Mmp3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Mmp3
Entrez Gene ID	171045
Full Name	matrix metallopeptidase 3
General protein information	Preferred Names matrix metallopeptidase 3 Names stromelysin-1 MMP-3 PTR1 protein SL-1 matrix metalloproteinase-3 transin-1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 8 Map Location: 8q11
Summary	endopeptidase that degrades extracellular matrix proteins [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_133523.3	NP_598207.2	stromelysin-1 preproprotein

Pathways from BioSystems

Homologies

	MMP3	XP_001098400.1
Gallus gallus (chicken)	LOC428086	XP_425644.4
Xenopus tropicalis (tropical clawed frog)	LOC100491547	XP_002934977.2
Rattus norvegicus (Norway rat)	Mmp3	NP_598207.2
Xenopus tropicalis (tropical clawed frog)	LOC100489571	XP_002934968.1
Xenopus tropicalis (tropical clawed frog)	LOC100489735	XP_002934969.2
Homo sapiens (human)	MMP3	NP_002413.1
Pan troglodytes (chimpanzee)	MMP3	XP_508723.2
Mus musculus (house mouse)	Mmp3	NP_034939.1
Xenopus tropicalis (tropical clawed frog)	mmp1	NP_001025501.1
Xenopus tropicalis (tropical clawed frog)	LOC100494588	XP_002944454.2
Canis lupus familiaris (dog)	MMP3	NP_001002967.1
Bos taurus (cattle)	MMP3	NP_001193566.1
Xenopus tropicalis (tropical clawed frog)	LOC100491214	XP_002934976.2

Gene Ontology
Bibliography

Related articles in PubMed

Exploration about changes of IL-10, NF-?B and MMP-3 in a rat model of cervical spondylosis.
Yin J, Ren K, Huang Y, Gao G, Nong L, Xu N
Molecular immunology93184-188(2018 Jan)

MiR-136 controls neurocytes apoptosis by regulating Tissue Inhibitor of Metalloproteinases-3 in spinal cord ischemic injury.
Jin R, Xu S, Lin X, Shen M
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie9447-54(2017 Oct)

Autophagy Protects Advanced Glycation End Product-Induced Apoptosis and Expression of MMP-3 and MMP-13 in Rat Chondrocytes.
Huang W, Ao P, Li J, Wu T, Xu L, Deng Z, Chen W, Yin C, Cheng X
BioMed research international20176341919(2017)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

upregulated expressions of MMP1/3 and downregulated expressions of TIMP1/3 at the messenger RNA (mRNA) and protein levels also appeared to be relevant to low Se intake. In conclusion, Se-deficient diet could cause low Se concentration in the liver, alterations of hepatocyte ultrastructure
Title: Long-Term Selenium-Deficient Diet Induces Liver Damage by Altering Hepatocyte Ultrastructure and MMP1/3 and TIMP1/3 Expression in Growing Rats.

autophagy is linked with Advanced Glycation End Product-related pathology in rat chondrocytes and plays a protective role in AGE-induced apoptosis and expression of MMP-3 and MMP-13.
Title: Autophagy Protects Advanced Glycation End Product-Induced Apoptosis and Expression of MMP-3 and MMP-13 in Rat Chondrocytes.

This study demonstrates the sequential involvement of Wnt5, MMP-3, DMP-1 expression, and DMP-1 degradation products by MMP-3, in effecting IL-1beta-induced proliferation of ESC-derived odontoblast-like cells.
Title: Products of dentin matrix protein-1 degradation by interleukin-1?-induced matrix metalloproteinase-3 promote proliferation of odontoblastic cells.

Wnt5 and MMP-3 are involved in inorganic polyphosphate-induced proliferation of rat dental pulp fibroblast-like cells
Title: Polyphosphate-induced matrix metalloproteinase-3-mediated proliferation in rat dental pulp fibroblast-like cells is mediated by a Wnt5 signaling cascade.

In a normoglycemic rat model of wound healing, pentoxifylline significantly reduced gene expression of MMP-3.
Title: Pentoxifylline Accelerates Wound Healing Process by Modulating Gene Expression of MMP-1, MMP-3, and TIMP-1 in Normoglycemic Rats.

The following Mmp3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mmp3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa40405	NM_133523.3 Latest version!	Rattus norvegicus matrix metallopeptidase 3 (Mmp3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$279.30 $399.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Mmp3 ( NM_133523.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_598207.2 Rattus norvegicus matrix metallopeptidase 3 (Mmp3), mRNA.

