Pomc cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Pomc
Entrez Gene ID	24664
Full Name	proopiomelanocortin
Synonyms	Pomc1,Pomc2,alphaMSH
General protein information	Preferred Names proopiomelanocortin Names pro-opiomelanocortin alpha-melanocyte-stimulating hormone corticotropin-lipotropin pro-opiomelanocortin-alpha proopiomelanocortin (adrenocorticotropin/ beta-lipotropin/ alpha-melanocyte stimulating hormone/ beta-melanocyte stimulating hormone/ beta-endorphin) proopiomelanocortin, beta (endorphin, beta) proopoimelanocortin, beta (endorphin, beta)
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 6 Map Location: 6q14

mRNA and Protein(s)

mRNA	Protein	Name
NM_139326.2	NP_647542.1	pro-opiomelanocortin precursor
XM_017594033.1	XP_017449522.1	pro-opiomelanocortin isoform X1

Pathways from BioSystems

Homologies

Homo sapiens (human)	POMC	NP_000930.1
Mus musculus (house mouse)	Pomc	NP_001265512.1
Rattus norvegicus (Norway rat)	Pomc	NP_647542.1
Danio rerio (zebrafish)	pomca	NP_852103.1
	POMC	XP_001082999.1
Canis lupus familiaris (dog)	POMC	XP_849463.3
Xenopus tropicalis (tropical clawed frog)	pomc	NP_001011318.1
Pan troglodytes (chimpanzee)	POMC	XP_003309010.1
Bos taurus (cattle)	POMC	NP_776576.1
Gallus gallus (chicken)	POMC	NP_001026269.1

Gene Ontology
Bibliography

Related articles in PubMed

Variable proopiomelanocortin expression in tanycytes of the adult rat hypothalamus and pituitary stalk.
Wittmann G, Farkas E, Szilv?sy-Szab? A, Gereben B, Fekete C, Lechan RM
The Journal of comparative neurology525(3)411-441(2017 Feb)

Localization of the dopamine receptors of types 1 and 2 on the bodies of POMC-expressing neurons of the arcuate nucleus of the hypothalamus in mice and rats.
Romanova IV, Mikhrina AL, Shpakov AO
Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections472(1)11-14(2017 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Study reveals a novel, unique type of POMC expression in tanycytes in the adult rat hypothalamus and pituitary stalk. The results indicate either a dynamic spatiotemporal pattern whereby low and high POMC syntheses in tanycytes occur periodically in each brain, or marked interindividual differences that may persist throughout adulthood.
Title: Variable proopiomelanocortin expression in tanycytes of the adult rat hypothalamus and pituitary stalk.

Localization of the dopamine receptors of types 1 and 2 on the bodies of POMC-expressing neurons of the arcuate nucleus of the hypothalamus in mice and rats.
Title: Localization of the dopamine receptors of types 1 and 2 on the bodies of POMC-expressing neurons of the arcuate nucleus of the hypothalamus in mice and rats.

This study demonstrated that Among the maternal undernutrition rats, the 48 h food deprivation group exhibited significantly lower hypothalamic proopiomelanocortin (POMC) mRNA expression than the Fed group.
Title: The expression of orexigenic and anorexigenic factors in middle-aged female rats that had been subjected to prenatal undernutrition.

Experimental hypothyroidism induced a negative energy balance accompanied by decreased NPY and increased POMC protein content in the arcuate nucleus, resulting in predominance of anorexigenic pathways, and impaired leptin signaling.
Title: Hypothyroidism Induces Hypophagia Associated with Alterations in Protein Expression of Neuropeptide Y and Proopiomelanocortin in the Arcuate Nucleus, Independently of Hypothalamic Nuclei-Specific Changes in Leptin Signaling.

The results are indicative of a novel role of ERK1/2 in glucose-regulated POMC expression and offer new mechanistic insights into hypothalamic glucose sensing.
Title: ERK1/2 mediates glucose-regulated POMC gene expression in hypothalamic neurons.

The following Pomc gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Pomc cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa13400	NM_139326.2 Latest version!	Rattus norvegicus proopiomelanocortin (Pomc), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
ORa13400	XM_017594033.1 Latest version!	Rattus norvegicus proopiomelanocortin (Pomc), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00

ORF Online Only Promotion

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2-4 Clone	40% OFF
5 or more Clone	50% OFF
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Pomc ( NM_139326.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_647542.1 Rattus norvegicus proopiomelanocortin (Pomc), mRNA.

