Stat1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Stat1
Entrez Gene ID	25124
Full Name	signal transducer and activator of transcription 1
Synonyms	DD6G4-4
General protein information	Preferred Names signal transducer and activator of transcription 1 Names signal transducer and activator of transcription 1-alpha/beta
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 9 Map Location: 9q22
Summary	component of the IFN-gamma receptor signaling pathway and other signaling pathways; plays a role in development of cytokine resistance [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_032612.3	NP_116001.2	signal transducer and activator of transcription 1-alpha/beta isoform alpha
NM_001034164.1	NP_001029336.1	signal transducer and activator of transcription 1-alpha/beta isoform beta

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	LOC488449	XP_848353.1
Bos taurus (cattle)	STAT1	NP_001071368.1
Rattus norvegicus (Norway rat)	Stat1	NP_116001.2
Gallus gallus (chicken)	STAT1	NP_001012932.1
Pan troglodytes (chimpanzee)	STAT1	XP_003309418.1
Mus musculus (house mouse)	Stat1	NP_001192242.1
Homo sapiens (human)	STAT1	NP_009330.1
	STAT1	XP_002799062.1
Danio rerio (zebrafish)	stat1a	NP_571555.1
Xenopus tropicalis (tropical clawed frog)	stat1	NP_001072935.1

Gene Ontology
Bibliography

Related articles in PubMed

The participation of fibroblast growth factor 23 (FGF23) in the progression of osteoporosis via JAK/STAT pathway.
Xu L, Zhang L, Zhang H, Yang Z, Qi L, Wang Y, Ren S
Journal of cellular biochemistry(2017 Aug)

Fludarabine inhibits STAT1-mediated up-regulation of caspase-3 expression in dexamethasone-induced osteoblasts apoptosis and slows the progression of steroid-induced avascular necrosis of the femoral head in rats.
Feng Z, Zheng W, Tang Q, Cheng L, Li H, Ni W, Pan X
Apoptosis : an international journal on programmed cell death22(8)1001-1012(2017 Aug)

Methyltransferase SETD2-Mediated Methylation of STAT1 Is Critical for Interferon Antiviral Activity.
Chen K, Liu J, Liu S, Xia M, Zhang X, Han D, Jiang Y, Wang C, Cao X
Cell170(3)492-506.e14(2017 Jul)

Activation of PI3K in response to high glucose leads to regulation of SOCS-3 and STAT1/3 signals and induction of glomerular mesangial extracellular matrix formation.
Sheu ML, Shen CC, Jheng JR, Chiang CK
Oncotarget8(10)16925-16938(2017 Mar)

Functional Selectivity in Cytokine Signaling Revealed Through a Pathogenic EPO Mutation.
Kim AR, Ulirsch JC, Wilmes S, Unal E, Moraga I, Karakukcu M, Yuan D, Kazerounian S, Abdulhay NJ, King DS, Gupta N, Gabriel SB, Lander ES, Patiroglu T, Ozcan A, Ozdemir MA, Garcia KC, Piehler J, Gazda HT, Klein DE, Sankaran VG
Cell168(6)1053-1064.e15(2017 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

disruption of the STAT1 and STAT3 signaling pathways may in part explain the deleterious effects of maternal marginal zinc deficiency on fetal brain development
Title: Zinc deficiency affects the STAT1/3 signaling pathways in part through redox-mediated mechanisms.

The phosphatidylinositol 3-Kinases (PI3K)/signal transducer and activator of transcription 1 and 3 (STAT1/3) signaling pathway mediated high glucose (HG)-triggered extracellular matrix (ECM) accumulation and suppressor of cytokine signaling-3 (SOCS-3) upregulation in mesangial cells (RMCs).
Title: Activation of PI3K in response to high glucose leads to regulation of SOCS-3 and STAT1/3 signals and induction of glomerular mesangial extracellular matrix formation.

activation of the MAPK and PI3K-AKT pathways primarily regulated Ser-727 phosphorylation, whereas a physical interaction between RET/PTC3 and STAT1, followed by a direct tyrosine phosphorylation event, was necessary for STAT1 Tyr-701 phosphorylation. These data provide the first evidence of a direct link between IDO1 expression and the oncogenic activation of RET in thyroid carcinoma
Title: Signal Transducer and Activator of Transcription 1 Plays a Pivotal Role in RET/PTC3 Oncogene-induced Expression of Indoleamine 2,3-Dioxygenase 1.

