Efnb1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Efnb1
Entrez Gene ID	25186
Full Name	ephrin B1
Synonyms	LERK2
General protein information	Preferred Names ephrin B1 Names ephrin-B1 ELK ligand ELK-L EPH-related receptor tyrosine kinase ligand 2 LERK-2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: X Map Location: Xq22
Summary	induces neurite outgrowth; may play a role in positive regulation of cerebellar development [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_017089.2	NP_058785.2	ephrin-B1 precursor

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	efnb1	NP_571880.1
Bos taurus (cattle)	EFNB1	NP_001073768.1
Mus musculus (house mouse)	Efnb1	NP_034240.1
Homo sapiens (human)	EFNB1	NP_004420.1
Pan troglodytes (chimpanzee)	EFNB1	XP_529024.3
	EFNB1	XP_001082851.2
Canis lupus familiaris (dog)	EFNB1	XP_849150.2
Gallus gallus (chicken)	EFNB1	NP_990366.1
Xenopus tropicalis (tropical clawed frog)	LOC100494328	XP_002934941.1
Rattus norvegicus (Norway rat)	Efnb1	NP_058785.2

Gene Ontology
Bibliography

Related articles in PubMed

Eph/ephrin reverse signalling induces axonal retraction through RhoA/ROCK pathway.
Takeuchi S, Katoh H, Negishi M
Journal of biochemistry158(3)245-52(2015 Sep)

Complementary expression and repulsive signaling suggest that EphB2 and ephrin-B1 are possibly involved in epithelial boundary formation at the squamocolumnar junction in the rodent stomach.
Ogawa K, Saeki N, Igura Y, Hayashi Y
Histochemistry and cell biology140(6)659-75(2013 Dec)

Identification of EphrinB1 expression in prostatic mesenchyme and a role for EphB-EphrinB signalling in prostate development.
Ashley GR, Grace OC, Vanpoucke G, Thomson AA
Differentiation; research in biological diversity80(2-3)89-98(2010 Sep-Oct)

Ephrin-B1 and ephrin-B2 mediate EphB-dependent presynaptic development via syntenin-1.
McClelland AC, Sheffler-Collins SI, Kayser MS, Dalva MB
Proceedings of the National Academy of Sciences of the United States of America106(48)20487-92(2009 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

we revealed that stimulation with the extracellular domain of EphB2 to activate Eph/ephrin reverse signalling induced axonal retraction in hippocampal neurons.
Title: Eph/ephrin reverse signalling induces axonal retraction through RhoA/ROCK pathway.

The EphB2 and ephrin-B1 are possibly involved in epithelial boundary formation at the squamocolumnar junction.
Title: Complementary expression and repulsive signaling suggest that EphB2 and ephrin-B1 are possibly involved in epithelial boundary formation at the squamocolumnar junction in the rodent stomach.

identified expression of EphrinB1 in prostatic mesenchyme and suggest that the EphrinB signalling system acts as a regulator of prostate growth. EphrinB-EphB signalling may function as an autocrine regulator of mesenchyme
Title: Identification of EphrinB1 expression in prostatic mesenchyme and a role for EphB-EphrinB signalling in prostate development.

Ephrin-B1 and ephrin-B2 mediate EphB-dependent presynaptic development via syntenin-1.
Title: Ephrin-B1 and ephrin-B2 mediate EphB-dependent presynaptic development via syntenin-1.

EphrinB1-EphB receptor signaling plays a critical role is induction and maintenance of neuropathic pain by regulating neural excitability and synaptic plasticity in the dorsal root ganglion and the spinal dorsal horn.
Title: EphrinB-EphB receptor signaling contributes to neuropathic pain by regulating neural excitability and spinal synaptic plasticity in rats.

The following Efnb1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Efnb1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa02787	NM_017089.2 Latest version!	Rattus norvegicus ephrin B1 (Efnb1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Efnb1 ( NM_017089.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_058785.2 Rattus norvegicus ephrin B1 (Efnb1), mRNA.

