Kcnh8 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Kcnh8
Entrez Gene ID	246325
Full Name	potassium voltage-gated channel subfamily H member 8
Synonyms	ELK3,Elk1,Ets-1
General protein information	Preferred Names potassium voltage-gated channel subfamily H member 8 Names potassium voltage-gated channel subfamily H member 8 ELK channel 3 ether-a-go-go-like potassium channel 1 ether-a-go-go-like potassium channel 3 potassium channel, voltage gated eag related subfamily H, member 8 potassium voltage-gated channel, subfamily H (eag-related), member 8 voltage-gated potassium channel subunit Kv12.1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 9 Map Location: 9q11

mRNA and Protein(s)

mRNA	Protein	Name
NM_145095.2	NP_659563.1	potassium voltage-gated channel subfamily H member 8

Pathways from BioSystems

Homologies

Homo sapiens (human)	KCNH8	NP_653234.2
Pan troglodytes (chimpanzee)	KCNH8	XP_001162672.1
	KCNH8	XP_001087569.1
Rattus norvegicus (Norway rat)	Kcnh8	NP_659563.1
Gallus gallus (chicken)	KCNH8	XP_418747.2
Xenopus tropicalis (tropical clawed frog)	kcnh8	XP_002932461.1
Danio rerio (zebrafish)	kcnh8	XP_001922595.3
Canis lupus familiaris (dog)	KCNH8	XP_542769.2
Bos taurus (cattle)	KCNH8	XP_002685134.1
Mus musculus (house mouse)	Kcnh8	NP_001026981.2

Gene Ontology
Bibliography

Related articles in PubMed

Eag1 potassium channel immunohistochemistry in the CNS of adult rat and selected regions of human brain.
Martin S, Lino de Oliveira C, Mello de Queiroz F, Pardo LA, St?hmer W, Del Bel E
Neuroscience155(3)833-44(2008 Aug)

Ets-1 protects vascular smooth muscle cells from undergoing apoptosis by activating p21WAF1/Cip1: ETS-1 regulates basal and and inducible p21WAF1/Cip: ETS-1 regulates basal and inducible p21WAF1/Cip1 transcription via distinct cis-acting elements in the p21WAF/Cip1 promoter.
Zhang C, Kavurma MM, Lai A, Khachigian LM
The Journal of biological chemistry278(30)27903-9(2003 Jul)

Differential expression of genes encoding subthreshold-operating voltage-gated K+ channels in brain.
Saganich MJ, Machado E, Rudy B
The Journal of neuroscience : the official journal of the Society for Neuroscience21(13)4609-24(2001 Jul)

Expression of mRNA for voltage-dependent and inward-rectifying K channels in GH3/B6 cells and rat pituitary.
Wulfsen I, Hauber HP, Schiemann D, Bauer CK, Schwarz JR
Journal of neuroendocrinology12(3)263-72(2000 Mar)

Cloning and functional expression of rat ether-?-go-go-like K+ channel genes.
Engeland B, Neu A, Ludwig J, Roeper J, Pongs O
The Journal of physiology513 ( Pt 3)647-54(1998 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The results indicate that Eag1 protein expression greatly overlaps with mRNA distribution in rat.
Title: Eag1 potassium channel immunohistochemistry in the CNS of adult rat and selected regions of human brain.

The following Kcnh8 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Kcnh8 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa42589	NM_145095.2 Latest version!	Rattus norvegicus potassium voltage-gated channel subfamily H member 8 (Kcnh8), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	16	$559.30 $799.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Kcnh8 ( NM_145095.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_659563.1 Rattus norvegicus potassium voltage-gated channel subfamily H member 8 (Kcnh8), mRNA.

Price & Availability↑

CloneID	ORa42589
Clone ID Related Accession (Same CDS sequence)	NM_145095.2
Accession Version	NM_145095.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3309bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	potassium voltage-gated channel subfamily H member 8
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF061957.1. On Feb 4, 2015 this sequence version replaced NM_145095.1. ##Evidence-Data-START## Transcript exon combination :: AF061957.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052297, SAMN04563758 [ECO:0000348] ##Evidence-Data-END##

