Hspa1b cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Hspa1b
Entrez Gene ID	294254
Full Name	heat shock 70kD protein 1B (mapped)
Synonyms	HSP70.2,Hsp70-1,Hsp70-2,Hsp72,Hspa1,Hspa1a,Hspa2
General protein information	Preferred Names heat shock 70kD protein 1B (mapped) Names heat shock 70 kDa protein 1A Heat shock 70 kDa protein 2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 20 Map Location: 20p12

mRNA and Protein(s)

mRNA	Protein	Name
NM_212504.1	NP_997669.1	heat shock 70 kDa protein 1A

Pathways from BioSystems

Homologies

Homo sapiens (human)	HSPA1B	NP_005337.2
Bos taurus (cattle)	HSPA1A	NP_976067.2
Mus musculus (house mouse)	Hspa1a	NP_034609.2
Rattus norvegicus (Norway rat)	Hspa1a	NP_114177.2
Drosophila melanogaster (fruit fly)	Hsp70Bbb	NP_788663.1
Arabidopsis thaliana (thale cress)	AT5G02490	NP_195869.1
	HSPA1B	XP_001115060.2
Danio rerio (zebrafish)	hsc70	NP_956908.1
Drosophila melanogaster (fruit fly)	Hsc70-2	NP_524339.1
Saccharomyces cerevisiae (baker's yeast)	SSA4	NP_011029.3
Saccharomyces cerevisiae (baker's yeast)	SSA3	NP_009478.1
Xenopus tropicalis (tropical clawed frog)	hspa1l	NP_001072429.1
Homo sapiens (human)	HSPA1A	NP_005336.3
Drosophila melanogaster (fruit fly)	Hsp70Ba	NP_731716.1
Drosophila melanogaster (fruit fly)	Hsp70Bc	NP_650209.1
Kluyveromyces lactis	KLLA0E20527g	XP_454878.1
Pan troglodytes (chimpanzee)	HSPA1A	XP_003311223.1
Canis lupus familiaris (dog)	LOC102155697	XP_005627221.1
Rattus norvegicus (Norway rat)	Hspa1b	NP_997669.1
Drosophila melanogaster (fruit fly)	Hsp70Ab	NP_524798.2
Drosophila melanogaster (fruit fly)	Hsp68	NP_524474.1
Drosophila melanogaster (fruit fly)	Hsp70Aa	NP_731651.1
Drosophila melanogaster (fruit fly)	Hsp70Bb	NP_524927.2
Eremothecium gossypii	AGOS_AER187W	NP_985044.2
Xenopus tropicalis (tropical clawed frog)	LOC100485441	XP_002937685.1
Xenopus tropicalis (tropical clawed frog)	hsp70	NP_001106370.1

Gene Ontology
Bibliography

Related articles in PubMed

Progranulin Recruits HSP70 to ?-Glucocerebrosidase and Is Therapeutic Against Gaucher Disease.
Jian J, Tian QY, Hettinghouse A, Zhao S, Liu H, Wei J, Grunig G, Zhang W, Setchell KDR, Sun Y, Overkleeft HS, Chan GL, Liu CJ
EBioMedicine13212-224(2016 Nov)

ARD1-mediated Hsp70 acetylation balances stress-induced protein refolding and degradation.
Seo JH, Park JH, Lee EJ, Vo TT, Choi H, Kim JY, Jang JK, Wee HJ, Lee HS, Jang SH, Park ZY, Jeong J, Lee KJ, Seok SH, Park JY, Lee BJ, Lee MN, Oh GT, Kim KW
Nature communications712882(2016 Oct)

HSP70 regulates the function of mitotic centrosomes.
Fang CT, Kuo HH, Pan TS, Yu FC, Yih LH
Cellular and molecular life sciences : CMLS73(20)3949-60(2016 Oct)

Nanoparticles Exacerbate Both Ubiquitin and Heat Shock Protein Expressions in Spinal Cord Injury: Neuroprotective Effects of the Proteasome Inhibitor Carfilzomib and the Antioxidant Compound H-290/51.
Sharma HS, Muresanu DF, Lafuente JV, Sj?quist PO, Patnaik R, Sharma A
Molecular neurobiology52(2)882-98(2015 Oct)

E-cadherin interactome complexity and robustness resolved by quantitative proteomics.
Guo Z, Neilson LJ, Zhong H, Murray PS, Zanivan S, Zaidel-Bar R
Science signaling7(354)rs7(2014 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Rats subjected to spinal cord injury after nanoparticle treatment showed an exacerbation of HSP72 immunoreactivities in the cord, vs normal rats following trauma. HSP expression plays a key role in neuronal injury in SCI, not reported earlier.
Title: Nanoparticles Exacerbate Both Ubiquitin and Heat Shock Protein Expressions in Spinal Cord Injury: Neuroprotective Effects of the Proteasome Inhibitor Carfilzomib and the Antioxidant Compound H-290/51.

