Ppp2cb cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ppp2cb
Entrez Gene ID	24673
Full Name	protein phosphatase 2 catalytic subunit beta
Synonyms	Pp2a2
General protein information	Preferred Names protein phosphatase 2 catalytic subunit beta Names serine/threonine-protein phosphatase 2A catalytic subunit beta isoform PP2A-beta protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform protein phosphatase 2, catalytic subunit, beta isoform protein phosphatase 2, catalytic subunit, beta isozyme protein phosphatase 2A catalytic alpha subunit protein phosphatase 2a, catalytic subunit, beta isoform protein phosphatase-2A-beta
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 16 Map Location: 16q12.3
Summary	catalytic subunit of multimeric serine/threonine phosphatase; involved in insulin signal transduction; negatively regulates the Ras/MAP kinase pathway by binding to Shc, inhibiting tyrosine phosphorylation [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_017040.1	NP_058736.1	serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
NM_017040.2	NP_058736.1	serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

Pathways from BioSystems

Homologies

Homo sapiens (human)	PPP2CB	NP_001009552.1
Pan troglodytes (chimpanzee)	PPP2CB	XP_519697.2
	PPP2CB	XP_001084560.1
Danio rerio (zebrafish)	ppp2cb	NP_998458.1
Saccharomyces cerevisiae (baker's yeast)	PPH22	NP_010093.1
Magnaporthe oryzae (rice blast fungus)	MGG_06099	XP_003711965.1
Oryza sativa (rice)	Os10g0410600	NP_001064578.1
Xenopus tropicalis (tropical clawed frog)	ppp2cb	NP_001005443.1
Saccharomyces cerevisiae (baker's yeast)	PPH21	NP_010147.1
Neurospora crassa	NCU06630	XP_961818.2
Canis lupus familiaris (dog)	PPP2CB	XP_539988.1
Mus musculus (house mouse)	Ppp2cb	NP_059070.1
Schizosaccharomyces pombe (fission yeast)	ppa2	NP_595940.1
Gallus gallus (chicken)	PPP2CB	NP_990455.1
Eremothecium gossypii	AGOS_ADR099C	NP_984195.1
Oryza sativa (rice)	Os03g0167700	NP_001049084.1
Bos taurus (cattle)	PPP2CB	NP_001069325.1
Rattus norvegicus (Norway rat)	Ppp2cb	NP_058736.1
Kluyveromyces lactis	KLLA0F05357g	XP_455323.1

Gene Ontology
Bibliography

Related articles in PubMed

Phosphatase: PP2A structural importance, regulation and its aberrant expression in cancer.
Seshacharyulu P, Pandey P, Datta K, Batra SK
Cancer letters335(1)9-18(2013 Jul)

Ferulic acid attenuates the injury-induced decrease of protein phosphatase 2A subunit B in ischemic brain injury.
Koh PO
PloS one8(1)e54217(2013)

Over activation of hippocampal serine/threonine protein phosphatases PP1 and PP2A is involved in lead-induced deficits in learning and memory in young rats.
Rahman A, Khan KM, Al-Khaledi G, Khan I, Al-Shemary T
Neurotoxicology33(3)370-83(2012 Jun)

DARPP-32, Jack of All Trades? Master of Which?
Yger M, Girault JA
Frontiers in behavioral neuroscience556(2011)

I1PP2A affects tau phosphorylation via association with the catalytic subunit of protein phosphatase 2A.
Chen S, Li B, Grundke-Iqbal I, Iqbal K
The Journal of biological chemistry283(16)10513-21(2008 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results suggest that the maintenance of PP2A subunit B by ferulic acid in ischemic brain injury plays an important role for the neuroprotective function of ferulic acid.
Title: Ferulic acid attenuates the injury-induced decrease of protein phosphatase 2A subunit B in ischemic brain injury.

I1PP2A affects tau phosphorylation via association with the catalytic subunit of protein phosphatase 2A
Title: I1PP2A affects tau phosphorylation via association with the catalytic subunit of protein phosphatase 2A.

a positive modulatory role for PP2Ac in signaling steps leading to glucose-stimulated insulin secretion
Title: Depletion of the catalytic subunit of protein phosphatase-2A (PP2Ac) markedly attenuates glucose-stimulated insulin secretion in pancreatic beta-cells.

the B'beta regulatory subunit of protein phosphatase 2A modulates tyrosine hydroxylase phosphorylation and catecholamine synthesis
Title: Differential expression of the B'beta regulatory subunit of protein phosphatase 2A modulates tyrosine hydroxylase phosphorylation and catecholamine synthesis.