Leading to a STAT1-IRF1 controlled upregulation of TLR3 expression in macrophages.
Title: Pristane induces autophagy in macrophages, promoting a STAT1-IRF1-TLR3 pathway and arthritis.

Bone marrow mesenchymal stromal cells expression CD47/STAT1/STAT3 prevent isoproterenol induced myocardial fibrosis.
Title: Bone marrow mesenchymal stromal cells with CD47 high expression via the signal transducer and activators of transcription signaling pathway preventing myocardial fibrosis.

The following Stat1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Stat1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12348	NM_032612.3 Latest version!	Rattus norvegicus signal transducer and activator of transcription 1 (Stat1), transcript variant alpha, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$440.30 $629.00
ORa12363	NM_001034164.1 Latest version!	Rattus norvegicus signal transducer and activator of transcription 1 (Stat1), transcript variant beta, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$419.30 $599.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Stat1 ( NM_032612.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_116001.2 Rattus norvegicus signal transducer and activator of transcription 1 (Stat1), transcript variant alpha, mRNA.

Price & Availability↑

CloneID	ORa12348
Clone ID Related Accession (Same CDS sequence)	NM_032612.3
Accession Version	NM_032612.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2250bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-12-22
Organism	Rattus norvegicus(Norway rat)
Product	signal transducer and activator of transcription 1-alpha/beta isoform alpha
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC062079.1, AF205604.1, DY564252.1, CF109416.1, BM386875.1 and AA901120.1. On Sep 17, 2008 this sequence version replaced NM_032612.2. Transcript Variant: This variant (alpha) represents the longer transcript and encodes the longer isoform (alpha). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: AF205604.1 [ECO:0000331] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGTCGCAGT GGTACGAGCT TCAGCAGCTG GACTCCAAGT TCCTGGAGCA GGTGCACCAG 
CTGTACGATG ACAGTTTCCC CATGGAAATC AGACAGTACC TGGCCCAGTG GCTAGAAAAG 
CAAGACTGGG AGCATGCTGC CTACGACGTC TCGTTCGCCA CCATCCGCTT CCATGACCTG 
CTCTCCCAGC TGGATGACCA GTACAGCCGC TTTTCTTTGG AGAATAATTT CTTGTTGCAG 
CACAACATAA GGAAAAGCAA GCGTAATCTC CAGGATAACT TCCAAGAAGA TCCCGTACAG 
ATGTCCATGA TTATCCACAA CTGTCTGAAG GAGGAGAGGA AGATTTTGGA AAACGCCCAG 
CGATTTAATC AGGCCCAGGA GGGAAATATT CAGAACACCG TGATGTTAGA TAAACAGAAG 
GAGCTGGACA GTAAAGTCAG AAATGTGAAG GACCAAGTCA TGTGCATAGA GCATGAAATC 
AAGACCCTAG AAGACTTACA AGATGAATAT GACTTTAAAT GCAAAACCTC TCAGAACAGA 
GAAAGCGAAG CCAATGGTGT GGCGAAGAGC GACCAGAAAC AGGAACAGCT GCTGCTGCAT 
