F2R cDNA ORF clone, Bos taurus(cattle)

Gene
Clones
gRNAs

Summary

Gene Symbol	F2R
Entrez Gene ID	526585
Full Name	coagulation factor II thrombin receptor
Synonyms	PAR1
General protein information	Preferred Names coagulation factor II thrombin receptor Names proteinase-activated receptor 1 PAR-1 protease-activated receptor 1 thrombin receptor
Gene Type	protein-coding
Organism	Bos taurus(cattle)

mRNA and Protein(s)

mRNA	Protein	Name
XM_024997572.1	XP_024853340.1	proteinase-activated receptor 1 isoform X1
NM_001103097.2	NP_001096567.1	proteinase-activated receptor 1 precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	F2R	XP_526888.3
Homo sapiens (human)	F2R	NP_001983.2
Canis lupus familiaris (dog)	F2R	XP_005618243.1
Danio rerio (zebrafish)	f2r	NP_001108318.1
	F2R	XP_001106136.1
Gallus gallus (chicken)	F2R	XP_004937394.1
Xenopus tropicalis (tropical clawed frog)	f2r	XP_004910450.1
Mus musculus (house mouse)	F2r	NP_034299.2
Bos taurus (cattle)	F2R	NP_001096567.1
Rattus norvegicus (Norway rat)	F2r	NP_037082.2

Gene Ontology
Bibliography

Related articles in PubMed

Matrix metalloproteinase-1-mediated up-regulation of vascular endothelial growth factor-2 in endothelial cells.
Mazor R, Alsaigh T, Shaked H, Altshuler AE, Pocock ES, Kistler EB, Karin M, Schmid-Sch?nbein GW
The Journal of biological chemistry288(1)598-607(2013 Jan)

Distinct roles of protease-activated receptors in signal transduction regulation of endothelial nitric oxide synthase.
Suzuki H, Motley ED, Eguchi K, Hinoki A, Shirai H, Watts V, Stemmle LN, Fields TA, Eguchi S
Hypertension (Dallas, Tex. : 1979)53(2)182-8(2009 Feb)

A whole-genome assembly of the domestic cow, Bos taurus.
Zimin AV, Delcher AL, Florea L, Kelley DR, Schatz MC, Puiu D, Hanrahan F, Pertea G, Van Tassell CP, Sonstegard TS, Mar?ais G, Roberts M, Subramanian P, Yorke JA, Salzberg SL
Genome biology10(4)R42(2009)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

MMP-1 promotes VEGFR2 expression and proliferation of endothelial cells through stimulation of PAR-1 and activation of NF-kappaB
Title: Matrix metalloproteinase-1-mediated up-regulation of vascular endothelial growth factor-2 in endothelial cells.

PAR1 and PAR2 regulate endothelial NO synthase phosphorylation and activity through G(12/13) and G(q), delineating the signaling pathways by which the proteases act on protease-activated receptors to modulate endothelial functions.
Title: Distinct roles of protease-activated receptors in signal transduction regulation of endothelial nitric oxide synthase.

The following F2R gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the F2R cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OBa44722	NM_001103097.2 Latest version!	Bos taurus coagulation factor II thrombin receptor (F2R), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$258.30 $369.00
OBa219586	XM_024997572.1 Latest version!	Bos taurus coagulation factor II thrombin receptor (F2R), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

F2R ( NM_001103097.2 ) cDNA ORF clone, Bos taurus(cattle) -> NP_001096567.1 Bos taurus coagulation factor II thrombin receptor (F2R), mRNA.

Price & Availability↑

CloneID	OBa44722
Clone ID Related Accession (Same CDS sequence)	NM_001103097.2
Accession Version	NM_001103097.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1284bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Bos taurus(cattle)
Product	proteinase-activated receptor 1 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC151272.1. On Aug 30, 2012 this sequence version replaced NM_001103097.1. ##Evidence-Data-START## Transcript exon combination :: BC151272.1, DY140874.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03145413, SAMN03145414 [ECO:0000348] ##Evidence-Data-END##

