Igfbp3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Igfbp3
Entrez Gene ID	24484
Full Name	insulin-like growth factor binding protein 3
Synonyms	IGF-BP3
General protein information	Preferred Names insulin-like growth factor binding protein 3 Names insulin-like growth factor-binding protein 3 IBP-3 IGF-binding protein 3 IGFBP-3 insulin-like growth factor-binding protein (IGF-BP3)
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 14 Map Location: 14q21
Summary	an insulin growth factor (Igf) binding protein; involved in modulating IGF-I action [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_012588.2	NP_036720.2	insulin-like growth factor-binding protein 3 precursor

Pathways from BioSystems

Homologies

	IGFBP3	XP_001085359.1
Mus musculus (house mouse)	Igfbp3	NP_032369.2
Pan troglodytes (chimpanzee)	IGFBP3	XP_003318467.1
Danio rerio (zebrafish)	igfbp3	NP_991314.2
Canis lupus familiaris (dog)	IGFBP3	XP_003639605.1
Rattus norvegicus (Norway rat)	Igfbp3	NP_036720.2
Homo sapiens (human)	IGFBP3	NP_001013416.1
Bos taurus (cattle)	IGFBP3	NP_776981.1
Gallus gallus (chicken)	IGFBP3	NP_001094504.1

Gene Ontology
Bibliography

Related articles in PubMed

Effects of Adenotonsillectomy on Serum Levels of IGF-1 and IGFBP-3 and Growth Indices in Children with Adenotonsillar Hypertrophy or Recurrent Tonsillitis.
Farmarzi M, Shishegar M, Heydari ST, Haghighi A, Sharouny H
Iranian journal of otorhinolaryngology28(88)329-335(2016 Sep)

Short hairpin ribonucleic acid constructs targeting insulin-like growth factor binding protein-3 rehabilitated dyslipidaemia in diabetic rats.
Zhou ZY, Cheng SP, Huang H, Wang J, Pan H, Liu CM, Xing C, Sun YL, Liu RH, Zhong GJ
Andrologia48(1)59-64(2016 Feb)

Compound 49b Restores Retinal Thickness and Reduces Degenerate Capillaries in the Rat Retina following Ischemia/Reperfusion.
Liu L, Jiang Y, Steinle JJ
PloS one11(7)e0159532(2016)

Short hairpin ribonucleic acid constructs targeting insulin-like growth factor binding protein-3 rehabilitated decreased testosterone concentrations in diabetic rats.
Zhou ZY, Li F, Cheng SP, Huang H, Peng BW, Wang J, Liu CM, Xing C, Sun YL, Bsoul N, Pan H, Yi CJ, Liu RH, Zhong GJ
Medical science monitor : international medical journal of experimental and clinical research2194-9(2015 Jan)

Amyloid beta-mediated epigenetic alteration of insulin-like growth factor binding protein 3 controls cell survival in Alzheimer's disease.
Sung HY, Choi EN, Lyu D, Mook-Jung I, Ahn JH
PloS one9(6)e99047(2014)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Study indicated that IGFBP-3 shRNA might rehabilitate erectile function via decreased concentrations of serum LDL lipoprotein and triglyceride, increased cavernosal smooth muscle and improvement in NO-cGMP signaling in diabetic rats.
Title: Short hairpin ribonucleic acid constructs targeting insulin-like growth factor binding protein-3 rehabilitated dyslipidaemia in diabetic rats.

Compound 49b treatment inhibited these retinal changes. In REC cultured in hypoxia, levels of IGFBP-3 were reduced, which were significantly increased by Compound 49b.
Title: Compound 49b Restores Retinal Thickness and Reduces Degenerate Capillaries in the Rat Retina following Ischemia/Reperfusion.

IGFBP-3 shRNA may rehabilitate erectile function via increases of concentrations of serum testosterone and cavernous cyclic guanosine monophosphate in streptozotocin-induced diabetic rats
Title: Short hairpin ribonucleic acid constructs targeting insulin-like growth factor binding protein-3 rehabilitated decreased testosterone concentrations in diabetic rats.

investigated the expression differences of insulin-like growth factor-1 (IGF1), IGF type 1 receptor (IGFR1) and IGF-binding protein-3 (IGFBP3) in mandibular condylar cartilage between male and female rats with experimentally created malocclusion
Title: Differential expression of IGF1, IGFR1 and IGFBP3 in mandibular condylar cartilage between male and female rats applied with malocclusion.