AAGATGTTCT TAATGCTTGA CAACAAGAGA AAGGAGATAA TTCACAAAAT CAGAGAGCTG 
CTGAACTCCA TCGAGCTCAC TCAGAACACT CTGATTAATG ATGAGCTTGT GGAGTGGAAG 
CGAAGACAGC AGAGTGCCTG CATTGGGGGA CCGCCCAATG CCTGCCTGGA TCAGCTGCAA 
AGCTGGTTCA CCATTGTTGC AGAGAGCCTG CAGCAGGTCC GTCAGCAGCT TAAAAAGCTG 
GAGGAGTTGG AACAGAAATT CACCTATGAG CAGGACCCTA TTACAAAAAA CAAGCAGGTG 
TTATCCGATC GCACCTTCGT CCTCTTCCAG CAGCTCATTC AGAGCTCCTT TGTGGTGGAA 
CGACAGCCGT GCATGCCAAC TCACCCTCAG AGGCCCCTGG TCTTGAAGAC TGGGGTACAG 
TTCACTGTGA AGCTGAGACT GTTGGTGAAA TTGCAAGAAC TGAACTATAA CTTGAAAGTG 
AAAGTCTCAT TTGACAAAGA TGTGAACGAG AAAAACACAG TGAAAGGATT CCGGAAGTTC 
AACATCTTGG GTACTCACAC AAAAGTGATG AACATGGAAG AATCCACCAA CGGAAGTTTG 
GCAGCTGAGT TCCGACACCT GCAACTGAAG GAACAGAAAA ATGCTGGGAA CAGAACCAAT 
GAGGGTCCTC TCATTGTCAC CGAAGAACTT CACTCTCTTA GCTTTGAAAC CCAGTTGTGC 
CAGCCAGGCT TGGTGATTGA CCTTGAGACC ACCTCTCTTC CCGTCGTGGT GATCTCCAAT 
GTCAGCCAGC TCCCCAGTGG CTGGGCTTCT ATCCTGTGGT ACAACATGCT GGTGACAGAG 
CCCAGGAATC TCTCCTTCTT CCTGAACCCC CCGTGTGCGT GGTGGTCCCA GCTCTCAGAG 
GTGCTGAGTT GGCAGTTTTC GTCAGTCACC AAGAGAGGTC TCAACGCTGA CCAGCTGAGC 
ATGCTGGGGG AGAAGCTTCT GGGCCCTAAT GCTGGCCCTG ATGGTCTTAT TCCATGGACA 
AGGTTCTGTA AGGAAAATAT TAACGATAAG AATTTCTCCT TCTGGCCTTG GATTGACACC 
ATCCTAGAAC TCATTAAGAA GCACCTGCTT TGCCTCTGGA ATGATGGGTG CATCATGGGC 
TTTATCAGCA AGGAGCGAGA ACGTGCTCTG CTCAAGGACC AGCAGCCCGG GACGTTCCTG 
CTTAGGTTCA GTGAGAGCTC CCGGGAAGGG GCCATCACAT TCACATGGGT GGAACGGTCC 
CAAAATGGAG GTGAACCCGA CTTCCATGCT GTTGAGCCCT ACACGAAGAA AGAACTTTCA 
GCTGTTACTT TCCCAGATAT TATTCGCAAT TACAAAGTCA TGGCTGCTGA GAATATACCA 
GAGAATCCCC TGAAGTATCT GTATCCCAAT ATTGACAAAG ACCATGCCTT CGGGAAGTAC 
TACTCCAGGC CAAAGGAAGC ACCAGAACCG ATGGAGCTCG ATGACCCTAA GAGAACTGGA 
TACATCAAGA CTGAGTTGAT TTCTGTGTCT GAAGTCCACC CTTCTAGACT TCAGAGCACA 
GAAAACCTGC TTCCCATGTC TCCAGAGGAG TTTGACGAGA TGTCCAAGAT AGTGGGCTCT 
GAATTTGACA GTATGATGAG CGCAGTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_116001.2
CDS	291..2540
Translation	MSQWYELQQLDSKFLEQVHQLYDDSFPMEIRQYLAQWLEKQDWEHAAYDVSFATIRFHDLLSQLDDQYSRFSLENNFLLQHNIRKSKRNLQDNFQEDPVQMSMIIHNCLKEERKILENAQRFNQAQEGNIQNTVMLDKQKELDSKVRNVKDQVMCIEHEIKTLEDLQDEYDFKCKTSQNRESEANGVAKSDQKQEQLLLHKMFLMLDNKRKEIIHKIRELLNSIELTQNTLINDELVEWKRRQQSACIGGPPNACLDQLQSWFTIVAESLQQVRQQLKKLEELEQKFTYEQDPITKNKQVLSDRTFVLFQQLIQSSFVVERQPCMPTHPQRPLVLKTGVQFTVKLRLLVKLQELNYNLKVKVSFDKDVNEKNTVKGFRKFNILGTHTKVMNMEESTNGSLAAEFRHLQLKEQKNAGNRTNEGPLIVTEELHSLSFETQLCQPGLVIDLETTSLPVVVISNVSQLPSGWASILWYNMLVTEPRNLSFFLNPPCAWWSQLSEVLSWQFSSVTKRGLNADQLSMLGEKLLGPNAGPDGLIPWTRFCKENINDKNFSFWPWIDTILELIKKHLLCLWNDGCIMGFISKERERALLKDQQPGTFLLRFSESSREGAITFTWVERSQNGGEPDFHAVEPYTKKELSAVTFPDIIRNYKVMAAENIPENPLKYLYPNIDKDHAFGKYYSRPKEAPEPMELDDPKRTGYIKTELISVSEVHPSRLQSTENLLPMSPEEFDEMSKIVGSEFDSMMSAV