Our data suggest that the protective effects of VitE and testosterone on VCL-induced derangements may depend on enhancing testicular antioxidant status and up-regulating endocrine activities, which enhanced the Hsp70-2 chaperone expression.
Title: Testosterone and vitamin E administration up-regulated varicocele-reduced Hsp70-2 protein expression and ameliorated biochemical alterations.

increasing the expression of intramuscular heat shock protein 72 (Hsp72) preserves muscle strength and ameliorates the dystrophic pathology in two mouse models of muscular dystrophy
Title: Hsp72 preserves muscle function and slows progression of severe muscular dystrophy.

In rat extensor digitorum longus muscle there is only ~1.1 millimol HSP72/kg wet muscle mass, whereas rat soleus muscle contains approximately fourfold more HSP72(~4.6 millimol/kg).
Title: Absolute amounts and diffusibility of HSP72, HSP25, and ?B-crystallin in fast- and slow-twitch skeletal muscle fibers of rat.

HSP70-2 induced by geldanamycin is expressed by hair cells and interdental cells of spiral limbus.
Title: Geldanamycin induces production of heat shock protein 70 and partially attenuates ototoxicity caused by gentamicin in the organ of Corti explants.

The following Hspa1b gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Hspa1b cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa13182	NM_212504.1 Latest version!	Rattus norvegicus heat shock 70kD protein 1B (mapped) (Hspa1b), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$377.30 $539.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Hspa1b ( NM_212504.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_997669.1 Rattus norvegicus heat shock 70kD protein 1B (mapped) (Hspa1b), mRNA.

Price & Availability↑

CloneID	ORa13182
Clone ID Related Accession (Same CDS sequence)	NM_212504.1
Accession Version	NM_212504.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1926bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Rattus norvegicus(Norway rat)
Product	heat shock 70 kDa protein 1A
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BX883045.1. On Aug 30, 2004 this sequence version replaced XM_215309.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.