IGFBP-3 has novel protective effects on retinal and systemic vasculature and may be a therapeutic candidate for ocular complications such as diabetic retinopathy.
Title: Protection of blood retinal barrier and systemic vasculature by insulin-like growth factor binding protein-3.

The following Igfbp3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Igfbp3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa39893	NM_012588.2 Latest version!	Rattus norvegicus insulin-like growth factor binding protein 3 (Igfbp3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Igfbp3 ( NM_012588.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_036720.2 Rattus norvegicus insulin-like growth factor binding protein 3 (Igfbp3), mRNA.

Price & Availability↑

CloneID	ORa39893
Clone ID Related Accession (Same CDS sequence)	NM_012588.2
Accession Version	NM_012588.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 879bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	insulin-like growth factor-binding protein 3 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC128764.1, M31837.1, BF281457.1 and AABR07015949.1. On Jun 13, 2010 this sequence version replaced NM_012588.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M31837.1, M33300.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01906355, SAMN01906356 [ECO:0000348] ##Evidence-Data-END##

ATGCATCCCG CGCGCCCCGC GCTCTGGGCG GCTGCGCTCA CCGCCCTCAC TCTGCTCCGC 
GGACCGCCAG TGGCGCGGGC CGGCGCGGGC GCGGTGGGCG CGGGCCCCGT GGTGCGCTGC 
GAACCGTGCG ACGCGCGTGC GCTGGCCCAG TGCGCGCCTC CGCCCACCGC GCCCGCGTGC 
ACGGAGCTGG TGCGAGAACC CGGCTGCGGC TGCTGCCTGA CTTGCGCGCT GCGCGAAGGC 
GACGCGTGCG GCGTCTACAC GGAGCGCTGT GGCACCGGCC TCCGCTGCCA GCCGCGACCG 
GCCGAGCAGT ATCCCCTGAA GGCGCTGCTG AATGGCCGCG GGTTCTGCGC CAACGCCAGC 
GCCGCCAGCA GCCTGAGTGC CTACCTCCCC TCCCAGCCGT CTCCTGGAAA CACCACTGAG 
TCTGAGGAGG ACCACAATGC TGGGAGTGTG GAAAGCCAGG TTGTCCCCAG CACACACCGC 
GTGACTGATT CCAAGTTCCA TCCACTCCAT TCAAAGATGG AGGTCATCAT AAAAGGCCAG 
GCTAGGGACA GCCAGCGCTA CAAAGTTGAC TATGAGTCCC AGAGCACAGA CACCCAGAAC 
TTCTCCTCCG AGTCTAAGCG GGAGACAGAA TATGGTCCCT GCCGCAGAGA AATGGAGGAC 
ACACTGAATC ATCTGAAGTT CCTCAATGTG CTGAGTCCCA GGGGCGTCCA CATCCCAAAC 
TGTGACAAGA AGGGGTTCTA TAAGAAGAAA CAGTGTCGCC CTTCCAAAGG CAGAAAGCGG 
GGCTTCTGCT GGTGCGTGGA CAAGTACGGG CAGCCATTGC CAGGCTATGA CACCAAGGGG 
AAAGACGACG TGCATTGCCT CAGCGTGCAG AGCCAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036720.2
CDS	104..982
Translation	MHPARPALWAAALTALTLLRGPPVARAGAGAVGAGPVVRCEPCDARALAQCAPPPTAPACTELVREPGCGCCLTCALREGDACGVYTERCGTGLRCQPRPAEQYPLKALLNGRGFCANASAASSLSAYLPSQPSPGNTTESEEDHNAGSVESQVVPSTHRVTDSKFHPLHSKMEVIIKGQARDSQRYKVDYESQSTDTQNFSSESKRETEYGPCRREMEDTLNHLKFLNVLSPRGVHIPNCDKKGFYKKKQCRPSKGRKRGFCWCVDKYGQPLPGYDTKGKDDVHCLSVQSQ

