IGFBP3 cDNA ORF clone, Bos taurus(cattle)

Gene
Clones
gRNAs

Summary

Gene Symbol	IGFBP3
Entrez Gene ID	282261
Full Name	insulin like growth factor binding protein 3
Synonyms	IGFBP-3
General protein information	Preferred Names insulin like growth factor binding protein 3 Names insulin-like growth factor-binding protein 3 IBP-3 IGF-binding protein 3 Insulin like growth factor binding protein-3
Gene Type	protein-coding
Organism	Bos taurus(cattle)

mRNA and Protein(s)

mRNA	Protein	Name
NM_174556.1	NP_776981.1	insulin-like growth factor-binding protein 3 precursor

Pathways from BioSystems

Homologies

	IGFBP3	XP_001085359.1
Mus musculus (house mouse)	Igfbp3	NP_032369.2
Pan troglodytes (chimpanzee)	IGFBP3	XP_003318467.1
Danio rerio (zebrafish)	igfbp3	NP_991314.2
Canis lupus familiaris (dog)	IGFBP3	XP_003639605.1
Rattus norvegicus (Norway rat)	Igfbp3	NP_036720.2
Homo sapiens (human)	IGFBP3	NP_001013416.1
Bos taurus (cattle)	IGFBP3	NP_776981.1
Gallus gallus (chicken)	IGFBP3	NP_001094504.1

Gene Ontology
Bibliography

Related articles in PubMed

Injectable hyaluronic acid down-regulates interferon signaling molecules, IGFBP3 and IFIT3 in the bovine intervertebral disc.
Kazezian Z, Li Z, Alini M, Grad S, Pandit A
Acta biomaterialia52118-129(2017 Apr)

Endogenous IGFBP-3 Mediates Intrinsic Apoptosis Through Modulation of Nur77 Phosphorylation and Nuclear Export.
Agostini-Dreyer A, Jetzt AE, Stires H, Cohick WS
Endocrinology156(11)4141-51(2015 Nov)

Influence of insulin-like growth factor-binding proteins-2 and -3 in the pathogenesis of cystic ovarian disease in cattle.
Rodr?guez FM, Salvetti NR, Panzani CG, Barbeito CG, Ortega HH, Rey F
Animal reproduction science128(1-4)1-10(2011 Oct)

Endogenous IGFBP-3 is required for both growth factor-stimulated cell proliferation and cytokine-induced apoptosis in mammary epithelial cells.
Leibowitz BJ, Cohick WS
Journal of cellular physiology220(1)182-8(2009 Jul)

A whole-genome assembly of the domestic cow, Bos taurus.
Zimin AV, Delcher AL, Florea L, Kelley DR, Schatz MC, Puiu D, Hanrahan F, Pertea G, Van Tassell CP, Sonstegard TS, Mar?ais G, Roberts M, Subramanian P, Yorke JA, Salzberg SL
Genome biology10(4)R42(2009)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The study demonstrates that hyaluronan acts as an anti-inflammatory molecule by down-regulating IFNAR1 and IFNAR2, the signaling molecules STAT1, STAT2, JAK1 and the downstream apoptotic targets IGFBP3 and IFIT3.
Title: Injectable hyaluronic acid down-regulates interferon signaling molecules, IGFBP3 and IFIT3 in the bovine intervertebral disc.

These data suggest that endogenous IGFBP-3 plays a role in intrinsic apoptosis by facilitating phosphorylation and nuclear export of Nur77 to the cytoplasm where it exerts its apoptotic effect.
Title: Endogenous IGFBP-3 Mediates Intrinsic Apoptosis Through Modulation of Nur77 Phosphorylation and Nuclear Export.

The present study suggests that the insulin like growth factor (IGF) system or imbalances between IGF and IGF binding proteins may be involved in cystic ovary disease of cattle.
Title: Influence of insulin-like growth factor-binding proteins-2 and -3 in the pathogenesis of cystic ovarian disease in cattle.

