Rasgrp4 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Rasgrp4
Entrez Gene ID	170668
Full Name	RAS guanyl releasing protein 4
General protein information	Preferred Names RAS guanyl releasing protein 4 Names RAS guanyl-releasing protein 4
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q21
Summary	mast cell specific guanine exchange factor [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_130824.2	NP_570837.2	RAS guanyl-releasing protein 4

Pathways from BioSystems

Homologies

Homo sapiens (human)	RASGRP4	NP_733749.1
Canis lupus familiaris (dog)	RASGRP4	XP_005616673.1
Rattus norvegicus (Norway rat)	Rasgrp4	NP_570837.2
	RASGRP4	XP_001114059.2
Bos taurus (cattle)	RASGRP4	NP_001030456.2
Mus musculus (house mouse)	Rasgrp4	NP_001167626.1
Pan troglodytes (chimpanzee)	RASGRP4	XP_524253.2

Gene Ontology
Bibliography

Related articles in PubMed

Ras guanine nucleotide-releasing protein 4 is aberrantly expressed in the fibroblast-like synoviocytes of patients with rheumatoid arthritis and controls their proliferation.
Kono M, Yasuda S, Stevens RL, Koide H, Kurita T, Shimizu Y, Kanetsuka Y, Oku K, Bohgaki T, Amengual O, Horita T, Shimizu T, Majima T, Koike T, Atsumi T
Arthritis & rheumatology (Hoboken, N.J.)67(2)396-407(2015 Feb)

RasGRP4 regulates the expression of prostaglandin D2 in human and rat mast cell lines.
Li L, Yang Y, Stevens RL
The Journal of biological chemistry278(7)4725-9(2003 Feb)

Cloning of rat Ras guanine nucleotide releasing protein 4, and evaluation of its expression in rat mast cells and their bone marrow progenitors.
Li L, Yang Y, Stevens RL
Molecular immunology38(16-18)1283-8(2002 Sep)

RasGRP4 is a novel Ras activator isolated from acute myeloid leukemia.
Reuther GW, Lambert QT, Rebhun JF, Caligiuri MA, Quilliam LA, Der CJ
The Journal of biological chemistry277(34)30508-14(2002 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

RasGRP-4 is aberrantly expressed in fibroblast-like synoviocytes and helps regulate their growth.
Title: Ras guanine nucleotide-releasing protein 4 is aberrantly expressed in the fibroblast-like synoviocytes of patients with rheumatoid arthritis and controls their proliferation.

RasGRP4 regulates the expression of prostaglandin D2 in mast cell
Title: RasGRP4 regulates the expression of prostaglandin D2 in human and rat mast cell lines.

Cloning of Ras guanine nucleotide releasing protein 4, and evaluation of its expression in mast cells and their bone marrow progenitors.
Title: Cloning of rat Ras guanine nucleotide releasing protein 4, and evaluation of its expression in rat mast cells and their bone marrow progenitors.

The following Rasgrp4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Rasgrp4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa00493	NM_130824.2 Latest version!	Rattus norvegicus RAS guanyl releasing protein 4 (Rasgrp4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Rasgrp4 ( NM_130824.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_570837.2 Rattus norvegicus RAS guanyl releasing protein 4 (Rasgrp4), mRNA.

Price & Availability↑

CloneID	ORa00493
Clone ID Related Accession (Same CDS sequence)	NM_130824.2
Accession Version	NM_130824.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2037bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-22
Organism	Rattus norvegicus(Norway rat)
Product	RAS guanyl-releasing protein 4
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF465263.1. On Mar 15, 2007 this sequence version replaced NM_130824.1. ##Evidence-Data-START## Transcript exon combination :: AF465263.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689594, SAMEA2689599 [ECO:0000348] ##Evidence-Data-END##