Target ORF information:

RefSeq Version	NM_032612.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus signal transducer and activator of transcription 1 (Stat1), transcript variant alpha, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_032612.3

ORF Insert Sequence:

ATGTCGCAGT GGTACGAGCT TCAGCAGCTG GACTCCAAGT TCCTGGAGCA GGTGCACCAG 
CTGTACGATG ACAGTTTCCC CATGGAAATC AGACAGTACC TGGCCCAGTG GCTAGAAAAG 
CAAGACTGGG AGCATGCTGC CTACGACGTC TCGTTCGCCA CCATCCGCTT CCATGACCTG 
CTCTCCCAGC TGGATGACCA GTACAGCCGC TTTTCTTTGG AGAATAATTT CTTGTTGCAG 
CACAACATAA GGAAAAGCAA GCGTAATCTC CAGGATAACT TCCAAGAAGA TCCCGTACAG 
ATGTCCATGA TTATCCACAA CTGTCTGAAG GAGGAGAGGA AGATTTTGGA AAACGCCCAG 
CGATTTAATC AGGCCCAGGA GGGAAATATT CAGAACACCG TGATGTTAGA TAAACAGAAG 
GAGCTGGACA GTAAAGTCAG AAATGTGAAG GACCAAGTCA TGTGCATAGA GCATGAAATC 
AAGACCCTAG AAGACTTACA AGATGAATAT GACTTTAAAT GCAAAACCTC TCAGAACAGA 
GAAAGCGAAG CCAATGGTGT GGCGAAGAGC GACCAGAAAC AGGAACAGCT GCTGCTGCAT 
AAGATGTTCT TAATGCTTGA CAACAAGAGA AAGGAGATAA TTCACAAAAT CAGAGAGCTG 
CTGAACTCCA TCGAGCTCAC TCAGAACACT CTGATTAATG ATGAGCTTGT GGAGTGGAAG 
CGAAGACAGC AGAGTGCCTG CATTGGGGGA CCGCCCAATG CCTGCCTGGA TCAGCTGCAA 
AGCTGGTTCA CCATTGTTGC AGAGAGCCTG CAGCAGGTCC GTCAGCAGCT TAAAAAGCTG 
GAGGAGTTGG AACAGAAATT CACCTATGAG CAGGACCCTA TTACAAAAAA CAAGCAGGTG 
TTATCCGATC GCACCTTCGT CCTCTTCCAG CAGCTCATTC AGAGCTCCTT TGTGGTGGAA 
CGACAGCCGT GCATGCCAAC TCACCCTCAG AGGCCCCTGG TCTTGAAGAC TGGGGTACAG 
TTCACTGTGA AGCTGAGACT GTTGGTGAAA TTGCAAGAAC TGAACTATAA CTTGAAAGTG 
AAAGTCTCAT TTGACAAAGA TGTGAACGAG AAAAACACAG TGAAAGGATT CCGGAAGTTC 
AACATCTTGG GTACTCACAC AAAAGTGATG AACATGGAAG AATCCACCAA CGGAAGTTTG 
GCAGCTGAGT TCCGACACCT GCAACTGAAG GAACAGAAAA ATGCTGGGAA CAGAACCAAT 
GAGGGTCCTC TCATTGTCAC CGAAGAACTT CACTCTCTTA GCTTTGAAAC CCAGTTGTGC 
CAGCCAGGCT TGGTGATTGA CCTTGAGACC ACCTCTCTTC CCGTCGTGGT GATCTCCAAT 
GTCAGCCAGC TCCCCAGTGG CTGGGCTTCT ATCCTGTGGT ACAACATGCT GGTGACAGAG 
CCCAGGAATC TCTCCTTCTT CCTGAACCCC CCGTGTGCGT GGTGGTCCCA GCTCTCAGAG 
GTGCTGAGTT GGCAGTTTTC GTCAGTCACC AAGAGAGGTC TCAACGCTGA CCAGCTGAGC 
ATGCTGGGGG AGAAGCTTCT GGGCCCTAAT GCTGGCCCTG ATGGTCTTAT TCCATGGACA 
AGGTTCTGTA AGGAAAATAT TAACGATAAG AATTTCTCCT TCTGGCCTTG GATTGACACC 
ATCCTAGAAC TCATTAAGAA GCACCTGCTT TGCCTCTGGA ATGATGGGTG CATCATGGGC 
TTTATCAGCA AGGAGCGAGA ACGTGCTCTG CTCAAGGACC AGCAGCCCGG GACGTTCCTG 
CTTAGGTTCA GTGAGAGCTC CCGGGAAGGG GCCATCACAT TCACATGGGT GGAACGGTCC 
CAAAATGGAG GTGAACCCGA CTTCCATGCT GTTGAGCCCT ACACGAAGAA AGAACTTTCA 
GCTGTTACTT TCCCAGATAT TATTCGCAAT TACAAAGTCA TGGCTGCTGA GAATATACCA 
GAGAATCCCC TGAAGTATCT GTATCCCAAT ATTGACAAAG ACCATGCCTT CGGGAAGTAC 
TACTCCAGGC CAAAGGAAGC ACCAGAACCG ATGGAGCTCG ATGACCCTAA GAGAACTGGA 
TACATCAAGA CTGAGTTGAT TTCTGTGTCT GAAGTCCACC CTTCTAGACT TCAGAGCACA 
GAAAACCTGC TTCCCATGTC TCCAGAGGAG TTTGACGAGA TGTCCAAGAT AGTGGGCTCT 
GAATTTGACA GTATGATGAG CGCAGTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Stat1 ( NM_001034164.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001029336.1 Rattus norvegicus signal transducer and activator of transcription 1 (Stat1), transcript variant beta, mRNA.

