Hspa1a cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Hspa1a
Entrez Gene ID	24472
Full Name	heat shock 70kD protein 1A
Synonyms	HSP70.1,HSP72,Hsp70-1,Hsp70-2,Hspa1,Hspa1b,Hspa2
General protein information	Preferred Names heat shock 70kD protein 1A Names heat shock 70 kDa protein 1B HSP70-1/HSP70-2 HSP70.1/2 HSP70.1/HSP70.2 Heat shock 70 kDa protein 1 heat shock 70 kDa protein 1/2 heat shock 70 kDa protein 1A/1B heat shock protein 70-1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 20 Map Location: 20p12
Summary	heat inducible gene; induced by global ischemia and kainic acid-induced seizures [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_031971.2	NP_114177.2	heat shock 70 kDa protein 1B

Pathways from BioSystems

Homologies

Homo sapiens (human)	HSPA1B	NP_005337.2
Bos taurus (cattle)	HSPA1A	NP_976067.2
Mus musculus (house mouse)	Hspa1a	NP_034609.2
Rattus norvegicus (Norway rat)	Hspa1a	NP_114177.2
Drosophila melanogaster (fruit fly)	Hsp70Bbb	NP_788663.1
Arabidopsis thaliana (thale cress)	AT5G02490	NP_195869.1
	HSPA1B	XP_001115060.2
Danio rerio (zebrafish)	hsc70	NP_956908.1
Drosophila melanogaster (fruit fly)	Hsc70-2	NP_524339.1
Saccharomyces cerevisiae (baker's yeast)	SSA4	NP_011029.3
Saccharomyces cerevisiae (baker's yeast)	SSA3	NP_009478.1
Xenopus tropicalis (tropical clawed frog)	hspa1l	NP_001072429.1
Homo sapiens (human)	HSPA1A	NP_005336.3
Drosophila melanogaster (fruit fly)	Hsp70Ba	NP_731716.1
Drosophila melanogaster (fruit fly)	Hsp70Bc	NP_650209.1
Kluyveromyces lactis	KLLA0E20527g	XP_454878.1
Pan troglodytes (chimpanzee)	HSPA1A	XP_003311223.1
Canis lupus familiaris (dog)	LOC102155697	XP_005627221.1
Rattus norvegicus (Norway rat)	Hspa1b	NP_997669.1
Drosophila melanogaster (fruit fly)	Hsp70Ab	NP_524798.2
Drosophila melanogaster (fruit fly)	Hsp68	NP_524474.1
Drosophila melanogaster (fruit fly)	Hsp70Aa	NP_731651.1
Drosophila melanogaster (fruit fly)	Hsp70Bb	NP_524927.2
Eremothecium gossypii	AGOS_AER187W	NP_985044.2
Xenopus tropicalis (tropical clawed frog)	LOC100485441	XP_002937685.1
Xenopus tropicalis (tropical clawed frog)	hsp70	NP_001106370.1

Gene Ontology
Bibliography

Related articles in PubMed

HSP72 is an early biomarker to detect cisplatin and acetaminophen nephrotoxicity.
P?rez-Villalva R, Barrera-Chimal J, Aguilar-Carrasco JC, Lima-Posada I, Cruz C, Ram?rez V, Gonz?lez-Bobadilla Y, Uribe N, Trumper L, Bobadilla NA
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals22(6)548-556(2017 Sep)

Heat shock protein 70 protects cardiomyocytes through suppressing SUMOylation and nucleus translocation of phosphorylated eukaryotic elongation factor 2 during myocardial ischemia and reperfusion.
Zhang C, Liu X, Miao J, Wang S, Wu L, Yan D, Li J, Guo W, Wu X, Shen A
Apoptosis : an international journal on programmed cell death22(5)608-625(2017 May)

Thermal Preconditioning May Prevent Tendon Adhesion by Up-Regulating HSP72 in Rats.
Tan Y, Wu QF, Wu Q, Tan XT, Chen LB, Wang X
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology42(4)1623-1634(2017)

Heat-shock protein 72 promotes platelet aggregation induced by various platelet activators in rats.
Suzuki H, Kosuge Y, Kobayashi K, Kurosaki Y, Ishii N, Aoyama N, Ishihara K, Ichikawa T
Biomedical research (Tokyo, Japan)38(3)175-182(2017)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The findings provide evidence that thermal preconditioning may alleviate tendon adhesions via upregulation of HSP72 expression.
Title: Thermal Preconditioning May Prevent Tendon Adhesion by Up-Regulating HSP72 in Rats.