ATGAACCGGA AAGACATCAA AAGGAAGTCT CATCAGGAAT GCTCTGGGAA GGCAGGAGGG 
CATGGTCGGC CGAGACAGGC CCGCCGCCAC AAGACGTGTC CCACCCCCCG GGAAATCAGC 
AAGGTCATGG CTTCCCTGAA CCTGGGCGTG CTGAGTGAGA GCAGCTGCAG TGTGGATGAG 
CTACTGGAGG AATGCATCCG GTGCTTTGAT TCAGCTGGCA GCTTACACCG AGGGGACCAC 
ATTCTCAAGA TGGTGCTTAC CATGCACAGC TGGGTGCTGC CATCCTCAGA CCTTGCCGCC 
CGCCTGCTGA CTTCGTATCA GAAGGCTGCC AAAGATGCCC GGGAGCTAAG ACAGCTACAG 
ATCTGTTACC TGGTCAGGTA CTGGCTGACC CATCACCCCG AGGTAGTGCA CCAGGAACCC 
CAGCTGGAAG CAATCATAAA CCGGTTTTGG ACCACTGTAG CTCAGGAGGG CAACATGGCC 
CAAAGGAGCC TAGGAGATGC CTCCAATCTG CTGAGTCCTG GAGGGCCCGG TCCCCCACCT 
CTCATGAGCA GCCCAGGCCT GGGCAAAAAG CGGAAAGTGT CCTTGCTGTT CGATCACCTG 
GAGACAGAGG AGCTGGCACA GCACCTTACT TACCTGGAGT TCCGGTCCTT CCAGGCCATC 
ACGCCCCAAG ACCTGCGGGG CTATGTTTTG CAGGGCTCGG TGAGAGGTTG TCCTGCTCTG 
GAAGGTTCTG TGGGTCTGAG CAACAGTGTG TCCCGCTGGG TACAGGTCAT GGTGCTGAGT 
CGTCCTGGGC CTGCGCAGCG TGCCCAGGTA CTGGACAAAT TCATTCGTGT GGCACAGAGG 
CTTCGCCAGA TGCAGAATTT CAACACGCTG ATGGCGGTCA CGGGGGGTCT GTGTCATAGC 
GCCATCTCCA GACTCAAGGA CTCCCACGTC CATCTGAGCC CTGACAGCAC TAAGGCCCTG 
CTGGAGCTGA CAGAGCTTCT CTCTTCCCAC AACAACTATG CCTACTACCG CCGCACCTGG 
GCCAGCTGCA CTGACTTCCG GCTGCCAGTA CTGGGTGTTC ACCTCAAGGA CCTGGTATCT 
CTGTATGAGG CCCATCCAGA CAGGTTGCCA GATGGCCGCC TGCACCTACC CAAGCTGAAT 
AGCCTCTATC TACGGCTGCA GGAGCTGGCA GCACTCCAGA GACAGCATCC CCCGTGCAGT 
GCCAATGAGG ACCTGCTACA CCTGCTGACG CTCTCCCTGG ATCTCTTCTA CACGGAAGAT 
GAGATCTACG AGCTTTCTTA TGCCCGGGAG CCACGTTGTC CCAAGAGTCT GCCCCTATCC 
CCCTTCAAAG CGCCTGTGGT GGTAGAGTGG GCCCATGGTG TGACGCCAAA GCCAGACAGT 
