Cort cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cort
Entrez Gene ID	25305
Full Name	cortistatin
General protein information	Preferred Names cortistatin Names cortistatin Preprocortistatin
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 5 Map Location: 5q36
Summary	inhibits growth hormone secretion; may act as a neuropeptide to mediate signaling via a somatostatin receptor subtype [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_012835.1	NP_036967.1	cortistatin preproprotein

Pathways from BioSystems

Homologies

Homo sapiens (human)	CORT	NP_001293.3
Pan troglodytes (chimpanzee)	CORT	NP_001191822.1
Bos taurus (cattle)	CORT	NP_001191825.1
Mus musculus (house mouse)	Cort	NP_031771.1
Rattus norvegicus (Norway rat)	Cort	NP_036967.1

Gene Ontology
Bibliography

Related articles in PubMed

Berberine ameliorates collagen-induced arthritis in rats by suppressing Th17 cell responses via inducing cortistatin in the gut.
Yue M, Xia Y, Shi C, Guan C, Li Y, Liu R, Wei Z, Dai Y
The FEBS journal284(17)2786-2801(2017 Sep)

Cortistatin inhibits calcification of vascular smooth muscle cells by depressing osteoblastic differentiation and endoplasmic reticulum stress.
Liu Y, Lin F, Fu Y, Chen W, Liu W, Chi J, Zhang X, Yin X
Amino acids48(11)2671-2681(2016 Nov)

Involvement of DDAH/ADMA pathway in the pathogenesis of rheumatoid arthritis in rats.
Chen XM, Xia J, Zhou T, Yuan Q, Zhang WF, Hu CP, Li YJ, Jiang JL
International immunopharmacology16(2)322-31(2013 Jun)

Cortistatin promotes and negatively correlates with slow-wave sleep.
Bourgin P, Fabre V, Huitr?n-Res?ndiz S, Henriksen SJ, Prospero-Garcia O, Criado JR, de Lecea L
The European journal of neuroscience26(3)729-38(2007 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Oral berberine exerted anti-arthritic effect through inhibiting the Th17 cell response, which was closely associated with the induction of cortistatin generation from gut through augmenting autocrine/paracrine action between enteric nerve cells and endocrine cells.
Title: Berberine ameliorates collagen-induced arthritis in rats by suppressing Th17 cell responses via inducing cortistatin in the gut.

CST directly inhibited beta-GP-induced calcification of VSMCs in vitro, probably by suppressing ERS and phenotypic transformation of VSMCs into osteoblastic cells.
Title: Cortistatin inhibits calcification of vascular smooth muscle cells by depressing osteoblastic differentiation and endoplasmic reticulum stress.

The DDAH/asymmetric dimethylarginine pathway participates in the pathogenesis of rheumatoid arthritis and may be mediated by cortistatin.
Title: Involvement of DDAH/ADMA pathway in the pathogenesis of rheumatoid arthritis in rats.

RT-PCR and immunocytochemistry studies support the presence of cortistatin in rat Kupffer cells.
Title: RT-PCR and immunocytochemistry studies support the presence of somatostatin, cortistatin and somatostatin receptor subtypes in rat Kupffer cells.

The capacity of CST-14 to increase SWA, together with preprocortistatin's inverse correlation with time spent in SWS, suggests a potential role in sleep homeostatic processes.
Title: Cortistatin promotes and negatively correlates with slow-wave sleep.

The following Cort gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cort cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa01081	NM_012835.1 Latest version!	Rattus norvegicus cortistatin (Cort), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cort ( NM_012835.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_036967.1 Rattus norvegicus cortistatin (Cort), mRNA.

Price & Availability↑

CloneID	ORa01081
Clone ID Related Accession (Same CDS sequence)	NM_012835.1
Accession Version	NM_012835.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 339bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Rattus norvegicus(Norway rat)
Product	cortistatin preproprotein
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from U51919.1. ##Evidence-Data-START## Transcript exon combination :: U51919.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689595, SAMN01906347 [ECO:0000348] ##Evidence-Data-END##

ATGGGTGGCT GCAGCACAAG AGGCAAGCGG CCGTCAGCCC TCAGTCTGCT GCTGCTGCTG 
CTGCTCTCGG GGATCGCAGC CTCTGCCCTC CCCCTGGAGA GCGGTCCCAC CGGCCAGGAC 
AGTGTGCAGG ATGCCACAGG CGGGAGGAGG ACCGGCCTTC TGACTTTCCT TGCCTGGTGG 
CATGAGTGGG CTTCCCAAGA CAGCTCCAGC ACCGCTTTCG AAGGGGGTAC CCCGGAGCTG 
TCTAAGCGGC AGGAAAGACC ACCCCTCCAG CAGCCCCCAC ACCGGGATAA AAAGCCCTGC 
AAGAACTTCT TCTGGAAAAC CTTCTCCTCG TGCAAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036967.1
CDS	30..368
Translation	MGGCSTRGKRPSALSLLLLLLLSGIAASALPLESGPTGQDSVQDATGGRRTGLLTFLAWWHEWASQDSSSTAFEGGTPELSKRQERPPLQQPPHRDKKPCKNFFWKTFSSCK

Target ORF information:

RefSeq Version	NM_012835.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus cortistatin (Cort), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012835.1

ORF Insert Sequence:

ATGGGTGGCT GCAGCACAAG AGGCAAGCGG CCGTCAGCCC TCAGTCTGCT GCTGCTGCTG 
CTGCTCTCGG GGATCGCAGC CTCTGCCCTC CCCCTGGAGA GCGGTCCCAC CGGCCAGGAC 
AGTGTGCAGG ATGCCACAGG CGGGAGGAGG ACCGGCCTTC TGACTTTCCT TGCCTGGTGG 
CATGAGTGGG CTTCCCAAGA CAGCTCCAGC ACCGCTTTCG AAGGGGGTAC CCCGGAGCTG 
TCTAAGCGGC AGGAAAGACC ACCCCTCCAG CAGCCCCCAC ACCGGGATAA AAAGCCCTGC 
AAGAACTTCT TCTGGAAAAC CTTCTCCTCG TGCAAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Berberine ameliorates collagen-induced arthritis in rats by suppressing Th17 cell responses via inducing cortistatin in the gut.
The FEBS journal284(17)2786-2801(2017 Sep)
Yue M,Xia Y,Shi C,Guan C,Li Y,Liu R,Wei Z,Dai Y

Cortistatin inhibits calcification of vascular smooth muscle cells by depressing osteoblastic differentiation and endoplasmic reticulum stress.
Amino acids48(11)2671-2681(2016 Nov)
Liu Y,Lin F,Fu Y,Chen W,Liu W,Chi J,Zhang X,Yin X

Involvement of DDAH/ADMA pathway in the pathogenesis of rheumatoid arthritis in rats.
International immunopharmacology16(2)322-31(2013 Jun)
Chen XM,Xia J,Zhou T,Yuan Q,Zhang WF,Hu CP,Li YJ,Jiang JL

Cortistatin promotes and negatively correlates with slow-wave sleep.
The European journal of neuroscience26(3)729-38(2007 Aug)
Bourgin P,Fabre V,Huitr?n-Res?ndiz S,Henriksen SJ,Prospero-Garcia O,Criado JR,de Lecea L

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Cort cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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