Sp1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Sp1
Entrez Gene ID	24790
Full Name	Sp1 transcription factor
General protein information	Preferred Names Sp1 transcription factor Names transcription factor Sp1 trans-acting transcription factor 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 7 Map Location: 7q36
Summary	transcription factor that recognizes 5'-CCGCCC promoter sequence; plays a role in transcriptional regulation of many genes [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_012655.2	NP_036787.2	transcription factor Sp1

Pathways from BioSystems

Homologies

	SP1	XP_001104948.1
Danio rerio (zebrafish)	sp1	NP_997827.1
Pan troglodytes (chimpanzee)	SP1	XP_003313713.1
Mus musculus (house mouse)	Sp1	NP_038700.2
Xenopus tropicalis (tropical clawed frog)	sp1	NP_989139.1
Homo sapiens (human)	SP1	NP_612482.2
Bos taurus (cattle)	SP1	NP_001071495.1
Gallus gallus (chicken)	SP1	NP_989935.1
Canis lupus familiaris (dog)	SP1	XP_005636828.1
Rattus norvegicus (Norway rat)	Sp1	NP_036787.2

Gene Ontology
Bibliography

Related articles in PubMed

Extracellular vesicles from human-induced pluripotent stem cell-derived mesenchymal stromal cells (hiPSC-MSCs) protect against renal ischemia/reperfusion injury via delivering specificity protein (SP1) and transcriptional activating of sphingosine kinase 1 and inhibiting necroptosis.
Yuan X, Li D, Chen X, Han C, Xu L, Huang T, Dong Z, Zhang M
Cell death & disease8(12)3200(2017 Dec)

miR-375 negatively regulates the synthesis and secretion of catecholamines by targeting Sp1 in rat adrenal medulla.
Gai Y, Zhang J, Wei C, Cao W, Cui Y, Cui S
American journal of physiology. Cell physiology312(5)C663-C672(2017 May)

Specificity protein 1-zinc finger protein 179 pathway is involved in the attenuation of oxidative stress following brain injury.
Chuang JY, Kao TJ, Lin SH, Wu AC, Lee PT, Su TP, Yeh SH, Lee YC, Wu CC, Chang WC
Redox biology11135-143(2017 04)

Prdx6 Upregulation by Curcumin Attenuates Ischemic Oxidative Damage via SP1 in Rats after Stroke.
Jia G, Tan B, Ma J, Zhang L, Jin X, Li C
BioMed research international20176597401(2017)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These novel findings suggest that miR-375 acts as a potent negative mediator in regulating the synthesis and secretion of CATs in the adrenal medulla during the maintenance of homeostasis under stress.
Title: miR-375 negatively regulates the synthesis and secretion of catecholamines by targeting Sp1 in rat adrenal medulla.

SP1 and TFAP2A regulate Gjb2 promoter activity during epididymal differentiation in rat.
Title: Role of Specificity Protein-1 and Activating Protein-2 Transcription Factors in the Regulation of the Gap Junction Protein Beta-2 Gene in the Epididymis of the Rat.

Hypoxia significantly increased CpG methylation at the cAMP-response elements and Sp1 binding sites and decreased Sp1 binding to GR exon 1 promoter, accounting for the repression of the GR gene in the developing heart.
Title: Antenatal hypoxia induces epigenetic repression of glucocorticoid receptor and promotes ischemic-sensitive phenotype in the developing heart.

Reduced binding of SP1 to the promoter region of folate transporters may be a part of the regulatory mechanism resulting in decreased expression of folate transporters on ethanol exposure.
Title: Reduced SP1-mediated transcriptional activation decreases expression of intestinal folate transporters in response to ethanol exposure.

There is competitive interaction between redox-sensitive transcription factors Egr1 and Sp1 in the early phases of gastric ulcer development.
Title: REDOX-SENSITIVE TRANSCRIPTION FACTORS EGR-1 AND SP1 IN THE PATHOGENESIS OF EXPERIMENTAL GASTRIC ULCER.

The following Sp1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Sp1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa00549	NM_012655.2 Latest version!	Rattus norvegicus Sp1 transcription factor (Sp1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Sp1 ( NM_012655.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_036787.2 Rattus norvegicus Sp1 transcription factor (Sp1), mRNA.