Price & Availability↑

CloneID	ORa12363
Clone ID Related Accession (Same CDS sequence)	NM_001034164.1
Accession Version	NM_001034164.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2139bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-12-22
Organism	Rattus norvegicus(Norway rat)
Product	signal transducer and activator of transcription 1-alpha/beta isoform beta
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC062079.1 and CV075250.1. Transcript Variant: This variant (beta) differs in the 3' coding region and 3' UTR compared to variant alpha. The resulting protein (isoform beta) is shorter and has a distinct C-terminus compared to isoform beta. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC062079.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGTCGCAGT GGTACGAGCT TCAGCAGCTG GACTCCAAGT TCCTGGAGCA GGTGCACCAG 
CTGTACGATG ACAGTTTCCC CATGGAAATC AGACAGTACC TGGCCCAGTG GCTAGAAAAG 
CAAGACTGGG AGCATGCTGC CTACGACGTC TCGTTCGCCA CCATCCGCTT CCATGACCTG 
CTCTCCCAGC TGGATGACCA GTACAGCCGC TTTTCTTTGG AGAATAATTT CTTGTTGCAG 
CACAACATAA GGAAAAGCAA GCGTAATCTC CAGGATAACT TCCAAGAAGA TCCCGTACAG 
ATGTCCATGA TCATCCACAA CTGTCTGAAG GAGGAGAGGA AGATTTTGGA AAACGCCCAG 
CGATTTAATC AGGCCCAGGA GGGAAATATT CAGAACACCG TGATGTTAGA TAAACAGAAG 
GAGCTGGACA GTAAAGTCAG AAATGTGAAG GACCAAGTCA TGTGCATAGA GCATGAAATC 
AAGACCCTAG AAGACTTACA AGATGAATAT GACTTTAAAT GCAAAACCTC TCAGAACAGA 
GAAAGCGAAG CCAATGGTGT GGCGAAGAGC GACCAGAAAC AGGAACAGCT GCTGCTGCAT 
AAGATGTTCT TAATGCTTGA CAACAAGAGA AAGGAGATAA TTCACAAAAT CAGAGAGCTG 
CTGAACTCCA TCGAGCTCAC TCAGAACACT CTGATTAATG ATGAGCTTGT GGAGTGGAAG 
CGAAGACAGC AGAGTGCCTG CATTGGGGGA CCGCCCAATG CCTGCCTGGA TCAGCTGCAA 
AGCTGGTTCA CCATTGTTGC AGAGAGCCTG CAGCAGGTCC GTCAGCAGCT TAAAAAGCTG 
GAGGAGTTGG AACAGAAATT CACCTATGAG CAGGACCCTA TTACAAAAAA CAAGCAGGTG 
TTATCCGATC GCACCTTCGT CCTCTTCCAG CAGCTCATTC AGAGCTCCTT TGTGGTGGAA 
CGACAGCCGT GCATGCCAAC TCACCCTCAG AGGCCCCTGG TCTTGAAGAC TGGGGTACAG 
TTCACTGTGA AGCTGAGACT GTTGGTGAAA TTGCAAGAAC TGAACTATAA CTTGAAAGTG 