GCGACTCTGG GTCAGCATGT GGAACAGCTA GTGGAGTCCG TGTTCAAGAA CTATGACCCA 
GAAGGCCATG GCTCTATTTC TCTGGAGGAC TTTGAGAAGC TGTCAGCCAA CTTCCCCTTT 
GCCTGCCATG GGCTTCACCC ACCTCCCCGC CACGGGAGTG GCTCCTTCAG CAGAGAGGAG 
CTGACCAAGT ATCTGCTCCA TGCCAGCGCC ATCTGCTCCA AGCTGGGCCT GGCTTTCCTG 
CACGCCTTCC AGGAGGTCAC CTTCCGCAAG CCCACCTTCT GTCACAGCTG CAACGGCTTC 
GTGAGCACTG GCCCTCTCTG GGGCGTCACC AAGCGAGGCT ATCGCTGTCA GGACTGTGGG 
CTGTGTTGTC ACAGACACTG CAGGGATCAA GTGAGAGTGG AGTGTAAGAA GAGGCCAGAG 
ACTAAAGGTG ACCCGGGTCC CCCTGGCGCA CCCGGGCCAG CCACACCACT TCCTCCTACC 
GGCTGTGGCT CCGAGGAAGG TCTCTCCTAT ACACTCTCCC CGCATCTGGA GTCTGGTTGC 
CACCTTCACC ATGCTTGGAC TCAGACGGAG TCCTCACACT CTTCCTGGGA GCCAGAGATG 
GTGCCCTGCC CAGCACCAGT TTTACCATCC AAAGCTTCCT CAAAGTCCAG TGTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_570837.2
CDS	1..2037
Translation	MNRKDIKRKSHQECSGKAGGHGRPRQARRHKTCPTPREISKVMASLNLGVLSESSCSVDELLEECIRCFDSAGSLHRGDHILKMVLTMHSWVLPSSDLAARLLTSYQKAAKDARELRQLQICYLVRYWLTHHPEVVHQEPQLEAIINRFWTTVAQEGNMAQRSLGDASNLLSPGGPGPPPLMSSPGLGKKRKVSLLFDHLETEELAQHLTYLEFRSFQAITPQDLRGYVLQGSVRGCPALEGSVGLSNSVSRWVQVMVLSRPGPAQRAQVLDKFIRVAQRLRQMQNFNTLMAVTGGLCHSAISRLKDSHVHLSPDSTKALLELTELLSSHNNYAYYRRTWASCTDFRLPVLGVHLKDLVSLYEAHPDRLPDGRLHLPKLNSLYLRLQELAALQRQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPRCPKSLPLSPFKAPVVVEWAHGVTPKPDSATLGQHVEQLVESVFKNYDPEGHGSISLEDFEKLSANFPFACHGLHPPPRHGSGSFSREELTKYLLHASAICSKLGLAFLHAFQEVTFRKPTFCHSCNGFVSTGPLWGVTKRGYRCQDCGLCCHRHCRDQVRVECKKRPETKGDPGPPGAPGPATPLPPTGCGSEEGLSYTLSPHLESGCHLHHAWTQTESSHSSWEPEMVPCPAPVLPSKASSKSSV

