EFNB1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	EFNB1
Entrez Gene ID	1947
Full Name	ephrin B1
Synonyms	CFND,CFNS,EFB1,EFL3,EPLG2,Elk-L,LERK2
General protein information	Preferred Names ephrin B1 Names ephrin-B1 ELK ligand eph-related receptor tyrosine kinase ligand 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xq13.1
Summary	The protein encoded by this gene is a type I membrane protein and a ligand of Eph-related receptor tyrosine kinases. It may play a role in cell adhesion and function in the development or maintenance of the nervous system. [provided by RefSeq, Jul 2008].
Disorder MIM:	300035
Disorder Html:	Craniofrontonasal dysplasia, 304110 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_004429.4	NP_004420.1	ephrin-B1 precursor

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	efnb1	NP_571880.1
Bos taurus (cattle)	EFNB1	NP_001073768.1
Mus musculus (house mouse)	Efnb1	NP_034240.1
Homo sapiens (human)	EFNB1	NP_004420.1
Pan troglodytes (chimpanzee)	EFNB1	XP_529024.3
	EFNB1	XP_001082851.2
Canis lupus familiaris (dog)	EFNB1	XP_849150.2
Gallus gallus (chicken)	EFNB1	NP_990366.1
Xenopus tropicalis (tropical clawed frog)	LOC100494328	XP_002934941.1
Rattus norvegicus (Norway rat)	Efnb1	NP_058785.2

Gene Ontology
Bibliography

Related articles in PubMed

Cellular interference in craniofrontonasal syndrome: males mosaic for mutations in the X-linked EFNB1 gene are more severely affected than true hemizygotes.
Twigg SR, Babbs C, van den Elzen ME, Goriely A, Taylor S, McGowan SJ, Giannoulatou E, Lonie L, Ragoussis J, Sadighi Akha E, Knight SJ, Zechi-Ceide RM, Hoogeboom JA, Pober BR, Toriello HV, Wall SA, Rita Passos-Bueno M, Brunner HG, Mathijssen IM, Wilkie AO
Human molecular genetics22(8)1654-62(2013 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

we demonstrate that mosaicism for EPHRIN-B1 expression induced by random X inactivation in heterozygous females results in robust cell segregation in human neuroepithelial cells, thus supplying experimental evidence that Eph/ephrin-mediated cell segregation is relevant to pathogenesis in human CFNS patients.
Title: EPHRIN-B1 Mosaicism Drives Cell Segregation in Craniofrontonasal Syndrome hiPSC-Derived Neuroepithelial Cells.

one novel (IVS2+3G>T) and one previously reported mutation (p.Gly151Ser) in EFNB1 Both patients were de novo cases without a family history of Craniofrontonasal syndrome.
Title: First Korean Patients with Craniofrontonasal Syndrome Confirmed by EFNB1 Analysis.

While ephrin-B1 deficiency leads to abnormal visual pathways in mice, it leaves the human visual system, apart from deficits in binocular vision, largely normal.
Title: Visual Pathways in Humans With Ephrin-B1 Deficiency Associated With the Cranio-Fronto-Nasal Syndrome.

T cells from rheumatoid arthritis (RA) patients expressed higher EFNB1 mRNA levels, which correlated with RA symptoms and laboratory findings. Expression of EFNB1 in T cells might be a parameter for monitoring RA disease activity and treatment responses.
Title: Role of EFNB1 and EFNB2 in Mouse Collagen-Induced Arthritis and Human Rheumatoid Arthritis.

EphB2/ephrin-B1 were invoked in dental pulp stem cells with TNF-alpha treatment via the JNK-dependent pathway, but not NF-kB, p38 MAPK or MEK signalling.
Title: Stimulation of EphB2/ephrin-B1 signalling by tumour necrosis factor alpha in human dental pulp stem cells.

The following EFNB1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the EFNB1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu26381	NM_004429.4 Latest version!	Homo sapiens ephrin B1 (EFNB1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

EFNB1 ( NM_004429.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_004420.1 Homo sapiens ephrin B1 (EFNB1), mRNA.