Price & Availability↑

CloneID	ORa13400
Clone ID Related Accession (Same CDS sequence)	NM_139326.2 , XM_017594033.1
Accession Version	NM_139326.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 708bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	pro-opiomelanocortin precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC058443.1. On Dec 20, 2003 this sequence version replaced NM_139326.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC058443.1, DV726474.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGCCGAGAT TCTGCTACAG TCGCTCAGGG GCCCTGCTGC TGGCCCTCCT GCTTCAGACC 
TCCATAGACG TGTGGAGCTG GTGCCTGGAG AGCAGCCAGT GCCAGGACCT CACCACGGAA 
AGCAACCTGC TGGCTTGCAT CCGGGCCTGC AGACTCGACC TCTCGGCGGA GACGCCCGTG 
TTTCCAGGCA ACGGAGATGA ACAGCCCTTG ACTGAAAATC CCCGGAAGTA CGTCATGGGT 
CACTTCCGCT GGGACCGCTT CGGCCCCAGA AACAGCAGCA GTGCTGGCGG CTCAGCGCAG 
AGGCGTGCGG AGGAAGAGAC GGCGGGGGGA GATGGCCGTC CGGAGCCAAG TCCACGGGAG 
GGCAAGCGCT CCTACTCCAT GGAGCACTTC CGCTGGGGCA AGCCGGTGGG CAAGAAGCGG 
CGCCCTGTGA AGGTGTACCC CAATGTCGCC GAGAACGAGT CGGCCGAGGC CTTTCCCCTA 
GAGTTCAAGA GGGAGCTGGA AGGCGAGCAG CCTGATGGCT TGGAGCACGT CCTGGAGCCG 
GATACCGAGA AGGCCGACGG GCCCTATCGG GTGGAGCACT TCCGCTGGGG CAACCCGCCC 
AAGGACAAGC GCTACGGCGG CTTCATGACC TCCGAGAAGA GCCAGACGCC CCTGGTGACG 
CTCTTCAAGA ACGCCATCAT CAAGAACGCG CACAAGAAGG GCCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_647542.1
CDS	122..829
Translation	MPRFCYSRSGALLLALLLQTSIDVWSWCLESSQCQDLTTESNLLACIRACRLDLSAETPVFPGNGDEQPLTENPRKYVMGHFRWDRFGPRNSSSAGGSAQRRAEEETAGGDGRPEPSPREGKRSYSMEHFRWGKPVGKKRRPVKVYPNVAENESAEAFPLEFKRELEGEQPDGLEHVLEPDTEKADGPYRVEHFRWGNPPKDKRYGGFMTSEKSQTPLVTLFKNAIIKNAHKKGQ

Target ORF information:

RefSeq Version	NM_139326.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus proopiomelanocortin (Pomc), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_139326.2

ORF Insert Sequence:

ATGCCGAGAT TCTGCTACAG TCGCTCAGGG GCCCTGCTGC TGGCCCTCCT GCTTCAGACC 
TCCATAGACG TGTGGAGCTG GTGCCTGGAG AGCAGCCAGT GCCAGGACCT CACCACGGAA 
AGCAACCTGC TGGCTTGCAT CCGGGCCTGC AGACTCGACC TCTCGGCGGA GACGCCCGTG 
TTTCCAGGCA ACGGAGATGA ACAGCCCTTG ACTGAAAATC CCCGGAAGTA CGTCATGGGT 
CACTTCCGCT GGGACCGCTT CGGCCCCAGA AACAGCAGCA GTGCTGGCGG CTCAGCGCAG 
AGGCGTGCGG AGGAAGAGAC GGCGGGGGGA GATGGCCGTC CGGAGCCAAG TCCACGGGAG 
GGCAAGCGCT CCTACTCCAT GGAGCACTTC CGCTGGGGCA AGCCGGTGGG CAAGAAGCGG 
CGCCCTGTGA AGGTGTACCC CAATGTCGCC GAGAACGAGT CGGCCGAGGC CTTTCCCCTA 
GAGTTCAAGA GGGAGCTGGA AGGCGAGCAG CCTGATGGCT TGGAGCACGT CCTGGAGCCG 
GATACCGAGA AGGCCGACGG GCCCTATCGG GTGGAGCACT TCCGCTGGGG CAACCCGCCC 
AAGGACAAGC GCTACGGCGG CTTCATGACC TCCGAGAAGA GCCAGACGCC CCTGGTGACG 
CTCTTCAAGA ACGCCATCAT CAAGAACGCG CACAAGAAGG GCCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Pomc ( XM_017594033.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017449522.1 Rattus norvegicus proopiomelanocortin (Pomc), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa13400
Clone ID Related Accession (Same CDS sequence)	NM_139326.2 , XM_017594033.1
Accession Version	XM_017594033.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 708bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	pro-opiomelanocortin isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005105.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCGAGAT TCTGCTACAG TCGCTCAGGG GCCCTGCTGC TGGCCCTCCT GCTTCAGACC 
TCCATAGACG TGTGGAGCTG GTGCCTGGAG AGCAGCCAGT GCCAGGACCT CACCACGGAA 
AGCAACCTGC TGGCTTGCAT CCGGGCCTGC AGACTCGACC TCTCGGCGGA GACGCCCGTG 
TTTCCAGGCA ACGGAGATGA ACAGCCCTTG ACTGAAAATC CCCGGAAGTA CGTCATGGGT 
CACTTCCGCT GGGACCGCTT CGGCCCCAGA AACAGCAGCA GTGCTGGCGG CTCAGCGCAG 
AGGCGTGCGG AGGAAGAGAC GGCGGGGGGA GATGGCCGTC CGGAGCCAAG TCCACGGGAG 
GGCAAGCGCT CCTACTCCAT GGAGCACTTC CGCTGGGGCA AGCCGGTGGG CAAGAAGCGG 
CGCCCTGTGA AGGTGTACCC CAATGTCGCC GAGAACGAGT CGGCCGAGGC CTTTCCCCTA 
GAGTTCAAGA GGGAGCTGGA AGGCGAGCAG CCTGATGGCT TGGAGCACGT CCTGGAGCCG 
GATACCGAGA AGGCCGACGG GCCCTATCGG GTGGAGCACT TCCGCTGGGG CAACCCGCCC 
AAGGACAAGC GCTACGGCGG CTTCATGACC TCCGAGAAGA GCCAGACGCC CCTGGTGACG 
CTCTTCAAGA ACGCCATCAT CAAGAACGCG CACAAGAAGG GCCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017449522.1
CDS	158..865
Translation	MPRFCYSRSGALLLALLLQTSIDVWSWCLESSQCQDLTTESNLLACIRACRLDLSAETPVFPGNGDEQPLTENPRKYVMGHFRWDRFGPRNSSSAGGSAQRRAEEETAGGDGRPEPSPREGKRSYSMEHFRWGKPVGKKRRPVKVYPNVAENESAEAFPLEFKRELEGEQPDGLEHVLEPDTEKADGPYRVEHFRWGNPPKDKRYGGFMTSEKSQTPLVTLFKNAIIKNAHKKGQ

Target ORF information:

RefSeq Version	XM_017594033.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus proopiomelanocortin (Pomc), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017594033.1

ORF Insert Sequence:

ATGCCGAGAT TCTGCTACAG TCGCTCAGGG GCCCTGCTGC TGGCCCTCCT GCTTCAGACC 
TCCATAGACG TGTGGAGCTG GTGCCTGGAG AGCAGCCAGT GCCAGGACCT CACCACGGAA 
AGCAACCTGC TGGCTTGCAT CCGGGCCTGC AGACTCGACC TCTCGGCGGA GACGCCCGTG 
TTTCCAGGCA ACGGAGATGA ACAGCCCTTG ACTGAAAATC CCCGGAAGTA CGTCATGGGT 
CACTTCCGCT GGGACCGCTT CGGCCCCAGA AACAGCAGCA GTGCTGGCGG CTCAGCGCAG 
AGGCGTGCGG AGGAAGAGAC GGCGGGGGGA GATGGCCGTC CGGAGCCAAG TCCACGGGAG 
GGCAAGCGCT CCTACTCCAT GGAGCACTTC CGCTGGGGCA AGCCGGTGGG CAAGAAGCGG 
CGCCCTGTGA AGGTGTACCC CAATGTCGCC GAGAACGAGT CGGCCGAGGC CTTTCCCCTA 
GAGTTCAAGA GGGAGCTGGA AGGCGAGCAG CCTGATGGCT TGGAGCACGT CCTGGAGCCG 
GATACCGAGA AGGCCGACGG GCCCTATCGG GTGGAGCACT TCCGCTGGGG CAACCCGCCC 
AAGGACAAGC GCTACGGCGG CTTCATGACC TCCGAGAAGA GCCAGACGCC CCTGGTGACG 
CTCTTCAAGA ACGCCATCAT CAAGAACGCG CACAAGAAGG GCCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Variable proopiomelanocortin expression in tanycytes of the adult rat hypothalamus and pituitary stalk.
The Journal of comparative neurology525(3)411-441(2017 Feb)
Wittmann G,Farkas E,Szilv?sy-Szab? A,Gereben B,Fekete C,Lechan RM

Localization of the dopamine receptors of types 1 and 2 on the bodies of POMC-expressing neurons of the arcuate nucleus of the hypothalamus in mice and rats.
Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections472(1)11-14(2017 Jan)
Romanova IV,Mikhrina AL,Shpakov AO

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Pomc cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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