Inhibition of protein phosphatase 2A by protein phosphatase inhibitors activates sodiun transport in rat erytrocytes.
Title: Activation of sodium transport in rat erythrocytes by inhibition of protein phosphatases 1 and 2A.

The following Ppp2cb gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ppp2cb cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa02588	NM_017040.2 Latest version!	Rattus norvegicus protein phosphatase 2 catalytic subunit beta (Ppp2cb), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
View Old Accession Versions >>
ORa02588	NM_017040.1	Rattus norvegicus protein phosphatase 2 catalytic subunit beta (Ppp2cb), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ppp2cb ( NM_017040.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_058736.1 Rattus norvegicus protein phosphatase 2 catalytic subunit beta (Ppp2cb), mRNA.

Price & Availability↑

CloneID	ORa02588
Clone ID Related Accession (Same CDS sequence)	NM_017040.1 , NM_017040.2
Accession Version	NM_017040.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 930bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-15
Organism	Rattus norvegicus(Norway rat)
Product	serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from M23591.1. On Jun 25, 2006 this sequence version replaced XM_001067962.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M23591.1, BC085926.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01906348, SAMN01906353 [ECO:0000348] ##Evidence-Data-END##

ATGGACGACA AGGCGTTCAC CAAGGAGCTG GACCAGTGGG TGGAGCAGCT GAACGAGTGT 
AAGCAGCTGA ACGAGAACCA AGTGCGGACG CTGTGCGAGA AGGCTAAGGA AATTTTAACA 
AAAGAATCAA ATGTACAAGA GGTTCGCTGT CCTGTTACCG TCTGTGGAGA TGTGCATGGC 
CAATTCCATG ACCTTATGGA ACTCTTCAGA ATTGGTGGAA AATCACCAGA CACCAACTAT 
CTATTCATGG GTGACTATGT AGACAGAGGA TATTATTCTG TGGAGACCGT GACTCTTCTT 
GTAGCATTAA AGGTGCGCTA TCCAGAGCGT ATCACAATAT TGCGAGGAAA TCATGAAAGC 
CGGCAGATCA CACAAGTATA TGGCTTTTAT GATGAATGCC TACGAAAGTA TGGGAACGCC 
AACGTGTGGA AATACTTTAC AGATCTCTTT GATTATCTTC CACTTACAGC TTTAGTAGAT 
GGACAGATAT TCTGCCTCCA CGGTGGCCTC TCTCCATCCA TAGATACACT GGATCACATA 
AGAGCCCTGG ATCGCTTACA GGAAGTTCCA CATGAGGGCC CAATGTGTGA TCTCTTATGG 
TCAGATCCAG ATGACCGTGG TGGCTGGGGC ATTTCTCCAC GTGGTGCTGG CTACACATTT 
GGACAAGACA TTTCTGAAAC ATTTAACCAT GCCAACGGCC TCACACTGGT GTCCCGTGCT 
CACCAGCTTG TAATGGAAGG ATATAATTGG TGCCATGATC GGAATGTGGT CACCATTTTT 
AGTGCACCCA ATTACTGCTA CCGCTGTGGG AACCAGGCTG CTATCATGGA ATTAGACGAC 
ACTTTAAAAT ACTCTTTTCT TCAGTTTGAC CCAGCACCTC GTCGTGGAGA GCCTCATGTG 
ACCCGGCGCA CCCCAGACTA CTTCCTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_058736.1
CDS	310..1239
Translation	MDDKAFTKELDQWVEQLNECKQLNENQVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYPERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPRRGEPHVTRRTPDYFL

Target ORF information:

RefSeq Version	NM_017040.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus protein phosphatase 2 catalytic subunit beta (Ppp2cb), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017040.1

ORF Insert Sequence:

ATGGACGACA AGGCGTTCAC CAAGGAGCTG GACCAGTGGG TGGAGCAGCT GAACGAGTGT 
AAGCAGCTGA ACGAGAACCA AGTGCGGACG CTGTGCGAGA AGGCTAAGGA AATTTTAACA 
AAAGAATCAA ATGTACAAGA GGTTCGCTGT CCTGTTACCG TCTGTGGAGA TGTGCATGGC 
CAATTCCATG ACCTTATGGA ACTCTTCAGA ATTGGTGGAA AATCACCAGA CACCAACTAT 
CTATTCATGG GTGACTATGT AGACAGAGGA TATTATTCTG TGGAGACCGT GACTCTTCTT 
GTAGCATTAA AGGTGCGCTA TCCAGAGCGT ATCACAATAT TGCGAGGAAA TCATGAAAGC 
CGGCAGATCA CACAAGTATA TGGCTTTTAT GATGAATGCC TACGAAAGTA TGGGAACGCC 
AACGTGTGGA AATACTTTAC AGATCTCTTT GATTATCTTC CACTTACAGC TTTAGTAGAT 
GGACAGATAT TCTGCCTCCA CGGTGGCCTC TCTCCATCCA TAGATACACT GGATCACATA 
AGAGCCCTGG ATCGCTTACA GGAAGTTCCA CATGAGGGCC CAATGTGTGA TCTCTTATGG 
TCAGATCCAG ATGACCGTGG TGGCTGGGGC ATTTCTCCAC GTGGTGCTGG CTACACATTT 
GGACAAGACA TTTCTGAAAC ATTTAACCAT GCCAACGGCC TCACACTGGT GTCCCGTGCT 
CACCAGCTTG TAATGGAAGG ATATAATTGG TGCCATGATC GGAATGTGGT CACCATTTTT 
AGTGCACCCA ATTACTGCTA CCGCTGTGGG AACCAGGCTG CTATCATGGA ATTAGACGAC 
ACTTTAAAAT ACTCTTTTCT TCAGTTTGAC CCAGCACCTC GTCGTGGAGA GCCTCATGTG 
ACCCGGCGCA CCCCAGACTA CTTCCTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Ppp2cb ( NM_017040.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_058736.1 Rattus norvegicus protein phosphatase 2 catalytic subunit beta (Ppp2cb), mRNA.

Price & Availability↑

CloneID	ORa02588
Clone ID Related Accession (Same CDS sequence)	NM_017040.1 , NM_017040.2
Accession Version	NM_017040.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 930bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Rattus norvegicus(Norway rat)
Product	serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AABR07026063.1. On Dec 27, 2019 this sequence version replaced NM_017040.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC085926.1, M23591.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01906348, SAMN01906353 [ECO:0000348] ##Evidence-Data-END##

ATGGACGACA AGGCGTTCAC CAAGGAGCTG GACCAGTGGG TGGAGCAGCT GAACGAGTGT 
AAGCAGCTGA ACGAGAACCA AGTGCGGACG CTGTGCGAGA AGGCTAAGGA AATTTTAACA 
AAAGAATCAA ATGTACAAGA GGTTCGCTGT CCTGTTACCG TCTGTGGAGA TGTGCATGGC 
CAATTCCATG ACCTTATGGA ACTCTTCAGA ATTGGTGGAA AATCACCAGA CACCAACTAT 
CTATTCATGG GTGACTATGT AGACAGAGGA TATTATTCTG TGGAGACCGT GACTCTTCTT 
GTAGCATTAA AGGTGCGCTA TCCAGAGCGT ATCACAATAT TGCGAGGAAA TCATGAAAGC 
CGGCAGATCA CACAAGTATA TGGCTTTTAT GATGAATGCC TACGAAAGTA TGGGAACGCC 
AACGTGTGGA AATACTTTAC AGATCTCTTT GATTATCTTC CACTTACAGC TTTAGTAGAT 
GGACAGATAT TCTGCCTCCA CGGTGGCCTC TCTCCATCCA TAGATACACT GGATCACATA 
AGAGCCCTGG ATCGCTTACA GGAAGTTCCA CATGAGGGCC CAATGTGTGA TCTCTTATGG 
TCAGATCCAG ATGACCGTGG TGGCTGGGGC ATTTCTCCAC GTGGTGCTGG CTACACATTT 
GGACAAGACA TTTCTGAAAC ATTTAACCAT GCCAACGGCC TCACACTGGT GTCCCGTGCT 
CACCAGCTTG TAATGGAAGG ATATAATTGG TGCCATGATC GGAATGTGGT CACCATTTTT 
AGTGCACCCA ATTACTGCTA CCGCTGTGGG AACCAGGCTG CTATCATGGA ATTAGACGAC 
ACTTTAAAAT ACTCTTTTCT TCAGTTTGAC CCAGCACCTC GTCGTGGAGA GCCTCATGTG 
ACCCGGCGCA CCCCAGACTA CTTCCTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_058736.1
CDS	49..978
Translation	MDDKAFTKELDQWVEQLNECKQLNENQVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYPERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPRRGEPHVTRRTPDYFL

Target ORF information:

RefSeq Version	NM_017040.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus protein phosphatase 2 catalytic subunit beta (Ppp2cb), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017040.2

ORF Insert Sequence:

ATGGACGACA AGGCGTTCAC CAAGGAGCTG GACCAGTGGG TGGAGCAGCT GAACGAGTGT 
AAGCAGCTGA ACGAGAACCA AGTGCGGACG CTGTGCGAGA AGGCTAAGGA AATTTTAACA 
AAAGAATCAA ATGTACAAGA GGTTCGCTGT CCTGTTACCG TCTGTGGAGA TGTGCATGGC 
CAATTCCATG ACCTTATGGA ACTCTTCAGA ATTGGTGGAA AATCACCAGA CACCAACTAT 
CTATTCATGG GTGACTATGT AGACAGAGGA TATTATTCTG TGGAGACCGT GACTCTTCTT 
GTAGCATTAA AGGTGCGCTA TCCAGAGCGT ATCACAATAT TGCGAGGAAA TCATGAAAGC 
CGGCAGATCA CACAAGTATA TGGCTTTTAT GATGAATGCC TACGAAAGTA TGGGAACGCC 
AACGTGTGGA AATACTTTAC AGATCTCTTT GATTATCTTC CACTTACAGC TTTAGTAGAT 
GGACAGATAT TCTGCCTCCA CGGTGGCCTC TCTCCATCCA TAGATACACT GGATCACATA 
AGAGCCCTGG ATCGCTTACA GGAAGTTCCA CATGAGGGCC CAATGTGTGA TCTCTTATGG 
TCAGATCCAG ATGACCGTGG TGGCTGGGGC ATTTCTCCAC GTGGTGCTGG CTACACATTT 
GGACAAGACA TTTCTGAAAC ATTTAACCAT GCCAACGGCC TCACACTGGT GTCCCGTGCT 
CACCAGCTTG TAATGGAAGG ATATAATTGG TGCCATGATC GGAATGTGGT CACCATTTTT 
AGTGCACCCA ATTACTGCTA CCGCTGTGGG AACCAGGCTG CTATCATGGA ATTAGACGAC 
ACTTTAAAAT ACTCTTTTCT TCAGTTTGAC CCAGCACCTC GTCGTGGAGA GCCTCATGTG 
ACCCGGCGCA CCCCAGACTA CTTCCTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Phosphatase: PP2A structural importance, regulation and its aberrant expression in cancer.
Cancer letters335(1)9-18(2013 Jul)
Seshacharyulu P,Pandey P,Datta K,Batra SK

Ferulic acid attenuates the injury-induced decrease of protein phosphatase 2A subunit B in ischemic brain injury.
PloS one8(1)e54217(2013)
Koh PO

Over activation of hippocampal serine/threonine protein phosphatases PP1 and PP2A is involved in lead-induced deficits in learning and memory in young rats.
Neurotoxicology33(3)370-83(2012 Jun)
Rahman A,Khan KM,Al-Khaledi G,Khan I,Al-Shemary T

DARPP-32, Jack of All Trades? Master of Which?
Frontiers in behavioral neuroscience556(2011)
Yger M,Girault JA

I1PP2A affects tau phosphorylation via association with the catalytic subunit of protein phosphatase 2A.
The Journal of biological chemistry283(16)10513-21(2008 Apr)
Chen S,Li B,Grundke-Iqbal I,Iqbal K

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Ppp2cb cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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