Target ORF information:

RefSeq Version	NM_012588.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus insulin-like growth factor binding protein 3 (Igfbp3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012588.2

ORF Insert Sequence:

ATGCATCCCG CGCGCCCCGC GCTCTGGGCG GCTGCGCTCA CCGCCCTCAC TCTGCTCCGC 
GGACCGCCAG TGGCGCGGGC CGGCGCGGGC GCGGTGGGCG CGGGCCCCGT GGTGCGCTGC 
GAACCGTGCG ACGCGCGTGC GCTGGCCCAG TGCGCGCCTC CGCCCACCGC GCCCGCGTGC 
ACGGAGCTGG TGCGAGAACC CGGCTGCGGC TGCTGCCTGA CTTGCGCGCT GCGCGAAGGC 
GACGCGTGCG GCGTCTACAC GGAGCGCTGT GGCACCGGCC TCCGCTGCCA GCCGCGACCG 
GCCGAGCAGT ATCCCCTGAA GGCGCTGCTG AATGGCCGCG GGTTCTGCGC CAACGCCAGC 
GCCGCCAGCA GCCTGAGTGC CTACCTCCCC TCCCAGCCGT CTCCTGGAAA CACCACTGAG 
TCTGAGGAGG ACCACAATGC TGGGAGTGTG GAAAGCCAGG TTGTCCCCAG CACACACCGC 
GTGACTGATT CCAAGTTCCA TCCACTCCAT TCAAAGATGG AGGTCATCAT AAAAGGCCAG 
GCTAGGGACA GCCAGCGCTA CAAAGTTGAC TATGAGTCCC AGAGCACAGA CACCCAGAAC 
TTCTCCTCCG AGTCTAAGCG GGAGACAGAA TATGGTCCCT GCCGCAGAGA AATGGAGGAC 
ACACTGAATC ATCTGAAGTT CCTCAATGTG CTGAGTCCCA GGGGCGTCCA CATCCCAAAC 
TGTGACAAGA AGGGGTTCTA TAAGAAGAAA CAGTGTCGCC CTTCCAAAGG CAGAAAGCGG 
GGCTTCTGCT GGTGCGTGGA CAAGTACGGG CAGCCATTGC CAGGCTATGA CACCAAGGGG 
AAAGACGACG TGCATTGCCT CAGCGTGCAG AGCCAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Effects of Adenotonsillectomy on Serum Levels of IGF-1 and IGFBP-3 and Growth Indices in Children with Adenotonsillar Hypertrophy or Recurrent Tonsillitis.
ian journal of otorhinolaryngology28(88)329-335(2016 Sep)
Farmarzi M,Shishegar M,Heydari ST,Haghighi A,Sharouny H

Short hairpin ribonucleic acid constructs targeting insulin-like growth factor binding protein-3 rehabilitated dyslipidaemia in diabetic rats.
Andrologia48(1)59-64(2016 Feb)
Zhou ZY,Cheng SP,Huang H,Wang J,Pan H,Liu CM,Xing C,Sun YL,Liu RH,Zhong GJ

Compound 49b Restores Retinal Thickness and Reduces Degenerate Capillaries in the Rat Retina following Ischemia/Reperfusion.
PloS one11(7)e0159532(2016)
Liu L,Jiang Y,Steinle JJ

Short hairpin ribonucleic acid constructs targeting insulin-like growth factor binding protein-3 rehabilitated decreased testosterone concentrations in diabetic rats.
Medical science monitor : international medical journal of experimental and clinical research2194-9(2015 Jan)
Zhou ZY,Li F,Cheng SP,Huang H,Peng BW,Wang J,Liu CM,Xing C,Sun YL,Bsoul N,Pan H,Yi CJ,Liu RH,Zhong GJ

Amyloid beta-mediated epigenetic alteration of insulin-like growth factor binding protein 3 controls cell survival in Alzheimer's disease.
PloS one9(6)e99047(2014)
Sung HY,Choi EN,Lyu D,Mook-Jung I,Ahn JH

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Igfbp3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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