Diet-induced elevation of circulating HSP70 could trigger cell adhesion with the help of IL-6 as a mediator.
Title: Diet-induced elevation of circulating HSP70 may trigger cell adhesion and promote the development of atherosclerosis in rats.

Twelve hours following heatstroke induction, cardiac HSP72 expression is increased, compared with normothermic controls.
Title: Heat shock protein 72 may improve hypotension by increasing cardiac mechanical efficiency and arterial elastance in heatstroke rats.

HSP72 blocks fibroblast activation and proliferation in renal fibrosis via targeting the STAT3 pathway and may serve as a novel therapeutic agent for chronic kidney disease regardless of the etiology
Title: Heat Shock Protein 72 Antagonizes STAT3 Signaling to Inhibit Fibroblast Accumulation in Renal Fibrogenesis.

Data show that heat shock 70 kDa protein (Hsp72) increased exclusively in the renal cortex of ischemia and reperfusion (I/R) group, indicating its performance as an acute kidney injury (AKI) biomarker.
Title: Heat shock protein 72 (Hsp72) specific induction and temporal stability in urine samples as a reliable biomarker of acute kidney injury (AKI).

The following Hspa1a gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Hspa1a cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa13182	NM_031971.2 Latest version!	Rattus norvegicus heat shock 70kD protein 1A (Hspa1a), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$377.30 $539.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Hspa1a ( NM_031971.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_114177.2 Rattus norvegicus heat shock 70kD protein 1A (Hspa1a), mRNA.

Price & Availability↑

CloneID	ORa13182
Clone ID Related Accession (Same CDS sequence)	NM_031971.2
Accession Version	NM_031971.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1926bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Rattus norvegicus(Norway rat)
Product	heat shock 70 kDa protein 1B
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BX883045.1. On Sep 29, 2009 this sequence version replaced NM_031971.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.