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CloneID	ORa40405
Clone ID Related Accession (Same CDS sequence)	NM_133523.3
Accession Version	NM_133523.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1428bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Rattus norvegicus(Norway rat)
Product	stromelysin-1 preproprotein
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AAHX01053076.1. On Oct 10, 2014 this sequence version replaced NM_133523.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMEA2689602, SAMN02642595 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAAGGGC TCCCAGTCCT GCTGTGGCTG TGTACGGCTG TGTGCTCATC CTACCCATTG 
CATGGCAGTG AAGAAGATGC TGGCATGGAG GTTCTGCAGA AATACCTAGA AAACTACTAT 
GGTCTTGAAA AGGATGTGAA GCAGTTTACT AAGAAAAAGG ACAGTAGCCC TGTTGTCAAA 
AAAATTCAAG AAATGCAGAA GTTCCTTGGG CTGAAGATGA CAGGGAAGCT GGACTCGAAC 
ACTATGGAGC TGATGCACAA GCCCCGGTGT GGTGTTCCCG ACGTCGGTGG CTTCAGTACC 
TTTCCAGGTT CACCCAAATG GAGGAAAAAC CACATCTCCT ACAGGATTGT GAATTATACA 
CTGGATTTAC CAAGAGAGAG TGTGGATTCT GCCATTGAGA GAGCTTTGAA GGTCTGGGAG 
GAGGTGACCC CACTCACATT CTCCAGGATC TCTGAAGGAG AGGCTGACAT AATGATCTCC 
TTTGCAGTTG AAGAACATGG AGACTTTATC CCTTTTGATG GGCCTGGAAT GGTCTTGGCT 
CATGCCTATG CCCCTGGACC AGGGATTAAT GGAGATGCTC ACTTTGATGA TGATGAACGA 
TGGACAGATG ATGTCACAGG TACCAACCTA TTCCTGGTTG CTGCTCATGA ACTTGGCCAC 
TCCCTGGGTC TCTTTCACTC AGCCAATGCT GAAGCTTTGA TGTACCCAGT CTACAAGTCC 
TCCACAGACC TGGCCCGTTT CCATCTCTCT CAAGATGATG TAGATGGTAT TCAATCCCTC 
TATGGACCTC CCACAGAATC CCCTGATGTC CTCGTGGTAC CCACCAAATC TAACTCTCTG 
GACCCTGAGA CCTTACCAAT GTGTAGCTCT GCTTTGTCCT TCGATGCAGT CAGCACCCTG 
CGGGGAGAAG TCTTGTTCTT TAAAGACAGG CACTTTTGGC GAAAATCTCT CAGGACCCCT 
GAGCCTGGCT TTTATTTGAT CTCTTCATTT TGGCCGTCTC TTCCATCCAA CATGGATGCT 
GCATATGAAG TTACTAACAG AGACACTGTT TTCATTCTTA AAGGAAATCA GATCTGGGCT 
ATCCGAGGTC ATGAAGAGCT AGCAGGTTAT CCTAAAAGCA TTCACACTCT GGGCCTCCCT 
GAAACCGTCC AGAAGATCGA TGCAGCCATT TCTTTAAAGG ACCAAAAGAA GACGTACTTC 
TTTGTAGAGG ACAAATTCTG GAGATTTGAT GAGAAGAAAC AATCCATGGA TCCAGGATTT 
CCCAGGAAAA TAGCTGAGAA CTTTCCAGGC ATTGGCACAA AGGTGGATGC TGTCTTTGAA 
GCATTTGGGT TTCTTTACTT CTTCAGCGGA TCTTCACAGT TGGAGTTTGA TCCAAATGCA 
GGGAAAGTGA CCCACATATT GAAGAGCAAC AGCTGGTTTA ATTGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_598207.2
CDS	58..1485
Translation	MKGLPVLLWLCTAVCSSYPLHGSEEDAGMEVLQKYLENYYGLEKDVKQFTKKKDSSPVVKKIQEMQKFLGLKMTGKLDSNTMELMHKPRCGVPDVGGFSTFPGSPKWRKNHISYRIVNYTLDLPRESVDSAIERALKVWEEVTPLTFSRISEGEADIMISFAVEEHGDFIPFDGPGMVLAHAYAPGPGINGDAHFDDDERWTDDVTGTNLFLVAAHELGHSLGLFHSANAEALMYPVYKSSTDLARFHLSQDDVDGIQSLYGPPTESPDVLVVPTKSNSLDPETLPMCSSALSFDAVSTLRGEVLFFKDRHFWRKSLRTPEPGFYLISSFWPSLPSNMDAAYEVTNRDTVFILKGNQIWAIRGHEELAGYPKSIHTLGLPETVQKIDAAISLKDQKKTYFFVEDKFWRFDEKKQSMDPGFPRKIAENFPGIGTKVDAVFEAFGFLYFFSGSSQLEFDPNAGKVTHILKSNSWFNC