AAAGTCTCAT TTGACAAAGA TGTGAACGAG AAAAACACAG TGAAAGGATT CCGGAAGTTC 
AACATCTTGG GTACTCACAC AAAAGTGATG AACATGGAAG AATCCACCAA CGGAAGTTTG 
GCAGCTGAGT TCCGACACCT GCAACTGAAG GAACAGAAAA ATGCTGGGAA CAGAACCAAT 
GAGGGTCCTC TCATTGTCAC CGAAGAACTT CACTCTCTTA GCTTTGAAAC CCAGTTGTGC 
CAGCCAGGCT TGGTGATTGA CCTTGAGACC ACCTCTCTTC CCGTCGTGGT GATCTCCAAT 
GTCAGCCAGC TCCCCAGTGG CTGGGCTTCT ATCCTGTGGT ACAACATGCT GGTGACAGAG 
CCCAGGAATC TCTCCTTCTT CCTGAACCCC CCGTGTGCGT GGTGGTCCCA GCTCTCAGAG 
GTGCTGAGTT GGCAGTTTTC GTCAGTCACC AAGAGAGGTC TCAACGCTGA CCAGCTGAGC 
ATGCTGGGGG AGAAGCTTCT GGGCCCTAAT GCTGGCCCTG ATGGTCTTAT TCCATGGACA 
AGGTTCTGTA AGGAAAATAT TAACGATAAG AATTTCTCCT TCTGGCCTTG GATTGACACC 
ATCCTAGAAC TCATTAAGAA GCACCTGCTT TGCCTCTGGA ATGATGGGTG CATCATGGGC 
TTTATCAGCA AGGAGCGAGA ACGTGCTCTG CTCAAGGACC AGCAGCCCGG GACGTTCCTG 
CTTAGGTTCA GTGAGAGCTC CCGGGAAGGG GCCATCACAT TCACATGGGT GGAACGGTCC 
CAAAATGGAG GTGAACCCGA CTTCCATGCT GTTGAGCCCT ACACGAAGAA AGAACTTTCA 
GCTGTTACTT TCCCAGATAT TATTCGCAAT TACAAAGTCA TGGCTGCTGA GAATATACCA 
GAGAATCCCC TGAAGTATCT GTATCCCAAT ATTGACAAAG ACCATGCCTT CGGGAAGTAC 
TACTCCAGGC CAAAGGAAGC ACCAGAACCG ATGGAGCTCG ATGACCCTAA GAGAACTGGA 
TACATCAAGA CTGAGTTGAT TTCTGTGTCT GAAGTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001029336.1
CDS	291..2429
Translation	MSQWYELQQLDSKFLEQVHQLYDDSFPMEIRQYLAQWLEKQDWEHAAYDVSFATIRFHDLLSQLDDQYSRFSLENNFLLQHNIRKSKRNLQDNFQEDPVQMSMIIHNCLKEERKILENAQRFNQAQEGNIQNTVMLDKQKELDSKVRNVKDQVMCIEHEIKTLEDLQDEYDFKCKTSQNRESEANGVAKSDQKQEQLLLHKMFLMLDNKRKEIIHKIRELLNSIELTQNTLINDELVEWKRRQQSACIGGPPNACLDQLQSWFTIVAESLQQVRQQLKKLEELEQKFTYEQDPITKNKQVLSDRTFVLFQQLIQSSFVVERQPCMPTHPQRPLVLKTGVQFTVKLRLLVKLQELNYNLKVKVSFDKDVNEKNTVKGFRKFNILGTHTKVMNMEESTNGSLAAEFRHLQLKEQKNAGNRTNEGPLIVTEELHSLSFETQLCQPGLVIDLETTSLPVVVISNVSQLPSGWASILWYNMLVTEPRNLSFFLNPPCAWWSQLSEVLSWQFSSVTKRGLNADQLSMLGEKLLGPNAGPDGLIPWTRFCKENINDKNFSFWPWIDTILELIKKHLLCLWNDGCIMGFISKERERALLKDQQPGTFLLRFSESSREGAITFTWVERSQNGGEPDFHAVEPYTKKELSAVTFPDIIRNYKVMAAENIPENPLKYLYPNIDKDHAFGKYYSRPKEAPEPMELDDPKRTGYIKTELISVSEV

