F2r cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	F2r
Entrez Gene ID	25439
Full Name	coagulation factor II (thrombin) receptor
Synonyms	Par1,TRGPC
General protein information	Preferred Names coagulation factor II (thrombin) receptor Names proteinase-activated receptor 1 PAR-1 Thrombin receptor coagulation factor II receptor protease-activated receptor 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 2 Map Location: 2q12
Summary	plays a role in blood coagulation, inflammatory response, and cell proliferation; mediates signal transduction via MAP kinase and other signaling pathways [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_012950.2	NP_037082.2	proteinase-activated receptor 1 precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	F2R	XP_526888.3
Homo sapiens (human)	F2R	NP_001983.2
Canis lupus familiaris (dog)	F2R	XP_005618243.1
Danio rerio (zebrafish)	f2r	NP_001108318.1
	F2R	XP_001106136.1
Gallus gallus (chicken)	F2R	XP_004937394.1
Xenopus tropicalis (tropical clawed frog)	f2r	XP_004910450.1
Mus musculus (house mouse)	F2r	NP_034299.2
Bos taurus (cattle)	F2R	NP_001096567.1
Rattus norvegicus (Norway rat)	F2r	NP_037082.2

Gene Ontology
Bibliography

Related articles in PubMed

The role of spinal thrombin through protease-activated receptor 1 in hyperalgesia after neural injury.
Smith JR, Winkelstein BA
Journal of neurosurgery. Spine26(4)532-541(2017 Apr)

Interference with Protease-activated Receptor 1 Alleviates Neuronal Cell Death Induced by Lipopolysaccharide-Stimulated Microglial Cells through the PI3K/Akt Pathway.
Li Y, Yang W, Quinones-Hinojosa A, Wang B, Xu S, Zhu W, Yu F, Yuan S, Lu P
Scientific reports638247(2016 Dec)

Protease activated receptor 1 (PAR1) enhances Src-mediated tyrosine phosphorylation of NMDA receptor in intracerebral hemorrhage (ICH).
Duan ZZ, Zhang F, Li FY, Luan YF, Guo P, Li YH, Liu Y, Qi SH
Scientific reports629246(2016 Jul)

Cross Talk Pathways Between Coagulation and Inflammation.
Foley JH, Conway EM
Circulation research118(9)1392-408(2016 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Study suggests a potent role for spinal thrombin and its activation of PAR1 in pain onset following neuropathic injury
Title: The role of spinal thrombin through protease-activated receptor 1 in hyperalgesia after neural injury.

PAR1 and PAR2 play a critical role in Ang II-induced adventitial fibroblasts activation, and this may contribute to adventitia-related pathological changes.
Title: Protease-activated receptor 1 and 2 contribute to angiotensin II-induced activation of adventitial fibroblasts from rat aorta.

increased thrombin activity 6 to 24 hours after germinal matrix hemorrhage, and PAR-1, PAR-4, inhibition normalized cyclooxygenase-2, and mammalian target of rapamycin by 72 hours.
Title: Protease-activated receptor 1 and 4 signal inhibition reduces preterm neonatal hemorrhagic brain injury.

Data suggest that the protease-activated receptor 1 signaling pathway contributes to epileptogenesis following status epilepticus.
Title: Contribution of protease-activated receptor 1 in status epilepticus-induced epileptogenesis.

Inflammatory bowel disease is associated with production of prothrombin in the dorsal motor nucleus of the vagus (DMV). Thrombin in the DMV causes vagal neuron apoptosis and decreased sensitivity to neurotransmitters.
Title: Thrombin mediates vagal apoptosis and dysfunction in inflammatory bowel disease.

The following F2r gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the F2r cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12196	NM_012950.2 Latest version!	Rattus norvegicus coagulation factor II (thrombin) receptor (F2r), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

F2r ( NM_012950.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_037082.2 Rattus norvegicus coagulation factor II (thrombin) receptor (F2r), mRNA.