Price & Availability↑

CloneID	ORa00549
Clone ID Related Accession (Same CDS sequence)	NM_012655.2
Accession Version	NM_012655.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2361bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-04
Organism	Rattus norvegicus(Norway rat)
Product	transcription factor Sp1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC097309.7. On Jan 1, 2008 this sequence version replaced NM_012655.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGCGACC AAGATCACTC AATGGATGAA GTGACAGCTG TGAAGATTGA AAAAGGTGTT 
GGTGGCAATA ACGGGGGTAG CGGGAACGGT GGTGGTGCCG CCTTTTCTCA GACTCGAAGC 
AGCAGCACAG GCAGTAGCAG CAGCAGTGGT GGCGGAGGAG GGCAGGAATC CCAGCCATCT 
CCTTTGGCTC TGCTGGCAGC AACCTGCAGC AGAATTGAGT CACCCAATGA GAACAGCAAC 
AACTCCCAGG GTCCGAGTCA GTCAGGGGGC ACAGGTGAAC TTGACCTCAC AGCCACACAA 
CTTTCACAGG GTGCCAATGG CTGGCAGATC ATCTCTTCCT CCTCTGGGGC TACCCCTACC 
TCAAAGGAAC AGAGTGGCAA CAGTACCAAT GGCAGCAATG GCAGTGAGTC TTCCAAGAAC 
CGCACAGTCT CTGGTGGGCA GTATGTTGTG GCTGCTACCC CCAACTTACA GAACCAGCAA 
GTTCTGACAG GTCTACCTGG AGTAATGCCT AATATTCAGT ATCAAGTAAT CCCACAGTTC 
CAGACTGTTG ATGGGCAACA GCTGCAGTTT GCTGCCACTG GGGCCCAAGT GCAGCAGGAT 
GGTTCTGGTC AAATACAGAT CATACCAGGT GCAAATCAAC AGATCATCAC AAATAGAGGA 
AGTGGGGGCA ACATTATTGC TGCTATGCCA AATCTACTCC AGCAAGCTGT CCCCCTCCAA 
GGCCTTGCTA ATAATGTGCT CTCAGGACAG ACTCAGTATG TGACCAATGT ACCAGTGGCC 
CTGAATGGGA ACATCACCTT GCTACCTGTC AACAGCGTTT CTGCAGCTAC CCTGACTCCC 
AGCTCTCAGG CAGGCACGAT CAGCAGCTCT GGATCCCAGG AGAGTGGCTC ACAGCCTGTC 
ACCTCAGGGA CTGCCATCAG TTCTGCCAGC TTGGTGTCAT CACAAGCCAG TTCCAGCTCC 
TTTTTCACCA ATGCCAACAG CTATTCAACA ACTACCACCA CCAGCAACAT GGGAATTATG 
AACTTTACCA GCAGCGGATC ATCAGGGACT AGTTCTCAAG GCCAGACATC CCAGAGAGTT 
GGTGGGCTGC AAGGGTCTGA TTCTCTAAAC ATCCAGCAGA ACCAGACATC AGGAGGATCA 
CTGCAAGGAA GTCAGCAAAA AGAGGGAGAG CAAAGTCAGC AGACACAGCA ACAACAAATT 
CTTATTCAGC CTCAGCTAGT TCAAGGTGGA CAAGCTCTTC AGGCCCTCCA AGCAGCACCA 
TTGTCAGGAC AGACCTTCAC AACTCAAGCT ATTTCCCAGG AAACCCTCCA GAACCTCCAG 
CTTCAGGCTG TTCAAAACTC TGGCCCCATC ATCATTCGGA CACCAACCGT GGGGCCCAAT 