Price & Availability↑

CloneID	ORa02787
Clone ID Related Accession (Same CDS sequence)	NM_017089.2
Accession Version	NM_017089.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1038bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-15
Organism	Rattus norvegicus(Norway rat)
Product	ephrin-B1 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC061744.1. On or before Jun 25, 2006 this sequence version replaced XM_001057992.1, XM_001057932.1, NM_017089.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC061744.1, U07560.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGCCCGGC CTGGGCAGCG TTGGCTCAGC AAGTGGCTTG TGGCTATGGT CGTGCTGACG 
CTGTGCCGGC TTGCCACGCC GTTGGCCAAG AACCTGGAGC CCGTGTCCTG GAGCTCTCTT 
AACCCTAAGT TCCTAAGTGG GAAGGGCTTG GTGATCTACC CGAAGATTGG AGATAAGCTG 
GACATCATCT GCCCCCGAGC AGAAGCAGGA CGGCCCTACG AGTACTACAA GCTGTACCTG 
GTGCGGCCGG AGCAGGCAGC TGCTTGCAGC ACTGTGCTTG ATCCCAATGT ACTGGTCACT 
TGCAACAAGC CACAGCAGGA AATCCGCTTT ACCATCAAGT TCCAGGAGTT CAGCCCCAAC 
TACATGGGCC TGGAATTCAA AAAGTACCAT GATTACTACA TTACATCAAC ATCCAATGGG 
AGCTTGGAAG GGCTGGAGAA CCGAGAGGGA GGTGTGTGCC GTACACGCAC TATGAAGATT 
GTTATGAAGG TTGGGCAAGA TCCAAATGCC GTAACGCCTG AGCAGTTGAC TACCAGCCGG 
CCAAGCAAAG AGTCAGACAA CACTGTCAAG ACAGCCACAC AGGCTCCTGG TCGGGGGTCC 
CAGGGGGACT CTGATGGCAA GCATGAGACT GTGAACCAGC AAGAGAAGAG TGGCCCAGGT 
GCAGGTGGTA GTGGCAGCGG GGACACCGAC AGCTTCTTTA ACTCCAAGGT AGCATTGTTC 
GCAGCTGTAG GTGCTGGCTG CGTCATCTTC CTGCTCATTA TCATCTTTTT GACAGTCCTA 
CTACTCAAGC TCCGCAAGCG ACATCGCAAG CATACACAGC AGCGGGCGGC TGCCCTCTCG 
CTCAGTACCC TAGCCAGCCC CAAAGGGGGT AGTGGTACAG CGGGCACTGA GCCCAGCGAC 
ATCATCATCC CCTTACGGAC TACAGAGAAC AACTACTGCC CCCACTATGA GAAGGTGAGT 
GGGGACTACG GGCATCCTGT CTACATCGTC CAGGAGATGC CACCTCAGAG CCCGGCGAAC 
ATCTACTACA AGGTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_058785.2
CDS	752..1789
Translation	MARPGQRWLSKWLVAMVVLTLCRLATPLAKNLEPVSWSSLNPKFLSGKGLVIYPKIGDKLDIICPRAEAGRPYEYYKLYLVRPEQAAACSTVLDPNVLVTCNKPQQEIRFTIKFQEFSPNYMGLEFKKYHDYYITSTSNGSLEGLENREGGVCRTRTMKIVMKVGQDPNAVTPEQLTTSRPSKESDNTVKTATQAPGRGSQGDSDGKHETVNQQEKSGPGAGGSGSGDTDSFFNSKVALFAAVGAGCVIFLLIIIFLTVLLLKLRKRHRKHTQQRAAALSLSTLASPKGGSGTAGTEPSDIIIPLRTTENNYCPHYEKVSGDYGHPVYIVQEMPPQSPANIYYKV

Target ORF information:

RefSeq Version	NM_017089.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus ephrin B1 (Efnb1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017089.2

ORF Insert Sequence:

ATGGCCCGGC CTGGGCAGCG TTGGCTCAGC AAGTGGCTTG TGGCTATGGT CGTGCTGACG 
CTGTGCCGGC TTGCCACGCC GTTGGCCAAG AACCTGGAGC CCGTGTCCTG GAGCTCTCTT 
AACCCTAAGT TCCTAAGTGG GAAGGGCTTG GTGATCTACC CGAAGATTGG AGATAAGCTG 
GACATCATCT GCCCCCGAGC AGAAGCAGGA CGGCCCTACG AGTACTACAA GCTGTACCTG 
GTGCGGCCGG AGCAGGCAGC TGCTTGCAGC ACTGTGCTTG ATCCCAATGT ACTGGTCACT 
TGCAACAAGC CACAGCAGGA AATCCGCTTT ACCATCAAGT TCCAGGAGTT CAGCCCCAAC 
TACATGGGCC TGGAATTCAA AAAGTACCAT GATTACTACA TTACATCAAC ATCCAATGGG 
AGCTTGGAAG GGCTGGAGAA CCGAGAGGGA GGTGTGTGCC GTACACGCAC TATGAAGATT 
GTTATGAAGG TTGGGCAAGA TCCAAATGCC GTAACGCCTG AGCAGTTGAC TACCAGCCGG 
CCAAGCAAAG AGTCAGACAA CACTGTCAAG ACAGCCACAC AGGCTCCTGG TCGGGGGTCC 
CAGGGGGACT CTGATGGCAA GCATGAGACT GTGAACCAGC AAGAGAAGAG TGGCCCAGGT 
GCAGGTGGTA GTGGCAGCGG GGACACCGAC AGCTTCTTTA ACTCCAAGGT AGCATTGTTC 
GCAGCTGTAG GTGCTGGCTG CGTCATCTTC CTGCTCATTA TCATCTTTTT GACAGTCCTA 
CTACTCAAGC TCCGCAAGCG ACATCGCAAG CATACACAGC AGCGGGCGGC TGCCCTCTCG 
CTCAGTACCC TAGCCAGCCC CAAAGGGGGT AGTGGTACAG CGGGCACTGA GCCCAGCGAC 
ATCATCATCC CCTTACGGAC TACAGAGAAC AACTACTGCC CCCACTATGA GAAGGTGAGT 
GGGGACTACG GGCATCCTGT CTACATCGTC CAGGAGATGC CACCTCAGAG CCCGGCGAAC 
ATCTACTACA AGGTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Eph/ephrin reverse signalling induces axonal retraction through RhoA/ROCK pathway.
Journal of biochemistry158(3)245-52(2015 Sep)
Takeuchi S,Katoh H,Negishi M

Complementary expression and repulsive signaling suggest that EphB2 and ephrin-B1 are possibly involved in epithelial boundary formation at the squamocolumnar junction in the rodent stomach.
Histochemistry and cell biology140(6)659-75(2013 Dec)
Ogawa K,Saeki N,Igura Y,Hayashi Y

Identification of EphrinB1 expression in prostatic mesenchyme and a role for EphB-EphrinB signalling in prostate development.
Differentiation; research in biological diversity80(2-3)89-98(2010 Sep-Oct)
Ashley GR,Grace OC,Vanpoucke G,Thomson AA

Ephrin-B1 and ephrin-B2 mediate EphB-dependent presynaptic development via syntenin-1.
Proceedings of the National Academy of Sciences of the United States of America106(48)20487-92(2009 Dec)
McClelland AC,Sheffler-Collins SI,Kayser MS,Dalva MB

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Efnb1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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