ATGCCGGTTA TGAAAGGATT GCTGGCGCCA CAGAACACCT TCCTGGACAC TATTGCCACC 
CGTTTCGACG GAACACATAG CAACTTCATC CTGGCCAATG CCCAAGTGGC AAAAGGTTTC 
CCCATAGTCT ACTGTTCAGA TGGCTTCTGT GAGCTGGCTG GGTTTGCTCG AACTGAAGTC 
ATGCAGAAGA GTTGCAGCTG CAAGTTTCTG TTTGGGGTGG AGACCAACGA GCAGCTGATG 
CTTCAGATCG AAAAGTCCCT GGAGGAGAAG GTAGAGTTCA AAGGAGAAAT TATGTTCTAC 
AAGAAGAATG GGGCTCCATT TTGGTGCCTG TTGGATATCG TTCCTATAAA GAATGAGAAA 
GGAGATGTGG TCCTTTTCCT GGCCTCATTC AAAGATATAA CAGACACGAA AGTGAAGATT 
ACTTCAGAAG ATAAAAAAGA AGACAGAGCC AAAGGAAGAT CAAGAGCAGG GAGCCACTTC 
GACTCAGCCC GCAGACGGAG CCGAGCAGTC CTTTATCACA TCTCAGGACA CCTGCAAAGA 
AGAGAAAAGA ACAAATTGAA AATAAATAAT AACGTGTTTG TAGATAAACC GGCGTTTCCA 
GAGTATAAGG TTTCCGATGC AAAAAAGTCC AAGTTCATCC TGCTGCACTT CAGCACTTTT 
AAAGCTGGCT GGGACTGGCT CATTTTGCTG GCAACGTTTT ATGTTGCTGT GACAGTCCCT 
TACAACGTGT GCTTCATTGG CAATGAGGAT CTGTCCACAA CTCGGAGCAC AACGGTCAGT 
GACATCGCTG TGGAGATTCT CTTCATTATA GATATTATTC TAAATTTCCG AACAACTTAT 
GTCAGCAAGT CTGGCCAAGT TATCTTTGAA GCGAGATCCA TTTGCATCCA CTACGTCACC 
ACCTGGTTCA TCATTGATCT GATTGCTGCC CTGCCCTTTG ACCTCCTGTA TGCTTTCAAT 
GTCACAGTGG TGTCCCTCGT ACATCTTCTG AAGACTGTTC GGCTGCTCCG TCTTTTGCGC 
CTCCTGCAGA AGCTGGACCG TTATTCTCAG CACAGCACAA TTGTCCTCAC CCTGCTCATG 
TCCATGTTTG CTCTCCTTGC ACACTGGATG GCATGTATCT GGTATGTCAT TGGAAAAATG 
GAGAGGGAGG ACAACAGCCT TCTCAAGTGG GAAGTCGGTT GGCTTCACGA GCTGGGAAAG 
AGACTGGAAT CTCCGTACTA CGGCAACAAC ACGCTGGGCG GCCCGTCCAT CCGCAGTGCC 
TATATCGCAG CCTTGTACTT CACTCTCAGC AGCCTCACCA GCGTGGGATT TGGGAATGTG 
TCCGCTAACA CGGATGCAGA GAAGATCTTC TCCATCTGTA CCATGTTGAT TGGAGCCCTG 
ATGCATGCCT TGGTATTTGG GAATGTGACT GCCATCATAC AGAGAATGTA CTCTAGATGG 
AGCCTGTACC ATACTAGAAC CAAGGACCTA AAGGACTTCA TCCGTGTGCA TCACCTGCCC 
CAGCAACTCA AGCAGAGGAT GCTTGAGTAC TTTCAGACAA CTTGGTCTGT CAACAATGGA 
ATAGATTCAA ATGAGCTTTT GAAAGACTTT CCAGATGAGC TGCGCTCTGA CATCACAATG 
CATCTGAACA AGGAGATCTT ACAGCTGTCC CTGTTTGAAT GTGCTAGCCG GGGCTGCCTC 
AGGTCTCTGT CTCTCCATAT TAAAACCTCA TTCTGTGCCC CAGGAGAGTA TCTGCTGCGC 
CAGGGAGATG CGTTGCAGGC CATCTACTTC GTGTGCTCAG GCTCTATGGA GGTTCTTAAA 
GACAGCATGG TGTTGGCTAT TCTAGGGAAG GGGGATTTAA TTGGAGCAAA TTTATCAATT 
AAAGACCAAG TGATCAAGAC CAACGCTGAC GTGAAGGCTC TGACCTACTG TGATCTACAG 
TGCATCATCC TGAAAGGTCT CTTTGAGGTG CTGGGCCTTT ACCCAGAGTA CGCACACAAA 
TTCGTAGAAG ACATCCAGCA CGACCTCACA TACAACCTTC GAGAAGGTCA TGAGAGTGAT 
GTAATATCAA GATTATCGAA CAAATCTACA GTCCCACAGG CAGAGCCCAA GGGGAATGGA 
AGCATCAAGA AGAGACTCCC ATCCATTGTG GAAGATGAGG AAGAGGAGGA AGTGGAGGAA 