Target ORF information:

RefSeq Version	NM_130824.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus RAS guanyl releasing protein 4 (Rasgrp4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_130824.2

ORF Insert Sequence:

ATGAACCGGA AAGACATCAA AAGGAAGTCT CATCAGGAAT GCTCTGGGAA GGCAGGAGGG 
CATGGTCGGC CGAGACAGGC CCGCCGCCAC AAGACGTGTC CCACCCCCCG GGAAATCAGC 
AAGGTCATGG CTTCCCTGAA CCTGGGCGTG CTGAGTGAGA GCAGCTGCAG TGTGGATGAG 
CTACTGGAGG AATGCATCCG GTGCTTTGAT TCAGCTGGCA GCTTACACCG AGGGGACCAC 
ATTCTCAAGA TGGTGCTTAC CATGCACAGC TGGGTGCTGC CATCCTCAGA CCTTGCCGCC 
CGCCTGCTGA CTTCGTATCA GAAGGCTGCC AAAGATGCCC GGGAGCTAAG ACAGCTACAG 
ATCTGTTACC TGGTCAGGTA CTGGCTGACC CATCACCCCG AGGTAGTGCA CCAGGAACCC 
CAGCTGGAAG CAATCATAAA CCGGTTTTGG ACCACTGTAG CTCAGGAGGG CAACATGGCC 
CAAAGGAGCC TAGGAGATGC CTCCAATCTG CTGAGTCCTG GAGGGCCCGG TCCCCCACCT 
CTCATGAGCA GCCCAGGCCT GGGCAAAAAG CGGAAAGTGT CCTTGCTGTT CGATCACCTG 
GAGACAGAGG AGCTGGCACA GCACCTTACT TACCTGGAGT TCCGGTCCTT CCAGGCCATC 
ACGCCCCAAG ACCTGCGGGG CTATGTTTTG CAGGGCTCGG TGAGAGGTTG TCCTGCTCTG 
GAAGGTTCTG TGGGTCTGAG CAACAGTGTG TCCCGCTGGG TACAGGTCAT GGTGCTGAGT 
CGTCCTGGGC CTGCGCAGCG TGCCCAGGTA CTGGACAAAT TCATTCGTGT GGCACAGAGG 
CTTCGCCAGA TGCAGAATTT CAACACGCTG ATGGCGGTCA CGGGGGGTCT GTGTCATAGC 
GCCATCTCCA GACTCAAGGA CTCCCACGTC CATCTGAGCC CTGACAGCAC TAAGGCCCTG 
CTGGAGCTGA CAGAGCTTCT CTCTTCCCAC AACAACTATG CCTACTACCG CCGCACCTGG 
GCCAGCTGCA CTGACTTCCG GCTGCCAGTA CTGGGTGTTC ACCTCAAGGA CCTGGTATCT 
CTGTATGAGG CCCATCCAGA CAGGTTGCCA GATGGCCGCC TGCACCTACC CAAGCTGAAT 
AGCCTCTATC TACGGCTGCA GGAGCTGGCA GCACTCCAGA GACAGCATCC CCCGTGCAGT 
GCCAATGAGG ACCTGCTACA CCTGCTGACG CTCTCCCTGG ATCTCTTCTA CACGGAAGAT 
GAGATCTACG AGCTTTCTTA TGCCCGGGAG CCACGTTGTC CCAAGAGTCT GCCCCTATCC 
CCCTTCAAAG CGCCTGTGGT GGTAGAGTGG GCCCATGGTG TGACGCCAAA GCCAGACAGT 
GCGACTCTGG GTCAGCATGT GGAACAGCTA GTGGAGTCCG TGTTCAAGAA CTATGACCCA 
GAAGGCCATG GCTCTATTTC TCTGGAGGAC TTTGAGAAGC TGTCAGCCAA CTTCCCCTTT 
GCCTGCCATG GGCTTCACCC ACCTCCCCGC CACGGGAGTG GCTCCTTCAG CAGAGAGGAG 
CTGACCAAGT ATCTGCTCCA TGCCAGCGCC ATCTGCTCCA AGCTGGGCCT GGCTTTCCTG 
CACGCCTTCC AGGAGGTCAC CTTCCGCAAG CCCACCTTCT GTCACAGCTG CAACGGCTTC 
GTGAGCACTG GCCCTCTCTG GGGCGTCACC AAGCGAGGCT ATCGCTGTCA GGACTGTGGG 
CTGTGTTGTC ACAGACACTG CAGGGATCAA GTGAGAGTGG AGTGTAAGAA GAGGCCAGAG 
ACTAAAGGTG ACCCGGGTCC CCCTGGCGCA CCCGGGCCAG CCACACCACT TCCTCCTACC 
GGCTGTGGCT CCGAGGAAGG TCTCTCCTAT ACACTCTCCC CGCATCTGGA GTCTGGTTGC 
CACCTTCACC ATGCTTGGAC TCAGACGGAG TCCTCACACT CTTCCTGGGA GCCAGAGATG 
GTGCCCTGCC CAGCACCAGT TTTACCATCC AAAGCTTCCT CAAAGTCCAG TGTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Ras guanine nucleotide-releasing protein 4 is aberrantly expressed in the fibroblast-like synoviocytes of patients with rheumatoid arthritis and controls their proliferation.
Arthritis & rheumatology (Hoboken, N.J.)67(2)396-407(2015 Feb)
Kono M,Yasuda S,Stevens RL,Koide H,Kurita T,Shimizu Y,Kanetsuka Y,Oku K,Bohgaki T,Amengual O,Horita T,Shimizu T,Majima T,Koike T,Atsumi T

RasGRP4 regulates the expression of prostaglandin D2 in human and rat mast cell lines.
The Journal of biological chemistry278(7)4725-9(2003 Feb)
Li L,Yang Y,Stevens RL

Cloning of rat Ras guanine nucleotide releasing protein 4, and evaluation of its expression in rat mast cells and their bone marrow progenitors.
Molecular immunology38(16-18)1283-8(2002 Sep)
Li L,Yang Y,Stevens RL

RasGRP4 is a novel Ras activator isolated from acute myeloid leukemia.
The Journal of biological chemistry277(34)30508-14(2002 Aug)
Reuther GW,Lambert QT,Rebhun JF,Caligiuri MA,Quilliam LA,Der CJ

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Rasgrp4 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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