ATGGGGCCGC GGTGGCTGCT GCTCTGGGCC GCGGGGCTCG GTCTGTGCAG CCCCCTGGTG 
TCGGCCCGCA CCCGAGGCCC CAGACCAGGG ACAGACCCAA CAAACGGTAC TCTGGGTCCT 
CGGTCTTTCT TTCTCAGGAA TTCCAATGAC GGATATGAAC AAATCCCACT GCCAGAGGAT 
GAGGACTCGA GTGAAGGTGA ATTCACAGAA GACAGATTAA GCTCAGGCAA CAGAAGCAGC 
CCGCCTCAAA AGTCACCCCC TGGGTTTATC TCCAAATCCG CCTCAGGATA TCTGACCAGC 
GCCTGGCTGA CTGTCTTTAT CCCCTCAGTC TACACGGGCG TGTTCCTCGT CAGCCTTCCT 
CTGAACATCA TGGCCGTCGT GGTGTTCGTC TTGAAGATGA AGGTCAAGAA GCCGGCCGTG 
GTGTACATGC TGCACCTGGC CGCGGCAGAC GTACTCTTCG TGTGTGTGCT TCCGTTCAAG 
ATCAGCTACT ACTTCTCCGG AAGCGACTGG AGGTTCGGGT CTGCCATGTG CCGCTTCGTC 
ACGGCGGCCT TCTACGGGAA CATGTACGCC TCCATCATGC TCATGACGGC CATCAGCGTC 
GACCGCTTCC TGGCCGTGGT GTACCCCATC CAGTCCCTCT CCTGGCGGAC CCTGGGGCGC 
GCTTCCTTCA TCTGCCTGGC CATCTGGGCC ATGGCCATCG CGGGGGTGGC GCCCCTGCTC 
CTGCAGGAGC AGGCCACCCA GGTGCCGGGG CTCAACATCA CCGCCTGCCA CGACGTGCTC 
AACCAGACGC TGCTGGAAGG CTACTACTCG TACTACTTCT CCGCCTTCTC CGCCGTCTTC 
TTCTTCGTGC CGCTGACCCT TTCCACCGTC TCTTACGTGT CCATCATCCG ATGCCTCAGC 
TCTTCCACGG TTGCCAACCA GAACAAGAAG TCCCGGGCTT TGCTCCTGTC CGCGGCTGTC 
TTCTGCATCT TCATCCTTTG CTTTGGACCC ACAAACATCC TTCTGCTTCT CCACTACGCG 
TTCCTTTCCT CTGATCCCAT GACAGAGGCC GCCTACTTTG CCTACCTCCT GTGTGTCTGC 
GTCAGCAGCA TAAGCTGTTG CATCGACCCC TTGATATACT ACTATGCTTC CTCGGAGTGC 
CAGAGGCACC TCTTTGCTAT CTTACACTGC AAAGAAAGTT CAGATCCCGG CAGCTGTAAC 
AGCAGCGGTC AGCTGATGCC AAGTAAAATG GACACCTGCT CTAGTAACCT GAGTAGCAGT 
CTATACAAAA AGCTCTTAAC TTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001096567.1
CDS	134..1417
Translation	MGPRWLLLWAAGLGLCSPLVSARTRGPRPGTDPTNGTLGPRSFFLRNSNDGYEQIPLPEDEDSSEGEFTEDRLSSGNRSSPPQKSPPGFISKSASGYLTSAWLTVFIPSVYTGVFLVSLPLNIMAVVVFVLKMKVKKPAVVYMLHLAAADVLFVCVLPFKISYYFSGSDWRFGSAMCRFVTAAFYGNMYASIMLMTAISVDRFLAVVYPIQSLSWRTLGRASFICLAIWAMAIAGVAPLLLQEQATQVPGLNITACHDVLNQTLLEGYYSYYFSAFSAVFFFVPLTLSTVSYVSIIRCLSSSTVANQNKKSRALLLSAAVFCIFILCFGPTNILLLLHYAFLSSDPMTEAAYFAYLLCVCVSSISCCIDPLIYYYASSECQRHLFAILHCKESSDPGSCNSSGQLMPSKMDTCSSNLSSSLYKKLLT

Target ORF information:

RefSeq Version	NM_001103097.2
Organism	Bos taurus(cattle)
Definition	Bos taurus coagulation factor II thrombin receptor (F2R), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001103097.2

ORF Insert Sequence:

ATGGGGCCGC GGTGGCTGCT GCTCTGGGCC GCGGGGCTCG GTCTGTGCAG CCCCCTGGTG 
TCGGCCCGCA CCCGAGGCCC CAGACCAGGG ACAGACCCAA CAAACGGTAC TCTGGGTCCT 
CGGTCTTTCT TTCTCAGGAA TTCCAATGAC GGATATGAAC AAATCCCACT GCCAGAGGAT 
GAGGACTCGA GTGAAGGTGA ATTCACAGAA GACAGATTAA GCTCAGGCAA CAGAAGCAGC 
CCGCCTCAAA AGTCACCCCC TGGGTTTATC TCCAAATCCG CCTCAGGATA TCTGACCAGC 
GCCTGGCTGA CTGTCTTTAT CCCCTCAGTC TACACGGGCG TGTTCCTCGT CAGCCTTCCT 
CTGAACATCA TGGCCGTCGT GGTGTTCGTC TTGAAGATGA AGGTCAAGAA GCCGGCCGTG 
GTGTACATGC TGCACCTGGC CGCGGCAGAC GTACTCTTCG TGTGTGTGCT TCCGTTCAAG 
ATCAGCTACT ACTTCTCCGG AAGCGACTGG AGGTTCGGGT CTGCCATGTG CCGCTTCGTC 
ACGGCGGCCT TCTACGGGAA CATGTACGCC TCCATCATGC TCATGACGGC CATCAGCGTC 
GACCGCTTCC TGGCCGTGGT GTACCCCATC CAGTCCCTCT CCTGGCGGAC CCTGGGGCGC 
GCTTCCTTCA TCTGCCTGGC CATCTGGGCC ATGGCCATCG CGGGGGTGGC GCCCCTGCTC 
CTGCAGGAGC AGGCCACCCA GGTGCCGGGG CTCAACATCA CCGCCTGCCA CGACGTGCTC 
AACCAGACGC TGCTGGAAGG CTACTACTCG TACTACTTCT CCGCCTTCTC CGCCGTCTTC 
TTCTTCGTGC CGCTGACCCT TTCCACCGTC TCTTACGTGT CCATCATCCG ATGCCTCAGC 
TCTTCCACGG TTGCCAACCA GAACAAGAAG TCCCGGGCTT TGCTCCTGTC CGCGGCTGTC 
TTCTGCATCT TCATCCTTTG CTTTGGACCC ACAAACATCC TTCTGCTTCT CCACTACGCG 
TTCCTTTCCT CTGATCCCAT GACAGAGGCC GCCTACTTTG CCTACCTCCT GTGTGTCTGC 
GTCAGCAGCA TAAGCTGTTG CATCGACCCC TTGATATACT ACTATGCTTC CTCGGAGTGC 
CAGAGGCACC TCTTTGCTAT CTTACACTGC AAAGAAAGTT CAGATCCCGG CAGCTGTAAC 
AGCAGCGGTC AGCTGATGCC AAGTAAAATG GACACCTGCT CTAGTAACCT GAGTAGCAGT 
CTATACAAAA AGCTCTTAAC TTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

F2R ( XM_024997572.1 ) cDNA ORF clone, Bos taurus(cattle) -> XP_024853340.1 Bos taurus coagulation factor II thrombin receptor (F2R), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OBa219586
Clone ID Related Accession (Same CDS sequence)	XM_024997572.1
Accession Version	XM_024997572.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 915bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-06
Organism	Bos taurus(cattle)
Product	proteinase-activated receptor 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_037337.1) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Bos taurus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCCGTCG TGGTGTTCGT CTTGAAGATG AAGGTCAAGA AGCCGGCCGT GGTGTACATG 
CTGCACCTGG CCGCGGCAGA CGTACTCTTC GTGTGTGTGC TTCCGTTCAA GATCAGCTAC 
TACTTCTCCG GAAGCGACTG GAGGTTCGGG TCTGCCATGT GCCGCTTCGT CACGGCGGCC 
TTCTACGGGA ACATGTACGC CTCCATCATG CTCATGACGG CCATCAGCGT CGACCGCTTC 
CTGGCCGTGG TGTACCCCAT CCAGTCCCTC TCCTGGCGGA CCCTGGGGCG CGCTTCCTTC 
ATCTGCCTGG CCATCTGGGC CATGGCCATC GCGGGGGTGG CGCCCCTGCT CCTGCAGGAG 
CAGGCCACCC AGGTGCCGGG GCTCAACATC ACCGCCTGCC ACGACGTGCT CAACCAGACG 
CTGCTGGAAG GCTACTACTC GTACTACTTC TCCGCCTTCT CCGCCGTCTT CTTCTTCGTG 
CCGCTGACCC TTTCCACCGT CTGTTACGTG TCCATCATCC GATGCCTCAG CTCTTCCACG 
GTTGCCAACC AGAACAAGAA GTCCCGGGCT TTGCTCCTGT CCGCGGCTGT CTTCTGCATC 
TTCATCCTTT GCTTTGGACC CACAAACATC CTTCTGCTTC TCCACTACGC GTTCCTTTCC 
TCTGATCCCA TGACAGAGGC CGCCTACTTT GCCTACCTCC TGTGTGTCTG CGTCAGCAGC 
ATAAGCTGTT GCATCGACCC CTTGATATAC TACTATGCTT CCTCGGAGTG CCAGAGGCAC 
CTCTTTGCTA TCTTACACTG CAAAGAAAGT TCAGATCCCG GCAGCTGTAA CAGCAGCGGT 
CAGCTGATGC CAAGTAAAAT GGACACCTGC TCTAGTAACC TGAGTAGCAG TCTATACAAA 
AAGCTCTTAA CTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_024853340.1
CDS	424..1338
Translation	MAVVVFVLKMKVKKPAVVYMLHLAAADVLFVCVLPFKISYYFSGSDWRFGSAMCRFVTAAFYGNMYASIMLMTAISVDRFLAVVYPIQSLSWRTLGRASFICLAIWAMAIAGVAPLLLQEQATQVPGLNITACHDVLNQTLLEGYYSYYFSAFSAVFFFVPLTLSTVCYVSIIRCLSSSTVANQNKKSRALLLSAAVFCIFILCFGPTNILLLLHYAFLSSDPMTEAAYFAYLLCVCVSSISCCIDPLIYYYASSECQRHLFAILHCKESSDPGSCNSSGQLMPSKMDTCSSNLSSSLYKKLLT