GGACAGGTCA GTTGGCAGAC CCTTCAGCTG CAGAACCTTC AAGTTCAGAA CCCACAAGCC 
CAGACAATCA CCTTGGCCCC TATGCAGGGT GTTTCCTTGG GGCAGACTAG CAGCAGCAAT 
ACCACCCTTA CACCCATTGC CTCAGCTGCC TCCATTCCTG CTGGCACAGT CACTGTGAAT 
GCTGCTCAAC TGTCCTCCAT GCCAGGCCTC CAGACCATTA ACCTCAGTGC ATTGGGTACT 
TCAGGGATCC AGGTGCACCA GCTTCCAGGC CTGCCTTTGG CTATAGCAAA CACCCCAGGT 
GATCATGGAG CTCAACTTGG CCTTCATGGA CCTGGCGGTG ATGGAATACA TGATGAGACA 
GCAGGTGGAG AAGAAGGAGA GAACAGCCCT GATCCCCAAC CCCAAGCTGG TCGCAGGACT 
CGGCGGGAAG CATGTACATG CCCCTATTGT AAAGACAGTG AGGGGAGGGG CTCTGGAGAT 
CCTGGCAAAA AGAAACAGCA CATTTGTCAT ATCCAAGGAT GCGGCAAAGT ATATGGCAAA 
ACCTCACATC TCCGTGCACA CTTGCGCTGG CATACAGGGG AGAGGCCATT CATGTGTAAT 
TGGTCATACT GTGGGAAGCG CTTTACTCGT TCGGATGAGC TTCAGAGACA TAAACGTACA 
CATACAGGAG AGAAGAAATT TGCCTGCCCT GAGTGCCCTA AGCGTTTCAT GAGGAGCGAT 
CATCTGTCAA AGCATATCAA GACCCACCAG AACAAAAAGG GAGGCCCAGG TGTAGCCTTG 
AGCGTGGGCA CATTGCCCCT GGACAGTGGG GCAGGTTCAG AAGGCAGTGG CACTGCCACT 
CCTTCAGCCC TTATTACCAC CAATATGGTA GCCATGGAGG CCATCTGTCC AGAGGGTATT 
GCCCGTCTTG CCAACAGTGG CATCAACGTC ATGCAGGTGA CAGAGCTGCA GTCCATTAAT 
ATCAGTGGCA ATGGTTTCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036787.2
CDS	39..2399
Translation	MSDQDHSMDEVTAVKIEKGVGGNNGGSGNGGGAAFSQTRSSSTGSSSSSGGGGGQESQPSPLALLAATCSRIESPNENSNNSQGPSQSGGTGELDLTATQLSQGANGWQIISSSSGATPTSKEQSGNSTNGSNGSESSKNRTVSGGQYVVAATPNLQNQQVLTGLPGVMPNIQYQVIPQFQTVDGQQLQFAATGAQVQQDGSGQIQIIPGANQQIITNRGSGGNIIAAMPNLLQQAVPLQGLANNVLSGQTQYVTNVPVALNGNITLLPVNSVSAATLTPSSQAGTISSSGSQESGSQPVTSGTAISSASLVSSQASSSSFFTNANSYSTTTTTSNMGIMNFTSSGSSGTSSQGQTSQRVGGLQGSDSLNIQQNQTSGGSLQGSQQKEGEQSQQTQQQQILIQPQLVQGGQALQALQAAPLSGQTFTTQAISQETLQNLQLQAVQNSGPIIIRTPTVGPNGQVSWQTLQLQNLQVQNPQAQTITLAPMQGVSLGQTSSSNTTLTPIASAASIPAGTVTVNAAQLSSMPGLQTINLSALGTSGIQVHQLPGLPLAIANTPGDHGAQLGLHGPGGDGIHDETAGGEEGENSPDPQPQAGRRTRREACTCPYCKDSEGRGSGDPGKKKQHICHIQGCGKVYGKTSHLRAHLRWHTGERPFMCNWSYCGKRFTRSDELQRHKRTHTGEKKFACPECPKRFMRSDHLSKHIKTHQNKKGGPGVALSVGTLPLDSGAGSEGSGTATPSALITTNMVAMEAICPEGIARLANSGINVMQVTELQSINISGNGF