Endogenous IGFBP-3 is required for both growth factor-stimulated cell proliferation and cytokine-induced apoptosis in mammary epithelial cells.
Title: Endogenous IGFBP-3 is required for both growth factor-stimulated cell proliferation and cytokine-induced apoptosis in mammary epithelial cells.

Multivariable adjusted analyses did not reveal a statistically significant linear relationship between IGF1 or IGFBP3 concentrations or their molar ratio and risk of myocardial infarction
Title: Plasma insulinlike growth factor 1 and binding-protein 3 and risk of myocardial infarction in women: a prospective study.

The following IGFBP3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the IGFBP3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OBa01400	NM_174556.1 Latest version!	Bos taurus insulin like growth factor binding protein 3 (IGFBP3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$174.30 $249.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

IGFBP3 ( NM_174556.1 ) cDNA ORF clone, Bos taurus(cattle) -> NP_776981.1 Bos taurus insulin like growth factor binding protein 3 (IGFBP3), mRNA.

Price & Availability↑

CloneID	OBa01400
Clone ID Related Accession (Same CDS sequence)	NM_174556.1
Accession Version	NM_174556.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 876bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Bos taurus(cattle)
Product	insulin-like growth factor-binding protein 3 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF305712.1. On Dec 7, 2011 this sequence version replaced XM_003582113.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF305199.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03145412, SAMN03145413 [ECO:0000348] ##Evidence-Data-END##

ATGCTGCGGG CACGCCCCGC GCTCTGGGCT GCGGCTTTGA CCGCACTGAC GTTGCTCCGC 
GGACCGCCGG CGGCACGAGC TGGGGCGGGC ACGATGGGCG CCGGCCCAGT GGTGCGCTGC 
GAGCCGTGCG ACGCGCGTGC CGTTGCCCAG TGCGCGCCGC CGCCCCCCTC GCCCCCGTGC 
GCCGAGCTGG TGCGCGAGCC GGGCTGCGGT TGCTGTCTCA CGTGCGCGCT GCGCGAGGGT 
CAGCCTTGCG GCGTCTACAC CGAGCGCTGT GGCTCCGGCC TCCGCTGCCA GCCGCCGCCT 
GGCGATCCGC GCCCGCTACA AGCGTTGTTG GACGGCCGCG GGCTCTGCGC CAACGCCAGC 
GCCGTCGGCC GCCTGCGCCC TTACCTGCTA CCGTCCGCGT CAGGAAATGG CAGTGAGTCG 
GAAGAAGACC ACAGCATGGG GAGCACAGAG AACCAGGCTG GCCCCAGCAC ACACCGGGTG 
CCCGTCTCCA AATTCCACCC CATCCACACC AAGATGGATG TCATCAAGAA AGGTCATGCC 
AAGGACAGCC AGCGCTACAA GGTTGACTAC GAGTCTCAGA GCACAGACAC CCAGAACTTC 
TCCTCTGAGT CCAAGCGTGA GACAGAATAC GGGCCCTGCC GCCGGGAAAT GGAAGACACG 
CTGAACCACC TCAAGTTCCT GAACATGCTC AGCCCCAGGG GCATCCACAT TCCCAACTGC 
GACAAGAAGG GCTTTTACAA GAAAAAGCAG TGCCGCCCTT CCAAGGGCAG GAAGCGGGGT 
TTCTGCTGGT GTGTGGATAA GTACGGGCAG CCCCTCCCGG GCTTCGACGT GAAGGGGAAA 
GGGGACGTGC ACTGCTACAG CATGGAGAGC AAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_776981.1
CDS	137..1012
Translation	MLRARPALWAAALTALTLLRGPPAARAGAGTMGAGPVVRCEPCDARAVAQCAPPPPSPPCAELVREPGCGCCLTCALREGQPCGVYTERCGSGLRCQPPPGDPRPLQALLDGRGLCANASAVGRLRPYLLPSASGNGSESEEDHSMGSTENQAGPSTHRVPVSKFHPIHTKMDVIKKGHAKDSQRYKVDYESQSTDTQNFSSESKRETEYGPCRREMEDTLNHLKFLNMLSPRGIHIPNCDKKGFYKKKQCRPSKGRKRGFCWCVDKYGQPLPGFDVKGKGDVHCYSMESK

