Marcks cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Marcks
Entrez Gene ID	25603
Full Name	myristoylated alanine rich protein kinase C substrate
Synonyms	KINC,Macs
General protein information	Preferred Names myristoylated alanine rich protein kinase C substrate Names myristoylated alanine-rich C-kinase substrate Myristoylated alanine-rich protein kinase C substrate protein kinase C substrate 80 kDa protein
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 20 Map Location: 20q12
Summary	protein kinase C (PKC) substrate and scaffolding protein [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001271090.2	NP_001258019.1	myristoylated alanine-rich C-kinase substrate

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Marcks	NP_001258019.1
Danio rerio (zebrafish)	marcksa	NP_001019575.2

Gene Ontology
Bibliography

Related articles in PubMed

MARCKS is Necessary for Oligodendrocyte Precursor Cell Maturation.
Zhang ZH, Ma FF, Zhang H, Xu XH
Neurochemical research42(10)2933-2939(2017 Oct)

MARCKS regulates membrane targeting of Rab10 vesicles to promote axon development.
Xu XH, Deng CY, Liu Y, He M, Peng J, Wang T, Yuan L, Zheng ZS, Blackshear PJ, Luo ZG
Cell research24(5)576-94(2014 May)

Alterations of the myristoylated, alanine-rich C kinase substrate (MARCKS) in prefrontal cortex in schizophrenia.
Pinner AL, Haroutunian V, Meador-Woodruff JH
Schizophrenia research154(1-3)36-41(2014 Apr)

Immunoelectron microscopic study of BASP1 and MARCKS location in the early and late rat spermatids.
Mosevitsky MI, Snigirevskaya ES, Komissarchik YY
Acta histochemica114(3)237-43(2012 May)

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for ?-Pix in negative regulation of focal adhesion maturation.
Kuo JC, Han X, Hsiao CT, Yates JR 3rd, Waterman CM
Nature cell biology13(4)383-93(2011 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Either genetic silencing of MARCKS or disruption of its interaction with Rab10 inhibited axon growth of cortical neurons.
Title: MARCKS regulates membrane targeting of Rab10 vesicles to promote axon development.

decreased MARCKS and pMARCKS in the frontal cortex in schizophrenia was found; results suggest a mechanism other than myristoylation was responsible for decreased MARCKS expression in schizophrenia
Title: Alterations of the myristoylated, alanine-rich C kinase substrate (MARCKS) in prefrontal cortex in schizophrenia.

In spermatozoa, as in chromatoid body, BASP1 and MARCKS may bind Ca(2+)-calmodulin and therefore contribute to the activation of calcium-dependent biochemical processes.
Title: Immunoelectron microscopic study of BASP1 and MARCKS location in the early and late rat spermatids.

MARCKS phosphorylation via the activation of PKCdelta, which is downstream of PKA activation, is involved in the cAMP-dependent amylase release in parotid acinar cells.
Title: Phosphorylation of myristoylated alanine-rich C kinase substrate is involved in the cAMP-dependent amylase release in parotid acinar cells.

These findings demonstrate a critical role for MARCKS-phosphatidylinositol-4,5-diphosphate signaling in regulating dendrite development.
Title: Actin filament assembly by myristoylated alanine-rich C kinase substrate-phosphatidylinositol-4,5-diphosphate signaling is critical for dendrite branching.

The following Marcks gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Marcks cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa10229	NM_001271090.2 Latest version!	Rattus norvegicus myristoylated alanine rich protein kinase C substrate (Marcks), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Marcks ( NM_001271090.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001258019.1 Rattus norvegicus myristoylated alanine rich protein kinase C substrate (Marcks), mRNA.

Price & Availability↑

CloneID	ORa10229
Clone ID Related Accession (Same CDS sequence)	NM_001271090.2
Accession Version	NM_001271090.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 930bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Rattus norvegicus(Norway rat)
Product	myristoylated alanine-rich C-kinase substrate
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AABR07045321.1 and M59859.1. On Sep 4, 2012 this sequence version replaced NM_001271090.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BF281934.1, M59859.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGGTGCAC AGTTCTCCAA GACCGCAGCG AAGGGAGAAG CCGCCGCTGA GAGGCCCGGG 
GAGGCGGCTG TGGCCTCGTC GCCTTCCAAA GCAAATGGGC AGGAGAATGG CCACGTAAAA 
GTGAACGGGG ACGCGTCGCC CGCCGCCGCC GAGCCGGGCG CCAAGGAGGA GCTGCACGCC 
AACTTTTTCT CCCCGGCCGC CGACAAGGAG GAGCCTGCGA GCGGCGGCGC CGCGACCCCC 
GCCGCGGCCG ATAAGGATGA GGCAGCCGCG GCCCCCGAGT CGGGCGCCGC CACGGCCGAC 
AAGGAGGCTG CGGAGGCCGA GCCCGCCGAG CCCGGCTCCC CCTCCGCGGA GACCGAGGGC 
GCGTCTGCCT CCTCCACGTC GTCCCCCAAG GCGGAGGACG GGGCCGCGCC GTCTCCCAGC 
AGCGAGACCC CGAAAAAAAA AAAGAAGCGC TTTTCCTTCA AGAAGTCCTT CAAGCTGAGC 
GGCTTCTCCT TCAAGAAGAG CAAGAAGGAG GCCGGCGAGG GCGCTGAGGC GGAAGGCGCG 
ACCGCCGACG GCGCCAAGGA CGAGGCCGCA GCTGCAGCCG GCGGCGACGC GGCCGCGGCC 
CCGGGGGAGC AGGCGGGCGG GGCGGGCGCC GAGGGCGCGG AGGGCGGAGA GTCCCGGGAG 
GCCGAGGCGG CGGAGCCGGA GCAGCCGGAG CAGCCTGAGC AGCCCGCGGC GGAAGAGCCA 
AGGGCCGAGG AGCCGTCGGA GGCCGTGGGG GAGAAGGCCG AGGAGCCCGC GCCGGGCGCC 
ACCGCAGATG ACGCGCCCTC CGCTGCGGGG CCCGAGCAGG AGGCGCCCGC CGCCACCGAC 
GAGCCCGCGG CGTCCGCAGC TCCCTCCGCG TCACCGGAGC CGCAGCCCGA GTGCAGTCCG 
GAGGCGCCCC CCGCGCCGGT GGCCGAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001258019.1
CDS	383..1312
Translation	MGAQFSKTAAKGEAAAERPGEAAVASSPSKANGQENGHVKVNGDASPAAAEPGAKEELHANFFSPAADKEEPASGGAATPAAADKDEAAAAPESGAATADKEAAEAEPAEPGSPSAETEGASASSTSSPKAEDGAAPSPSSETPKKKKKRFSFKKSFKLSGFSFKKSKKEAGEGAEAEGATADGAKDEAAAAAGGDAAAAPGEQAGGAGAEGAEGGESREAEAAEPEQPEQPEQPAAEEPRAEEPSEAVGEKAEEPAPGATADDAPSAAGPEQEAPAATDEPAASAAPSASPEPQPECSPEAPPAPVAE