Target ORF information:

RefSeq Version	NM_012655.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus Sp1 transcription factor (Sp1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012655.2

ORF Insert Sequence:

ATGAGCGACC AAGATCACTC AATGGATGAA GTGACAGCTG TGAAGATTGA AAAAGGTGTT 
GGTGGCAATA ACGGGGGTAG CGGGAACGGT GGTGGTGCCG CCTTTTCTCA GACTCGAAGC 
AGCAGCACAG GCAGTAGCAG CAGCAGTGGT GGCGGAGGAG GGCAGGAATC CCAGCCATCT 
CCTTTGGCTC TGCTGGCAGC AACCTGCAGC AGAATTGAGT CACCCAATGA GAACAGCAAC 
AACTCCCAGG GTCCGAGTCA GTCAGGGGGC ACAGGTGAAC TTGACCTCAC AGCCACACAA 
CTTTCACAGG GTGCCAATGG CTGGCAGATC ATCTCTTCCT CCTCTGGGGC TACCCCTACC 
TCAAAGGAAC AGAGTGGCAA CAGTACCAAT GGCAGCAATG GCAGTGAGTC TTCCAAGAAC 
CGCACAGTCT CTGGTGGGCA GTATGTTGTG GCTGCTACCC CCAACTTACA GAACCAGCAA 
GTTCTGACAG GTCTACCTGG AGTAATGCCT AATATTCAGT ATCAAGTAAT CCCACAGTTC 
CAGACTGTTG ATGGGCAACA GCTGCAGTTT GCTGCCACTG GGGCCCAAGT GCAGCAGGAT 
GGTTCTGGTC AAATACAGAT CATACCAGGT GCAAATCAAC AGATCATCAC AAATAGAGGA 
AGTGGGGGCA ACATTATTGC TGCTATGCCA AATCTACTCC AGCAAGCTGT CCCCCTCCAA 
GGCCTTGCTA ATAATGTGCT CTCAGGACAG ACTCAGTATG TGACCAATGT ACCAGTGGCC 
CTGAATGGGA ACATCACCTT GCTACCTGTC AACAGCGTTT CTGCAGCTAC CCTGACTCCC 
AGCTCTCAGG CAGGCACGAT CAGCAGCTCT GGATCCCAGG AGAGTGGCTC ACAGCCTGTC 
ACCTCAGGGA CTGCCATCAG TTCTGCCAGC TTGGTGTCAT CACAAGCCAG TTCCAGCTCC 
TTTTTCACCA ATGCCAACAG CTATTCAACA ACTACCACCA CCAGCAACAT GGGAATTATG 
AACTTTACCA GCAGCGGATC ATCAGGGACT AGTTCTCAAG GCCAGACATC CCAGAGAGTT 
GGTGGGCTGC AAGGGTCTGA TTCTCTAAAC ATCCAGCAGA ACCAGACATC AGGAGGATCA 
CTGCAAGGAA GTCAGCAAAA AGAGGGAGAG CAAAGTCAGC AGACACAGCA ACAACAAATT 
CTTATTCAGC CTCAGCTAGT TCAAGGTGGA CAAGCTCTTC AGGCCCTCCA AGCAGCACCA 
TTGTCAGGAC AGACCTTCAC AACTCAAGCT ATTTCCCAGG AAACCCTCCA GAACCTCCAG 
CTTCAGGCTG TTCAAAACTC TGGCCCCATC ATCATTCGGA CACCAACCGT GGGGCCCAAT 
GGACAGGTCA GTTGGCAGAC CCTTCAGCTG CAGAACCTTC AAGTTCAGAA CCCACAAGCC 
CAGACAATCA CCTTGGCCCC TATGCAGGGT GTTTCCTTGG GGCAGACTAG CAGCAGCAAT 
ACCACCCTTA CACCCATTGC CTCAGCTGCC TCCATTCCTG CTGGCACAGT CACTGTGAAT 
GCTGCTCAAC TGTCCTCCAT GCCAGGCCTC CAGACCATTA ACCTCAGTGC ATTGGGTACT 
TCAGGGATCC AGGTGCACCA GCTTCCAGGC CTGCCTTTGG CTATAGCAAA CACCCCAGGT 
GATCATGGAG CTCAACTTGG CCTTCATGGA CCTGGCGGTG ATGGAATACA TGATGAGACA 
GCAGGTGGAG AAGAAGGAGA GAACAGCCCT GATCCCCAAC CCCAAGCTGG TCGCAGGACT 
CGGCGGGAAG CATGTACATG CCCCTATTGT AAAGACAGTG AGGGGAGGGG CTCTGGAGAT 
CCTGGCAAAA AGAAACAGCA CATTTGTCAT ATCCAAGGAT GCGGCAAAGT ATATGGCAAA 
ACCTCACATC TCCGTGCACA CTTGCGCTGG CATACAGGGG AGAGGCCATT CATGTGTAAT 
TGGTCATACT GTGGGAAGCG CTTTACTCGT TCGGATGAGC TTCAGAGACA TAAACGTACA 
CATACAGGAG AGAAGAAATT TGCCTGCCCT GAGTGCCCTA AGCGTTTCAT GAGGAGCGAT 
CATCTGTCAA AGCATATCAA GACCCACCAG AACAAAAAGG GAGGCCCAGG TGTAGCCTTG 
AGCGTGGGCA CATTGCCCCT GGACAGTGGG GCAGGTTCAG AAGGCAGTGG CACTGCCACT 
CCTTCAGCCC TTATTACCAC CAATATGGTA GCCATGGAGG CCATCTGTCC AGAGGGTATT 
GCCCGTCTTG CCAACAGTGG CATCAACGTC ATGCAGGTGA CAGAGCTGCA GTCCATTAAT 
ATCAGTGGCA ATGGTTTCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Extracellular vesicles from human-induced pluripotent stem cell-derived mesenchymal stromal cells (hiPSC-MSCs) protect against renal ischemia/reperfusion injury via delivering specificity protein (SP1) and transcriptional activating of sphingosine kinase 1 and inhibiting necroptosis.
Cell death & disease8(12)3200(2017 Dec)
Yuan X,Li D,Chen X,Han C,Xu L,Huang T,Dong Z,Zhang M

miR-375 negatively regulates the synthesis and secretion of catecholamines by targeting Sp1 in rat adrenal medulla.
American journal of physiology. Cell physiology312(5)C663-C672(2017 May)
Gai Y,Zhang J,Wei C,Cao W,Cui Y,Cui S

Specificity protein 1-zinc finger protein 179 pathway is involved in the attenuation of oxidative stress following brain injury.
Redox biology11135-143(2017 04)
Chuang JY,Kao TJ,Lin SH,Wu AC,Lee PT,Su TP,Yeh SH,Lee YC,Wu CC,Chang WC

Prdx6 Upregulation by Curcumin Attenuates Ischemic Oxidative Damage via SP1 in Rats after Stroke.
BioMed research international20176597401(2017)
Jia G,Tan B,Ma J,Zhang L,Jin X,Li C

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Sp1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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