Price & Availability↑

CloneID	OHu26381
Clone ID Related Accession (Same CDS sequence)	NM_004429.4
Accession Version	NM_004429.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1041bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	ephrin-B1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC016649.1, CB132233.1 and BM972960.1. This sequence is a reference standard in the RefSeqGene project. On Apr 18, 2008 this sequence version replaced NM_004429.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC016649.1, BC052979.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript regulatory uORF :: PMID: 23335590 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCTCGGC CTGGGCAGCG TTGGCTCGGC AAGTGGCTTG TGGCGATGGT CGTGTGGGCG 
CTGTGCCGGC TCGCCACACC GCTGGCCAAG AACCTGGAGC CCGTATCCTG GAGCTCCCTC 
AACCCCAAGT TCCTGAGTGG GAAGGGCTTG GTGATCTATC CGAAAATTGG AGACAAGCTG 
GACATCATCT GCCCCCGAGC AGAAGCAGGG CGGCCCTATG AGTACTACAA GCTGTACCTG 
GTGCGGCCTG AGCAGGCAGC TGCCTGTAGC ACAGTTCTCG ACCCCAACGT GTTGGTCACC 
TGCAATAGGC CAGAGCAGGA AATACGCTTT ACCATCAAGT TCCAGGAGTT CAGCCCCAAC 
TACATGGGCC TGGAGTTCAA GAAGCACCAT GATTACTACA TTACCTCAAC ATCCAATGGA 
AGCCTGGAGG GGCTGGAAAA CCGGGAGGGC GGTGTGTGCC GCACACGCAC CATGAAGATC 
ATCATGAAGG TTGGGCAAGA TCCCAATGCT GTGACGCCTG AGCAGCTGAC TACCAGCAGG 
CCCAGCAAGG AGGCAGACAA CACTGTCAAG ATGGCCACAC AGGCCCCTGG TAGTCGGGGC 
TCCCTGGGTG ACTCTGATGG CAAGCATGAG ACTGTGAACC AGGAAGAGAA GAGTGGCCCA 
GGTGCAAGTG GGGGCAGCAG CGGGGACCCT GATGGCTTCT TCAACTCCAA GGTGGCATTG 
TTCGCGGCTG TCGGTGCCGG TTGCGTCATC TTCCTGCTCA TCATCATCTT CCTGACGGTC 
CTACTACTGA AGCTACGCAA GCGGCACCGC AAGCACACAC AGCAGCGGGC GGCTGCCCTC 
TCGCTCAGTA CCCTGGCCAG TCCCAAGGGG GGCAGTGGCA CAGCGGGCAC CGAGCCCAGC 
GACATCATCA TTCCCTTACG GACTACAGAG AACAACTACT GCCCCCACTA TGAGAAGGTG 
AGTGGGGACT ACGGGCACCC TGTCTACATC GTCCAAGAGA TGCCGCCCCA GAGCCCGGCG 
AACATCTACT ACAAGGTCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004420.1
CDS	781..1821
Translation	MARPGQRWLGKWLVAMVVWALCRLATPLAKNLEPVSWSSLNPKFLSGKGLVIYPKIGDKLDIICPRAEAGRPYEYYKLYLVRPEQAAACSTVLDPNVLVTCNRPEQEIRFTIKFQEFSPNYMGLEFKKHHDYYITSTSNGSLEGLENREGGVCRTRTMKIIMKVGQDPNAVTPEQLTTSRPSKEADNTVKMATQAPGSRGSLGDSDGKHETVNQEEKSGPGASGGSSGDPDGFFNSKVALFAAVGAGCVIFLLIIIFLTVLLLKLRKRHRKHTQQRAAALSLSTLASPKGGSGTAGTEPSDIIIPLRTTENNYCPHYEKVSGDYGHPVYIVQEMPPQSPANIYYKV

Target ORF information:

RefSeq Version	NM_004429.4
Organism	Homo sapiens(human)
Definition	Homo sapiens ephrin B1 (EFNB1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004429.4

ORF Insert Sequence:

ATGGCTCGGC CTGGGCAGCG TTGGCTCGGC AAGTGGCTTG TGGCGATGGT CGTGTGGGCG 
CTGTGCCGGC TCGCCACACC GCTGGCCAAG AACCTGGAGC CCGTATCCTG GAGCTCCCTC 
AACCCCAAGT TCCTGAGTGG GAAGGGCTTG GTGATCTATC CGAAAATTGG AGACAAGCTG 
GACATCATCT GCCCCCGAGC AGAAGCAGGG CGGCCCTATG AGTACTACAA GCTGTACCTG 
GTGCGGCCTG AGCAGGCAGC TGCCTGTAGC ACAGTTCTCG ACCCCAACGT GTTGGTCACC 
TGCAATAGGC CAGAGCAGGA AATACGCTTT ACCATCAAGT TCCAGGAGTT CAGCCCCAAC 
TACATGGGCC TGGAGTTCAA GAAGCACCAT GATTACTACA TTACCTCAAC ATCCAATGGA 
AGCCTGGAGG GGCTGGAAAA CCGGGAGGGC GGTGTGTGCC GCACACGCAC CATGAAGATC 
ATCATGAAGG TTGGGCAAGA TCCCAATGCT GTGACGCCTG AGCAGCTGAC TACCAGCAGG 
CCCAGCAAGG AGGCAGACAA CACTGTCAAG ATGGCCACAC AGGCCCCTGG TAGTCGGGGC 
TCCCTGGGTG ACTCTGATGG CAAGCATGAG ACTGTGAACC AGGAAGAGAA GAGTGGCCCA 
GGTGCAAGTG GGGGCAGCAG CGGGGACCCT GATGGCTTCT TCAACTCCAA GGTGGCATTG 
TTCGCGGCTG TCGGTGCCGG TTGCGTCATC TTCCTGCTCA TCATCATCTT CCTGACGGTC 
CTACTACTGA AGCTACGCAA GCGGCACCGC AAGCACACAC AGCAGCGGGC GGCTGCCCTC 
TCGCTCAGTA CCCTGGCCAG TCCCAAGGGG GGCAGTGGCA CAGCGGGCAC CGAGCCCAGC 
GACATCATCA TTCCCTTACG GACTACAGAG AACAACTACT GCCCCCACTA TGAGAAGGTG 
AGTGGGGACT ACGGGCACCC TGTCTACATC GTCCAAGAGA TGCCGCCCCA GAGCCCGGCG 
AACATCTACT ACAAGGTCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Cellular interference in craniofrontonasal syndrome: males mosaic for mutations in the X-linked EFNB1 gene are more severely affected than true hemizygotes.
Human molecular genetics22(8)1654-62(2013 Apr)
Twigg SR,Babbs C,van den Elzen ME,Goriely A,Taylor S,McGowan SJ,Giannoulatou E,Lonie L,Ragoussis J,Sadighi Akha E,Knight SJ,Zechi-Ceide RM,Hoogeboom JA,Pober BR,Toriello HV,Wall SA,Rita Passos-Bueno M,Brunner HG,Mathijssen IM,Wilkie AO

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EFNB1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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