Price & Availability↑

CloneID	ORa12196
Clone ID Related Accession (Same CDS sequence)	NM_012950.2
Accession Version	NM_012950.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1299bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Rattus norvegicus(Norway rat)
Product	proteinase-activated receptor 1 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC085759.1 and CV116337.1. On Nov 23, 2005 this sequence version replaced NM_012950.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: BC085759.1 [ECO:0000345] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGGGCCCC GGCGCTTGCT GCTCGTCGCG GTCGGCCTCA GCCTGTGCGG TCCTTTGCTG 
TCTTCCCGCG TTCCTATGAG ACAGCCAGAA TCTGAGAGGA TGTATGCTAC GCCGTATGCT 
ACGCCAAACC CCCGCTCATT TTTTCTCAGG AATCCCAGTG AAGATACATT TGAACAGTTC 
CCCCTAGGGG ATGAGGAGGA GAAAAATGAA AGCATACCGC TCGAGGGCAG GGCAGTCTAC 
TTAAATAAAA GCCGTTTTCC TCCCATGCCG CCTCCTCCCT TCATCTCCGA GGACGCCTCC 
GGATATCTGA CCAGCCCCTG GCTGACGCTC TTCATACCCT CCGTGTACAC GTTTGTGTTC 
ATAGTCAGCC TTCCCCTGAA CATCCTGGCC ATCGCTGTGT TTGTCTTTCG GATGAAGGTC 
AAGAAGCCGG CCGTGGTGTA CATGCTGCAC CTGGCCATGG CCGATGTCCT CTTCGTGTCC 
GTGCTCCCCT TCAAGATCAG CTACTACTTC TCCGGCACCG ATTGGCAGTT CGGGTCCGGA 
ATGTGTCGCT TCGCCACCGC AGCGTTTTAT TGTAACATGT ACGCCTCCAT CATGCTCATG 
ACAGTCATAA GCATTGACCG GTTCCTGGCA GTGGTGTACC CCATCCAGTC CCTGTCCTGG 
CGCACTCTGG GCCGAGCCAA CTTCACCTGC GTGGTCATCT GGGTGATGGC CATCATGGGG 
GTGGTGCCCC TCCTCCTCAA AGAGCAGACC ACCCAGGTTC CGGGGCTCAA CATCACCACC 
TGCCACGACG TCCTCAACGA GACCCTGCTG CATGGCTTTT ACTCGTACTA TTTCTCCGCC 
TTCTCCGCCA TCTTCTTTCT TGTGCCGTTG ATCATTTCCA CAGTCTGCTA CACGTCCATC 
ATCCGATGCC TCAGCTCCTC CGCGGTGGCG AACCGGAGCA AGAAGTCGCG GGCTTTGTTC 
CTGTCCGCCG CCGTGTTCTG CATCTTCATC GTCTGCTTTG GGCCCACCAA CGTCCTCCTG 
ATTGTGCACT ACCTGCTCCT CTCCGACAGT CCTGGCACAG AGACGGCCTA TTTTGCTTAC 
CTCCTCTGCG TCTGCGTGAG CAGCGTGAGC TGCTGCATCG ACCCCTTGAT TTACTACTAT 
GCCTCCTCCG AGTGCCAGAA GCACCTTTAC AGCATTTTGT GCTGCAGAGA AAGCTCTGAT 
TCCAACAGTT GCAACAGCAC CGGCCAGCTG ATGCCCAGTA AGATGGATAC CTGCTCTAGC 
CACCTGAATA ATAGCATATA CAAAAAGCTA CTAGCTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_037082.2
CDS	66..1364
Translation	MGPRRLLLVAVGLSLCGPLLSSRVPMRQPESERMYATPYATPNPRSFFLRNPSEDTFEQFPLGDEEEKNESIPLEGRAVYLNKSRFPPMPPPPFISEDASGYLTSPWLTLFIPSVYTFVFIVSLPLNILAIAVFVFRMKVKKPAVVYMLHLAMADVLFVSVLPFKISYYFSGTDWQFGSGMCRFATAAFYCNMYASIMLMTVISIDRFLAVVYPIQSLSWRTLGRANFTCVVIWVMAIMGVVPLLLKEQTTQVPGLNITTCHDVLNETLLHGFYSYYFSAFSAIFFLVPLIISTVCYTSIIRCLSSSAVANRSKKSRALFLSAAVFCIFIVCFGPTNVLLIVHYLLLSDSPGTETAYFAYLLCVCVSSVSCCIDPLIYYYASSECQKHLYSILCCRESSDSNSCNSTGQLMPSKMDTCSSHLNNSIYKKLLA

Target ORF information:

RefSeq Version	NM_012950.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus coagulation factor II (thrombin) receptor (F2r), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012950.2

ORF Insert Sequence:

ATGGGGCCCC GGCGCTTGCT GCTCGTCGCG GTCGGCCTCA GCCTGTGCGG TCCTTTGCTG 
TCTTCCCGCG TTCCTATGAG ACAGCCAGAA TCTGAGAGGA TGTATGCTAC GCCGTATGCT 
ACGCCAAACC CCCGCTCATT TTTTCTCAGG AATCCCAGTG AAGATACATT TGAACAGTTC 
CCCCTAGGGG ATGAGGAGGA GAAAAATGAA AGCATACCGC TCGAGGGCAG GGCAGTCTAC 
TTAAATAAAA GCCGTTTTCC TCCCATGCCG CCTCCTCCCT TCATCTCCGA GGACGCCTCC 
GGATATCTGA CCAGCCCCTG GCTGACGCTC TTCATACCCT CCGTGTACAC GTTTGTGTTC 
ATAGTCAGCC TTCCCCTGAA CATCCTGGCC ATCGCTGTGT TTGTCTTTCG GATGAAGGTC 
AAGAAGCCGG CCGTGGTGTA CATGCTGCAC CTGGCCATGG CCGATGTCCT CTTCGTGTCC 
GTGCTCCCCT TCAAGATCAG CTACTACTTC TCCGGCACCG ATTGGCAGTT CGGGTCCGGA 
ATGTGTCGCT TCGCCACCGC AGCGTTTTAT TGTAACATGT ACGCCTCCAT CATGCTCATG 
ACAGTCATAA GCATTGACCG GTTCCTGGCA GTGGTGTACC CCATCCAGTC CCTGTCCTGG 
CGCACTCTGG GCCGAGCCAA CTTCACCTGC GTGGTCATCT GGGTGATGGC CATCATGGGG 
GTGGTGCCCC TCCTCCTCAA AGAGCAGACC ACCCAGGTTC CGGGGCTCAA CATCACCACC 
TGCCACGACG TCCTCAACGA GACCCTGCTG CATGGCTTTT ACTCGTACTA TTTCTCCGCC 
TTCTCCGCCA TCTTCTTTCT TGTGCCGTTG ATCATTTCCA CAGTCTGCTA CACGTCCATC 
ATCCGATGCC TCAGCTCCTC CGCGGTGGCG AACCGGAGCA AGAAGTCGCG GGCTTTGTTC 
CTGTCCGCCG CCGTGTTCTG CATCTTCATC GTCTGCTTTG GGCCCACCAA CGTCCTCCTG 
ATTGTGCACT ACCTGCTCCT CTCCGACAGT CCTGGCACAG AGACGGCCTA TTTTGCTTAC 
CTCCTCTGCG TCTGCGTGAG CAGCGTGAGC TGCTGCATCG ACCCCTTGAT TTACTACTAT 
GCCTCCTCCG AGTGCCAGAA GCACCTTTAC AGCATTTTGT GCTGCAGAGA AAGCTCTGAT 
TCCAACAGTT GCAACAGCAC CGGCCAGCTG ATGCCCAGTA AGATGGATAC CTGCTCTAGC 
CACCTGAATA ATAGCATATA CAAAAAGCTA CTAGCTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The role of spinal thrombin through protease-activated receptor 1 in hyperalgesia after neural injury.
Journal of neurosurgery. Spine26(4)532-541(2017 Apr)
Smith JR,Winkelstein BA

Interference with Protease-activated Receptor 1 Alleviates Neuronal Cell Death Induced by Lipopolysaccharide-Stimulated Microglial Cells through the PI3K/Akt Pathway.
Scientific reports638247(2016 Dec)
Li Y,Yang W,Quinones-Hinojosa A,Wang B,Xu S,Zhu W,Yu F,Yuan S,Lu P

Protease activated receptor 1 (PAR1) enhances Src-mediated tyrosine phosphorylation of NMDA receptor in intracerebral hemorrhage (ICH).
Scientific reports629246(2016 Jul)
Duan ZZ,Zhang F,Li FY,Luan YF,Guo P,Li YH,Liu Y,Qi SH

Cross Talk Pathways Between Coagulation and Inflammation.
Circulation research118(9)1392-408(2016 Apr)
Foley JH,Conway EM

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F2r cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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