GAGGAGACCA CCTCCCTTTC TCCCATCTAC ACAAGGGGAT CCTCTGTTTC ACACAGCAAA 
AAGACTGGAA GCAGTAAGAG CTATCTAGGT TTGAGCTTAA AGCAACTGAC CTCAGGAACA 
GTTCCATTCC ACTCACCTAT CAGAGTCTCC AGTGCCAACT CCCCTAAAAC CAAGCAGGAA 
GCTGACCCAC CTAACCATGG CACACGGAAA GAGAAGAATC TGAAAGTTCA GCTCTGCAGC 
CTGGGTACTG CTGGAACCCC AGAGCTCAGT CCGAGGATTG TCGATGGAAT TGAAGATGGC 
AACAGCAGTG AGGAAACTCA GACTTTTGAT TTTGGCTCTG AACAAATCAG GCCAGAGCCC 
AGGATTTCCC CTTCCCTTGG AGAATCAGAG ATTGGAGCTG CGTTTCTGTT CATCAAGGCT 
GAAGAAACCA AGCAGCAGAT AAACAAGCTC AACAGTGAGG TCACAACATT GACTCAGGAG 
GTCTCCCAGC TAGGGAAAGA TATGAGAAGC ATCATGCAAC TTCTGGAAAA CATCTTGTCA 
CCTCAGCAGC CATCACAATT TTGTTCTCTG CATCCCACTT CAATCTGTCC TTCCAGAGAA 
AGTTTCCAGA CTAGGGTGAG CTGGAGTGCT CACCAGCCTT GCCTACACTT GCAGGCAAAT 
GGAGCACATC TTTACCATGG CAATGTCACC TCTGACATCT GGAGTGTCGA CCCCTCCTTG 
GTGGGCAGCA ACCCTCAACG AACTGAAGCT CATGAGCAAA GTCCAGTAGA TAGTGAACTG 
CATCATTCTC CAAACCTGGC TTATTCCCCC TCTCACTGCC AGGTTATCCA AGAAGGCCAC 
TTGCAGTTCC TAAGGTGCAT CTCCCCTCAT TCAGATACCA CACTGACACC TTTGCAGTCC 
ATCTCAGCCA CTCTCTCATC CTCTGTGTGC TCCTCATCAG AAACATCCTT GCACCTCGTT 
CTCCCAAGTA GGTCAGAGGA GGGCAGCATC ACTCATGGAC CTGTGAGTTC TTTCAGTTTG 
GAAAACTTAC CAGGATCTTG GGACCGAGAA GGAATGATGT CAGCCTCTAC AGAACCCTTG 
GAGAACTTTC CAGTAGAAGT TGTCACAAGC ACAGCGGATG TAAAAGACAG CAAAGCCATA 
AACGTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_659563.1
CDS	49..3357
Translation	MPVMKGLLAPQNTFLDTIATRFDGTHSNFILANAQVAKGFPIVYCSDGFCELAGFARTEVMQKSCSCKFLFGVETNEQLMLQIEKSLEEKVEFKGEIMFYKKNGAPFWCLLDIVPIKNEKGDVVLFLASFKDITDTKVKITSEDKKEDRAKGRSRAGSHFDSARRRSRAVLYHISGHLQRREKNKLKINNNVFVDKPAFPEYKVSDAKKSKFILLHFSTFKAGWDWLILLATFYVAVTVPYNVCFIGNEDLSTTRSTTVSDIAVEILFIIDIILNFRTTYVSKSGQVIFEARSICIHYVTTWFIIDLIAALPFDLLYAFNVTVVSLVHLLKTVRLLRLLRLLQKLDRYSQHSTIVLTLLMSMFALLAHWMACIWYVIGKMEREDNSLLKWEVGWLHELGKRLESPYYGNNTLGGPSIRSAYIAALYFTLSSLTSVGFGNVSANTDAEKIFSICTMLIGALMHALVFGNVTAIIQRMYSRWSLYHTRTKDLKDFIRVHHLPQQLKQRMLEYFQTTWSVNNGIDSNELLKDFPDELRSDITMHLNKEILQLSLFECASRGCLRSLSLHIKTSFCAPGEYLLRQGDALQAIYFVCSGSMEVLKDSMVLAILGKGDLIGANLSIKDQVIKTNADVKALTYCDLQCIILKGLFEVLGLYPEYAHKFVEDIQHDLTYNLREGHESDVISRLSNKSTVPQAEPKGNGSIKKRLPSIVEDEEEEEVEEEETTSLSPIYTRGSSVSHSKKTGSSKSYLGLSLKQLTSGTVPFHSPIRVSSANSPKTKQEADPPNHGTRKEKNLKVQLCSLGTAGTPELSPRIVDGIEDGNSSEETQTFDFGSEQIRPEPRISPSLGESEIGAAFLFIKAEETKQQINKLNSEVTTLTQEVSQLGKDMRSIMQLLENILSPQQPSQFCSLHPTSICPSRESFQTRVSWSAHQPCLHLQANGAHLYHGNVTSDIWSVDPSLVGSNPQRTEAHEQSPVDSELHHSPNLAYSPSHCQVIQEGHLQFLRCISPHSDTTLTPLQSISATLSSSVCSSSETSLHLVLPSRSEEGSITHGPVSSFSLENLPGSWDREGMMSASTEPLENFPVEVVTSTADVKDSKAINV