Target ORF information:

RefSeq Version	XM_024997572.1
Organism	Bos taurus(cattle)
Definition	Bos taurus coagulation factor II thrombin receptor (F2R), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_024997572.1

ORF Insert Sequence:

ATGGCCGTCG TGGTGTTCGT CTTGAAGATG AAGGTCAAGA AGCCGGCCGT GGTGTACATG 
CTGCACCTGG CCGCGGCAGA CGTACTCTTC GTGTGTGTGC TTCCGTTCAA GATCAGCTAC 
TACTTCTCCG GAAGCGACTG GAGGTTCGGG TCTGCCATGT GCCGCTTCGT CACGGCGGCC 
TTCTACGGGA ACATGTACGC CTCCATCATG CTCATGACGG CCATCAGCGT CGACCGCTTC 
CTGGCCGTGG TGTACCCCAT CCAGTCCCTC TCCTGGCGGA CCCTGGGGCG CGCTTCCTTC 
ATCTGCCTGG CCATCTGGGC CATGGCCATC GCGGGGGTGG CGCCCCTGCT CCTGCAGGAG 
CAGGCCACCC AGGTGCCGGG GCTCAACATC ACCGCCTGCC ACGACGTGCT CAACCAGACG 
CTGCTGGAAG GCTACTACTC GTACTACTTC TCCGCCTTCT CCGCCGTCTT CTTCTTCGTG 
CCGCTGACCC TTTCCACCGT CTGTTACGTG TCCATCATCC GATGCCTCAG CTCTTCCACG 
GTTGCCAACC AGAACAAGAA GTCCCGGGCT TTGCTCCTGT CCGCGGCTGT CTTCTGCATC 
TTCATCCTTT GCTTTGGACC CACAAACATC CTTCTGCTTC TCCACTACGC GTTCCTTTCC 
TCTGATCCCA TGACAGAGGC CGCCTACTTT GCCTACCTCC TGTGTGTCTG CGTCAGCAGC 
ATAAGCTGTT GCATCGACCC CTTGATATAC TACTATGCTT CCTCGGAGTG CCAGAGGCAC 
CTCTTTGCTA TCTTACACTG CAAAGAAAGT TCAGATCCCG GCAGCTGTAA CAGCAGCGGT 
CAGCTGATGC CAAGTAAAAT GGACACCTGC TCTAGTAACC TGAGTAGCAG TCTATACAAA 
AAGCTCTTAA CTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Matrix metalloproteinase-1-mediated up-regulation of vascular endothelial growth factor-2 in endothelial cells.
The Journal of biological chemistry288(1)598-607(2013 Jan)
Mazor R,Alsaigh T,Shaked H,Altshuler AE,Pocock ES,Kistler EB,Karin M,Schmid-Sch?nbein GW

Distinct roles of protease-activated receptors in signal transduction regulation of endothelial nitric oxide synthase.
Hypertension (Dallas, Tex. : 1979)53(2)182-8(2009 Feb)
Suzuki H,Motley ED,Eguchi K,Hinoki A,Shirai H,Watts V,Stemmle LN,Fields TA,Eguchi S

A whole-genome assembly of the domestic cow, Bos taurus.
Genome biology10(4)R42(2009)
Zimin AV,Delcher AL,Florea L,Kelley DR,Schatz MC,Puiu D,Hanrahan F,Pertea G,Van Tassell CP,Sonstegard TS,Mar?ais G,Roberts M,Subramanian P,Yorke JA,Salzberg SL

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F2R cDNA ORF clone, Bos taurus(cattle)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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