Target ORF information:

RefSeq Version	NM_133523.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus matrix metallopeptidase 3 (Mmp3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_133523.3

ORF Insert Sequence:

ATGAAAGGGC TCCCAGTCCT GCTGTGGCTG TGTACGGCTG TGTGCTCATC CTACCCATTG 
CATGGCAGTG AAGAAGATGC TGGCATGGAG GTTCTGCAGA AATACCTAGA AAACTACTAT 
GGTCTTGAAA AGGATGTGAA GCAGTTTACT AAGAAAAAGG ACAGTAGCCC TGTTGTCAAA 
AAAATTCAAG AAATGCAGAA GTTCCTTGGG CTGAAGATGA CAGGGAAGCT GGACTCGAAC 
ACTATGGAGC TGATGCACAA GCCCCGGTGT GGTGTTCCCG ACGTCGGTGG CTTCAGTACC 
TTTCCAGGTT CACCCAAATG GAGGAAAAAC CACATCTCCT ACAGGATTGT GAATTATACA 
CTGGATTTAC CAAGAGAGAG TGTGGATTCT GCCATTGAGA GAGCTTTGAA GGTCTGGGAG 
GAGGTGACCC CACTCACATT CTCCAGGATC TCTGAAGGAG AGGCTGACAT AATGATCTCC 
TTTGCAGTTG AAGAACATGG AGACTTTATC CCTTTTGATG GGCCTGGAAT GGTCTTGGCT 
CATGCCTATG CCCCTGGACC AGGGATTAAT GGAGATGCTC ACTTTGATGA TGATGAACGA 
TGGACAGATG ATGTCACAGG TACCAACCTA TTCCTGGTTG CTGCTCATGA ACTTGGCCAC 
TCCCTGGGTC TCTTTCACTC AGCCAATGCT GAAGCTTTGA TGTACCCAGT CTACAAGTCC 
TCCACAGACC TGGCCCGTTT CCATCTCTCT CAAGATGATG TAGATGGTAT TCAATCCCTC 
TATGGACCTC CCACAGAATC CCCTGATGTC CTCGTGGTAC CCACCAAATC TAACTCTCTG 
GACCCTGAGA CCTTACCAAT GTGTAGCTCT GCTTTGTCCT TCGATGCAGT CAGCACCCTG 
CGGGGAGAAG TCTTGTTCTT TAAAGACAGG CACTTTTGGC GAAAATCTCT CAGGACCCCT 
GAGCCTGGCT TTTATTTGAT CTCTTCATTT TGGCCGTCTC TTCCATCCAA CATGGATGCT 
GCATATGAAG TTACTAACAG AGACACTGTT TTCATTCTTA AAGGAAATCA GATCTGGGCT 
ATCCGAGGTC ATGAAGAGCT AGCAGGTTAT CCTAAAAGCA TTCACACTCT GGGCCTCCCT 
GAAACCGTCC AGAAGATCGA TGCAGCCATT TCTTTAAAGG ACCAAAAGAA GACGTACTTC 
TTTGTAGAGG ACAAATTCTG GAGATTTGAT GAGAAGAAAC AATCCATGGA TCCAGGATTT 
CCCAGGAAAA TAGCTGAGAA CTTTCCAGGC ATTGGCACAA AGGTGGATGC TGTCTTTGAA 
GCATTTGGGT TTCTTTACTT CTTCAGCGGA TCTTCACAGT TGGAGTTTGA TCCAAATGCA 
GGGAAAGTGA CCCACATATT GAAGAGCAAC AGCTGGTTTA ATTGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Exploration about changes of IL-10, NF-?B and MMP-3 in a rat model of cervical spondylosis.
Molecular immunology93184-188(2018 Jan)
Yin J,Ren K,Huang Y,Gao G,Nong L,Xu N

MiR-136 controls neurocytes apoptosis by regulating Tissue Inhibitor of Metalloproteinases-3 in spinal cord ischemic injury.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie9447-54(2017 Oct)
Jin R,Xu S,Lin X,Shen M

Autophagy Protects Advanced Glycation End Product-Induced Apoptosis and Expression of MMP-3 and MMP-13 in Rat Chondrocytes.
BioMed research international20176341919(2017)
Huang W,Ao P,Li J,Wu T,Xu L,Deng Z,Chen W,Yin C,Cheng X

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Mmp3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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