Target ORF information:

RefSeq Version	NM_145095.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus potassium voltage-gated channel subfamily H member 8 (Kcnh8), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_145095.2

ORF Insert Sequence:

ATGCCGGTTA TGAAAGGATT GCTGGCGCCA CAGAACACCT TCCTGGACAC TATTGCCACC 
CGTTTCGACG GAACACATAG CAACTTCATC CTGGCCAATG CCCAAGTGGC AAAAGGTTTC 
CCCATAGTCT ACTGTTCAGA TGGCTTCTGT GAGCTGGCTG GGTTTGCTCG AACTGAAGTC 
ATGCAGAAGA GTTGCAGCTG CAAGTTTCTG TTTGGGGTGG AGACCAACGA GCAGCTGATG 
CTTCAGATCG AAAAGTCCCT GGAGGAGAAG GTAGAGTTCA AAGGAGAAAT TATGTTCTAC 
AAGAAGAATG GGGCTCCATT TTGGTGCCTG TTGGATATCG TTCCTATAAA GAATGAGAAA 
GGAGATGTGG TCCTTTTCCT GGCCTCATTC AAAGATATAA CAGACACGAA AGTGAAGATT 
ACTTCAGAAG ATAAAAAAGA AGACAGAGCC AAAGGAAGAT CAAGAGCAGG GAGCCACTTC 
GACTCAGCCC GCAGACGGAG CCGAGCAGTC CTTTATCACA TCTCAGGACA CCTGCAAAGA 
AGAGAAAAGA ACAAATTGAA AATAAATAAT AACGTGTTTG TAGATAAACC GGCGTTTCCA 
GAGTATAAGG TTTCCGATGC AAAAAAGTCC AAGTTCATCC TGCTGCACTT CAGCACTTTT 
AAAGCTGGCT GGGACTGGCT CATTTTGCTG GCAACGTTTT ATGTTGCTGT GACAGTCCCT 
TACAACGTGT GCTTCATTGG CAATGAGGAT CTGTCCACAA CTCGGAGCAC AACGGTCAGT 
GACATCGCTG TGGAGATTCT CTTCATTATA GATATTATTC TAAATTTCCG AACAACTTAT 
GTCAGCAAGT CTGGCCAAGT TATCTTTGAA GCGAGATCCA TTTGCATCCA CTACGTCACC 
ACCTGGTTCA TCATTGATCT GATTGCTGCC CTGCCCTTTG ACCTCCTGTA TGCTTTCAAT 
GTCACAGTGG TGTCCCTCGT ACATCTTCTG AAGACTGTTC GGCTGCTCCG TCTTTTGCGC 
CTCCTGCAGA AGCTGGACCG TTATTCTCAG CACAGCACAA TTGTCCTCAC CCTGCTCATG 
TCCATGTTTG CTCTCCTTGC ACACTGGATG GCATGTATCT GGTATGTCAT TGGAAAAATG 
GAGAGGGAGG ACAACAGCCT TCTCAAGTGG GAAGTCGGTT GGCTTCACGA GCTGGGAAAG 
AGACTGGAAT CTCCGTACTA CGGCAACAAC ACGCTGGGCG GCCCGTCCAT CCGCAGTGCC 
TATATCGCAG CCTTGTACTT CACTCTCAGC AGCCTCACCA GCGTGGGATT TGGGAATGTG 
TCCGCTAACA CGGATGCAGA GAAGATCTTC TCCATCTGTA CCATGTTGAT TGGAGCCCTG 
ATGCATGCCT TGGTATTTGG GAATGTGACT GCCATCATAC AGAGAATGTA CTCTAGATGG 
AGCCTGTACC ATACTAGAAC CAAGGACCTA AAGGACTTCA TCCGTGTGCA TCACCTGCCC 
CAGCAACTCA AGCAGAGGAT GCTTGAGTAC TTTCAGACAA CTTGGTCTGT CAACAATGGA 