Target ORF information:

RefSeq Version	NM_001271090.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus myristoylated alanine rich protein kinase C substrate (Marcks), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001271090.2

ORF Insert Sequence:

ATGGGTGCAC AGTTCTCCAA GACCGCAGCG AAGGGAGAAG CCGCCGCTGA GAGGCCCGGG 
GAGGCGGCTG TGGCCTCGTC GCCTTCCAAA GCAAATGGGC AGGAGAATGG CCACGTAAAA 
GTGAACGGGG ACGCGTCGCC CGCCGCCGCC GAGCCGGGCG CCAAGGAGGA GCTGCACGCC 
AACTTTTTCT CCCCGGCCGC CGACAAGGAG GAGCCTGCGA GCGGCGGCGC CGCGACCCCC 
GCCGCGGCCG ATAAGGATGA GGCAGCCGCG GCCCCCGAGT CGGGCGCCGC CACGGCCGAC 
AAGGAGGCTG CGGAGGCCGA GCCCGCCGAG CCCGGCTCCC CCTCCGCGGA GACCGAGGGC 
GCGTCTGCCT CCTCCACGTC GTCCCCCAAG GCGGAGGACG GGGCCGCGCC GTCTCCCAGC 
AGCGAGACCC CGAAAAAAAA AAAGAAGCGC TTTTCCTTCA AGAAGTCCTT CAAGCTGAGC 
GGCTTCTCCT TCAAGAAGAG CAAGAAGGAG GCCGGCGAGG GCGCTGAGGC GGAAGGCGCG 
ACCGCCGACG GCGCCAAGGA CGAGGCCGCA GCTGCAGCCG GCGGCGACGC GGCCGCGGCC 
CCGGGGGAGC AGGCGGGCGG GGCGGGCGCC GAGGGCGCGG AGGGCGGAGA GTCCCGGGAG 
GCCGAGGCGG CGGAGCCGGA GCAGCCGGAG CAGCCTGAGC AGCCCGCGGC GGAAGAGCCA 
AGGGCCGAGG AGCCGTCGGA GGCCGTGGGG GAGAAGGCCG AGGAGCCCGC GCCGGGCGCC 
ACCGCAGATG ACGCGCCCTC CGCTGCGGGG CCCGAGCAGG AGGCGCCCGC CGCCACCGAC 
GAGCCCGCGG CGTCCGCAGC TCCCTCCGCG TCACCGGAGC CGCAGCCCGA GTGCAGTCCG 
GAGGCGCCCC CCGCGCCGGT GGCCGAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

MARCKS is Necessary for Oligodendrocyte Precursor Cell Maturation.
Neurochemical research42(10)2933-2939(2017 Oct)
Zhang ZH,Ma FF,Zhang H,Xu XH

MARCKS regulates membrane targeting of Rab10 vesicles to promote axon development.
Cell research24(5)576-94(2014 May)
Xu XH,Deng CY,Liu Y,He M,Peng J,Wang T,Yuan L,Zheng ZS,Blackshear PJ,Luo ZG

Alterations of the myristoylated, alanine-rich C kinase substrate (MARCKS) in prefrontal cortex in schizophrenia.
Schizophrenia research154(1-3)36-41(2014 Apr)
Pinner AL,Haroutunian V,Meador-Woodruff JH

Immunoelectron microscopic study of BASP1 and MARCKS location in the early and late rat spermatids.
Acta histochemica114(3)237-43(2012 May)
Mosevitsky MI,Snigirevskaya ES,Komissarchik YY

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for ?-Pix in negative regulation of focal adhesion maturation.
Nature cell biology13(4)383-93(2011 Apr)
Kuo JC,Han X,Hsiao CT,Yates JR 3rd,Waterman CM

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Marcks cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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