Target ORF information:

RefSeq Version	NM_174556.1
Organism	Bos taurus(cattle)
Definition	Bos taurus insulin like growth factor binding protein 3 (IGFBP3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_174556.1

ORF Insert Sequence:

ATGCTGCGGG CACGCCCCGC GCTCTGGGCT GCGGCTTTGA CCGCACTGAC GTTGCTCCGC 
GGACCGCCGG CGGCACGAGC TGGGGCGGGC ACGATGGGCG CCGGCCCAGT GGTGCGCTGC 
GAGCCGTGCG ACGCGCGTGC CGTTGCCCAG TGCGCGCCGC CGCCCCCCTC GCCCCCGTGC 
GCCGAGCTGG TGCGCGAGCC GGGCTGCGGT TGCTGTCTCA CGTGCGCGCT GCGCGAGGGT 
CAGCCTTGCG GCGTCTACAC CGAGCGCTGT GGCTCCGGCC TCCGCTGCCA GCCGCCGCCT 
GGCGATCCGC GCCCGCTACA AGCGTTGTTG GACGGCCGCG GGCTCTGCGC CAACGCCAGC 
GCCGTCGGCC GCCTGCGCCC TTACCTGCTA CCGTCCGCGT CAGGAAATGG CAGTGAGTCG 
GAAGAAGACC ACAGCATGGG GAGCACAGAG AACCAGGCTG GCCCCAGCAC ACACCGGGTG 
CCCGTCTCCA AATTCCACCC CATCCACACC AAGATGGATG TCATCAAGAA AGGTCATGCC 
AAGGACAGCC AGCGCTACAA GGTTGACTAC GAGTCTCAGA GCACAGACAC CCAGAACTTC 
TCCTCTGAGT CCAAGCGTGA GACAGAATAC GGGCCCTGCC GCCGGGAAAT GGAAGACACG 
CTGAACCACC TCAAGTTCCT GAACATGCTC AGCCCCAGGG GCATCCACAT TCCCAACTGC 
GACAAGAAGG GCTTTTACAA GAAAAAGCAG TGCCGCCCTT CCAAGGGCAG GAAGCGGGGT 
TTCTGCTGGT GTGTGGATAA GTACGGGCAG CCCCTCCCGG GCTTCGACGT GAAGGGGAAA 
GGGGACGTGC ACTGCTACAG CATGGAGAGC AAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Injectable hyaluronic acid down-regulates interferon signaling molecules, IGFBP3 and IFIT3 in the bovine intervertebral disc.
Acta biomaterialia52118-129(2017 Apr)
Kazezian Z,Li Z,Alini M,Grad S,Pandit A

Endogenous IGFBP-3 Mediates Intrinsic Apoptosis Through Modulation of Nur77 Phosphorylation and Nuclear Export.
Endocrinology156(11)4141-51(2015 Nov)
Agostini-Dreyer A,Jetzt AE,Stires H,Cohick WS

Influence of insulin-like growth factor-binding proteins-2 and -3 in the pathogenesis of cystic ovarian disease in cattle.
Animal reproduction science128(1-4)1-10(2011 Oct)
Rodr?guez FM,Salvetti NR,Panzani CG,Barbeito CG,Ortega HH,Rey F

Endogenous IGFBP-3 is required for both growth factor-stimulated cell proliferation and cytokine-induced apoptosis in mammary epithelial cells.
Journal of cellular physiology220(1)182-8(2009 Jul)
Leibowitz BJ,Cohick WS

A whole-genome assembly of the domestic cow, Bos taurus.
Genome biology10(4)R42(2009)
Zimin AV,Delcher AL,Florea L,Kelley DR,Schatz MC,Puiu D,Hanrahan F,Pertea G,Van Tassell CP,Sonstegard TS,Mar?ais G,Roberts M,Subramanian P,Yorke JA,Salzberg SL

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IGFBP3 cDNA ORF clone, Bos taurus(cattle)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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