ATAGATTCAA ATGAGCTTTT GAAAGACTTT CCAGATGAGC TGCGCTCTGA CATCACAATG 
CATCTGAACA AGGAGATCTT ACAGCTGTCC CTGTTTGAAT GTGCTAGCCG GGGCTGCCTC 
AGGTCTCTGT CTCTCCATAT TAAAACCTCA TTCTGTGCCC CAGGAGAGTA TCTGCTGCGC 
CAGGGAGATG CGTTGCAGGC CATCTACTTC GTGTGCTCAG GCTCTATGGA GGTTCTTAAA 
GACAGCATGG TGTTGGCTAT TCTAGGGAAG GGGGATTTAA TTGGAGCAAA TTTATCAATT 
AAAGACCAAG TGATCAAGAC CAACGCTGAC GTGAAGGCTC TGACCTACTG TGATCTACAG 
TGCATCATCC TGAAAGGTCT CTTTGAGGTG CTGGGCCTTT ACCCAGAGTA CGCACACAAA 
TTCGTAGAAG ACATCCAGCA CGACCTCACA TACAACCTTC GAGAAGGTCA TGAGAGTGAT 
GTAATATCAA GATTATCGAA CAAATCTACA GTCCCACAGG CAGAGCCCAA GGGGAATGGA 
AGCATCAAGA AGAGACTCCC ATCCATTGTG GAAGATGAGG AAGAGGAGGA AGTGGAGGAA 
GAGGAGACCA CCTCCCTTTC TCCCATCTAC ACAAGGGGAT CCTCTGTTTC ACACAGCAAA 
AAGACTGGAA GCAGTAAGAG CTATCTAGGT TTGAGCTTAA AGCAACTGAC CTCAGGAACA 
GTTCCATTCC ACTCACCTAT CAGAGTCTCC AGTGCCAACT CCCCTAAAAC CAAGCAGGAA 
GCTGACCCAC CTAACCATGG CACACGGAAA GAGAAGAATC TGAAAGTTCA GCTCTGCAGC 
CTGGGTACTG CTGGAACCCC AGAGCTCAGT CCGAGGATTG TCGATGGAAT TGAAGATGGC 
AACAGCAGTG AGGAAACTCA GACTTTTGAT TTTGGCTCTG AACAAATCAG GCCAGAGCCC 
AGGATTTCCC CTTCCCTTGG AGAATCAGAG ATTGGAGCTG CGTTTCTGTT CATCAAGGCT 
GAAGAAACCA AGCAGCAGAT AAACAAGCTC AACAGTGAGG TCACAACATT GACTCAGGAG 
GTCTCCCAGC TAGGGAAAGA TATGAGAAGC ATCATGCAAC TTCTGGAAAA CATCTTGTCA 
CCTCAGCAGC CATCACAATT TTGTTCTCTG CATCCCACTT CAATCTGTCC TTCCAGAGAA 
AGTTTCCAGA CTAGGGTGAG CTGGAGTGCT CACCAGCCTT GCCTACACTT GCAGGCAAAT 
GGAGCACATC TTTACCATGG CAATGTCACC TCTGACATCT GGAGTGTCGA CCCCTCCTTG 
GTGGGCAGCA ACCCTCAACG AACTGAAGCT CATGAGCAAA GTCCAGTAGA TAGTGAACTG 
CATCATTCTC CAAACCTGGC TTATTCCCCC TCTCACTGCC AGGTTATCCA AGAAGGCCAC 
TTGCAGTTCC TAAGGTGCAT CTCCCCTCAT TCAGATACCA CACTGACACC TTTGCAGTCC 
ATCTCAGCCA CTCTCTCATC CTCTGTGTGC TCCTCATCAG AAACATCCTT GCACCTCGTT 
CTCCCAAGTA GGTCAGAGGA GGGCAGCATC ACTCATGGAC CTGTGAGTTC TTTCAGTTTG 
GAAAACTTAC CAGGATCTTG GGACCGAGAA GGAATGATGT CAGCCTCTAC AGAACCCTTG 
GAGAACTTTC CAGTAGAAGT TGTCACAAGC ACAGCGGATG TAAAAGACAG CAAAGCCATA 
AACGTATAA