ATGGCCAAGA AAACAGCGAT CGGCATCGAC CTGGGCACCA CCTACTCGTG CGTGGGCGTG 
TTCCAGCACG GCAAGGTGGA GATCATCGCC AACGACCAGG GCAACCGCAC GACCCCCAGC 
TACGTGGCCT TCACCGACAC CGAGCGGCTC ATCGGGGACG CCGCCAAGAA CCAGGTGGCG 
CTGAACCCGC AGAACACCGT GTTCGACGCG AAGCGGCTGA TCGGCCGCAA GTTCGGCGAC 
CCGGTGGTGC AGTCGGACAT GAAGCACTGG CCCTTCCAGG TGGTGAACGA CGGCGACAAG 
CCCAAGGTGC AGGTGAACTA CAAGGGCGAG AACCGGTCGT TCTACCCGGA GGAGATCTCG 
TCCATGGTGC TGACCAAGAT GAAGGAGATC GCCGAGGCGT ACCTGGGCCA CCCGGTGACC 
AACGCGGTGA TCACCGTGCC CGCCTACTTC AACGACTCGC AGCGGCAGGC CACCAAGGAC 
GCGGGCGTGA TCGCGGGTCT GAACGTGCTG CGGATCATCA ACGAGCCCAC GGCGGCCGCC 
ATCGCCTACG GGCTGGACCG GACCGGCAAG GGCGAGCGCA ACGTGCTCAT CTTCGACCTG 
GGGGGCGGCA CGTTCGACGT GTCCATCCTG ACGATCGACG ACGGCATCTT CGAGGTGAAG 
GCCACGGCGG GCGACACGCA CCTGGGCGGG GAGGACTTCG ACAACCGGCT GGTGAGCCAC 
TTCGTGGAGG AGTTCAAGAG GAAGCACAAG AAGGACATCA GCCAGAACAA GCGCGCGGTG 
CGGCGACTGC GCACGGCGTG CGAGAGGGCC AAGAGGACGC TGTCGTCCAG CACCCAGGCC 
AGCCTGGAGA TCGACTCTCT GTTCGAGGGC ATCGACTTCT ACACGTCCAT CACGCGGGCG 
CGGTTCGAGG AGCTGTGCTC GGACCTGTTC CGCGGCACGC TGGAGCCCGT GGAGAAGGCC 
CTGCGCGACG CCAAGCTGGA CAAGGCGCAG ATCCACGACC TGGTGCTGGT GGGCGGCTCG 
ACGCGCATCC CCAAGGTGCA GAAGCTGCTG CAGGACTTCT TCAACGGGCG CGACCTGAAC 
AAGAGCATCA ATCCGGACGA GGCGGTGGCC TACGGGGCGG CGGTGCAGGC GGCCATCCTG 
ATGGGGGACA AGTCGGAGAA CGTGCAGGAC CTGCTGCTGC TGGACGTGGC GCCGCTGTCG 
CTGGGTCTGG AGACCGCGGG CGGCGTGATG ACGGCGCTCA TCAAGCGCAA CTCCACCATC 
CCCACCAAGC AGACGCAGAC CTTCACCACC TACTCGGACA ACCAGCCCGG GGTGCTGATC 
CAGGTGTACG AGGGCGAGAG GGCCATGACG CGCGACAACA ACCTGCTGGG GCGCTTCGAG 
TTGAGCGGCA TCCCGCCGGC TCCCAGGGGC GTGCCCCAGA TCGAGGTGAC CTTCGACATC 
GACGCCAACG GCATCCTGAA CGTCACGGCC ACTGACAAGA GCACCGGCAA GGCCAACAAG 
ATCACCATCA CCAACGACAA GGGCCGCCTG AGCAAGGAGG AGATCGAGCG CATGGTGCAG 
GAGGCCGAGC GCTACAAGGC GGAGGACGAG GTGCAGCGCG AGAGGGTGGC TGCCAAGAAT 
GCGCTCGAGT CCTATGCCTT CAACATGAAG AGCGCCGTGG AGGACGAGGG TCTCAAGGGC 
AAGATCAGCG AGGCTGACAA GAAGAAGGTG CTGGACAAGT GCCAGGAGGT CATCTCCTGG 
CTGGACTCTA ACACGCTGGC TGAGAAAGAG GAGTTCGTGC ACAAGCGGGA GGAGCTGGAG 
CGGGTGTGCA ACCCGATCAT CAGCGGGCTG TATCAGGGTG CGGGTGCTCC CGGGGCTGGG 
GGCTTCGGGG CCCAGGCGCC CAAGGGAGGC TCTGGGTCGG GGCCCACCAT CGAGGAGGTG 
GATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_997669.1
CDS	2151..4076
Translation	MAKKTAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDPVVQSDMKHWPFQVVNDGDKPKVQVNYKGENRSFYPEEISSMVLTKMKEIAEAYLGHPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVSHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRGTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTRDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAERYKAEDEVQRERVAAKNALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDSNTLAEKEEFVHKREELERVCNPIISGLYQGAGAPGAGGFGAQAPKGGSGSGPTIEEVD

Target ORF information:

RefSeq Version	NM_212504.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus heat shock 70kD protein 1B (mapped) (Hspa1b), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_212504.1

ORF Insert Sequence:

ATGGCCAAGA AAACAGCGAT CGGCATCGAC CTGGGCACCA CCTACTCGTG CGTGGGCGTG 
TTCCAGCACG GCAAGGTGGA GATCATCGCC AACGACCAGG GCAACCGCAC GACCCCCAGC 
TACGTGGCCT TCACCGACAC CGAGCGGCTC ATCGGGGACG CCGCCAAGAA CCAGGTGGCG 
CTGAACCCGC AGAACACCGT GTTCGACGCG AAGCGGCTGA TCGGCCGCAA GTTCGGCGAC 
CCGGTGGTGC AGTCGGACAT GAAGCACTGG CCCTTCCAGG TGGTGAACGA CGGCGACAAG 
CCCAAGGTGC AGGTGAACTA CAAGGGCGAG AACCGGTCGT TCTACCCGGA GGAGATCTCG 
TCCATGGTGC TGACCAAGAT GAAGGAGATC GCCGAGGCGT ACCTGGGCCA CCCGGTGACC 
AACGCGGTGA TCACCGTGCC CGCCTACTTC AACGACTCGC AGCGGCAGGC CACCAAGGAC 
GCGGGCGTGA TCGCGGGTCT GAACGTGCTG CGGATCATCA ACGAGCCCAC GGCGGCCGCC 
ATCGCCTACG GGCTGGACCG GACCGGCAAG GGCGAGCGCA ACGTGCTCAT CTTCGACCTG 
GGGGGCGGCA CGTTCGACGT GTCCATCCTG ACGATCGACG ACGGCATCTT CGAGGTGAAG 
GCCACGGCGG GCGACACGCA CCTGGGCGGG GAGGACTTCG ACAACCGGCT GGTGAGCCAC 
TTCGTGGAGG AGTTCAAGAG GAAGCACAAG AAGGACATCA GCCAGAACAA GCGCGCGGTG 
CGGCGACTGC GCACGGCGTG CGAGAGGGCC AAGAGGACGC TGTCGTCCAG CACCCAGGCC 
AGCCTGGAGA TCGACTCTCT GTTCGAGGGC ATCGACTTCT ACACGTCCAT CACGCGGGCG 
CGGTTCGAGG AGCTGTGCTC GGACCTGTTC CGCGGCACGC TGGAGCCCGT GGAGAAGGCC 
CTGCGCGACG CCAAGCTGGA CAAGGCGCAG ATCCACGACC TGGTGCTGGT GGGCGGCTCG 
ACGCGCATCC CCAAGGTGCA GAAGCTGCTG CAGGACTTCT TCAACGGGCG CGACCTGAAC 
AAGAGCATCA ATCCGGACGA GGCGGTGGCC TACGGGGCGG CGGTGCAGGC GGCCATCCTG 
ATGGGGGACA AGTCGGAGAA CGTGCAGGAC CTGCTGCTGC TGGACGTGGC GCCGCTGTCG 
CTGGGTCTGG AGACCGCGGG CGGCGTGATG ACGGCGCTCA TCAAGCGCAA CTCCACCATC 
CCCACCAAGC AGACGCAGAC CTTCACCACC TACTCGGACA ACCAGCCCGG GGTGCTGATC 
CAGGTGTACG AGGGCGAGAG GGCCATGACG CGCGACAACA ACCTGCTGGG GCGCTTCGAG 
TTGAGCGGCA TCCCGCCGGC TCCCAGGGGC GTGCCCCAGA TCGAGGTGAC CTTCGACATC 
GACGCCAACG GCATCCTGAA CGTCACGGCC ACTGACAAGA GCACCGGCAA GGCCAACAAG 
ATCACCATCA CCAACGACAA GGGCCGCCTG AGCAAGGAGG AGATCGAGCG CATGGTGCAG 
GAGGCCGAGC GCTACAAGGC GGAGGACGAG GTGCAGCGCG AGAGGGTGGC TGCCAAGAAT 
GCGCTCGAGT CCTATGCCTT CAACATGAAG AGCGCCGTGG AGGACGAGGG TCTCAAGGGC 
AAGATCAGCG AGGCTGACAA GAAGAAGGTG CTGGACAAGT GCCAGGAGGT CATCTCCTGG 
CTGGACTCTA ACACGCTGGC TGAGAAAGAG GAGTTCGTGC ACAAGCGGGA GGAGCTGGAG 
CGGGTGTGCA ACCCGATCAT CAGCGGGCTG TATCAGGGTG CGGGTGCTCC CGGGGCTGGG 
GGCTTCGGGG CCCAGGCGCC CAAGGGAGGC TCTGGGTCGG GGCCCACCAT CGAGGAGGTG 
GATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Progranulin Recruits HSP70 to ?-Glucocerebrosidase and Is Therapeutic Against Gaucher Disease.
EBioMedicine13212-224(2016 Nov)
Jian J,Tian QY,Hettinghouse A,Zhao S,Liu H,Wei J,Grunig G,Zhang W,Setchell KDR,Sun Y,Overkleeft HS,Chan GL,Liu CJ

ARD1-mediated Hsp70 acetylation balances stress-induced protein refolding and degradation.
Nature communications712882(2016 Oct)
Seo JH,Park JH,Lee EJ,Vo TT,Choi H,Kim JY,Jang JK,Wee HJ,Lee HS,Jang SH,Park ZY,Jeong J,Lee KJ,Seok SH,Park JY,Lee BJ,Lee MN,Oh GT,Kim KW

HSP70 regulates the function of mitotic centrosomes.
Cellular and molecular life sciences : CMLS73(20)3949-60(2016 Oct)
Fang CT,Kuo HH,Pan TS,Yu FC,Yih LH

Nanoparticles Exacerbate Both Ubiquitin and Heat Shock Protein Expressions in Spinal Cord Injury: Neuroprotective Effects of the Proteasome Inhibitor Carfilzomib and the Antioxidant Compound H-290/51.
Molecular neurobiology52(2)882-98(2015 Oct)
Sharma HS,Muresanu DF,Lafuente JV,Sj?quist PO,Patnaik R,Sharma A

E-cadherin interactome complexity and robustness resolved by quantitative proteomics.
Science signaling7(354)rs7(2014 Dec)
Guo Z,Neilson LJ,Zhong H,Murray PS,Zanivan S,Zaidel-Bar R

- Most Popular Services
  - 人工遺伝子合成& DNA合成-納期保証
- Services & Products

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

Hspa1b cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Most Popular Services

Services & Products

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報