Target ORF information:

RefSeq Version	NM_001034164.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus signal transducer and activator of transcription 1 (Stat1), transcript variant beta, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001034164.1

ORF Insert Sequence:

ATGTCGCAGT GGTACGAGCT TCAGCAGCTG GACTCCAAGT TCCTGGAGCA GGTGCACCAG 
CTGTACGATG ACAGTTTCCC CATGGAAATC AGACAGTACC TGGCCCAGTG GCTAGAAAAG 
CAAGACTGGG AGCATGCTGC CTACGACGTC TCGTTCGCCA CCATCCGCTT CCATGACCTG 
CTCTCCCAGC TGGATGACCA GTACAGCCGC TTTTCTTTGG AGAATAATTT CTTGTTGCAG 
CACAACATAA GGAAAAGCAA GCGTAATCTC CAGGATAACT TCCAAGAAGA TCCCGTACAG 
ATGTCCATGA TCATCCACAA CTGTCTGAAG GAGGAGAGGA AGATTTTGGA AAACGCCCAG 
CGATTTAATC AGGCCCAGGA GGGAAATATT CAGAACACCG TGATGTTAGA TAAACAGAAG 
GAGCTGGACA GTAAAGTCAG AAATGTGAAG GACCAAGTCA TGTGCATAGA GCATGAAATC 
AAGACCCTAG AAGACTTACA AGATGAATAT GACTTTAAAT GCAAAACCTC TCAGAACAGA 
GAAAGCGAAG CCAATGGTGT GGCGAAGAGC GACCAGAAAC AGGAACAGCT GCTGCTGCAT 
AAGATGTTCT TAATGCTTGA CAACAAGAGA AAGGAGATAA TTCACAAAAT CAGAGAGCTG 
CTGAACTCCA TCGAGCTCAC TCAGAACACT CTGATTAATG ATGAGCTTGT GGAGTGGAAG 
CGAAGACAGC AGAGTGCCTG CATTGGGGGA CCGCCCAATG CCTGCCTGGA TCAGCTGCAA 
AGCTGGTTCA CCATTGTTGC AGAGAGCCTG CAGCAGGTCC GTCAGCAGCT TAAAAAGCTG 
GAGGAGTTGG AACAGAAATT CACCTATGAG CAGGACCCTA TTACAAAAAA CAAGCAGGTG 
TTATCCGATC GCACCTTCGT CCTCTTCCAG CAGCTCATTC AGAGCTCCTT TGTGGTGGAA 
CGACAGCCGT GCATGCCAAC TCACCCTCAG AGGCCCCTGG TCTTGAAGAC TGGGGTACAG 
TTCACTGTGA AGCTGAGACT GTTGGTGAAA TTGCAAGAAC TGAACTATAA CTTGAAAGTG 
AAAGTCTCAT TTGACAAAGA TGTGAACGAG AAAAACACAG TGAAAGGATT CCGGAAGTTC 
AACATCTTGG GTACTCACAC AAAAGTGATG AACATGGAAG AATCCACCAA CGGAAGTTTG 
GCAGCTGAGT TCCGACACCT GCAACTGAAG GAACAGAAAA ATGCTGGGAA CAGAACCAAT 
GAGGGTCCTC TCATTGTCAC CGAAGAACTT CACTCTCTTA GCTTTGAAAC CCAGTTGTGC 
CAGCCAGGCT TGGTGATTGA CCTTGAGACC ACCTCTCTTC CCGTCGTGGT GATCTCCAAT 
GTCAGCCAGC TCCCCAGTGG CTGGGCTTCT ATCCTGTGGT ACAACATGCT GGTGACAGAG 
CCCAGGAATC TCTCCTTCTT CCTGAACCCC CCGTGTGCGT GGTGGTCCCA GCTCTCAGAG 
GTGCTGAGTT GGCAGTTTTC GTCAGTCACC AAGAGAGGTC TCAACGCTGA CCAGCTGAGC 
ATGCTGGGGG AGAAGCTTCT GGGCCCTAAT GCTGGCCCTG ATGGTCTTAT TCCATGGACA 
AGGTTCTGTA AGGAAAATAT TAACGATAAG AATTTCTCCT TCTGGCCTTG GATTGACACC 
ATCCTAGAAC TCATTAAGAA GCACCTGCTT TGCCTCTGGA ATGATGGGTG CATCATGGGC 
TTTATCAGCA AGGAGCGAGA ACGTGCTCTG CTCAAGGACC AGCAGCCCGG GACGTTCCTG 
CTTAGGTTCA GTGAGAGCTC CCGGGAAGGG GCCATCACAT TCACATGGGT GGAACGGTCC 
CAAAATGGAG GTGAACCCGA CTTCCATGCT GTTGAGCCCT ACACGAAGAA AGAACTTTCA 
GCTGTTACTT TCCCAGATAT TATTCGCAAT TACAAAGTCA TGGCTGCTGA GAATATACCA 
GAGAATCCCC TGAAGTATCT GTATCCCAAT ATTGACAAAG ACCATGCCTT CGGGAAGTAC 
TACTCCAGGC CAAAGGAAGC ACCAGAACCG ATGGAGCTCG ATGACCCTAA GAGAACTGGA 
TACATCAAGA CTGAGTTGAT TTCTGTGTCT GAAGTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The participation of fibroblast growth factor 23 (FGF23) in the progression of osteoporosis via JAK/STAT pathway.
Journal of cellular biochemistry(2017 Aug)
Xu L,Zhang L,Zhang H,Yang Z,Qi L,Wang Y,Ren S

