGGGTC TTTAACTGCC 
TGGTTCTTAA AGGAGGTGAC GGACCATGCA GACGGTAAAC ACGTCATTGC CCAATTCCAT 
GAATGGCAGG CTGGAACTGG GCTGATCCTT TCTCGTGCCA GGAAACTCCC CATCGCCACA 
ATATTTACAA CCCATGCCAC ACTGCTGGGG CGGTATCTCT GTGCAGCAAA TATTGACTTC 
TACAACCAGC TTGATAAGTT CAACATAGAC AAAGAGGCCG GGGAGAGGCA GATTTATCAC 
CGCTACTGCA TGGAGCGGGC TTCCGTGCAC TGTGCGCACG TGTTTACCAC AGTGTCAGAA 
ATCACAGCCA TCGAGGCGGA GCACATGCTG AAGAGGAAGC CTGATGTGGT GACTCCAAAC 
GGCTTGAACG TTAAGAAGTT TTCTGCGGTG CACGAGTTTC AAAATCTCCA TGCCACATAC 
AAGGCCAGGA TACAGGATTT TGTTCGAGGT CATTTCTATG GCCACCTGGA CTTCGATCTT 
GAAAAGACGT TATTTCTTTT CATTGCTGGG AGGTATGAGT TCTCCAACAA GGGAGCAGAC 
ATCTTCCTAG AATCCTTATC CAGGCTCAAT TTCCTCCTAA GGATGCATAA GAGTAACGTC 
ACTGTGGTAG TGTTTTTCAT CATGCCTGCC AAGACAAACA ATTTCAACGT GGAAACCCTG 
AAGGGCCAGG CGGTGCGGAA ACAGCTGTGG GACACTGTGC ACTGTATGAA GGAAAAGTTT 
GGAAAGAAAC TCTACGATGG GTTATTAAGA GGAGAAATAC CCGACATGAA TAGTATTTTG 
GATCGAGATG ACTTAACAAT TATGAAAAGA GCCATTTTTT CAACTCAGAG ACACTCTTTG 
CCTCCTGTGA CCACTCACAA TATGATCGAC GATTCCACGG ATCCCATCCT CAGCACCATT 
CGACGAATTG GACTTTTCAA CAATCGCACA GACAGAGTCA AGGTGATTTT ACACCCAGAA 
TTCCTGTCCT CCACCAGCCC CCTACTACCA ATGGATTATG AAGAGTTTGT CCGAGGCTGT 
CACCTTGGGG TATTTCCATC ATACTATGAG CCCTGGGGTT ACACGCCAGC CGAATGCACA 
GTGATGGGCA TCCCCAGTGT GACTACGAAC CTCTCTGGTT TCGGGTGTTT CATGCAGGAG 
CATGTGGCTG ACCCTACCGC GTACGGTATT TATATCGTCG ACAGACGCTT CCGCTCTCCA 
GATGATTCTT GCAACCAGCT GACTCAGTTT CTCTATGGGT TCTGTAAACA GTCCCGCCGC 
CAAAGAATCA TCCAGAGGAA CCGCACCGAG AGGCTTTCAG ATCTTCTGGA CTGGAGATAC 
CTGGGCAGAT ATTACCAGCA TGCCAGACAT CTGACACTGA GCAGGGCTTT TCCAGACAAA 
TTCCACCTGG AGCCCACATC CCCACCAACG ACGGATGGCT TTAAGTATCC CAGGCCCTCC 
TCAGTACCAC CTTCCCCATC AGGATCCCAG ACTTCAAGTC CTCAGAGCAG CGATGTGGAA 
AACGAAGGGG ATGAGGATGA GAGATATGAT GAGGAAGAGG AGGCTGAGAG GGACCGGCTA 
AACATCAAGT CACCATTTTC CCTGAACCAC ATCCCAAAGG GGAAGAAAAA GCTTCATGGA 
GAATATAAGA ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_037221.2
CDS	230..2344
Translation	MLRGRSLSVTSLGGLPAWEAERLPVEDLLLFEVSWEVTNKVGGICTVIQSKAKTTANEWGENYFLIGPYFEHNVKTQVEPCEPANDAVRKAVDAMNKHGCQVHFGRWLIEGSPYVVLFDISSSAWNLDRWKGDFWEACGVGIPHDDREANDMLIFGSLTAWFLKEVTDHADGKHVIAQFHEWQAGTGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNQLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHATYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSNVTVVVFFIMPAKTNNFNVETLKGQAVRKQLWDTVHCMKEKFGKKLYDGLLRGEIPDMNSILDRDDLTIMKRAIFSTQRHSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTQFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHLEPTSPPTTDGFKYPRPSSVPPSPSGSQTSSPQSSDVENEGDEDERYDEEEEAERDRLNIKSPFSLNHIPKGKKKLHGEYKN

Target ORF information:

RefSeq Version	NM_013089.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus glycogen synthase 2 (Gys2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013089.2

ORF Insert Sequence:

ATGCTCAGGG GCCGCTCCTT GTCTGTGACG TCCCTTGGTG GGCTCCCTGC ATGGGAAGCT 
GAAAGACTCC CCGTGGAAGA CTTATTGCTT TTTGAAGTTT CCTGGGAAGT GACCAACAAA 
GTTGGGGGCA TCTGTACTGT GATCCAGAGC AAAGCCAAAA CCACAGCCAA TGAATGGGGA 
GAGAATTACT TCCTGATAGG TCCGTATTTT GAGCATAATG TGAAGACTCA AGTAGAGCCA 
TGCGAGCCCG CCAACGATGC CGTCAGAAAA GCTGTGGATG CCATGAACAA ACATGGCTGC 
CAGGTGCATT TTGGAAGATG GCTGATAGAA GGGAGTCCGT ATGTGGTGCT TTTTGACATC 
AGCTCCTCAG CGTGGAACCT GGACAGGTGG AAGGGAGACT TCTGGGAAGC ATGTGGCGTT 
GGCATCCCTC ACGACGACCG AGAAGCCAAT GACATGCTCA TATTTGGGTC TTTAACTGCC 
TGGTTCTTAA AGGAGGTGAC GGACCATGCA GACGGTAAAC ACGTCATTGC CCAATTCCAT 
GAATGGCAGG CTGGAACTGG GCTGATCCTT TCTCGTGCCA GGAAACTCCC CATCGCCACA 
ATATTTACAA CCCATGCCAC ACTGCTGGGG CGGTATCTCT GTGCAGCAAA TATTGACTTC 
TACAACCAGC TTGATAAGTT CAACATAGAC AAAGAGGCCG GGGAGAGGCA GATTTATCAC 
CGCTACTGCA TGGAGCGGGC TTCCGTGCAC TGTGCGCACG TGTTTACCAC AGTGTCAGAA 
ATCACAGCCA TCGAGGCGGA GCACATGCTG AAGAGGAAGC CTGATGTGGT GACTCCAAAC 
GGCTTGAACG TTAAGAAGTT TTCTGCGGTG CACGAGTTTC AAAATCTCCA TGCCACATAC 
AAGGCCAGGA TACAGGATTT TGTTCGAGGT CATTTCTATG GCCACCTGGA CTTCGATCTT 
GAAAAGACGT TATTTCTTTT CATTGCTGGG AGGTATGAGT TCTCCAACAA GGGAGCAGAC 
ATCTTCCTAG AATCCTTATC CAGGCTCAAT TTCCTCCTAA GGATGCATAA GAGTAACGTC 
ACTGTGGTAG TGTTTTTCAT CATGCCTGCC AAGACAAACA ATTTCAACGT GGAAACCCTG 
AAGGGCCAGG CGGTGCGGAA ACAGCTGTGG GACACTGTGC ACTGTATGAA GGAAAAGTTT 
GGAAAGAAAC TCTACGATGG GTTATTAAGA GGAGAAATAC CCGACATGAA TAGTATTTTG 
GATCGAGATG ACTTAACAAT TATGAAAAGA GCCATTTTTT CAACTCAGAG ACACTCTTTG 
CCTCCTGTGA CCACTCACAA TATGATCGAC GATTCCACGG ATCCCATCCT CAGCACCATT 
CGACGAATTG GACTTTTCAA CAATCGCACA GACAGAGTCA AGGTGATTTT ACACCCAGAA 
TTCCTGTCCT CCACCAGCCC CCTACTACCA ATGGATTATG AAGAGTTTGT CCGAGGCTGT 
CACCTTGGGG TATTTCCATC ATACTATGAG CCCTGGGGTT ACACGCCAGC CGAATGCACA 
GTGATGGGCA TCCCCAGTGT GACTACGAAC CTCTCTGGTT TCGGGTGTTT CATGCAGGAG 
CATGTGGCTG ACCCTACCGC GTACGGTATT TATATCGTCG ACAGACGCTT CCGCTCTCCA 
GATGATTCTT GCAACCAGCT GACTCAGTTT CTCTATGGGT TCTGTAAACA GTCCCGCCGC 
CAAAGAATCA TCCAGAGGAA CCGCACCGAG AGGCTTTCAG ATCTTCTGGA CTGGAGATAC 
CTGGGCAGAT ATTACCAGCA TGCCAGACAT CTGACACTGA GCAGGGCTTT TCCAGACAAA 
TTCCACCTGG AGCCCACATC CCCACCAACG ACGGATGGCT TTAAGTATCC CAGGCCCTCC 
TCAGTACCAC CTTCCCCATC AGGATCCCAG ACTTCAAGTC CTCAGAGCAG CGATGTGGAA 
AACGAAGGGG ATGAGGATGA GAGATATGAT GAGGAAGAGG AGGCTGAGAG GGACCGGCTA 
AACATCAAGT CACCATTTTC CCTGAACCAC ATCCCAAAGG GGAAGAAAAA GCTTCATGGA 
GAATATAAGA ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Hepatic overexpression of a constitutively active form of liver glycogen synthase improves glucose homeostasis.
The Journal of biological chemistry285(48)37170-7(2010 Nov)
Ros S,Zafra D,Valles-Ortega J,Garc?a-Rocha M,Forrow S,Dom?nguez J,Calb? J,Guinovart JJ

Control of liver glycogen synthase activity and intracellular distribution by phosphorylation.
The Journal of biological chemistry284(10)6370-8(2009 Mar)
Ros S,Garc?a-Rocha M,Dom?nguez J,Ferrer JC,Guinovart JJ

Metabolic impact of overexpression of liver glycogen synthase with serine-to-alanine substitutions in rat primary hepatocytes.
Archives of biochemistry and biophysics466(2)283-9(2007 Oct)
Kadotani A,Fujimura M,Nakamura T,Ohyama S,Harada N,Maruki H,Tamai Y,Kanatani A,Eiki J,Nagata Y

Conjugated bile acids regulate hepatocyte glycogen synthase activity in vitro and in vivo via Galphai signaling.
Molecular pharmacology71(4)1122-8(2007 Apr)
Fang Y,Studer E,Mitchell C,Grant S,Pandak WM,Hylemon PB,Dent P

Defect in glucokinase translocation in Zucker diabetic fatty rats.
American journal of physiology. Endocrinology and metabolism287(3)E414-23(2004 Sep)
Fujimoto Y,Donahue EP,Shiota M

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Gys2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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