ATGGCCAAGA AAACAGCGAT CGGCATCGAC CTGGGCACCA CCTACTCGTG CGTGGGCGTG 
TTCCAGCACG GCAAGGTGGA GATCATCGCC AACGACCAGG GCAACCGCAC GACCCCCAGC 
TACGTGGCCT TCACCGACAC CGAGCGGCTC ATCGGGGACG CCGCCAAGAA CCAGGTGGCG 
CTGAACCCGC AGAACACCGT GTTCGACGCG AAGCGGCTGA TCGGCCGCAA GTTCGGCGAC 
CCGGTGGTGC AGTCGGACAT GAAGCACTGG CCCTTCCAGG TGGTGAACGA CGGCGACAAG 
CCCAAGGTGC AGGTGAACTA CAAGGGCGAG AACCGGTCGT TCTACCCGGA GGAGATCTCG 
TCCATGGTGC TGACCAAGAT GAAGGAGATC GCCGAGGCGT ACCTGGGCCA CCCGGTGACC 
AACGCGGTGA TCACCGTGCC CGCCTACTTC AACGACTCGC AGCGGCAGGC CACCAAGGAC 
GCGGGCGTGA TCGCGGGTCT GAACGTGCTG CGGATCATCA ACGAGCCCAC GGCGGCCGCC 
ATCGCCTACG GGCTGGACCG GACCGGCAAG GGCGAGCGCA ACGTGCTCAT CTTCGACCTG 
GGGGGCGGCA CGTTCGACGT GTCCATCCTG ACGATCGACG ACGGCATCTT CGAGGTGAAG 
GCCACGGCGG GCGACACGCA CCTGGGCGGG GAGGACTTCG ACAACCGGCT GGTGAGCCAC 
TTCGTGGAGG AGTTCAAGAG GAAGCACAAG AAGGACATCA GCCAGAACAA GCGCGCGGTG 
CGGCGACTGC GCACGGCGTG CGAGAGGGCC AAGAGGACGC TGTCGTCCAG CACCCAGGCC 
AGCCTGGAGA TCGACTCTCT GTTCGAGGGC ATCGACTTCT ACACGTCCAT CACGCGGGCG 
CGGTTCGAGG AGCTGTGCTC GGACCTGTTC CGCGGCACGC TGGAGCCCGT GGAGAAGGCC 
CTGCGCGACG CCAAGCTGGA CAAGGCGCAG ATCCACGACC TGGTGCTGGT GGGCGGCTCG 
ACGCGCATCC CCAAGGTGCA GAAGCTGCTG CAGGACTTCT TCAACGGGCG CGACCTGAAC 
AAGAGCATCA ATCCGGACGA GGCGGTGGCC TACGGGGCGG CGGTGCAGGC GGCCATCCTG 
ATGGGGGACA AGTCGGAGAA CGTGCAGGAC CTGCTGCTGC TGGACGTGGC GCCGCTGTCG 
CTGGGTCTGG AGACCGCGGG CGGCGTGATG ACGGCGCTCA TCAAGCGCAA CTCCACCATC 
CCCACCAAGC AGACGCAGAC CTTCACCACC TACTCGGACA ACCAGCCCGG GGTGCTGATC 
CAGGTGTACG AGGGCGAGAG GGCCATGACG CGCGACAACA ACCTGCTGGG GCGCTTCGAG 
TTGAGCGGCA TCCCGCCGGC TCCCAGGGGC GTGCCCCAGA TCGAGGTGAC CTTCGACATC 
GACGCCAACG GCATCCTGAA CGTCACGGCC ACTGACAAGA GCACCGGCAA GGCCAACAAG 
ATCACCATCA CCAACGACAA GGGCCGCCTG AGCAAGGAGG AGATCGAGCG CATGGTGCAG 
GAGGCCGAGC GCTACAAGGC GGAGGACGAG GTGCAGCGCG AGAGGGTGGC TGCCAAGAAT 
GCGCTCGAGT CCTATGCCTT CAACATGAAG AGCGCCGTGG AGGACGAGGG TCTCAAGGGC 
AAGATCAGCG AGGCTGACAA GAAGAAGGTG CTGGACAAGT GCCAGGAGGT CATCTCCTGG 
CTGGACTCTA ACACGCTGGC TGAGAAAGAG GAGTTCGTGC ACAAGCGGGA GGAGCTGGAG 
CGGGTGTGCA ACCCGATCAT CAGCGGGCTG TATCAGGGTG CGGGTGCTCC CGGGGCTGGG 
GGCTTCGGGG CCCAGGCGCC CAAGGGAGGC TCTGGGTCGG GGCCCACCAT CGAGGAGGTG 
GATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_114177.2
CDS	1248..3173
Translation	MAKKTAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDPVVQSDMKHWPFQVVNDGDKPKVQVNYKGENRSFYPEEISSMVLTKMKEIAEAYLGHPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVSHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRGTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTRDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAERYKAEDEVQRERVAAKNALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDSNTLAEKEEFVHKREELERVCNPIISGLYQGAGAPGAGGFGAQAPKGGSGSGPTIEEVD

Target ORF information:

RefSeq Version	NM_031971.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus heat shock 70kD protein 1A (Hspa1a), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031971.2

ORF Insert Sequence:

ATGGCCAAGA AAACAGCGAT CGGCATCGAC CTGGGCACCA CCTACTCGTG CGTGGGCGTG 
TTCCAGCACG GCAAGGTGGA GATCATCGCC AACGACCAGG GCAACCGCAC GACCCCCAGC 
TACGTGGCCT TCACCGACAC CGAGCGGCTC ATCGGGGACG CCGCCAAGAA CCAGGTGGCG 
CTGAACCCGC AGAACACCGT GTTCGACGCG AAGCGGCTGA TCGGCCGCAA GTTCGGCGAC 
CCGGTGGTGC AGTCGGACAT GAAGCACTGG CCCTTCCAGG TGGTGAACGA CGGCGACAAG 
CCCAAGGTGC AGGTGAACTA CAAGGGCGAG AACCGGTCGT TCTACCCGGA GGAGATCTCG 
TCCATGGTGC TGACCAAGAT GAAGGAGATC GCCGAGGCGT ACCTGGGCCA CCCGGTGACC 
AACGCGGTGA TCACCGTGCC CGCCTACTTC AACGACTCGC AGCGGCAGGC CACCAAGGAC 
GCGGGCGTGA TCGCGGGTCT GAACGTGCTG CGGATCATCA ACGAGCCCAC GGCGGCCGCC 
ATCGCCTACG GGCTGGACCG GACCGGCAAG GGCGAGCGCA ACGTGCTCAT CTTCGACCTG 
GGGGGCGGCA CGTTCGACGT GTCCATCCTG ACGATCGACG ACGGCATCTT CGAGGTGAAG 
GCCACGGCGG GCGACACGCA CCTGGGCGGG GAGGACTTCG ACAACCGGCT GGTGAGCCAC 
TTCGTGGAGG AGTTCAAGAG GAAGCACAAG AAGGACATCA GCCAGAACAA GCGCGCGGTG 
CGGCGACTGC GCACGGCGTG CGAGAGGGCC AAGAGGACGC TGTCGTCCAG CACCCAGGCC 
AGCCTGGAGA TCGACTCTCT GTTCGAGGGC ATCGACTTCT ACACGTCCAT CACGCGGGCG 
CGGTTCGAGG AGCTGTGCTC GGACCTGTTC CGCGGCACGC TGGAGCCCGT GGAGAAGGCC 
CTGCGCGACG CCAAGCTGGA CAAGGCGCAG ATCCACGACC TGGTGCTGGT GGGCGGCTCG 
ACGCGCATCC CCAAGGTGCA GAAGCTGCTG CAGGACTTCT TCAACGGGCG CGACCTGAAC 
AAGAGCATCA ATCCGGACGA GGCGGTGGCC TACGGGGCGG CGGTGCAGGC GGCCATCCTG 
ATGGGGGACA AGTCGGAGAA CGTGCAGGAC CTGCTGCTGC TGGACGTGGC GCCGCTGTCG 
CTGGGTCTGG AGACCGCGGG CGGCGTGATG ACGGCGCTCA TCAAGCGCAA CTCCACCATC 
CCCACCAAGC AGACGCAGAC CTTCACCACC TACTCGGACA ACCAGCCCGG GGTGCTGATC 
CAGGTGTACG AGGGCGAGAG GGCCATGACG CGCGACAACA ACCTGCTGGG GCGCTTCGAG 
TTGAGCGGCA TCCCGCCGGC TCCCAGGGGC GTGCCCCAGA TCGAGGTGAC CTTCGACATC 
GACGCCAACG GCATCCTGAA CGTCACGGCC ACTGACAAGA GCACCGGCAA GGCCAACAAG 
ATCACCATCA CCAACGACAA GGGCCGCCTG AGCAAGGAGG AGATCGAGCG CATGGTGCAG 
GAGGCCGAGC GCTACAAGGC GGAGGACGAG GTGCAGCGCG AGAGGGTGGC TGCCAAGAAT 
GCGCTCGAGT CCTATGCCTT CAACATGAAG AGCGCCGTGG AGGACGAGGG TCTCAAGGGC 
AAGATCAGCG AGGCTGACAA GAAGAAGGTG CTGGACAAGT GCCAGGAGGT CATCTCCTGG 
CTGGACTCTA ACACGCTGGC TGAGAAAGAG GAGTTCGTGC ACAAGCGGGA GGAGCTGGAG 
CGGGTGTGCA ACCCGATCAT CAGCGGGCTG TATCAGGGTG CGGGTGCTCC CGGGGCTGGG 
GGCTTCGGGG CCCAGGCGCC CAAGGGAGGC TCTGGGTCGG GGCCCACCAT CGAGGAGGTG 
GATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

HSP72 is an early biomarker to detect cisplatin and acetaminophen nephrotoxicity.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals22(6)548-556(2017 Sep)
P?rez-Villalva R,Barrera-Chimal J,Aguilar-Carrasco JC,Lima-Posada I,Cruz C,Ram?rez V,Gonz?lez-Bobadilla Y,Uribe N,Trumper L,Bobadilla NA

Heat shock protein 70 protects cardiomyocytes through suppressing SUMOylation and nucleus translocation of phosphorylated eukaryotic elongation factor 2 during myocardial ischemia and reperfusion.
Apoptosis : an international journal on programmed cell death22(5)608-625(2017 May)
Zhang C,Liu X,Miao J,Wang S,Wu L,Yan D,Li J,Guo W,Wu X,Shen A

Thermal Preconditioning May Prevent Tendon Adhesion by Up-Regulating HSP72 in Rats.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology42(4)1623-1634(2017)
Tan Y,Wu QF,Wu Q,Tan XT,Chen LB,Wang X

Heat-shock protein 72 promotes platelet aggregation induced by various platelet activators in rats.
Biomedical research (Tokyo, Japan)38(3)175-182(2017)
Suzuki H,Kosuge Y,Kobayashi K,Kurosaki Y,Ishii N,Aoyama N,Ishihara K,Ichikawa T

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Hspa1a cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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