Fludarabine inhibits STAT1-mediated up-regulation of caspase-3 expression in dexamethasone-induced osteoblasts apoptosis and slows the progression of steroid-induced avascular necrosis of the femoral head in rats.
Apoptosis : an international journal on programmed cell death22(8)1001-1012(2017 Aug)
Feng Z,Zheng W,Tang Q,Cheng L,Li H,Ni W,Pan X

Methyltransferase SETD2-Mediated Methylation of STAT1 Is Critical for Interferon Antiviral Activity.
Cell170(3)492-506.e14(2017 Jul)
Chen K,Liu J,Liu S,Xia M,Zhang X,Han D,Jiang Y,Wang C,Cao X

Activation of PI3K in response to high glucose leads to regulation of SOCS-3 and STAT1/3 signals and induction of glomerular mesangial extracellular matrix formation.
Oncotarget8(10)16925-16938(2017 Mar)
Sheu ML,Shen CC,Jheng JR,Chiang CK

Functional Selectivity in Cytokine Signaling Revealed Through a Pathogenic EPO Mutation.
Cell168(6)1053-1064.e15(2017 Mar)
Kim AR,Ulirsch JC,Wilmes S,Unal E,Moraga I,Karakukcu M,Yuan D,Kazerounian S,Abdulhay NJ,King DS,Gupta N,Gabriel SB,Lander ES,Patiroglu T,Ozcan A,Ozdemir MA,Garcia KC,Piehler J,Gazda HT,Klein DE,Sankaran VG

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Stat1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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